Prevalence and risk factors of morphometric vertebral fracture in apparently healthy osteopenic postmenopausal Thai women
Conclusions: Almost one third of apparently healthy postmenopausal women with osteopenia had morphometric VF. Advancing age and greater FRAX scores were associated with higher prevalence of morphometric VF. (Source: Menopause)
Source: Menopause - January 1, 2021 Category: OBGYN Tags: Original Studies Source Type: research

Unnecessary bilateral salpingo-oophorectomy at the time of hysterectomy and potential for ovarian preservation
Objective: To evaluate predictors of bilateral salpingo-oophorectomy at hysterectomy and determine rate of unnecessary bilateral salpingo-oophorectomy. Methods: Retrospective review of hysterectomies at six Ontario, Canada hospitals from July 2016 to June 2018. Data was extracted from health records coding and electronic medical records. Of patients with concurrent bilateral salpingo-oophorectomy, age, preoperative diagnoses, surgical factors (presence of endometriosis/adhesions), and surgeon training (fellowship/no fellowship) were recorded. Chi-square tests compared indicated and nonindicated bilateral salping...
Source: Menopause - January 1, 2021 Category: OBGYN Tags: Original Studies Source Type: research

Early menarche and worse cardiovascular health: an emerging risk factor?
No abstract available (Source: Menopause)
Source: Menopause - January 1, 2021 Category: OBGYN Tags: Editorials Source Type: research

Clinically undiagnosed vertebral fractures: why and how to approach when we do not know they exist?
No abstract available (Source: Menopause)
Source: Menopause - January 1, 2021 Category: OBGYN Tags: Editorials Source Type: research

Surgical menopause: health implications and hormonal management
No abstract available (Source: Menopause)
Source: Menopause - January 1, 2021 Category: OBGYN Tags: Editorials Source Type: research

Subject Index
No abstract available (Source: Menopause)
Source: Menopause - December 1, 2020 Category: OBGYN Tags: Index Source Type: research

Abstract Author Index
No abstract available (Source: Menopause)
Source: Menopause - December 1, 2020 Category: OBGYN Tags: Abstracts Source Type: research

2020 NAMS Virtual Annual Meeting
No abstract available (Source: Menopause)
Source: Menopause - December 1, 2020 Category: OBGYN Tags: Abstracts Source Type: research

Acknowledgements of Reviewers, 2019-2020
No abstract available (Source: Menopause)
Source: Menopause - December 1, 2020 Category: OBGYN Tags: Acknowledgment of Reviewers Source Type: research

In Reply:
No abstract available (Source: Menopause)
Source: Menopause - December 1, 2020 Category: OBGYN Tags: Letters to the Editor Source Type: research

To the Editor:
No abstract available (Source: Menopause)
Source: Menopause - December 1, 2020 Category: OBGYN Tags: Letters to the Editor Source Type: research

Menopausal transition experiences and management strategies of Chinese immigrant women: a scoping review
Conclusion: Findings suggested that CIW experienced a variety of physical symptoms, including muscle and joint pain, urogenital symptoms, vasomotor symptoms, weight gain, decreased physical strength, vision changes, and skin changes. Muscle and joint pain were particularly prevalent and emphasized. CIW also experienced psycho-behavioral symptoms including emotional changes, depression, memory loss, and sexual dysfunction. However, they had a decreased concern regarding symptoms of sexual dysfunction and decreased libido when compared with women from Western cultures. CIW interpreted menopause as a natural aging process...
Source: Menopause - December 1, 2020 Category: OBGYN Tags: Review Articles Source Type: research

Effect of soy protein containing isoflavones on endothelial and vascular function in postmenopausal women: a systematic review and meta-analysis of randomized controlled trials
Conclusions and Relevance: Our findings suggest that soy protein supplementation does not lead to meaningful improvement in FMD in postmenopausal women. However, this finding is based on a limited number of studies. Additional high-quality large-scale RCTs are warranted. (Source: Menopause)
Source: Menopause - December 1, 2020 Category: OBGYN Tags: Review Articles Source Type: research

Vaginal elasticity is significantly decreased in vaginal atrophy: a strain elastography study
Objectives: Strain elastography is a novel method to assess the elasticity of tissues. We aimed to evaluate the value of vaginal strain elastography in women with vulvovaginal atrophy (VVA). Methods: Women with or without VVA were enrolled in this prospective study. Participants underwent vaginal cytology and vaginal wall elastography. Vaginal Health Index (VHI) was calculated. Based on Vaginal Maturation Value (VMV), participants were divided into atrophic and nonatrophic groups. Elastography parameters of the vaginal walls were measured in nine regions of interest (ROI). Elastography Index (EI) was defined by ...
Source: Menopause - December 1, 2020 Category: OBGYN Tags: Original Studies Source Type: research

Medroxyprogesterone opposes estradiol-induced renal damage in midlife ovariectomized Long Evans rats
Conclusion: MPA was protective against E2-induced renal damage and dysfunction in middle-aged female Long Evans rats. Assessing the impact of hormone therapy on renal outcomes may be an important clinical factor when considering treatment options for postmenopausal women. (Source: Menopause)
Source: Menopause - December 1, 2020 Category: OBGYN Tags: Original Studies Source Type: research

Reproductive risk factors for angiographic obstructive coronary artery disease among postmenopausal women
Conclusions: Multigravidity (three or more pregnancies), early menopause, and a shorter reproductive life span were independent risk factors of angiographic obstructive CAD among postmenopausal women, which suggested that pregnancy and ovarian function may be important for the early identification and prevention of increased risk of female angiographic obstructive CAD. (Source: Menopause)
Source: Menopause - December 1, 2020 Category: OBGYN Tags: Original Studies Source Type: research

Factors associated with use of hormone therapy after preventive oophorectomy in BRCA mutation carriers
Conclusions: The uptake of HT after oophorectomy in women with a BRCA1 or BRCA2 mutation varies by age, education, and surgical history. Clinician and patient awareness may lead to better utilization of HT in women who undergo oophorectomy at an early age to help mitigate the adverse effects associated with surgical menopause. (Source: Menopause)
Source: Menopause - December 1, 2020 Category: OBGYN Tags: Original Studies Source Type: research

Breast effects of oral, combined 17β-estradiol, and progesterone capsules in menopausal women: a randomized controlled trial
Conclusions: In this phase 3 trial of a combined E2/P4, results of secondary outcomes suggest that E2/P4 may not be associated with increased risk of abnormal mammograms versus placebo, and the incidence of breast tenderness was low relative to most of the rates reported in other studies using hormone therapy. (Source: Menopause)
Source: Menopause - December 1, 2020 Category: OBGYN Tags: Original Studies Source Type: research

17β-estradiol/progesterone in a single, oral, softgel capsule (TX-001HR) significantly increased the number of vasomotor symptom-free days in the REPLENISH trial
Objective: To examine responder rates and vasomotor symptom-free days with oral 17β-estradiol/progesterone (E2/P4; TX-001HR) versus placebo in the REPLENISH trial. Methods: REPLENISH (NCT01942668) was a phase 3, randomized, double-blind, placebo-controlled, multicenter trial, evaluating single, oral, softgel E2/P4 capsules in postmenopausal women (40-65 y) with a uterus and vasomotor symptoms (VMS). Women with moderate to severe hot flushes (≥7/d or ≥50/wk) were randomized (VMS substudy) to daily E2/P4 (mg/mg) of 1/100, 0.5/100, 0.5/50, 0.25/50, or placebo. Proportions of women with ≥50% or ≥7...
Source: Menopause - December 1, 2020 Category: OBGYN Tags: Original Studies Source Type: research

Effect of sex hormones on coronavirus disease 2019: an analysis of 5,061 laboratory-confirmed cases in South Korea
Conclusions: This study, using nationwide data, suggests that female sex hormones are not associated with the morbidity and clinical outcomes of coronavirus disease 2019 in South Korea. (Source: Menopause)
Source: Menopause - December 1, 2020 Category: OBGYN Tags: Original Studies Source Type: research

Protocol for development of a core outcome set for menopausal symptoms (COMMA)
Conclusions: This Core Outcome Set will better enable women and clinicians to select effective treatments, improve the quality of trial reporting, reduce research wastage, and improve care for women with troublesome menopausal symptoms. Video Summary: http://links.lww.com/MENO/A633. (Source: Menopause)
Source: Menopause - December 1, 2020 Category: OBGYN Tags: Original Studies Source Type: research

Impact of nulliparity, hypertensive disorders of pregnancy, and gestational diabetes on vasomotor symptoms in midlife women
Conclusions: History of HDP/GDM may be associated with more VMS and nulliparity with fewer VMS, but not independently of sociodemographic factors. Our findings underscore the importance of social and economic disparities in both reproductive outcomes and VMS. Video Summary: http://links.lww.com/MENO/A631. (Source: Menopause)
Source: Menopause - December 1, 2020 Category: OBGYN Tags: Original Studies Source Type: research

Female reproductive health and cognitive function
Objective: The impact of sex hormones milieu on women's cognitive performance at different reproductive stages has caused increased caution. Our research aims to explore whether parity is negatively correlated with cognitive function. Methods: There were 1,093 postmenopausal participants recruited from the Health and Nutrition Examination Survey dataset. Cognitive functioning was evaluated by digit symbol substitution test (DSST). We performed log transformation to normalize the distributions of the DSST values. Results: Participants were categorized into tertile groups based on the number of pregnancies....
Source: Menopause - December 1, 2020 Category: OBGYN Tags: Original Studies Source Type: research

Effect of the neurokinin 3 receptor antagonist fezolinetant on patient-reported outcomes in postmenopausal women with vasomotor symptoms: results of a randomized, placebo-controlled, double-blind, dose-ranging study (VESTA)
Conclusions: Oral fezolinetant was associated with higher responder rates than placebo and larger improvements in QoL and other PRO measures, including a reduction in VMS-related interference with daily life. (Source: Menopause)
Source: Menopause - December 1, 2020 Category: OBGYN Tags: Original Studies Source Type: research

Parity, education, and postmenopausal cognitive function
No abstract available (Source: Menopause)
Source: Menopause - December 1, 2020 Category: OBGYN Tags: Editorials Source Type: research

Fezolinetant findings can fuel future instrumentation inquiries
No abstract available (Source: Menopause)
Source: Menopause - December 1, 2020 Category: OBGYN Tags: Editorials Source Type: research

Hadine Joffe, MD, MSc 2020-2021 NAMS President
No abstract available (Source: Menopause)
Source: Menopause - December 1, 2020 Category: OBGYN Tags: Editorials Source Type: research

To the Editor:
No abstract available (Source: Menopause)
Source: Menopause - October 30, 2020 Category: OBGYN Tags: Letter to the Editor Source Type: research

Expression of androgen receptors in the structures of vulvovaginal tissue
Conclusions: Estrogens play a major role in the maintenance of vaginal physiology. Although little is known about the role of androgens in the genital apparatus of women, specifically in the vulvovaginal area, the abundance of androgen receptors could enable us to explain their role. Androgens and estrogens play a major role in the maintenance of vaginal physiology. Better knowledge of the role of androgens and their receptors in vulvovaginal tissue would make it possible to discern their effects on female genitalia and help us to understand new therapeutic strategies. (Source: Menopause)
Source: Menopause - October 30, 2020 Category: OBGYN Tags: Review Article Source Type: research

It's not that mesh, is it? What providers should know about the transvaginal mesh controversy
The U.S. Food and Drug Administration recent ban on surgical mesh intended for the transvaginal repair of pelvic organ prolapse has called into question the safety of surgical mesh implants in general. As the media firestorm around vaginal mesh kits has continued to grow, important details about the specific type of mesh involved have been lost in the public discourse surrounding the controversy. This has left healthcare providers across the nation in the difficult position of addressing patient anxieties about the use of mesh in gynecologic surgery. This review seeks to educate women's health providers on the historical b...
Source: Menopause - October 30, 2020 Category: OBGYN Tags: Clinical Corner: Invited Review Source Type: research

The safety of oral versus transdermal estrogen
There exists a growing number of treatment options available to women who choose hormone therapy for management of systemic menopause symptoms. Choosing the product that is the “best fit” for each individual woman can be a challenging task. One of these decisions pertains to the optimal route of estrogen administration. This Practice Pearl will explore some of the differences between oral and transdermal estrogens. (Source: Menopause)
Source: Menopause - October 30, 2020 Category: OBGYN Tags: Clinical Corner: NAMS Practice Pearl Source Type: research

Perimenopausal vasomotor symptoms and the cortisol awakening response
Conclusion: Findings suggest that women who suffer from more severe and bothersome perimenopausal VMS exhibit alterations in HPA axis activity. Within an individual, short-term changes in VMS are, however, not associated with concurrent changes in HPA axis functioning. Further research investigating the role of the HPA axis in linking VMS and increased cardiovascular disease risk is warranted. Video Summary:http://links.lww.com/MENO/A607. (Source: Menopause)
Source: Menopause - October 30, 2020 Category: OBGYN Tags: Brief Report Source Type: research

The association of depressive symptoms to sleep-related symptoms during menopausal transition: racial/ethnic differences
Objectives: Despite an increasing number of studies reporting significant associations of depression to sleep problems in general, few studies have been conducted on racial/ethnic variations in the associations among midlife women in their menopausal transition. The purpose of this study was to determine the associations between depressive symptoms and sleep-related symptoms in a multiethnic group of midlife women while considering the women's race/ethnicity and menopausal status. Methods: This was a secondary analysis of the data from 1,054 midlife women in two larger studies. The depression index for midlife women a...
Source: Menopause - October 30, 2020 Category: OBGYN Tags: Original Studies Source Type: research

lncRNA HEIH accelerates cell proliferation and inhibits cell senescence by targeting miR-3619-5p/CTTNBP2 axis in ovarian cancer
Objective: Epithelial ovarian cancer is the most lethal malignancy in gynecology. Numerous studies have confirmed that long noncoding RNAs (lncRNAs) are abnormally expressed in ovarian cancer and are closely associated with the cell proliferation and senescence in cancers. However, the role and underlying molecular mechanism of long noncoding RNA high expression in hepatocellular carcinoma (HEIH) in ovarian cancer remain unknown. Methods: Experiments including Real-time quantitative polymerase chain reaction, RNA immunoprecipitation, luciferase reporter, Fluorescence in situ hybridization, western blot, colony formati...
Source: Menopause - October 30, 2020 Category: OBGYN Tags: Original Studies Source Type: research

Improving the identification of genitourinary syndrome of menopause through the utilization of the Day-to-Day Impact of Vaginal Aging questionnaire
Objective: Genitourinary syndrome of menopause (GSM) affects nearly 50% of postmenopausal women. Yet women fail to recognize GSM as a chronic condition and are reluctant to discuss their vaginal or sexual complaints with a health care provider. This quality improvement project implemented the Day-to-Day Impact of Vaginal Aging (DIVA) questionnaire to improve the identification and diagnosis of GSM in women ≥ 45 years of age presenting for an annual wellness examination or a vulvovaginal/genitourinary complaint. Methods: From October 2019 to February 2020, the DIVA questionnaire was distributed in a large women's he...
Source: Menopause - October 30, 2020 Category: OBGYN Tags: Original Studies Source Type: research

Association of cytochrome P450 1B1 gene polymorphisms and environmental biomarkers with hypertension in Slovak midlife women
Conclusions: In this pilot study, we have provided novel data that supports the significant association of CYP1B1 Leu432Val gene polymorphism with HT in Slovak midlife women. (Source: Menopause)
Source: Menopause - October 30, 2020 Category: OBGYN Tags: Original Studies Source Type: research

The effect of Fennel seed powder on estradiol levels, menopausal symptoms, and sexual desire in postmenopausal women
Conclusions: The results of the present study indicated that daily use of Fennel seed significantly improved menopausal symptoms in postmenopausal women over 8 weeks, though its effect on estradiol levels and sexual desire was not significant. Further studies with a larger sample size and longer duration are needed to verify these findings. (Source: Menopause)
Source: Menopause - October 30, 2020 Category: OBGYN Tags: Original Studies Source Type: research

The prevalence of hypoactive sexual desire disorder in Australian and Iranian women at midlife
This study was undertaken to examine whether the prevalence of low sexual desire, sexually related personal distress, and epidemiological hypoactive sexual desire disorder (eHSDD) differed between midlife Australian and Iranian married women. Methods: Cross-sectional, community-based studies of women aged 40 to 65 years conducted in Australia (2013-2014, n = 2,020) and Iran (2016-2017, n = 1,520) included 60% and 89% married women, respectively. Participants completed the Female Sexual Function Index and the Female Sexual Distress Scale-Revised. eHSDD was defined as low desire with sexually related personal dist...
Source: Menopause - October 30, 2020 Category: OBGYN Tags: Original Studies Source Type: research

The severity of vasomotor symptoms and number of menopausal symptoms in postmenopausal women and select clinical health outcomes in the Women's Health Initiative Calcium and Vitamin D randomized clinical trial
This study evaluated whether vasomotor symptom (VMS) severity and number of moderate/severe menopausal symptoms (nMS) were associated with health outcomes, and whether calcium and vitamin D (CaD) modified the risks. Methods: The Women's Health Initiative CaD study was a double blind, randomized, placebo-controlled trial, which tested 400 IU of 25-hydroxyvitamin-D and 1,000 mg of calcium per day in women aged 50 to 79 years. This study included 20,050 women (median follow-up of 7 y). The outcomes included hip fracture, colorectal cancer, invasive breast cancer, all-cause mortality, coronary heart disease, stroke, cardi...
Source: Menopause - October 30, 2020 Category: OBGYN Tags: Original Studies Source Type: research

Association of phthalate exposure and endogenous hormones with self-reported sleep disruptions: results from the Midlife Women's Health Study
Conclusions: Our study supports previous literature that hormones beyond follicle-stimulating hormone and E2 are associated with sleep disruptions in menopause. Further, we are among the first to show that phthalate exposure is associated with sleep disruptions in midlife women. (Source: Menopause)
Source: Menopause - October 30, 2020 Category: OBGYN Tags: Original Studies Source Type: research

Maternal age at last birth and leukocyte telomere length in a nationally representative population of perimenopausal and postmenopausal women
Objective: The primary aim of this study was to evaluate if maternal age at birth of last child is associated with leukocyte telomere length in a nationally representative population of perimenopausal and postmenopausal women. Methods: We conducted a cross-sectional analysis of 1,232 women from the National Health and Nutrition Examination Survey to examine maternal age at last birth and telomere length, surveyed between 1999 and 2002. We included perimenopausal and postmenopausal women age 40 years and older. Maternal age at last live birth was self-reported, and leukocyte telomere length was measured using quantitat...
Source: Menopause - October 30, 2020 Category: OBGYN Tags: Original Studies Source Type: research

TX-001HR is associated with a clinically meaningful effect on severity of moderate to severe vasomotor symptoms in the REPLENISH trial
Objective: The aim of the study was to evaluate the clinically meaningful effect of oral TX-001HR (17β-estradiol [E2]/progesterone [P4]) capsules on hot flushes severity (vasomotor symptoms [VMS] severity scale) using the patient-reported Clinical Global Impression (CGI). Methods: REPLENISH (NCT01942668) was a phase 3, randomized, double-blind, placebo-controlled, multicenter trial that evaluated TX-001HR in postmenopausal women (40-65 y) with a uterus. Those with frequent moderate to severe hot flushes (≥7/d or ≥50/wk) were randomized in a VMS substudy to daily E2/P4 (1/100, 0.5/100, 0.5/50, or 0.25/50 m...
Source: Menopause - October 30, 2020 Category: OBGYN Tags: Original Studies Source Type: research

A selective serotonin receptor agonist for weight loss and management of menopausal vasomotor symptoms in overweight midlife women: a pilot study
Objective: Weight gain and vasomotor symptoms (VMS) are common complaints in midlife women going through the menopause transition. A selective serotonin 2C (5-HT2C) receptor agonist, lorcaserin, which was previously approved by the Food and Drug Administration for weight loss, has unreported observational evidence suggesting improvement in VMS with its use. The goal of this pilot study was to evaluate the efficacy of lorcaserin for weight loss and management of VMS in overweight midlife women. Methods: This was a 24-week open label pilot study of 20 overweight midlife women, aged 45-60 years, who were experiencing sev...
Source: Menopause - October 30, 2020 Category: OBGYN Tags: Original Studies Source Type: research

Cognitive complaints are associated with smaller right medial temporal gray-matter volume in younger postmenopausal women
Objective: Menopause is associated with increasing cognitive complaints and older women are at increased risk of developing Alzheimer disease compared to men. However, there is difficulty in early markers of risk using objective performance measures. We investigated the impact of subjective cognitive complaints on the cortical structure in a sample of younger postmenopausal women. Methods: Data for this cross-sectional study were drawn from the baseline visit of a longer double-blind study examining estrogen-cholinergic interactions in normal postmenopausal women. Structural Magnetic Resonance Imaging was acquired on ...
Source: Menopause - October 30, 2020 Category: OBGYN Tags: Original Studies Source Type: research

Physiologic vasomotor symptoms are associated with verbal memory dysfunction in breast cancer survivors
Conclusions: Independent of their effect on sleep, VMS may be a modifiable contributor to memory difficulties in women with breast cancer. These findings underscore the importance of objective measurement of VMS in cognitive studies. Video Summary:http://links.lww.com/MENO/A623. (Source: Menopause)
Source: Menopause - October 30, 2020 Category: OBGYN Tags: Original Studies Source Type: research

An intervention to reduce vasomotor symptoms and induce weight loss at the menopause transition: can we really get two for the price of one?
No abstract available (Source: Menopause)
Source: Menopause - October 30, 2020 Category: OBGYN Tags: Editorials Source Type: research

The clinical significance of cognitive complaints early in the postmenopause
No abstract available (Source: Menopause)
Source: Menopause - October 30, 2020 Category: OBGYN Tags: Editorials Source Type: research

Vasomotor symptoms, cognition, and breast cancer: another important piece of the puzzle
No abstract available (Source: Menopause)
Source: Menopause - October 30, 2020 Category: OBGYN Tags: Editorials Source Type: research

The National Academies of Science, Engineering, and Medicine (NASEM) Report on Compounded Bioidentical Hormone Therapy
No abstract available (Source: Menopause)
Source: Menopause - October 30, 2020 Category: OBGYN Tags: Editorials Source Type: research

Statin Use and Incident Diabetes Among the Women's Health Initiative Postmenopausal Women
No abstract available (Source: Menopause)
Source: Menopause - September 26, 2020 Category: OBGYN Tags: Letters to the Editor Source Type: research