Factors associated with high placebo response in clinical studies of hot flashes: a meta-analysis
Conclusions and Relevance: We identified several factors associated with high placebo response in clinical studies of women with hot flashes. Knowing these factors may enable proactive implementation of operational and analytic strategies that further aid in determining the true treatment effect of an intervention. (Source: Menopause)
Source: Menopause - February 1, 2022 Category: OBGYN Tags: Review Article Source Type: research

Practice considerations for behavioral therapies for depression and anxiety in midlife women
No abstract available (Source: Menopause)
Source: Menopause - February 1, 2022 Category: OBGYN Tags: Clinical Corner: NAMS Practice Pearl Source Type: research

Stress predicts depression symptoms for women living with bipolar disorder during the menopause transition
Conclusion: Stress plays an important role in the experience of depression for women living with bipolar disorder during the perimenopausal phase. More research is needed to determine if stress management programs may be helpful for women living with bipolar disorder during this time of life and if these in turn, may improve depressive symptoms. (Source: Menopause)
Source: Menopause - February 1, 2022 Category: OBGYN Tags: Brief Reports Source Type: research

Association of oral contraceptives and tubal ligation with antimüllerian hormone
We examined the association of OC use and tubal ligation with AMH in the Nurses’ Health Study II prospective cohort among a subset of 1,420 premenopausal participants who provided a blood sample in 1996-1999. History of OC use and tubal ligation were reported in 1989 and updated every 2 years until blood collection. We utilized generalized linear models to assess whether mean AMH levels varied by duration of and age at first use of OCs and history, age, and type of tubal ligation. Results: In multivariable models adjusted for smoking, reproductive events, and other lifestyle factors, we observed a significant, inv...
Source: Menopause - February 1, 2022 Category: OBGYN Tags: Brief Reports Source Type: research

Perceived risk factors for weight gain, barriers, and facilitators related to weight loss experienced by perimenopausal women: focus group discussion and thematic analysis
Conclusion: Women during their perimenopausal phase of life encounter a range of barriers and challenges related to weight loss. An understanding of these barriers might be useful to consider while planning strategies to regulate their weight. (Source: Menopause)
Source: Menopause - February 1, 2022 Category: OBGYN Tags: Original Studies Source Type: research

Which injected antiosteoporotic medication is worth paying for? A cost-effectiveness analysis of teriparatide, zoledronate, ibandronate, and denosumab for postmenopausal osteoporotic women in China
Conclusions: Among postmenopausal osteoporotic women in China, denosumab therapy is cost-effective at all ages examined from the health care payer perspective, compared with teriparatide, zoledronate, or ibandronate. This study will help clinicians and policymakers make better decisions about the relative economic value of osteoporosis treatments in China. (Source: Menopause)
Source: Menopause - February 1, 2022 Category: OBGYN Tags: Original Studies Source Type: research

Bidirectional associations between cognitive functions and walking performance among middle-aged women
This study investigated whether (1) cognitive functions change after the transition from the perimenopausal to the postmenopausal stage, (2) cognitive functions and walking are associated in middle-aged women, and (3) cognitive functions assessed in perimenopause are associated with walking after reaching the postmenopause or vice versa. Methods: In total, 342 women, categorized as early (n = 158) or late perimenopausal (n = 184), were included in the study and followed up until postmenopausal. Psychomotor speed, executive functions related to set-shifting and updating, working memory, and visual memory were...
Source: Menopause - February 1, 2022 Category: OBGYN Tags: Original Studies Source Type: research

Management of cardiovascular disease in women with premature ovarian insufficiency: critical quality appraisal of clinical guidelines and algorithm development
Conclusions: The overall methodological quality of most CPGs regarding CVD in women with POI is moderate to poor. A management algorithm with a clear implementation strategy was developed from high-scoring CPGs. Further research is needed to provide evidence-based health care in this field. (Source: Menopause)
Source: Menopause - February 1, 2022 Category: OBGYN Tags: Original Studies Source Type: research

Delivery of menopause care during a pandemic: an evaluation of patient satisfaction with telephone visits
Conclusions: Menopause clinic telephone appointments had high patient satisfaction, with most preferring this visit type, although in-person visits are preferred among a minority of women. (Source: Menopause)
Source: Menopause - February 1, 2022 Category: OBGYN Tags: Original Studies Source Type: research

Decision aids and shared decision making in urogynecology
Conclusions: There were no statistically significant differences between the control group and the intervention group. The use of DAs was acceptable to providers and indicated a trend toward increased patient knowledge, treatment preference, and satisfaction. A larger study is warranted to examine the impact of DAs on decision making and patient experience. Video Summary:http://links.lww.com/MENO/A856. (Source: Menopause)
Source: Menopause - February 1, 2022 Category: OBGYN Tags: Original Studies Source Type: research

Is cognitive performance of women sensitive to the severity of menopausal symptoms?
Objective: Menopause is a natural phenomenon among women during their midlife, which is accompanied by unfavorable physical, physiological, and psychological consequences. Therefore, the major aim of the present cross-sectional study was to examine whether the cognitive performance of women is sensitive to the severity of menopausal symptoms. Methods: A total number of 404 rural women aged between 40 and 65 years were included in the present study. The menopausal symptoms and cognitive performance of the women were assessed using the Greene Climacteric Scale and Hindi Mini-Mental State Examination scale respec...
Source: Menopause - February 1, 2022 Category: OBGYN Tags: Original Studies Source Type: research

Hypertensive disorders of pregnancy increase the risk of future menopausal hot flashes in Japanese women: results from the Japan Nurses’ Health Study
Conclusions: In this prospective study, we found that women with a history of HDP have a significantly increased risk of problematic hot flashes, compared with their counterparts without a history of HDP. (Source: Menopause)
Source: Menopause - February 1, 2022 Category: OBGYN Tags: Original Studies Source Type: research

Gastrointestinal symptoms in four major racial/ethnic groups of midlife women: race/ethnicity and menopausal status
Conclusions: This study supports the association of race/ethnicity and menopausal status to GI symptoms experienced during the menopausal transition. Video Summary:http://links.lww.com/MENO/A854. (Source: Menopause)
Source: Menopause - February 1, 2022 Category: OBGYN Tags: Original Studies Source Type: research

Factors affecting surgical decision-making in carriers of BRCA1/2 pathogenic variants undergoing risk-reducing surgery at a dedicated hereditary ovarian cancer clinic
Conclusion: Women with BRCA1/2 pathogenic variants face challenging decisions regarding risk reduction and care providers must be knowledgeable and supportive in helping women make informed and individualized choices about their care. Video Summary:http://links.lww.com/MENO/A857. (Source: Menopause)
Source: Menopause - February 1, 2022 Category: OBGYN Tags: Original Studies Source Type: research

MsFLASH analysis of diurnal salivary cortisol and palpitations in peri- and postmenopausal women
Conclusions: Palpitations among midlife women may be associated with blunted morning cortisol, and this relationship is not explained by demographics, clinical variables, vasomotor symptoms, medications, depression, stress, or insomnia. (Source: Menopause)
Source: Menopause - February 1, 2022 Category: OBGYN Tags: Original Studies Source Type: research