Risk factors for future osteoporosis in perimenopausal Japanese women
Conclusions
We have identified a cutoff value for BMD to predict future osteoporosis in menopausal women and found a negative correlation between WT and BMI in menopausal women and changes in BMD of the FN over the next 10 years. (Source: Menopause)
Source: Menopause - September 30, 2022 Category: OBGYN Tags: Original Studies Source Type: research
Endometrial microbiota from endometrial cancer and paired pericancer tissues in postmenopausal women: differences and clinical relevance
Objective
The incidence of postmenopausal endometrial cancer (EC) is rising, and the uterine microbiota has recently been suggested to be an etiology of EC. However, the differences in microbiota profiles in paired EC and the adjacent non-EC endometrium, and the functional microbiota of clinical relevance remain largely unknown. Therefore, we examined the differences in microbiota profiles between EC and non-EC endometrium and investigated their clinical relevance to EC.
Methods
Twenty-eight EC-affected postmenopausal women undergoing hysterectomy were enrolled. Endometrial microbiome from paired EC and adjacent...
Source: Menopause - September 30, 2022 Category: OBGYN Tags: Original Studies Source Type: research
Association of lifetime lactation and age at natural menopause: a prospective cohort study
Conclusions
Duration of lifetime lactation was not associated with age at natural menopause after controlling for sociodemographic characteristics. (Source: Menopause)
Source: Menopause - September 30, 2022 Category: OBGYN Tags: Original Studies Source Type: research
Long-term changes in plasma proteomic profiles in premenopausal and postmenopausal Black and White women: the Atherosclerosis Risk in Communities study
Conclusions
We observed significantly different changes between premenopausal and postmenopausal women in several plasma proteins that reflect many biological processes. These processes may help to understand disease development during the postmenopausal period. (Source: Menopause)
Source: Menopause - September 30, 2022 Category: OBGYN Tags: Original Studies Source Type: research
Menopausal vasomotor symptoms and adiponectin among midlife women
Conclusions
Physiologic VMS were associated with lower adiponectin after considering potential confounders. The role of adipokines in VMS and in links between VMS and health warrants further attention. (Source: Menopause)
Source: Menopause - September 30, 2022 Category: OBGYN Tags: Original Studies Source Type: research
Association between lower parity and low muscle mass in postmenopausal women: data from KNHANES (2010-2011)
This study aimed to investigate whether parity is associated with the prevalence of low muscle mass in postmenopausal women.
Methods
This study was performed using data from the 2010-2011 Korean National Health and Nutrition Examination Survey, which included 1,338 postmenopausal women aged 46 to 70 years. The association between parity and low muscle mass was analyzed after adjusting parity, multiparity, age, body mass index, diabetes mellitus, education level, and Homeostatic Model Assessment of Insulin Resistance and using weighted multiple logistic regression analysis. Modifiable risk factors were evaluated in a...
Source: Menopause - September 30, 2022 Category: OBGYN Tags: Original Studies Source Type: research
Self-reported menstrual cycle length during reproductive years in relation to menopausal symptoms at midlife in Project Viva
Conclusions
Compared with women with normal menstrual cycle length, those with short menstrual cycles during their reproductive years had a higher frequency of total and certain menopausal symptoms at midlife and reached menopause earlier. (Source: Menopause)
Source: Menopause - September 30, 2022 Category: OBGYN Tags: Original Studies Source Type: research
Perception of higher frequency of daily hot flashes in 50-year-old women today: a study of trends over time during 48 years in the Population Study of Women in Gothenburg, Sweden
Conclusions
In this prospective longitudinal study of 50-year-old women, we found nearly twice as high odds of reporting daily hot flashes in the later-born women compared with earlier-born. When controlling for potential predictors, there was still an obvious difference, which cannot be explained in our study. These findings have not earlier been described, and there is a need for further longitudinal population studies investigating the prevalence of hot flashes over time. Moreover, additional research is required exploring the underlying mechanism of hot flashes, as well as studies that take into account potential r...
Source: Menopause - September 30, 2022 Category: OBGYN Tags: Original Studies Source Type: research
A lifetime approach to disease manifestation
No abstract available (Source: Menopause)
Source: Menopause - September 30, 2022 Category: OBGYN Tags: Editorials Source Type: research
Short cycles: more menopause symptoms during transition
No abstract available (Source: Menopause)
Source: Menopause - September 30, 2022 Category: OBGYN Tags: Editorials Source Type: research
Increasing vasomotor symptoms: did your great grandmother really not feel them?
No abstract available (Source: Menopause)
Source: Menopause - September 30, 2022 Category: OBGYN Tags: Editorials Source Type: research
Potential effects of virtual interventions for menopause management: a systematic review
Conclusions and Relevance
Virtual interventions might have the potential to improve the physical and psychosocial health outcomes of menopausal women, although some conflicting findings arose. Future studies should focus on including diverse menopausal women and ethnic minorities, conducting research within low- to middle-income countries and communities, further exploring intervention design to incorporate features that are age and culture sensitive, and conducting full randomized controlled trials to evaluate the effects of the interventions. (Source: Menopause)
Source: Menopause - August 31, 2022 Category: OBGYN Tags: Review Articles Source Type: research
Gonadotropin-releasing hormone agonists for ovarian protection during breast cancer chemotherapy: a systematic review and meta-analysis
Importance
The increasing trend of delaying childbirth means that more women are being diagnosed with breast cancer before having given birth to their desired number of children. Although chemotherapy can significantly improve the prognosis of this population, it also causes ovarian damage, including premature ovarian insufficiency and infertility. Gonadotropin-releasing hormone agonists (GnRHa) have shown promising fertility protective activity in premenopausal women, but their clinical usage remains controversial.
Objective
Here, we conducted a meta-analysis to assess the efficacy of GnRHa when administered co...
Source: Menopause - August 31, 2022 Category: OBGYN Tags: Review Articles Source Type: research
Estrogen therapy and breast cancer in randomized clinical trials: a narrative review
Conclusions
Consideration of the smaller randomized trials evaluating estrogen alone with breast cancer signals that the WHI findings of lower breast cancer incidence and lower breast cancer mortality with CEE-alone use are not a “stand-alone” outcome or due to the play of chance. The serial reports of consistent favorable breast cancer findings through 20 years of cumulative follow-up suggest CEE-alone use initiates changes that persist. After full consideration of risks and benefits, randomized trial evidence provides reassurance for postmenopausal women with prior hysterectomy who are close to menopause consider...
Source: Menopause - August 31, 2022 Category: OBGYN Tags: Review Articles Source Type: research
Clinical management of hypoactive sexual desire disorder in postmenopausal women
Approximately 10% to 12% of women meet the criteria for hypoactive sexual desire disorder, with the highest prevalence in midlife women, ranging from 14.5% to 33%. Despite the negative effect on health and quality of life, most women are reluctant to discuss sexual concerns with healthcare professionals. Although healthcare professionals have the best opportunities to address these problems, most of them have limited awareness, education, and comfort about addressing sexual concerns, resulting in a conspiracy of silence. The purpose of this Practice Pearl is to improve the understanding of hypoactive sexual desire disorder...
Source: Menopause - August 31, 2022 Category: OBGYN Tags: Clinical Corner: NAMS Practice Pearl Source Type: research
