Uterine fibroids in menopause and perimenopause
Uterine fibroids (UFs) are benign tumors that arise from a single genetically altered mesenchymal stem cell under the influence of gonadal hormones. UFs are the most common benign gynecologic tumors in premenopausal women worldwide. It is estimated that nearly 70% to 80% of women will develop UFs at some point during their lifetime. UFs often present with abnormal uterine bleeding (AUB), pelvic fullness, and may have deleterious effects on fertility. The natural regression of UFs begins in menopause. This is, however, a generality as this pathology may still be present in this age group. Many clinicians are concerned about...
Source: Menopause - January 31, 2020 Category: OBGYN Tags: Clinical Corner: Invited Review Source Type: research

Association between physical activity, cardiorespiratory fitness, and body composition with menopausal symptoms in early postmenopausal women
Conclusion: Reducing sitting time, improving VO2max, decreasing WHR, and exercise can be recommended by priority to alleviate menopausal symptoms. Considering the small number of participants in this investigation, future studies are, however, recommended. (Source: Menopause)
Source: Menopause - January 31, 2020 Category: OBGYN Tags: Original Studies Source Type: research

Genetic polymorphisms in collagen-related genes are associated with pelvic organ prolapse
Conclusion: We are the first to evaluate the relationship between COL14A1, COL5A1, and COL4A2 polymorphisms and POP, besides COL3A1, COL1A1, and COL18A1, which have been reported previously. We found several candidate SNPs that were significantly associated with prolapse in Chinese women. Our results provide new evidence for further investigation of the involvement of these potential genes in the etiology of POP. (Source: Menopause)
Source: Menopause - January 31, 2020 Category: OBGYN Tags: Original Studies Source Type: research

Duration of reproductive years and time since menopause were associated with metabolic syndrome in postmenopausal parous women of Chinese ancestry
Conclusions: Longer duration of reproductive years and time since menopause were associated with higher prevalence of metabolic syndrome in postmenopausal parous women from Southeast China. (Source: Menopause)
Source: Menopause - January 31, 2020 Category: OBGYN Tags: Original Studies Source Type: research

Structural equation model analysis for the evaluation of factors associated with overweight and obesity in menopausal women in RaNCD cohort study
Conclusions: The direct and indirect effects of well-known risk factors associated with overweight and obesity were found to be different in pre/perimenopausal and menopausal groups. Some risk factors showed stronger effects among menopausal women compared with the pre/perimenopausal women. Physical activity and healthy dietary pattern had a mediator impact in the two study groups. (Source: Menopause)
Source: Menopause - January 31, 2020 Category: OBGYN Tags: Original Studies Source Type: research

Twelve weeks of resistance band exercise training improves age-associated hormonal decline, blood pressure, and body composition in postmenopausal women with stage 1 hypertension: a randomized clinical trial
Objective: Menopause is often accompanied by an age-associated hormonal decline, increased blood pressure (BP), and poor body composition, which may collectively increase risks for cardiovascular disease. It is important to combat the negative effects on age-associated hormonal decline, BP, and body composition by incorporating appropriate lifestyle interventions, such as exercise. We sought to examine the effects of a 12-week resistance band exercise training program on aging-related hormones including estradiol, growth hormone (GH), insulin-like growth factor-1 (IGF-1), and dehydroepiandrosterone sulfate (DHEA-S), BP, ...
Source: Menopause - January 31, 2020 Category: OBGYN Tags: Original Studies Source Type: research

Impact of evening primrose oil consumption on psychological symptoms of postmenopausal women: a randomized double-blinded placebo-controlled clinical trial
Objective: The purpose of this study was to determine the efficacy and safety of evening primrose oil on women's psychological symptoms during menopause. Methods: A double-blinded randomized placebo-controlled trial carried out from September 2018 to February 2019 in Bandar Abbas, Iran. Eligible women randomly received either 1,000 mg of evening primrose oil capsules daily or matching placebo for 8 weeks. The Main outcome measures were psychological symptoms based on the psychological subscale of the Menopause Rating Scale. Independent samples t test was used for intergroup comparisons and paired samples t test for ...
Source: Menopause - January 31, 2020 Category: OBGYN Tags: Original Studies Source Type: research

Association of circulating Progesterone Receptor Membrane Component-1 (PGRMC1) with breast tumor characteristics and comparison with known tumor markers
Objectives: Progesterone receptor membrane component-1 (PGRMC1) expressed in breast cancer tissue has been suggested to predict a worse prognosis. The aim of this study was to assess for the first time if blood concentrations of PGRMC1 are also associated with receptor status, tumor diameter, grading, and lymphatic status. The second aim was comparison with known tumor markers. Methods: A total of 372 women, including 278 patients with invasive breast cancer, 65 with benign breast disease, and 29 healthy women (control), were recruited. PGRMC1 blood concentrations were measured by a recently developed enzyme-linked im...
Source: Menopause - January 31, 2020 Category: OBGYN Tags: Original Studies Source Type: research

Cerebral and peripheral vascular differences between pre- and postmenopausal women
Objective: Menopause is associated with lower peripheral vascular function; however, cerebrovascular responses to this time-period are unclear. We aimed to describe peripheral vascular and cerebrovascular differences between pre- and postmenopausal women. Methods: Fifty pre- and postmenopausal women (N = 100) underwent assessments of cerebral blood flow; cerebrovascular reactivity and autoregulation; carotid artery reactivity; brachial and femoral artery flow-mediated dilation; and carotid, brachial, and femoral artery intima-media thickness. Comparisons were made between pre- and postmenopausal women followed by ...
Source: Menopause - January 31, 2020 Category: OBGYN Tags: Original Studies Source Type: research

Ultralow 0.03 mg vaginal estriol in postmenopausal women who underwent surgical treatment for stress urinary incontinence: effects on quality of life and sexual function
Conclusions: Ultralow-dose topical vaginal ovules containing 0.03 mg estriol administrated before and after TOT placement could improve the vaginal epithelium maturation of postmenopausal women affected by SUI. Moreover, vaginal estriol ovules also improved the surgical outcome investigated by SF-36 and FSFI. (Source: Menopause)
Source: Menopause - January 31, 2020 Category: OBGYN Tags: Original Studies Source Type: research

Does preventive oophorectomy increase the risk of depression in BRCA mutation carriers?
Conclusions: Although based on a small number of women, these findings suggest that oophorectomy does not increase psychological distress among women at an elevated risk of ovarian cancer. (Source: Menopause)
Source: Menopause - January 31, 2020 Category: OBGYN Tags: Original Studies Source Type: research

Physical characteristics and properties of estradiol softgel vaginal inserts
Conclusions: The presented data support rapid dissolution of the softgel capsule and similar E2 pharmacokinetic parameters regardless of body position after dosing. (Source: Menopause)
Source: Menopause - January 31, 2020 Category: OBGYN Tags: Original Studies Source Type: research

Biocompatibility and zinc release testing of a zinc-containing vaginal gel
Conclusions: The zinc-containing (20 μM) vaginal gel was not toxic. The release of zinc is rapid from the vaginal gel. Zinc permeated rapidly through the vaginal epithelial cell layers. (Source: Menopause)
Source: Menopause - January 31, 2020 Category: OBGYN Tags: Original Studies Source Type: research

Prevalence of depression and anxiety in women newly diagnosed with vulvovaginal atrophy and dyspareunia
Objective: To quantify the association between vulvovaginal atrophy and depression, major depressive disorder, and anxiety. Methods: Women with vulvovaginal atrophy from the Truven Health MarketScan Commercial and Medicare Supplemental Databases (01/2010-09/2016) with ≥365 days of continuous insurance coverage before and after the first vulvovaginal atrophy/dyspareunia diagnosis (index date) were selected. Women with vulvovaginal atrophy were matched 1:3 to women without (controls) according to age, calendar year, health plan, and region. The study period spanned from 12 months before to 12 months after index date....
Source: Menopause - January 31, 2020 Category: OBGYN Tags: Original Studies Source Type: research

Daily luteal serum and urinary hormone profiles in the menopause transition: Study of Women's Health Across the Nation
Conclusions: Urine and serum hormones maintain a close relationship in women into their sixth decade of life. Serum luteal P was weakly reflective of luteal Pdg excretion. (Source: Menopause)
Source: Menopause - January 31, 2020 Category: OBGYN Tags: Original Studies Source Type: research

Depression, anxiety, and “the incredible shrinking vagina”*
No abstract available (Source: Menopause)
Source: Menopause - January 31, 2020 Category: OBGYN Tags: Editorials Source Type: research

Chronicling of female endocrinology -from “waltz” to the “tango” of transition
No abstract available (Source: Menopause)
Source: Menopause - January 31, 2020 Category: OBGYN Tags: Editorials Source Type: research

Association between soft drink consumption and osteoporotic fractures among postmenopausal women: the Women's Health Initiative: Erratum
No abstract available (Source: Menopause)
Source: Menopause - January 1, 2020 Category: OBGYN Tags: Errata Source Type: research

Age at natural menopause and physical functioning in postmenopausal women: the Canadian Longitudinal Study on Aging: Erratum
No abstract available (Source: Menopause)
Source: Menopause - January 1, 2020 Category: OBGYN Tags: Errata Source Type: research

In Reply
No abstract available (Source: Menopause)
Source: Menopause - January 1, 2020 Category: OBGYN Tags: Letters to the Editor Source Type: research

To the Editor
No abstract available (Source: Menopause)
Source: Menopause - January 1, 2020 Category: OBGYN Tags: Letters to the Editor Source Type: research

Association between soft drink consumption and osteoporotic fractures among postmenopausal women: the Women's Health Initiative: Erratum
No abstract available (Source: Menopause)
Source: Menopause - January 1, 2020 Category: OBGYN Tags: Errata Source Type: research

Age at natural menopause and physical functioning in postmenopausal women: the Canadian Longitudinal Study on Aging: Erratum
No abstract available (Source: Menopause)
Source: Menopause - January 1, 2020 Category: OBGYN Tags: Errata Source Type: research

Education level and breast cancer incidence: a meta-analysis of cohort studies
Conclusions: A higher education level may be associated with an increased risk of developing breast cancer, in which alcohol use, age at menopause, and hormone therapy may, at least partially, play a mediating role. (Source: Menopause)
Source: Menopause - January 1, 2020 Category: OBGYN Tags: Review Article Source Type: research

Supplemental screening in the dense breast: does molecular breast imaging have a role?
With the passage of a 2019 US federal law directing FDA to ensure that mammography facilities provide a summary to patients categorizing their breast density and explaining how it can influence mammography accuracy, providers will increasingly be called on to discuss the options for supplemental screening. Numerous studies have elucidated the extent of masking that occurs with mammography screening in dense breasts when mammography is compared with other supplemental screening modalities. Despite this evidence, there is currently no consensus among experts or imaging societies as to whether or with what supplemental screen...
Source: Menopause - January 1, 2020 Category: OBGYN Tags: Clinical Corner: NAMS Practice Pearl Source Type: research

Development and evaluation of an early menopause question prompt list
Conclusions: Women with EM have unmet information and communication needs, and are supportive of a comprehensive EM QPL. The EM QPL was perceived as an acceptable and feasible resource for women to use during medical consultations. Video Summary:http://links.lww.com/MENO/A484. (Source: Menopause)
Source: Menopause - January 1, 2020 Category: OBGYN Tags: Original Studies Source Type: research

Randomized crossover study investigating resident retention of menopause-related knowledge after completion of learning modules
Objective: The aim of this study was to evaluate residents’ retention of menopause-based knowledge immediately after, and 3 months after completion of, self-administered modules that varied by menopause-related topic and delivery format. Methods: Prospective crossover study of Obstetrics and Gynecology and Family Medicine residents at one institution over the 2017 to 2018 academic year. Residents were randomized to a series of three PowerPoints (Microsoft, Redwood, WA), each (Source: Menopause)
Source: Menopause - January 1, 2020 Category: OBGYN Tags: Original Studies Source Type: research

Comparison of anthropometric indices for the screening of nonalcoholic fatty liver disease in pre- and postmenopausal women
Conclusions: In premenopausal women, BMI, WC, and WHR hold similar potential in predicting the risk of NAFLD, whereas, in postmenopausal women, WHR is the most useful discriminative indicator for NAFLD. Women's optimal cutoff values for NAFLD were different according to menopausal status. (Source: Menopause)
Source: Menopause - January 1, 2020 Category: OBGYN Tags: Original Studies Source Type: research

Menopausal hormone therapy for BRCA-mutation carriers: attitudes of Israeli healthcare providers before and after a brief educational intervention
Objective: BRCA-mutation carriers are offered risk-reducing bilateral salpingo-oophorectomy (RRBSO) at age 35 to 40 years, leading to major life-quality and health-related issues associated with early menopause. Hormone therapy (HT) may significantly alleviate menopausal symptoms without increasing breast or ovarian cancer risk in BRCA carriers. We investigated attitudes of Israeli healthcare providers to HT post-RRBSO in BRCA carriers, before and after a brief educational intervention. Methods: In this pre-post survey of gynecologic departments in Israel, healthcare providers were given questionnaires (based on score...
Source: Menopause - January 1, 2020 Category: OBGYN Tags: Original Studies Source Type: research

Comparing written and verbal delivery of a treatment regimen to women with overactive bladder: a randomized controlled trial
Conclusions: A written list of recommendations is a quality improvement initiative that can improve overactive bladder participants’ immediate retention of a suggested treatment regimen, but lacks impact 2 weeks later. (Source: Menopause)
Source: Menopause - January 1, 2020 Category: OBGYN Tags: Original Studies Source Type: research

Prevalence and correlates of early-onset menopause among women living with HIV in Canada
Objective: Menopause is a pivotal transition for women. Previous studies have suggested increased risk of early menopause (40-45 years) and premature menopause ( (Source: Menopause)
Source: Menopause - January 1, 2020 Category: OBGYN Tags: Original Studies Source Type: research

Retrospective analysis of phytoSERM for management of menopause-associated vasomotor symptoms and cognitive decline: a pilot study on pharmacogenomic effects of mitochondrial haplogroup and APOE genotype on therapeutic efficacy
Conclusion: Our data support a precision medicine approach for further development of PhytoSERM as a safe and effective alternative to hormone therapy for menopause-associated hot flash and cognitive decline. While definitive determination of PhytoSERM efficacy is limited by the small sample size, these data provide a reasonable rationale to extend analyses to a larger study set powered to address statistical significance. (Source: Menopause)
Source: Menopause - January 1, 2020 Category: OBGYN Tags: Original Studies Source Type: research

A randomized clinical trial comparing vaginal laser therapy to vaginal estrogen therapy in women with genitourinary syndrome of menopause: The VeLVET Trial
Conclusions: At 6 months, fractionated CO2 vaginal laser and vaginal estrogen treatment resulted in similar improvement in genitourinary syndrome of menopause symptoms as well as urinary and sexual function. Overall, 70% to 80% of participants were satisfied or very satisfied with either treatment and there were no serious adverse events. Video Summary:http://links.lww.com/MENO/A470. (Source: Menopause)
Source: Menopause - January 1, 2020 Category: OBGYN Tags: Original Studies Source Type: research

Efficacy of fractional CO2 laser treatment in postmenopausal women with genitourinary syndrome: a multicenter study
Objective: Genitourinary syndrome of menopause (GSM), especially vulvovaginal atrophy (VVA), is one of the most common conditions among women in either natural (4%-47%) or medically induced (23.4%-61.5%) menopause. The aims of this study are to assess the efficacy and effectiveness of CO2 laser in postmenopausal women with clinical signs and symptoms of GSM, in particular VVA, and to evaluate both possible early and late side effects related to this kind of treatment. Methods: This retrospective, multicenter study was conducted after collecting data from a pre-existing database. We performed three to four CO2 laser tr...
Source: Menopause - January 1, 2020 Category: OBGYN Tags: Original Studies Source Type: research

Long-term risk of de novo mental health conditions after hysterectomy with ovarian conservation: a cohort study
Conclusions: Hysterectomy, even with ovarian conservation, is associated with an increased long-term risk of de novo depression and anxiety, especially when performed in women who are younger. Video Summary:http://links.lww.com/MENO/A465. (Source: Menopause)
Source: Menopause - January 1, 2020 Category: OBGYN Tags: Original Studies Source Type: research

Exploring factors that impact uptake of risk-reducing bilateral salpingo-oophorectomy (RRBSO) in high-risk women
Conclusions: Concerns about surgical menopause and loss of fertility are barriers to RRBSO for high-risk women despite understanding the benefits of reduced cancer risk. There is an unmet need for more information about effectively managing the noncancer consequences of RRBSO in premenopausal women. Video Summary:http://links.lww.com/MENO/A478. (Source: Menopause)
Source: Menopause - January 1, 2020 Category: OBGYN Tags: Original Studies Source Type: research

What information do healthcare professionals need to inform premenopausal women about risk-reducing salpingo-oophorectomy?
Conclusions: There is uncertainty around the roles and responsibilities of healthcare professionals managing high-risk women around RRBSO. Surgical menopause is perceived as a major barrier to RRBSO and healthcare professionals lack confidence in managing this outcome. Video Summary:http://links.lww.com/MENO/A477. (Source: Menopause)
Source: Menopause - January 1, 2020 Category: OBGYN Tags: Original Studies Source Type: research

Female sexuality and vaginal health across the menopausal age
Objective: The primary aim was to evaluate changes in female sexuality across the menopausal period, and the secondary objective was to test the associations of female sexuality domains with vaginal atrophy and its symptoms. Methods: A cross-sectional multicenter study was performed involving 518 women, 40 to 55 years of age, consulting outpatient gynecological services at 30 centers across Italy. Vaginal atrophy was identified by the contemporaneous presence of a pH>5, subjective vaginal dryness, and an objective sign. The relationships between vaginal atrophy and its main symptoms (vaginal dryness and dyspareunia...
Source: Menopause - January 1, 2020 Category: OBGYN Tags: Original Studies Source Type: research

Monthly variation of hot flashes, night sweats, and trouble sleeping: effect of season and proximity to the final menstrual period (FMP) in the SWAN Menstrual Calendar substudy
Conclusion: Menopausal symptoms exhibit seasonal variation associated with the summer and winter equinoxes. Seasonal increases in night sweats precede increases in hot flashes. Prospectively recorded monthly symptom data demonstrate that hot flashes and night sweats increase notably coincident with the FMP. Video Summary:http://links.lww.com/MENO/A476. (Source: Menopause)
Source: Menopause - January 1, 2020 Category: OBGYN Tags: Original Studies Source Type: research

Menopausal symptoms: continued need for counseling and clinical management
No abstract available (Source: Menopause)
Source: Menopause - January 1, 2020 Category: OBGYN Tags: Editorials Source Type: research

Seasonality and symptoms
No abstract available (Source: Menopause)
Source: Menopause - January 1, 2020 Category: OBGYN Tags: Editorials Source Type: research

Subject Index
No abstract available (Source: Menopause)
Source: Menopause - December 1, 2019 Category: OBGYN Tags: Index Source Type: research

Author Index
No abstract available (Source: Menopause)
Source: Menopause - December 1, 2019 Category: OBGYN Tags: Index Source Type: research

Abstract Author Index
No abstract available (Source: Menopause)
Source: Menopause - December 1, 2019 Category: OBGYN Tags: Abstracts Source Type: research

30th Annual Meeting of The North America Menopause Society September 25 – 28, 2019, Chicago, IL
No abstract available (Source: Menopause)
Source: Menopause - December 1, 2019 Category: OBGYN Tags: Abstracts Source Type: research

Acknowledgment of Reviewers
No abstract available (Source: Menopause)
Source: Menopause - December 1, 2019 Category: OBGYN Tags: Acknowledgment of Reviewers Source Type: research

To the Editor
No abstract available (Source: Menopause)
Source: Menopause - December 1, 2019 Category: OBGYN Tags: Letter to the Editor Source Type: research

Critical analysis of methods for assessing genitourinary syndrome of menopause used in clinical trials
Conclusions: Despite the heterogeneity observed, particularly for subjective assessment of symptoms, there was a tendency to standardize methods and to use an objective method together with a subjective, which seems to be fundamental to guarantee reproducibility and comparability of results of each treatment analyzed. Histological and immunohistochemistry tests may be an option as an objective method in further studies, to better assess thickness, vascularization, among other parameters. (Source: Menopause)
Source: Menopause - December 1, 2019 Category: OBGYN Tags: Clinical Corner: Review Article Source Type: research

Statin therapy: does sex matter?
Conclusions: Many of the trials that have established the efficacy and safety of statins were conducted predominantly or entirely in men, with results extrapolated to women. Additional research is needed to guide clinical recommendations specific to women. Video Summary:http://links.lww.com/MENO/A462. (Source: Menopause)
Source: Menopause - December 1, 2019 Category: OBGYN Tags: Clinical Corner: Invited Review Source Type: research

FADS1 and FADS2 polymorphism are associated with changes in fatty acid concentrations after calorie-restricted Central European and Mediterranean diets
Objective: In the present study, we tested whether calorie-restricted diets differing in their percentage of energy derived from monounsaturated fatty acids and carbohydrates can affect the metabolism of fatty acids (FAs) in postmenopausal women. Moreover, we examined whether polymorphisms of FADS1 and FADS2 are associated with these changes. Methods: Postmenopausal women (the mean age: 60.5 ± 5.0 y) were randomized for 16 weeks to two different calorie-restricted diets: a Central European diet (CED) or a Mediterranean diet (MED). Results: After the intervention, levels of most FAs in red blood cells decreas...
Source: Menopause - December 1, 2019 Category: OBGYN Tags: Original Articles Source Type: research