Dairy intake is not associated with improvements in bone mineral density or risk of fractures across the menopause transition: data from the Study of Women's Health Across the Nation
Objective: Menopause represents a period in which bone deterioration is accelerated; thus, primary prevention strategies to address age-related bone loss are crucial. Dairy products contain more than a dozen essential nutrients, including calcium, phosphorus, vitamin D, and high-quality protein, as well as bioactive compounds that may promote bone mineralization. However, the relationship between dairy consumption and bone health across the menopause transition remains largely unknown. The purpose of this analysis was to estimate the change in lumbar spine and femoral neck bone mineral density and the risk of bone fractu...
Source: Menopause - August 1, 2020 Category: OBGYN Tags: Original Studies Source Type: research

Associations of pituitary-ovarian hormones and white matter hyperintensities in recently menopausal women using hormone therapy
Conclusions: Circulating levels of pituitary-ovarian hormones associate with changes in WMH volume in recently menopausal women using HT. Whether these relationships would be influenced by different doses of tE2 or oCEE remains to be determined. Video Summary:http://links.lww.com/MENO/A590. (Source: Menopause)
Source: Menopause - August 1, 2020 Category: OBGYN Tags: Original Studies Source Type: research

Incidence of venous thromboembolism among postmenopausal women prescribed ospemifene, selective estrogen receptor modulators for noncancer indications, or untreated vulvar and vaginal atrophy
Conclusions: This interim analysis of an ongoing study suggests a favorable safety profile for ospemifene with respect to VTE. Comparative analyses with covariate adjustment will be performed when data accrual is complete. (Source: Menopause)
Source: Menopause - August 1, 2020 Category: OBGYN Tags: Original Studies Source Type: research

Treatment for vaginal atrophy using microablative fractional CO2 laser: a randomized double-blinded sham-controlled trial
Objective: The aim of this study was to evaluate the efficacy of vaginal CO2 laser for the treatment of vaginal atrophy compared to the sham procedure. Methods: Between June 2016 and May 2017, postmenopausal women with moderate to severe intensity of any vaginal atrophy symptoms (VAS) were invited to participate in the study. A total of 88 women were randomized to receive treatment with either vaginal CO2 laser or sham procedures every 4 weeks for three sessions. Both the participants and the evaluators were blinded to the treatment. Vaginal Health Index (VHI) score (primary outcome), VAS score, and the item for vagin...
Source: Menopause - August 1, 2020 Category: OBGYN Tags: Original Studies Source Type: research

A multicenter, randomized study to select the minimum effective dose of estetrol (E4) in postmenopausal women (E4Relief): part 1. Vasomotor symptoms and overall safety
Conclusions: Estetrol 15 mg is considered to be the minimum effective daily oral dose for treatment of vasomotor symptoms. Its current seemingly favorable safety profile is further to be confirmed in phase 3 clinical development. Video Summary:http://links.lww.com/MENO/A591. (Source: Menopause)
Source: Menopause - August 1, 2020 Category: OBGYN Tags: Original Studies Source Type: research

Ospemifene: less venous thrombosis than other selective estrogen receptor modulators in postmenopausal women with vulvo vaginal atrophy
No abstract available (Source: Menopause)
Source: Menopause - August 1, 2020 Category: OBGYN Tags: Editorials Source Type: research

How do we measure success in the treatment of genitourinary syndrome of menopause?
No abstract available (Source: Menopause)
Source: Menopause - August 1, 2020 Category: OBGYN Tags: Editorials Source Type: research

Estetrol for menopause symptoms: the Cinderella of estrogens or just another fairy tale?
No abstract available (Source: Menopause)
Source: Menopause - August 1, 2020 Category: OBGYN Tags: Editorials Source Type: research

In Reply:
No abstract available (Source: Menopause)
Source: Menopause - July 1, 2020 Category: OBGYN Tags: Letters to the Editor Source Type: research

To the Editor:
No abstract available (Source: Menopause)
Source: Menopause - July 1, 2020 Category: OBGYN Tags: Letters to the Editor Source Type: research

Effect of hormone therapy on muscle strength in postmenopausal women: a systematic review and meta-analysis of randomized controlled trials
Conclusions: The use of HT was not associated with the improvement of muscle strength in postmenopausal women. This finding suggested that HT might not improve muscle strength or that the effect size was too small to identify significant therapeutic efficacy. (Source: Menopause)
Source: Menopause - July 1, 2020 Category: OBGYN Tags: Review Articles Source Type: research

Relationship between age at menarche and risk of glucose metabolism disorder: a systematic review and dose-response meta-analysis
Conclusions: Older age at menarche (range 8-18 years old) is associated with reduced risk of glucose metabolism disorder. The strongest reduction in risk of GDM is observed at menarche age of 14.5 years. (Source: Menopause)
Source: Menopause - July 1, 2020 Category: OBGYN Tags: Review Articles Source Type: research

Climate change and its potential impact on menopausal hot flashes: a commentary
Climate change is known to impact men and women differently and yet how it will change the health impact of menopause, specifically hot flashes, has not been well researched or understood. Given the duration of symptoms, the high number of women suffering from them, and the associated consequences, any marginal change in incidence due to climate change could result in a very large number of women being affected. Global health systems need to be prepared for this and ensure that gendered issues like menopause do not fall through the cracks as we prepare for our future climate. Video Summary:http://links.lww.com/MENO/A549. (Source: Menopause)
Source: Menopause - July 1, 2020 Category: OBGYN Tags: Personal Perspective Source Type: research

Linguistic translation and validation of the Menopause-specific Quality of Life (MENQOL) questionnaire in Greek menopausal women
Conclusions: The Greek version of MENQOL is a reliable instrument for evaluating menopausal women. Availability of an online form will allow wider dissemination of the questionnaire. Further use of the questionnaire in Greece may lead to better understanding of the bothersome symptoms of menopause; a prerequisite to develop intervention studies for amelioration of quality of life. (Source: Menopause)
Source: Menopause - July 1, 2020 Category: OBGYN Tags: Original Studies Source Type: research

Effect of Chinese herbal medicine on serum lipids in postmenopausal women with mild dyslipidemia: a randomized, placebo-controlled clinical trial
This study was aimed to evaluate the effect of Chinese herbal medicine, tonifying kidney and descending turbidity (TKDT) granule, on serum lipid profiles in postmenopausal women with dyslipidemia. Methods: A double-blind randomized, placebo-controlled trial was conducted among 104 postmenopausal Chinese women with mild dyslipidemia. Participants were randomized into treatment group (n = 53) and control group (n = 51). The participants in the treatment group received TKDT granule once per day for 24 weeks, whereas the control group received placebo in the same manner. All participants were subjected to healthy li...
Source: Menopause - July 1, 2020 Category: OBGYN Tags: Original Studies Source Type: research

Changes in ultrasound uterine morphology and endometrial thickness during ovarian aging and possible associated factors: findings from a prospective study
Conclusions: The figures for uterine volume and endometrial thickness decrease around menopause using ultrasound measurments with large reductions in the first and second year after the final menstrual period. A higher body mass index is associated with increased endometrial thickness. (Source: Menopause)
Source: Menopause - July 1, 2020 Category: OBGYN Tags: Original Studies Source Type: research

Sex differences of the association between marital status and coronary artery disease in patients experiencing chest pain: The Korean Women's Chest Pain Registry
Conclusions: In contrast to men, a without spouse status is independently associated with significant CAD in women experiencing chest pain. Women with a spouse had the lowest presence of CAD among all groups. In the management of female patients experiencing chest pain, clinicians should consider their social characteristics, including marital status, to predict subsequent cardiovascular disease and determine the appropriate treatment. Video Summary:http://links.lww.com/MENO/A567. (Source: Menopause)
Source: Menopause - July 1, 2020 Category: OBGYN Tags: Original Studies Source Type: research

Lipid profile changes during the menopausal transition
Objectives: There is evidence that the menopausal transition in women is accompanied by changes in the metabolic profile. We evaluated the lipid profile during the perimenopause to postmenopause transition and its association with menopausal status. Methods: This is a retrospective observational study of laboratory studies from women presenting to the gynecology unit of Hospital Quirón Salud, Madrid (2007-2018) with irregular menstruation, amenorrhea or menopausal symptoms. Inclusion criteria were one or more blood samples with determinations of fasting glucose and lipids (total cholesterol, low-density lipopro...
Source: Menopause - July 1, 2020 Category: OBGYN Tags: Original Studies Source Type: research

Cervicovaginal lavage fluid zinc level as a marker of vaginal atrophy
This study aimed to investigate the correlation between cervicovaginal fluid zinc levels and participants’ menopausal status and the presence of vulvovaginal symptoms of genitourinary syndrome of menopause. Methods: Women included in the study underwent a pelvic examination, collection of vaginal cytology, and cervicovaginal lavage was performed in a standardized fashion. The cervicovaginal lavage zinc content was determined. The vaginal health index was calculated, and the visual analog scale was obtained based on the participant's burning, itching, vaginal pain, dyspareunia, dryness, and dysuria. Results: One...
Source: Menopause - July 1, 2020 Category: OBGYN Tags: Original Studies Source Type: research

The accuracy of ascites cytology in diagnosis of advanced ovarian cancer in postmenopausal women prior to neoadjuvant chemotherapy
Conclusions: Ascites cytology for postmenopausal women older than 51 years with immunohistochemistry is highly accurate in diagnosis of ovarian cancer. Neoadjuvant chemotherapy can be safely prescribed based on paracentesis evaluations. Video Summary:http://links.lww.com/MENO/A570. (Source: Menopause)
Source: Menopause - July 1, 2020 Category: OBGYN Tags: Original Studies Source Type: research

Depression, hormone therapy, and the menopausal transition among women aged 45 to 64 years using Canadian Longitudinal Study on aging baseline data
Conclusions: Our findings highlight the association between depression and premature menopause among midlife women. Current HT use may be a proxy for more severe menopausal vasomotor symptoms, a known risk factor for depressive symptoms. Identification of risk factors, including social determinants of health, age at menopause, and menopausal symptoms can help guide clinicians when assessing mental health. Video Summary:http://links.lww.com/MENO/A576. (Source: Menopause)
Source: Menopause - July 1, 2020 Category: OBGYN Tags: Original Studies Source Type: research

Associations of social, physical, and financial factors with diet quality among older, community-dwelling women
Objective: This analysis examined whether specific social, physical, and financial factors were associated with diet quality among older, community-dwelling women. Methods: This cross-sectional analysis was conducted in a subset of 6,094 community-dwelling Women's Health Initiative participants who completed a food frequency questionnaire, administered from 2012 to 2013, and a self-administered supplemental questionnaire, administered approximately 1 year later. The supplemental questionnaire included five questions assessing social, physical, and financial factors related to eating. Diet quality was assessed with the...
Source: Menopause - July 1, 2020 Category: OBGYN Tags: Original Studies Source Type: research

Executive function after risk-reducing salpingo-oophorectomy in BRCA1 and BRCA2 mutation carriers: does current mood and early life adversity matter?
Conclusions: The relationship between childhood adversity and executive dysfunction is partially mediated by mood symptoms. These data indicate that assessing history of childhood adversity and current anxiety and depression symptoms may play a role in treating women who report cognitive complaints after RRSO. Video Summary:http://links.lww.com/MENO/A571. (Source: Menopause)
Source: Menopause - July 1, 2020 Category: OBGYN Tags: Original Studies Source Type: research

NAMS 2019 Pre-Meeting Symposium, September 2019, Chicago Illinois: The Perimenopause
The North American Menopause Society held the 2019 Pre-Meeting Symposium on September 25, 2019, in Chicago, Illinois, to review the current state of the science related to the physiology of the perimenopause and to address management of the most prevalent and pressing clinical issues. The perimenopause, as defined by the Stages of Reproductive Aging Workshop + 10, encompasses the menopause transition as well as the first year following menopause, the final menstrual period. This phase in the continuum of women's reproductive lives had been one of the least well understood. Fortunately, contributions from a number of prospe...
Source: Menopause - July 1, 2020 Category: OBGYN Tags: NAMS Symposium Report Source Type: research

A Canadian perspective on depression, menopause status, and hormone therapy
No abstract available (Source: Menopause)
Source: Menopause - July 1, 2020 Category: OBGYN Tags: Editorials Source Type: research

Insights into improving diet quality among postmenopausal women: a matter of context
No abstract available (Source: Menopause)
Source: Menopause - July 1, 2020 Category: OBGYN Tags: Editorials Source Type: research

Difficult decisions in women at high genetic risk for cancer: toward an individualized approach
No abstract available (Source: Menopause)
Source: Menopause - July 1, 2020 Category: OBGYN Tags: Editorials Source Type: research

MsFLASH network vaginal health trial: absence of evidence is NOT evidence of absence
Approximately 50% of postmenopausal women experience vulvovaginal symptoms associated with genitourinary syndrome of menopause (GSM). GSM is a chronic and progressive condition with a well-defined treatment algorithm. Analysis of the MsFLASH Vaginal Health Trial data produced two main conclusions, which were that prescribed vaginal 10 μg estradiol tablet and over-the-counter (OTC) vaginal moisturizer did not provide additional benefit over placebo vaginal tablet and placebo gel in reducing postmenopausal vulvovaginal symptoms; or increasing the proportions of women reporting sexual activity or improving pain scores wi...
Source: Menopause - May 29, 2020 Category: OBGYN Tags: Personal Perspective Source Type: research

Investigation of eNOS gene polymorphism exposes a genetic association between endothelial dysfunction and osteoporosis in postmenopausal women
Objectives: To investigate the association of genetic polymorphisms of endothelial nitric oxide synthase (eNOS) gene with endothelial dysfunction associated osteoporosis in postmenopausal women of Punjab, India. Methods: The study involved 456 postmenopausal women having endothelial dysfunction categorized according to women with (n = 236) and without osteoporosis (n = 220). Bone mineral density (BMD) and reactive hyperemia index (RHI) were evaluated together with six single-nucleotide polymorphisms (SNPs) within the eNOS gene (rs2070744, rs1799983, rs1800780, rs3918181, rs891512, and rs1808593). Results: A...
Source: Menopause - May 29, 2020 Category: OBGYN Tags: Original Studies Source Type: research

Lung cancer aggressiveness in an intermittent hypoxia murine model of postmenopausal sleep apnea
Objective: Intermittent hypoxia (IH)—a hallmark of obstructive sleep apnea (OSA)—enhances lung cancer progression in mice via altered host immune responses that are also age and sex-dependent. However, the interactions of menopause with IH on tumor malignant properties remain unexplored. Here, we aimed to investigate lung cancer outcomes in the context of ovariectomy (OVX)-induced menopause in a murine model of OSA. Methods: Thirty-four female mice (C57BL/6, 12-week-old) were subjected to bilateral OVX or to Sham intervention. Six months after surgery, mice were pre-exposed to either IH or room air (RA) fo...
Source: Menopause - May 29, 2020 Category: OBGYN Tags: Original Studies Source Type: research

Cervical cancer survivors’ attitudes and understanding of menopause and hormone therapy
Conclusions: Menopausal symptoms were prevalent in this population. Our data indicate that women are experiencing climacteric symptoms, but are overall unmotivated to address symptoms using HT. Factors such as symptom severity, fear of side effects, income level, or education level were not associated with acceptability of HT for premature menopause. (Source: Menopause)
Source: Menopause - May 29, 2020 Category: OBGYN Tags: Original Studies Source Type: research

Baseline estrogen levels in postmenopausal women participating in the MAP.3 breast cancer chemoprevention trial
Objective: The aim of the study was to quantify baseline estradiol (E2) and estrone (E1) concentrations according to selected patient characteristics in a substudy nested within the MAP.3 chemoprevention trial. Methods: E2 and E1 levels were measured in 4,068 postmenopausal women using liquid chromatography-tandem mass spectrometry. Distributions were described by age, years since menopause, race, body mass index (BMI), smoking status, and use and duration of hormone therapy using the Kruskal-Wallis test. Multivariable linear regression was also used to identify characteristics associated with estrogen levels. Result...
Source: Menopause - May 29, 2020 Category: OBGYN Tags: Original Studies Source Type: research

Do trends of adiposity and metabolic parameters vary in women with different ovarian reserve status? A population-based cohort study
Conclusion: Women with lower ovarian reserve do not experience different over time trends of adiposity and glucose metabolism parameters during their reproductive life span. (Source: Menopause)
Source: Menopause - May 29, 2020 Category: OBGYN Tags: Original Studies Source Type: research

Bacterial vaginosis diagnosis and treatment in postmenopausal women: a survey of clinician practices
Objective: Some diagnostic features of the genitourinary syndrome of menopause (GSM) and bacterial vaginosis (BV) overlap, such as low levels of vaginal Lactobacillus and pH > 5. We sought to determine clinicians’ diagnostic and treatment practices for postmenopausal women presenting with BV and GSM scenarios and how commercial molecular screening tests are utilized. Methods: Anonymous surveys were sent to practicing women's health clinicians to evaluate assessment and treatment strategies for postmenopausal women presenting with BV and GSM scenarios. Results: When given a scenario of a postmenopausal ...
Source: Menopause - May 29, 2020 Category: OBGYN Tags: Original Studies Source Type: research

Coexistence of metabolic syndrome and osteopenia associated with social inequalities and unhealthy lifestyle among postmenopausal women in South Korea: the 2008 to 2011 Korea National Health and Nutritional Examination Survey (KNHANES)
We examined the associations between socioeconomic status-related factors, unhealthy lifestyle, and the coexistence of MetS and osteopenia or OP. Methods: One thousand nine hundred ninety-one postmenopausal women aged 45 to 65 years were used to select a representative sample of the civilian, noninstitutionalized South Korean population from the 2008 to 2011 Korea National Health and Nutrition Examination Survey data. Women were grouped as neither MetS nor OP (normal), MetS, OP, and both MetS and OP (MetS + OP). Socioeconomic status (education, household income, place of residence, employment status), health-related...
Source: Menopause - May 29, 2020 Category: OBGYN Tags: Original Studies Source Type: research

Family history of premature myocardial infarction modifies the associations between bilateral oophorectomy and cardiovascular disease mortality in a US national cohort of postmenopausal women
Objective: To test the hypothesis that a family history of premature myocardial infarction (FHPMI) will modify the associations between bilateral salpingo-oophorectomy (BSO) and mortality due to heart disease (HD), cardiovascular disease (CVD), or all-cause mortality with stronger associations observed for BSO occurring before 45 years. Methods: We analyzed data from 2,763 postmenopausal women aged 40 years or older who participated in the National Health and Nutrition Examination Survey (1988-1994) and were followed through December 31, 2015. Cox regression was used to estimate adjusted hazard ratios (HRs) and 95% co...
Source: Menopause - May 29, 2020 Category: OBGYN Tags: Original Studies Source Type: research

Knowledge and attitudes associated with menopause among women aged 45 to 60 years: a pilot study among rural and urban women in Bangladesh
Conclusions: Menopause is a neglected issue in Bangladesh. Accurate and appropriate information regarding premenopause and menopause can help women cope with this life transition. Social and familial support may also play a role in minimizing isolation and depression. Public health messaging to increase awareness and knowledge about menopause should be undertaken to overcome the stigma and shame associated with menopause in Bangladesh. Video Summary:http://links.lww.com/MENO/A556. (Source: Menopause)
Source: Menopause - May 29, 2020 Category: OBGYN Tags: Original Studies Source Type: research

Incidence of diabetes according to metabolically healthy or unhealthy normal weight or overweight/obesity in postmenopausal women: the Women's Health Initiative
Objective: To determine the relationship of metabolic weight categories with incident diabetes mellitus (DM) in postmenopausal women. Methods: The Women's Health Initiative (WHI) enrolled 161,808 postmenopausal women aged 50 to 79 years. We included those with cardiovascular disease (CVD) biomarkers and free of CVD and prevalent DM (n = 17,043) at baseline. Normal weight was defined as a body mass index (BMI) ≥18.5 and (Source: Menopause)
Source: Menopause - May 29, 2020 Category: OBGYN Tags: Original Studies Source Type: research

The Women's Health Initiative Estrogen-alone Trial had differential disease and medical expenditure consequences across age groups
Conclusion: The decline in ET utilization had differential disease and expenditure consequences by age groups in the United States. These results are limited by the lack of inclusion of vasomotor symptom benefit and costs of alternative medications for these symptoms in the analysis. (Source: Menopause)
Source: Menopause - May 29, 2020 Category: OBGYN Tags: Original Studies Source Type: research

Menopause and society: the association of educational level, social status, and financial status with positive versus negative perceptions about menopause
No abstract available (Source: Menopause)
Source: Menopause - May 29, 2020 Category: OBGYN Tags: Editorials Source Type: research

Is metabolically healthy obesity really healthy?
No abstract available (Source: Menopause)
Source: Menopause - May 29, 2020 Category: OBGYN Tags: Editorials Source Type: research

Adding up the healthcare costs when estrogen therapy is avoided after hysterectomy
No abstract available (Source: Menopause)
Source: Menopause - May 29, 2020 Category: OBGYN Tags: Editorials Source Type: research

Workshop on normal reference ranges for estradiol in postmenopausal women, September 2019, Chicago, Illinois
The North American Menopause Society (NAMS) organized the Workshop on Normal Ranges for Estradiol in Postmenopausal Women from September 23 to 24, 2019, in Chicago, Illinois. The aim of the workshop was to review existing analytical methodologies for measuring estradiol in postmenopausal women and to assess existing data and study cohorts of postmenopausal women for their suitability to establish normal postmenopausal ranges. The anticipated outcome of the workshop was to develop recommendations for establishing normal ranges generated with a standardized and certified assay that could be adopted by clinical and research c...
Source: Menopause - May 29, 2020 Category: OBGYN Tags: Symposium Report Source Type: research

Workshop on normal reference ranges for estradiol in postmenopausal women: commentary from The North American Menopause Society on low-dose vaginal estrogen therapy labeling
No abstract available (Source: Menopause)
Source: Menopause - May 29, 2020 Category: OBGYN Tags: NAMS Commentary Source Type: research

The effects of swimming training on arterial function, muscular strength, and cardiorespiratory capacity in postmenopausal women with stage 2 hypertension: Erratum
No abstract available (Source: Menopause)
Source: Menopause - May 1, 2020 Category: OBGYN Tags: Erratum Source Type: research

In Reply
No abstract available (Source: Menopause)
Source: Menopause - May 1, 2020 Category: OBGYN Tags: Letters to the Editor Source Type: research

To the Editor
No abstract available (Source: Menopause)
Source: Menopause - May 1, 2020 Category: OBGYN Tags: Letters to the Editor Source Type: research

Aspirin for primary prevention of cardiovascular disease in women
For primary prevention, low-dose aspirin should be considered in women aged 40 to 70 years with a 10-year cardiovascular risk of 20% or more or in women with diabetes and a 10-year cardiovascular risk of 10% or more. The risk of bleeding outweighs the benefits in low-risk women and in women aged 70 years and older. (Source: Menopause)
Source: Menopause - May 1, 2020 Category: OBGYN Tags: Clinical Corner: NAMS Practice Pearl Source Type: research

Higher intakes of fruits and vegetables are related to fewer menopausal symptoms: a cross-sectional study
Conclusion: The results of the present study showed that some FV subgroups had inverse associations with climacteric symptoms, whereas higher intake of some subgroups of FV appeared to be associated with more urogenital symptoms in postmenopausal women. (Source: Menopause)
Source: Menopause - May 1, 2020 Category: OBGYN Tags: Original Studies Source Type: research

Does vitamin D status influence lumbar disc degeneration and low back pain in postmenopausal women? A retrospective single-center study
Objective: To investigate the relationship between serum vitamin D concentration and lumbar disc degeneration (LDD) in postmenopausal women and the epidemiologic factors affecting low back pain (LBP). Methods: Between July 2017 and December 2018, 232 participants were retrospectively enrolled. Serum concentrations of bone turnover markers were measured using electrochemiluminescence assays. Disc degeneration was evaluated using the Pfirrmann grading system. Other variables were assessed using relevant questionnaires. Results: The mean age of the women was 65.6 ± 10.1 and their serum 25(OH)D concentration...
Source: Menopause - May 1, 2020 Category: OBGYN Tags: Original Studies Source Type: research