Response to letter to editor
No abstract available (Source: Menopause)
Source: Menopause - January 18, 2018 Category: OBGYN Tags: Letters to the Editor Source Type: research

Letter to the Editor
No abstract available (Source: Menopause)
Source: Menopause - January 18, 2018 Category: OBGYN Tags: Letters to the Editor Source Type: research

Postmenopausal choriocarcinoma: a rare case report and review of the literature
We report a rare case of a postmenopausal woman with choriocarcinoma. The 61-year-old patient presented with irregular vaginal bleeding, 11 years after menopause and 30 years after the birth of the last child.Results:Radiological investigation found a 3-cm mass on the lower left part of the vaginal wall, and also bilateral lung nodules. Gynecological examination found 3-4 cm blue and purple nodules in the lower left part of the vaginal wall. Her serum CA125 and serum β-hCG levels were 10.2 and 9273.9 mIU/mL, respectively. The early diagnosis was a choriocarcinoma, and combination chemotherapy (etoposide, kengsheng...
Source: Menopause - January 18, 2018 Category: OBGYN Tags: Case Report Source Type: research

Prevalence of sexual symptoms in relation to menopause in women in Asia: a systematic review
Conclusions:The available data, despite its limitations, suggests that after menopause, lowered sexual desire and vulvovaginal atrophy symptoms, including dryness, irritation, soreness, and dyspareunia, are common in women in Asia. The extent to which such symptoms cause women distress is not known. Studies of representative samples of premenopausal, perimenopausal, and postmenopausal women that use robustly translated and culturally appropriate validated questionnaires, and that collect detailed demographic data are still needed to determine the prevalence of sexual symptoms in relation to menopause in women in Asia. Ob...
Source: Menopause - January 18, 2018 Category: OBGYN Tags: Review Article Source Type: research

Clinical trials in menopause
Conclusions:The available literature suggests that HT is a viable option for the primary prevention of cardiovascular disease in postmenopausal women. Newer trials will likely verify this assessment. If this is enough to change clinical practice, however, remains to be seen given the general fear of HT by many with prescriptive authority, and also the women in our care. Objective: Clinical trials in menopause have undergone much scrutiny over the years. This has led to significant shifts in the treatment of symptomatic menopause and a substantial impact on women. We aim to delineate the key studies contributing to this...
Source: Menopause - January 18, 2018 Category: OBGYN Tags: Clinical Corner: Invited Review Source Type: research

Resistance training reduces inflammation and fatigue and improves physical function in older breast cancer survivors
AbstractObjective:Resistance training (RT) reduces fatigue and improves physical function and quality of life (QOL) in breast cancer survivors (BCS). This may be related to reductions in systemic and tissue-specific inflammation. This pilot study examines the hypothesis that RT induces changes in systemic and tissue-specific inflammation that contribute to improvements in physical and behavioral function in postmenopausal BCS.Methods:Eleven BCS (60 ± 2 years old, body mass index 30 ± 1 kg/m2, mean ± SEM) underwent assessments of fatigue (Piper Fatigue Scale), physical function, QOL (SF-36...
Source: Menopause - January 18, 2018 Category: OBGYN Tags: Brief Report Source Type: research

Orthosiphon stamineus (Misai Kucing) ameliorated postmenopausal osteoporosis in rat model
This study investigated the potential use of OS leaf extracts to ameliorate osteoporosis in ovariectomized rats.Methods:Fifty-six female Sprague-Dawley rats were randomly allocated into eight groups (n = 7): SHAM (healthy sham control); OVX (ovarietomized) nontreated rats (negative control); OVX + Remifemin (100 mg/kg body weight), and 2% green tea extract (positive controls); OVX + OS 50% ethanolic and aqueous extracts, both at either 150 or 300 mg/kg. After 16 weeks, the rats’ bones and blood were evaluated for osteoporosis indicators (protein and mRNA expressions), micro-computed tomography for bon...
Source: Menopause - January 18, 2018 Category: OBGYN Tags: Original Articles Source Type: research

Associations among circulating colony-stimulating factor-1, estrogen, and bone mineral density in postmenopausal women: results from a randomized placebo-controlled trial
Conclusions:This study did not demonstrate a meaningful relationship between circulating levels of CSF-1 and bone mineral density in either the placebo group or estrogen-treated group. Although CSF-1 is required for osteoclastic bone resorption, our data suggest that circulating levels of the cytokine may not reflect this process. Objective: This study addresses the relationship between circulating levels of colony-stimulating factor 1 (CSF-1) and rates of postmenopausal bone loss. The purpose was to test the hypothesis that CSF-1 levels would correlate with the rate of bone loss in estrogen-deficient woman. We further...
Source: Menopause - January 18, 2018 Category: OBGYN Tags: Original Articles Source Type: research

Pharmacokinetics and safety profile of single-dose administration of an estrogen receptor β-selective phytoestrogenic (phytoSERM) formulation in perimenopausal and postmenopausal women
Conclusions:A single-dose oral administration of the phytoSERM formulation was well-tolerated and did not elicit any adverse events. It was rapidly absorbed, reached high plasma concentrations, and showed a linear dose-concentration response in its pharmacokinetics. These findings are consistent with previously reported parameters for each parent compound (Clinicaltrials.gov NCT01723917). Objective: Selected estrogen receptor β-selective phytoestrogen (phytoSERM), a preparation of genistein, daidzein, and S-equol, has an 83-fold selective affinity for estrogen receptor (ER) β, and may promote neuronal surviva...
Source: Menopause - January 18, 2018 Category: OBGYN Tags: Original Articles Source Type: research

Understanding the complex relationships underlying hot flashes: a Bayesian network approach
Conclusions:These models can serve as a guide for design of studies into the causal network underlying hot flashes. Objective: The mechanism underlying hot flashes is not well-understood, primarily because of complex relationships between and among hot flashes and their risk factors. Methods: We explored those relationships using a Bayesian network approach based on a 2006 to 2015 cohort study of hot flashes among 776 female residents, 45 to 54 years old, in the Baltimore area. Bayesian networks were fit for each outcome (current hot flashes, hot flashes before the end of the study, hot flash severity, hot flash fre...
Source: Menopause - January 18, 2018 Category: OBGYN Tags: Original Articles Source Type: research

Functional capacity depends on lower limb muscle strength rather than on abdominal obesity in active postmenopausal women
Conclusions:Our results demonstrate an association between abdominal obesity and FC in active postmenopausal women and that the strongest association and the best predictor of FC was lower limb muscle strength. Thus, active postmenopausal women with abdominal obesity may not necessarily have a reduced FC if lower limb muscle strength is preserved. Objective: An association has been found between abdominal obesity and functional capacity (FC) in the literature where waist circumference has been used to infer abdominal obesity. However, most studies focused on evaluating predictors of FC and functional disabilities only ...
Source: Menopause - January 18, 2018 Category: OBGYN Tags: Original Articles Source Type: research

Effects of menopause and high-intensity training on insulin sensitivity and muscle metabolism
AbstractObjective:To investigate peripheral insulin sensitivity and skeletal muscle glucose metabolism in premenopausal and postmenopausal women, and evaluate whether exercise training benefits are maintained after menopause.Methods:Sedentary, healthy, normal-weight, late premenopausal (n = 21), and early postmenopausal (n = 20) women were included in a 3-month high-intensity exercise training intervention. Body composition was assessed by magnetic resonance imaging and dual-energy x-ray absorptiometry, whole body glucose disposal rate (GDR) by hyperinsulinemic euglycemic clamp (40 mU/m2/min), and femoral muscle ...
Source: Menopause - January 18, 2018 Category: OBGYN Tags: Original Articles Source Type: research

Is outpatient hysteroscopy accurate for the diagnosis of endometrial pathology among perimenopausal and postmenopausal women?
Conclusions:Outpatient hysteroscopy is an adequate and reliable tool for the evaluation of benign pathology in the uterine cavity. Visual findings may not suffice, and directed biopsies may be required to improve diagnostic accuracy. Objective: To assess the histological and visual accuracy of outpatient hysteroscopy. Methods: This was a retrospective analysis of all women referred to a tertiary center outpatient hysteroscopy clinic between March 2011 and October 2016 for the following indications: postmenopausal bleeding, suspected polyp, and/or thick endometrium. Histological accuracy was evaluated by comparing sp...
Source: Menopause - January 18, 2018 Category: OBGYN Tags: Original Articles Source Type: research

Relative contribution of obesity and menopause to the association between serum adiponectin and incident metabolic syndrome
Conclusions:High serum adiponectin levels showed no inverse association with metabolic syndrome in postmenopausal women with obesity. These findings may suggest a need for closer management of metabolic risk in postmenopausal women. Objective: Metabolic syndrome is closely linked to obesity. Menopause may play a critical role in understanding the pathophysiology of metabolic syndrome in women. We investigated the relative contribution of obesity and menopause to the association between serum adiponectin levels and the development of metabolic syndrome. Methods: A prospective cohort study was conducted in which a tot...
Source: Menopause - January 18, 2018 Category: OBGYN Tags: Original Articles Source Type: research

Effects of oral versus transdermal menopausal hormone treatments on self-reported sleep domains and their association with vasomotor symptoms in recently menopausal women enrolled in the Kronos Early Estrogen Prevention Study (KEEPS)
This study determined whether two different formulations of hormone therapy (HT): oral conjugated equine estrogens (o-CEE; 0.45 mg/d, n = 209), transdermal 17β-estradiol (t-E2; 50 μg/d, n = 201) plus cyclic progesterone (Prometrium, 200 mg) or placebo (PBO, n = 243) affected sleep domains in participants of the Kronos Early Estrogen Prevention Study.Methods:Participants completed the Pittsburgh Sleep Quality Index at baseline and during the intervention at 6, 18, 36, and 48 months. Global sleep quality and individual sleep domain scores were compared between treatments using analysis of covariance...
Source: Menopause - January 18, 2018 Category: OBGYN Tags: Original Articles Source Type: research

Association between obesity and sleep disorders in postmenopausal women
AbstractObjective:To investigate the relationship between obesity and sleep architecture in postmenopausal women.Methods:One hundred seven postmenopausal women from the Ambulatory of Integrative Treatment for Female Sleep Disorders were invited by telephone to participate in this study. Fifty-three completed the study. We included women aged 50 to 70 years, and excluded women on hormone therapy or missing data. The study consisted of two meetings, including a full-night polysomnography. Menopause status was confirmed by amenorrhea for at least 1 year. Anthropometric measurements included: body mass, height, body mass index...
Source: Menopause - January 18, 2018 Category: OBGYN Tags: Original Articles Source Type: research

A randomized, multicenter, double-blind study to evaluate the safety and efficacy of estradiol vaginal cream 0.003% in postmenopausal women with dyspareunia as the most bothersome symptom
AbstractObjective:Vulvovaginal atrophy (VVA) is characterized by vaginal changes, dyspareunia, and itching/irritation. Efficacy and safety of a lower-dose estradiol vaginal cream (0.003%) were evaluated in postmenopausal women with VVA-related dyspareunia.Methods:This was a phase 3, randomized, double-blind, placebo-controlled study. Sexually active postmenopausal women with moderate–severe dyspareunia as the most bothersome symptom, ≤5% vaginal superficial cells, and vaginal pH>5.0 were randomized (1:1) to 0.003% estradiol vaginal cream (15 μg estradiol; 0.5 g cream) or placebo (0.5 g cream) applied d...
Source: Menopause - January 18, 2018 Category: OBGYN Tags: Original Articles Source Type: research

The big, bad obesity pandemic
No abstract available (Source: Menopause)
Source: Menopause - January 18, 2018 Category: OBGYN Tags: Editorials Source Type: research

Local estrogen benefits of postmenopausal women with dyspareunia: data confirming what clinicians already know!
No abstract available (Source: Menopause)
Source: Menopause - January 18, 2018 Category: OBGYN Tags: Editorials Source Type: research

Reflections on a life in menopause
No abstract available (Source: Menopause)
Source: Menopause - January 18, 2018 Category: OBGYN Tags: Editorials Source Type: research

The bidirectional relationship between vasomotor symptoms and depression across the menopausal transition: a systematic review of longitudinal studies
Conclusions:There is a bidirectional association between VMS and depressive symptoms. The menopausal transition appears to increase the risk of recurrent episodes of depression that might not be explained only by VMS. Further investigation is needed to explain the differential effect of night sweats and hot flashes on depression. Objective: To explore the nature of the bidirectional relationship between vasomotor symptoms (VMS) and depression, and to determine whether hot flashes and night sweats differentially affect the association between VMS and depression through their effect on sleep disruption. Methods: Multi...
Source: Menopause - January 1, 2018 Category: OBGYN Tags: Review Article Source Type: research

Restoring vaginal function in postmenopausal women with genitourinary syndrome of menopause
Menopause practitioners are often asked to help postmenopausal women restore vaginal health and function. A common scenario is the postmenopausal woman who has been without a sexual partner for many years and is now about to resume or has already unsuccessfully attempted penetrative sexual activity. This Practice Pearl addresses the pathophysiology and effect of atrophic genital changes and offers advice on how vaginal health and comfortable sexual activity can be restored. (Source: Menopause)
Source: Menopause - January 1, 2018 Category: OBGYN Tags: Clinical Corner: NAMS Practice Pearl Source Type: research

Patient characteristics, menopause symptoms, and care provided at an interdisciplinary menopause clinic: retrospective chart review
Conclusions:Our study addresses a gap in published information on patient characteristics and treatment in menopause-specific interdisciplinary clinics. The chart review highlights the variety of symptom experience and complexity of care faced in a menopause clinic. Rigorous prospective studies including standardized data collection and follow-up are needed to help guide clinicians in managing complex menopause patients. Objective: The goal of this study was to describe the characteristics, menopause symptoms, and treatment progressions in women cared for at an interdisciplinary menopause clinic. Methods: We conduct...
Source: Menopause - January 1, 2018 Category: OBGYN Tags: Brief Report Source Type: research

Perimenopausal arthralgia in the shoulder
AbstractObjective:To evaluate perimenopausal arthralgia in the shoulder and treatment thereof.Methods:Participants with perimenopausal (n = 197) or premenopausal (n = 113) shoulder arthralgia were included in the study. The prevalences of synovitis, adhesive capsulitis, rotator cuff disorder, arthritis, and other pathologies in the two groups were compared. Participants diagnosed with synovitis were treated with oral prednisolone for 9 to 12 weeks.Results:The most common diagnosis in the perimenopausal and premenopausal groups was adhesive capsulitis (35.4% and 31.8%, respectively), but the difference in prevalence...
Source: Menopause - January 1, 2018 Category: OBGYN Tags: Original Articles Source Type: research

Body composition, cardiometabolic risk factors, physical activity, and inflammatory markers in premenopausal women after a 10-year follow-up: a MONET study
This study investigated body composition, cardiometabolic risk factors, PAEE, and inflammatory markers in premenopausal women after a 10-year follow-up.Methods:In all, 102 premenopausal women participated in the 5-year observational longitudinal Montreal Ottawa New Emerging Team (MONET) study. This present substudy included 48 participants (age: 60.0 ± 1.7 years; body mass index: 23.2 ± 2.2 kg/m2) 6.0 ± 0.3 years after completion of the initial MONET study. Measures included body composition, waist circumference (WC), fasting glucose and insulin levels, insulin sensitivity (QUICKI model),...
Source: Menopause - January 1, 2018 Category: OBGYN Tags: Original Articles Source Type: research

Impact of age at first childbirth on primary open-angle glaucoma
Conclusions:First childbirth at the age of 27 years or above decreases the risk of POAG in postmenopausal women. Decreased parity, caused by late first childbirth, attenuated the magnitude of the total effects of age at first childbirth on POAG. Objective: No studies have addressed the relationship between the timing of first childbirth and primary open-angle glaucoma (POAG). The aim of the study was to identify the relationship between age at first childbirth and POAG and to examine the contribution of parity to the age at first childbirth–POAG relationship in postmenopausal women. Methods: The study populati...
Source: Menopause - January 1, 2018 Category: OBGYN Tags: Original Articles Source Type: research

Serum uric acid levels and hormone therapy type: a retrospective cohort study of postmenopausal women
AbstractObjective:Serum uric acid levels increase in postmenopausal women, but decrease when hormone therapy (HT) is administered. No study has, however, evaluated the effects of different types of HT on serum uric acid levels. We therefore examined whether estrogen therapy (ET), estrogen plus progestogen therapy (EPT), and tibolone use affected serum uric acid levels in this population.Methods:We performed a retrospective cohort study of postmenopausal women. From 2005 to 2015, postmenopausal women who had undergone blood uric acid-level testing at least twice were enrolled. Participants were grouped according to HT regim...
Source: Menopause - January 1, 2018 Category: OBGYN Tags: Original Articles Source Type: research

Is the age at menopause a cause of sexual dysfunction? A Brazilian population-based study
AbstractObjectives:The aim of the study was to evaluate the association between age at menopause and sexual dysfunction and the components of sexual function in postmenopausal women.Methods:In this cross-sectional population-based study, data of 540 women aged 45 to 60 years regarding the age they were when they achieved menopause and its association with sexual dysfunction (evaluated using the Short Personal Experiences Questionnaire) were obtained through interviews. We assessed the data for associations between age at menopause and sexual dysfunction and demographic, behavioral, and clinical characteristics.Results:Age ...
Source: Menopause - January 1, 2018 Category: OBGYN Tags: Original Articles Source Type: research

Sleep quality and its association with postural stability and fear of falling among Spanish postmenopausal women
AbstractObjective:To analyze the association of sleep quality with postural balance, as measured with objective stabilometric parameters, and fear of falling (FoF), among Spanish postmenopausal women.Methods:In all, 250 women (60 ± 8 years) took part in this cross-sectional study. Sociodemographic and anthropometric data were collected, as well as information concerning history of falls and FoF. Anxiety and depression were assessed using the Hospital Anxiety and Depression Scale, and the Pittsburgh Sleep Quality Index was used to analyze sleep quality. Measurements of sway area (S), velocity (V), and mediolatera...
Source: Menopause - January 1, 2018 Category: OBGYN Tags: Original Articles Source Type: research

In-utero cigarette smoke exposure and the risk of earlier menopause
Conclusions:In-utero smoke exposure was not associated with earlier menopause, but the effect of in-utero smoke exposure was modified by the smoking habits of the participants themselves increasing the risk for smokers who were in-utero exposed. Objective: Cigarette smoking is a risk factor for earlier menopause. Animal studies show that in-utero smoke exposure is toxic to developing ovaries. Our aim was to evaluate whether in-utero smoke exposed women reach menopause earlier compared with nonexposed women. Methods: This is a cohort study within the Avon Longitudinal Study of Parents and Children. Participants inclu...
Source: Menopause - January 1, 2018 Category: OBGYN Tags: Original Articles Source Type: research

Hormone therapy use in the Canadian Longitudinal Study on Aging: a cross-sectional analysis
Conclusions:These findings provide a recent national picture of HT use in Canada that may be used to inform opportunities for improved physician–patient communication regarding menopause management. Objective: The aim of the study was to assess the prevalence and factors associated with hormone therapy (HT) use among Canadian women. Methods: Baseline data from the Tracking cohort of the Canadian Longitudinal Study on Aging (CLSA) was used for this analysis. The main outcome was HT use among women aged 45-85 years, defined as current, past, and never users. Multinomial logistic regression models were used to ex...
Source: Menopause - January 1, 2018 Category: OBGYN Tags: Original Articles Source Type: research

Cardiovascular fat in women at midlife: effects of race, overall adiposity, and central adiposity. The SWAN Cardiovascular Fat Study
AbstractObjectives:Cardiovascular fat (CF) is associated with greater coronary heart disease (CHD) risk. Postmenopausal women have greater CF volumes than premenopausal women, and the association between specific CF depot volumes and CHD risk is more pronounced after menopause. Race, central adiposity, and visceral adiposity are important factors that could impact CF volumes. Whether racial differences in CF volumes and in their associations with central (visceral fat [VAT]) and general adiposity (body mass index [BMI]) exist in midlife women have not been addressed before.Methods:In all, 524 participants from the Study of...
Source: Menopause - January 1, 2018 Category: OBGYN Tags: Original Articles Source Type: research

Factors associated with reasons incontinent midlife women report for not seeking urinary incontinence treatment over 9 years across the menopausal transition
Conclusions:Over half of women who did not seek treatment for their UI reported reasons that could be addressed by public health and clinical efforts to make UI a discussion point during midlife well-women visits. Objective: We explored factors associated with reasons that women with urinary incontinence (UI) reported for not seeking treatment for their UI from a healthcare professional and whether reasons differed by race/ethnicity, socioeconomic status, or education. Methods: We analyzed questionnaire data collected from 1995 to 2005 in the Study of Women's Health Across the Nation. In visits 7 to 9, we elicited r...
Source: Menopause - January 1, 2018 Category: OBGYN Tags: Original Articles Source Type: research

Randomized, double-blind, placebo-controlled clinical trial for evaluating the efficacy of fractional CO2 laser compared with topical estriol in the treatment of vaginal atrophy in postmenopausal women
AbstractObjective:The aim of the study was to evaluate efficacy of fractional CO2 vaginal laser treatment (Laser, L) and compare it to local estrogen therapy (Estriol, E) and the combination of both treatments (Laser + Estriol, LE) in the treatment of vulvovaginal atrophy (VVA).Methods:A total of 45 postmenopausal women meeting inclusion criteria were randomized in L, E, or LE groups. Assessments at baseline, 8 and 20 weeks, were conducted using Vaginal Health Index (VHI), Visual Analog Scale for VVA symptoms (dyspareunia, dryness, and burning), Female Sexual Function Index, and maturation value (MV) of Meisels.Results:For...
Source: Menopause - January 1, 2018 Category: OBGYN Tags: Original Articles Source Type: research

Breast cancer, endometrial cancer, and cardiovascular events in participants who used vaginal estrogen in the Women's Health Initiative Observational Study
Conclusions:The risks of cardiovascular disease and cancer were not elevated among postmenopausal women using vaginal estrogens, providing reassurance about the safety of treatment. Objective: To determine the association between use of vaginal estrogen and risk of a global index event (GIE), defined as time to first occurrence of coronary heart disease (CHD), invasive breast cancer, stroke, pulmonary embolism, hip fracture, colorectal cancer, endometrial cancer, or death from any cause. Methods: For this prospective observational cohort study, we used data from participants of the Women's Health Initiative Observat...
Source: Menopause - January 1, 2018 Category: OBGYN Tags: Original Articles Source Type: research

Urinary incontinence: finding a voice to talk about “it”
No abstract available (Source: Menopause)
Source: Menopause - January 1, 2018 Category: OBGYN Tags: Editorials Source Type: research

Seeing the light: the need for randomized trials of vaginal laser in postmenopausal women
No abstract available (Source: Menopause)
Source: Menopause - January 1, 2018 Category: OBGYN Tags: Editorials Source Type: research

More evidence why the product labeling for low-dose vaginal estrogen should be changed?
No abstract available (Source: Menopause)
Source: Menopause - January 1, 2018 Category: OBGYN Tags: Editorials Source Type: research

Menopause 25th anniversary: past success and future direction
No abstract available (Source: Menopause)
Source: Menopause - January 1, 2018 Category: OBGYN Tags: Editorials Source Type: research

The bidirectional relationship between vasomotor symptoms and depression across the menopausal transition: a systematic review of longitudinal studies
Conclusions:There is a bidirectional association between VMS and depressive symptoms. The menopausal transition appears to increase the risk of recurrent episodes of depression that might not be explained only by VMS. Further investigation is needed to explain the differential effect of night sweats and hot flashes on depression. Objective: To explore the nature of the bidirectional relationship between vasomotor symptoms (VMS) and depression, and to determine whether hot flashes and night sweats differentially affect the association between VMS and depression through their effect on sleep disruption. Methods: Multi...
Source: Menopause - December 22, 2017 Category: OBGYN Tags: Review Article Source Type: research

Restoring vaginal function in postmenopausal women with genitourinary syndrome of menopause
Menopause practitioners are often asked to help postmenopausal women restore vaginal health and function. A common scenario is the postmenopausal woman who has been without a sexual partner for many years and is now about to resume or has already unsuccessfully attempted penetrative sexual activity. This Practice Pearl addresses the pathophysiology and effect of atrophic genital changes and offers advice on how vaginal health and comfortable sexual activity can be restored. (Source: Menopause)
Source: Menopause - December 22, 2017 Category: OBGYN Tags: Clinical Corner: NAMS Practice Pearl Source Type: research

Patient characteristics, menopause symptoms, and care provided at an interdisciplinary menopause clinic: retrospective chart review
Conclusions:Our study addresses a gap in published information on patient characteristics and treatment in menopause-specific interdisciplinary clinics. The chart review highlights the variety of symptom experience and complexity of care faced in a menopause clinic. Rigorous prospective studies including standardized data collection and follow-up are needed to help guide clinicians in managing complex menopause patients. Objective: The goal of this study was to describe the characteristics, menopause symptoms, and treatment progressions in women cared for at an interdisciplinary menopause clinic. Methods: We conduct...
Source: Menopause - December 22, 2017 Category: OBGYN Tags: Brief Report Source Type: research

Perimenopausal arthralgia in the shoulder
AbstractObjective:To evaluate perimenopausal arthralgia in the shoulder and treatment thereof.Methods:Participants with perimenopausal (n = 197) or premenopausal (n = 113) shoulder arthralgia were included in the study. The prevalences of synovitis, adhesive capsulitis, rotator cuff disorder, arthritis, and other pathologies in the two groups were compared. Participants diagnosed with synovitis were treated with oral prednisolone for 9 to 12 weeks.Results:The most common diagnosis in the perimenopausal and premenopausal groups was adhesive capsulitis (35.4% and 31.8%, respectively), but the difference in prevalence...
Source: Menopause - December 22, 2017 Category: OBGYN Tags: Original Articles Source Type: research

Body composition, cardiometabolic risk factors, physical activity, and inflammatory markers in premenopausal women after a 10-year follow-up: a MONET study
This study investigated body composition, cardiometabolic risk factors, PAEE, and inflammatory markers in premenopausal women after a 10-year follow-up.Methods:In all, 102 premenopausal women participated in the 5-year observational longitudinal Montreal Ottawa New Emerging Team (MONET) study. This present substudy included 48 participants (age: 60.0 ± 1.7 years; body mass index: 23.2 ± 2.2 kg/m2) 6.0 ± 0.3 years after completion of the initial MONET study. Measures included body composition, waist circumference (WC), fasting glucose and insulin levels, insulin sensitivity (QUICKI model),...
Source: Menopause - December 22, 2017 Category: OBGYN Tags: Original Articles Source Type: research

Impact of age at first childbirth on primary open-angle glaucoma
Conclusions:First childbirth at the age of 27 years or above decreases the risk of POAG in postmenopausal women. Decreased parity, caused by late first childbirth, attenuated the magnitude of the total effects of age at first childbirth on POAG. Objective: No studies have addressed the relationship between the timing of first childbirth and primary open-angle glaucoma (POAG). The aim of the study was to identify the relationship between age at first childbirth and POAG and to examine the contribution of parity to the age at first childbirth–POAG relationship in postmenopausal women. Methods: The study populati...
Source: Menopause - December 22, 2017 Category: OBGYN Tags: Original Articles Source Type: research

Serum uric acid levels and hormone therapy type: a retrospective cohort study of postmenopausal women
AbstractObjective:Serum uric acid levels increase in postmenopausal women, but decrease when hormone therapy (HT) is administered. No study has, however, evaluated the effects of different types of HT on serum uric acid levels. We therefore examined whether estrogen therapy (ET), estrogen plus progestogen therapy (EPT), and tibolone use affected serum uric acid levels in this population.Methods:We performed a retrospective cohort study of postmenopausal women. From 2005 to 2015, postmenopausal women who had undergone blood uric acid-level testing at least twice were enrolled. Participants were grouped according to HT regim...
Source: Menopause - December 22, 2017 Category: OBGYN Tags: Original Articles Source Type: research

Is the age at menopause a cause of sexual dysfunction? A Brazilian population-based study
AbstractObjectives:The aim of the study was to evaluate the association between age at menopause and sexual dysfunction and the components of sexual function in postmenopausal women.Methods:In this cross-sectional population-based study, data of 540 women aged 45 to 60 years regarding the age they were when they achieved menopause and its association with sexual dysfunction (evaluated using the Short Personal Experiences Questionnaire) were obtained through interviews. We assessed the data for associations between age at menopause and sexual dysfunction and demographic, behavioral, and clinical characteristics.Results:Age ...
Source: Menopause - December 22, 2017 Category: OBGYN Tags: Original Articles Source Type: research

Sleep quality and its association with postural stability and fear of falling among Spanish postmenopausal women
AbstractObjective:To analyze the association of sleep quality with postural balance, as measured with objective stabilometric parameters, and fear of falling (FoF), among Spanish postmenopausal women.Methods:In all, 250 women (60 ± 8 years) took part in this cross-sectional study. Sociodemographic and anthropometric data were collected, as well as information concerning history of falls and FoF. Anxiety and depression were assessed using the Hospital Anxiety and Depression Scale, and the Pittsburgh Sleep Quality Index was used to analyze sleep quality. Measurements of sway area (S), velocity (V), and mediolatera...
Source: Menopause - December 22, 2017 Category: OBGYN Tags: Original Articles Source Type: research

In-utero cigarette smoke exposure and the risk of earlier menopause
Conclusions:In-utero smoke exposure was not associated with earlier menopause, but the effect of in-utero smoke exposure was modified by the smoking habits of the participants themselves increasing the risk for smokers who were in-utero exposed. Objective: Cigarette smoking is a risk factor for earlier menopause. Animal studies show that in-utero smoke exposure is toxic to developing ovaries. Our aim was to evaluate whether in-utero smoke exposed women reach menopause earlier compared with nonexposed women. Methods: This is a cohort study within the Avon Longitudinal Study of Parents and Children. Participants inclu...
Source: Menopause - December 22, 2017 Category: OBGYN Tags: Original Articles Source Type: research

Hormone therapy use in the Canadian Longitudinal Study on Aging: a cross-sectional analysis
Conclusions:These findings provide a recent national picture of HT use in Canada that may be used to inform opportunities for improved physician–patient communication regarding menopause management. Objective: The aim of the study was to assess the prevalence and factors associated with hormone therapy (HT) use among Canadian women. Methods: Baseline data from the Tracking cohort of the Canadian Longitudinal Study on Aging (CLSA) was used for this analysis. The main outcome was HT use among women aged 45-85 years, defined as current, past, and never users. Multinomial logistic regression models were used to ex...
Source: Menopause - December 22, 2017 Category: OBGYN Tags: Original Articles Source Type: research