Pelvic organ prolapse: from estrogen to pessary
No abstract available (Source: Menopause)
Source: Menopause - January 29, 2019 Category: OBGYN Tags: Editorials Source Type: research

The unintended sexual health consequences of risk-reducing surgery: we must do more!
No abstract available (Source: Menopause)
Source: Menopause - January 29, 2019 Category: OBGYN Tags: Editorials Source Type: research

The WISDOM survey: toward wiser care of women with vulvovaginal atrophy
No abstract available (Source: Menopause)
Source: Menopause - January 29, 2019 Category: OBGYN Tags: Editorials Source Type: research

To the Editor
No abstract available (Source: Menopause)
Source: Menopause - December 28, 2018 Category: OBGYN Tags: Letters to the Editor Source Type: research

In Reply
No abstract available (Source: Menopause)
Source: Menopause - December 28, 2018 Category: OBGYN Tags: Letters to the Editor Source Type: research

To the Editor
No abstract available (Source: Menopause)
Source: Menopause - December 28, 2018 Category: OBGYN Tags: Letters to the Editor Source Type: research

The mysteries of menopause and urogynecologic health: clinical and scientific gaps
Conclusions: Innovative human studies, focused on the independent effects of menopausal estrogen levels, uncoupled from tissue and cellular senescence, are needed. (Source: Menopause)
Source: Menopause - December 28, 2018 Category: OBGYN Tags: Clinical Corner: Invited Review Source Type: research

Association between metabolic profiles in urine and bone mineral density of pre- and postmenopausal Chinese women
Conclusions: Based on the GC–MS metabolomic platform, four typical pathological phases during the progression of postmenopausal osteoporosis were described. Several differentiating metabolites and metabolic pathways were found to be closely related to the pathology of postmenopausal osteoporosis. Our results provided a solid foundation for further studies on early diagnosis and pathomechanistic evaluation. (Source: Menopause)
Source: Menopause - December 28, 2018 Category: OBGYN Tags: Original Articles Source Type: research

Serum androgen profiles in women with premature ovarian insufficiency: a systematic review and meta-analysis
Objective: This meta-analysis aims to investigate serum androgen profiles (testosterone, dehydroepiandrosterone sulfate, androstenedione, and sex hormone-binding globulin) in women with premature ovarian failure and to establish if there is evidence of diminished androgen levels in these women. Methods: Various Internet sources of PubMed, Cochrane library, and Medline were searched systematically until February, 2018. Out of a pool of 2,461 studies, after applying the inclusion/exclusion criterion, 14, 8, 10, and 9 studies were chosen for testosterone, dehydroepiandrosterone sulfate, androstenedione, and sex hormone-b...
Source: Menopause - December 28, 2018 Category: OBGYN Tags: Original Articles Source Type: research

The histological microstructure and in vitro mechanical properties of the human female postmenopausal perineal body
Conclusions: We determined the structural and mechanical parameters of the perineal body. The resultant data could be used as input for models simulating pelvic floor prolapse or dysfunction. (Source: Menopause)
Source: Menopause - December 28, 2018 Category: OBGYN Tags: Original Articles Source Type: research

The many menopauses: searching the cognitive research literature for menopause types
Conclusions: This review revealed that although some clinical studies differentiated between the many menopauses, most did not. This may limit their relevance to clinical practice. We found that when menopause types are distinguished, the differing cognitive outcomes of each type are clarified, yielding the strongest evidence, which in turn will be able to inform best clinical practice for treating all women. (Source: Menopause)
Source: Menopause - December 28, 2018 Category: OBGYN Tags: Original Articles Source Type: research

Difference in carotid intima-media thickness between pre and postmenopausal women
Conclusions: Our findings indicate that postmenopausal status is a significant factor of high mean CIMT. These findings add to the growing evidence showing that menopause transition is a critical period for subclinical atherosclerosis development. (Source: Menopause)
Source: Menopause - December 28, 2018 Category: OBGYN Tags: Original Articles Source Type: research

A prospective study of inflammatory biomarker levels and risk of early menopause
Conclusions: The observation of lower risk of early menopause among women with moderate sTNFR2 levels compared with women with lower and higher levels warrants further prospective study. (Source: Menopause)
Source: Menopause - December 28, 2018 Category: OBGYN Tags: Original Articles Source Type: research

Changes in carotid artery intima-media thickness 3 years after cessation of menopausal hormone therapy: follow-up from the Kronos Early Estrogen Prevention Study
Conclusions: Cessation of MHT at the lower doses and formulations used in KEEPS did not appear to alter the trajectory of CIMT over a 3-year follow-up period. CIMT, however, increased in all groups over the entire 7-year timeframe as expected with age and timing of menopause possibly key contributors. (Source: Menopause)
Source: Menopause - December 28, 2018 Category: OBGYN Tags: Original Articles Source Type: research

Physical activity and weight gain after smoking cessation in postmenopausal women
Conclusions: Our data demonstrate that even a modest increase in PA (equivalent to current recommendations) can attenuate weight gain after quitting smoking among postmenopausal women, especially in combination with improved diet. (Source: Menopause)
Source: Menopause - December 28, 2018 Category: OBGYN Tags: Original Articles Source Type: research

Apolipoprotein E4 genotype in combination with poor metabolic profile is associated with reduced cognitive performance in healthy postmenopausal women: implications for late onset Alzheimer's disease
Conclusions: In a general population of postmenopausal women, association between poor metabolic profile with reduction in cognitive performance is more apparent in women who carry an ApoE4 allele. These data indicate a window of opportunity for interventions to reverse the trajectory of the preclinical phase of Alzheimer's disease. (Source: Menopause)
Source: Menopause - December 28, 2018 Category: OBGYN Tags: Original Articles Source Type: research

Hormone therapy and carotid intima-media thickness: the thick and thin of it
No abstract available (Source: Menopause)
Source: Menopause - December 28, 2018 Category: OBGYN Tags: Editorials Source Type: research

Preventing postsmoking cessation weight gain: exercise helps, even if previously inactive
No abstract available (Source: Menopause)
Source: Menopause - December 28, 2018 Category: OBGYN Tags: Editorials Source Type: research

Toward a personalized lifestyle intervention approach to prevent Alzheimer's disease
No abstract available (Source: Menopause)
Source: Menopause - December 28, 2018 Category: OBGYN Tags: Editorials Source Type: research

29th Annual Meeting of The North American Menopause Society October 3-6, 2018, San Diego, CA
No abstract available (Source: Menopause)
Source: Menopause - November 29, 2018 Category: OBGYN Tags: Abstracts Source Type: research

Subject Index
No abstract available (Source: Menopause)
Source: Menopause - November 29, 2018 Category: OBGYN Tags: Index Source Type: research

Author Index
No abstract available (Source: Menopause)
Source: Menopause - November 29, 2018 Category: OBGYN Tags: Index Source Type: research

Abstract Author Index
No abstract available (Source: Menopause)
Source: Menopause - November 29, 2018 Category: OBGYN Tags: Abstracts Source Type: research

Acknowledgment of Reviewers
No abstract available (Source: Menopause)
Source: Menopause - November 29, 2018 Category: OBGYN Tags: Acknowledgment of Reviewers Source Type: research

Appropriate evaluation of postmenopausal bleeding
In clinical practice, although only 3% to 7% of women with postmenopausal bleeding (PMB) will ultimately be found to have cancer, it is the clinician's responsibility to ensure that endometrial cancer is not present. The diagnostic evaluation of PMB has evolved greatly. This Practice Pearl addresses the appropriate evaluation of women with PMB. (Source: Menopause)
Source: Menopause - November 29, 2018 Category: OBGYN Tags: Clinical Corner: NAMS Practice Pearl Source Type: research

Anxiety, depressive symptoms, and cardiac autonomic function in perimenopausal and postmenopausal women with hot flashes: a brief report
Objective: The aim of the study was to examine whether anxiety and depressive symptoms are associated with an adverse cardiac autonomic profile among midlife women with hot flashes. Methods: Anxiety and depressive symptoms were evaluated by validated self-administered questionnaires among peri- and postmenopausal women in a randomized trial of slow-paced respiration for hot flashes. Pre-ejection period (PEP), a marker of sympathetic activation, and respiratory sinus arrhythmia (RSA), a marker of parasympathetic activation, were measured at baseline and 12 weeks using impedance cardiography and electocardiography. Mult...
Source: Menopause - November 29, 2018 Category: OBGYN Tags: Brief Report Source Type: research

The naturally derived small compound Osthole inhibits osteoclastogenesis to prevent ovariectomy-induced bone loss in mice
This study was to determine the bone protective effects and underlying mechanisms of Osthole (OT) in ovariectomized (OVX) mice. We found that the inhibitory effects of OT on receptor activator of nuclear factor kappa-B ligand (RANKL)-activated osteoclastogenesis are responsible for its bone protective effects in OVX mice. Methods: Eight-week-old mice were ovariectomized and OT (10 mg/kg/d) was intraperitoneally administrated to OVX mice 7 days after the surgery and were sacrificed at the end of the 3 months. Osteoclasts were generated from primary bone marrow macrophages (BMMs) to investigate the inhibitory effects of...
Source: Menopause - November 29, 2018 Category: OBGYN Tags: Original Articles Source Type: research

Ovariectomy and obesity have equal impact in causing mitochondrial dysfunction and impaired skeletal muscle contraction in rats
Objective: Previous studies have demonstrated that either an obese-insulin resistance condition or a condition involving loss of estrogen impaired skeletal muscle function as indicated by a decrease in muscle contraction. The differing effects of combined estrogen deficiency over obese-insulin resistance on skeletal muscle function have, however, not yet been determined. Our hypothesis was that estrogen deficiency aggravates skeletal muscle dysfunction in obese-insulin resistant rats, via increased muscle oxidative stress and mitochondrial dysfunction. Methods: Twenty-four female Wistar rats were divided into 2 groups...
Source: Menopause - November 29, 2018 Category: OBGYN Tags: Original Articles Source Type: research

Effect of combined circuit exercise on arterial stiffness in hypertensive postmenopausal women: a local public health center-based pilot study
This study examined the effect of combined circuit exercise on arterial stiffness in hypertensive postmenopausal women. Furthermore, it ascertained whether performing this exercise program is feasible in local public health centers with better accessibility than research and commercial facilities. Methods: Among 24 hypertensive postmenopausal women, 16 finished this study in either the control (n = 8) or exercise (n = 8) group. Except for one participant who withdrew from the study due to the difficulty of the exercise program, seven participants withdrew due to reasons unrelated to the study. Circuit-type exerc...
Source: Menopause - November 29, 2018 Category: OBGYN Tags: Original Articles Source Type: research

Physical performance in relation to menopause status and physical activity
Objective: The aim of this study was to examine differences in physical performance (muscle power, muscle strength, aerobic capacity, and walking speed) across menopausal stages and potential of leisure physical activity (PA) to modify the impact of menopause on physical performance. Methods: In this cross-sectional study, women aged 47 to 55 were randomly selected from the Finnish National Registry and categorized as premenopausal (n = 233), perimenopausal (n = 381), or postmenopausal (n = 299) based on serum concentrations of follicle-stimulating hormone and bleeding diary. Physical performance was measu...
Source: Menopause - November 29, 2018 Category: OBGYN Tags: Original Articles Source Type: research

Postmenopausal hormone treatment alters neural pathways but does not improve verbal cognitive function
Objective: Cognitive outcomes in trials of postmenopausal hormone treatment have been inconsistent. Differing outcomes may be attributed to hormone formulation, treatment duration and timing, and differential cognitive domain effects. We previously demonstrated treatment benefits on visual cognitive function. In the present study, we describe the effects of hormone treatment on verbal outcomes in the same women, seeking to understand the effects of prior versus current hormone treatment on verbal function. Methods: This is a cross-sectional evaluation of 57 women (38 hormone users [25 prior long-term users and 13 curr...
Source: Menopause - November 29, 2018 Category: OBGYN Tags: Original Articles Source Type: research

The impact of genitourinary syndrome of menopause on well-being, functioning, and quality of life in postmenopausal women
Conclusions: Vaginal symptoms impact the well-being, functioning, and QoL of postmenopausal women, especially sexual function, self-perception, and body image. This impact is significantly higher in women with GSM. Identifying and treating patients affected by vaginal symptoms and GSM may be beneficial for improving their QoL. (Source: Menopause)
Source: Menopause - November 29, 2018 Category: OBGYN Tags: Original Articles Source Type: research

Advances in osteoporosis from 1970 to 2018
In 1970, there were no drugs under study for osteoporosis. Estrogen was used, but little was known about the correct dose for preventing bone loss. At that time, fractures were not even recognized as a disease, but regarded as part of normal aging. From 1970 to this year (2018), there have been extensive advances in the osteoporosis field ranging from fracture epidemiology to the remarkable invention of bone density measurements. There have been major advances in therapeutic options available for patients for prevention and treatment of osteoporosis. In parallel, the advances in the laboratory helped elucidate the process ...
Source: Menopause - November 29, 2018 Category: OBGYN Tags: 2018 NAMS/Pfizer – Wulf H. Utian Endowed Lecture Source Type: research

High and dry: recognizing the impact of genitourinary syndrome of menopause
No abstract available (Source: Menopause)
Source: Menopause - November 29, 2018 Category: OBGYN Tags: Editorials Source Type: research

A long and winding road: reflections on the evolution of menopause medicine over a professional lifetime
No abstract available (Source: Menopause)
Source: Menopause - November 29, 2018 Category: OBGYN Tags: Editorial Source Type: research

James H. Liu, MD, NCMP 2018-2019 NAMS President
No abstract available (Source: Menopause)
Source: Menopause - November 29, 2018 Category: OBGYN Tags: Editorials Source Type: research

Menopause Board Members: Past and Present
No abstract available (Source: Menopause)
Source: Menopause - October 25, 2018 Category: OBGYN Tags: Board Members Past and Present Source Type: research

A Selection of Notable Papers from the Past 25 Years
No abstract available (Source: Menopause)
Source: Menopause - October 25, 2018 Category: OBGYN Tags: Other Notable Papers Source Type: research

The 2017 hormone therapy position statement of The North American Menopause Society
The 2017 Hormone Therapy Position Statement of The North American Menopause Society (NAMS) updates the 2012 Hormone Therapy Position Statement of The North American Menopause Society and identifies future research needs. An Advisory Panel of clinicians and researchers expert in the field of women's health and menopause was recruited by NAMS to review the 2012 Position Statement, evaluate new literature, assess the evidence, and reach consensus on recommendations, using the level of evidence to identify the strength of recommendations and the quality of the evidence. The Panel's recommendations were reviewed and approved by...
Source: Menopause - October 25, 2018 Category: OBGYN Tags: Commemorative Papers Source Type: research

Physiologically assessed hot flashes and endothelial function among midlife women
Objective: Hot flashes are experienced by most midlife women. Emerging data indicate that they may be associated with endothelial dysfunction. No studies have tested whether hot flashes are associated with endothelial function using physiologic measures of hot flashes. We tested whether physiologically assessed hot flashes were associated with poorer endothelial function. We also considered whether age modified associations. Methods: Two hundred seventy-two nonsmoking women reporting either daily hot flashes or no hot flashes, aged 40 to 60 years, and free of clinical cardiovascular disease, underwent ambulatory physi...
Source: Menopause - October 25, 2018 Category: OBGYN Tags: Commemorative Papers Source Type: research

Efficacy of intravaginal dehydroepiandrosterone (DHEA) on moderate to severe dyspareunia and vaginal dryness, symptoms of vulvovaginal atrophy, and of the genitourinary syndrome of menopause
Objective: The aim of this study is to confirm the local beneficial effects of intravaginal dehydroepiandrosterone (DHEA, Prasterone) on moderate to severe dyspareunia or pain at sexual activity, the most frequent symptom of vulvovaginal atrophy due to menopause or genitourinary syndrome of menopause (GSM). Methods: In a prospective, randomized, double-blind, and placebo-controlled phase III clinical trial, the effect of daily intravaginal 0.50% DHEA (6.5 mg) (Prasterone, EndoCeutics) was examined on four coprimary objectives, namely percentage of parabasal cells, percentage or superficial cells, vaginal pH, and mod...
Source: Menopause - October 25, 2018 Category: OBGYN Tags: Commemorative Papers Source Type: research

Moderate to severe vasomotor and sexual symptoms remain problematic for women aged 60 to 65 years
This study aims to determine the prevalence and severity of menopausal symptoms in older postmenopausal women and, hence, the need for treatment options for women of this age. Methods: This is a cross-sectional questionnaire-based study conducted between October 2013 and March 2014 among 2,020 women aged 40 to 65 years and living independently across Australia. The main outcome measures were the prevalence of moderate to severe vasomotor symptoms (VMS), as measured by the Menopause-Specific Quality of Life Questionnaire, and the current use of prescription therapy for menopausal symptoms. Results: The prevalence of m...
Source: Menopause - October 25, 2018 Category: OBGYN Tags: Commemorative Papers Source Type: research

Association between the vaginal microbiota, menopause status, and signs of vulvovaginal atrophy
Conclusions: A distinct bacterial community state (CST IV-A) with a low relative abundance of Lactobacillus is associated with VVA. Future studies recruiting a larger number of women are needed to replicate the findings. This study provides an impetus for future longitudinal studies designed to manage, modulate, and restore vaginal microbiota homeostasis, which would provide stronger evidence for a causal relationship with VVA and ultimately improve the treatment and prevention of atrophic vaginitis in menopause. (Source: Menopause)
Source: Menopause - October 25, 2018 Category: OBGYN Tags: Commemorative Papers Source Type: research

Estrogen alone and joint symptoms in the Women's Health Initiative randomized trial
Conclusions: The current findings suggest that estrogen-alone use in postmenopausal women results in a modest but sustained reduction in the frequency of joint pain. (Source: Menopause)
Source: Menopause - October 25, 2018 Category: OBGYN Tags: Commemorative Papers Source Type: research

Evolution of postmenopausal hormone therapy between 2002 and 2009
Conclusions: Since the publication of the Women's Health Initiative results, there has been a sustained decrease in hormone therapy claims. The proportional use of low-dose oral and transdermal formulations has increased, but as of 2009, claims for these formulations accounted for approximately one in four total hormone therapy claims. (Source: Menopause)
Source: Menopause - October 25, 2018 Category: OBGYN Tags: Commemorative Papers Source Type: research

Does the route of administration for estrogen hormone therapy impact the risk of venous thromboembolism? Estradiol transdermal system versus oral estrogen-only hormone therapy
Conclusions: This large population-based study suggests that participants receiving an estradiol transdermal system have a significantly lower incidence of venous thromboembolism than do participants receiving oral estrogen-only hormone therapy. (Source: Menopause)
Source: Menopause - October 25, 2018 Category: OBGYN Tags: Commemorative Papers Source Type: research

History of hot flashes and aortic calcification among postmenopausal women
Objective: Menopausal hot flashes are considered largely a quality-of-life issue. However, emerging research also links hot flashes to cardiovascular risk. In some investigations, this risk is particularly apparent among women using hormone therapy. The aim of this study was to determine whether a longer history of reported hot flashes over the study period was associated with greater aortic and coronary artery calcification. Interactions with hormone therapy use were examined in an exploratory fashion. Methods: Participants included 302 women participating in the Healthy Women Study, a longitudinal study of cardiovas...
Source: Menopause - October 25, 2018 Category: OBGYN Tags: Commemorative Papers Source Type: research

Hot flushes, coronary heart disease, and hormone therapy in postmenopausal women
Conclusions: Among older postmenopausal women with CHD, EPT may increase risk of CHD events substantially in the first year of treatment among women with clinically significant hot flushes but not among those without hot flushes. (Source: Menopause)
Source: Menopause - October 25, 2018 Category: OBGYN Tags: Commemorative Papers Source Type: research

Long-term risk of depressive and anxiety symptoms after early bilateral oophorectomy
Conclusions: Bilateral oophorectomy performed before the onset of menopause is associated with an increased long-term risk of depressive and anxiety symptoms. (Source: Menopause)
Source: Menopause - October 25, 2018 Category: OBGYN Tags: Commemorative Papers Source Type: research

Estrogen effects on arteries vary with stage of reproductive life and extent of subclinical atherosclerosis progression
The past several years have been marked by confusion and controversy concerning whether estrogens are cardioprotective. The issue is of utmost public health importance because coronary heart disease (CHD) remains the leading cause of death among postmenopausal women. Fortunately, a unifying hypothesis has emerged that reproductive stage is a major determinant of the effect of estrogens on atherosclerosis progression, complications, and plaque vulnerability. Premenopausal Years: Premenopausal atherosclerosis progression seems to be an important determinant of postmenopausal atherosclerosis and thus the risk for CHD. Clea...
Source: Menopause - October 25, 2018 Category: OBGYN Tags: Commemorative Papers Source Type: research