The female sexual function index: reliability and validity in Spanish postmenopausal women
Objective: To examine the reliability and validity of the Spanish version of the Female Sexual Function Index (FSFI) and its ability to discriminate between women with and without female sexual dysfunction (FSD) among Spanish postmenopausal women. Methods: A total of 152 postmenopausal women completed the Spanish version of FSFI. Internal consistency, test-retest reliability, and construct validity (exploratory factor analysis) were analyzed. Concurrent and divergent validity were assessed using a visual analog scale for overall satisfaction with sexual life and the Hospital Anxiety and Depression Scale, respectively....
Source: Menopause - March 29, 2019 Category: OBGYN Tags: Original Articles Source Type: research

Clinical application and mid-term results of modified vaginal closure: pelvic symptoms, quality of life, satisfaction, and regret rate
Objective: To evaluate the safety and efficacy of a modified vaginal closure in older women with severe pelvic organ prolapse (POP) with respect to symptoms, quality of life, postoperative satisfaction, regret rate, and complications Methods: From March, 2014 to December, 2016, in all, 32 women were enrolled in the study. All the participants underwent a modified vaginal closure. Records were reviewed to collect demographic characteristics and perioperative parameters. The Pelvic Floor Distress Inventory—short form 20 (PFDI-20) and the Short Form 36 Health Survey Profile (SF-36) were used to evaluate pelvic symp...
Source: Menopause - March 29, 2019 Category: OBGYN Tags: Original Articles Source Type: research

Age at natural menopause and life expectancy with and without type 2 diabetes
Conclusions: Women who experienced early menopause lived less long and spent fewer years without diabetes than women who experienced normal or late menopause. (Source: Menopause)
Source: Menopause - March 29, 2019 Category: OBGYN Tags: Original Articles Source Type: research

Tissue-selective estrogen complex for women who experience breast discomfort or vaginal bleeding when on hormone therapy
Conclusions: This study suggests that TSEC is a good option for women who have breast discomfort or persistent bleeding during other hormone therapy when taking into account the differences in estrogen dose. (Source: Menopause)
Source: Menopause - March 29, 2019 Category: OBGYN Tags: Original Articles Source Type: research

Decreasing menopausal symptoms of Asian American breast cancer survivors through a technology-based information and coaching/support program
This study adopted a randomized pretest/post-test group design among 91 Asian American breast cancer survivors (42 in an intervention group who used the program and the American Cancer Society Web site and 49 in a control group who used only the American Cancer Society Web site). The intervention was a theory-driven and culturally tailored intervention program that aimed to provide information and coaching/support using computers and mobile devices. Multiple instruments were used to measure background characteristics and menopausal symptoms at pretest, post 1-month, and post 3 months. An intent-to-treat linear mixed-model ...
Source: Menopause - March 29, 2019 Category: OBGYN Tags: Original Articles Source Type: research

Dietary patterns and their association with menopausal symptoms: a cross-sectional study
Objective: Although menopause is a natural event in a woman's life, some of its symptoms can be severe enough to adversely affect her health. There is some evidence to suggest that diet has an influence on menopausal symptoms, but less attention has been paid to dietary patterns. The purpose of this study is to determine the association of dietary patterns with physical, mental, and genitourinary menopausal symptoms. Methods: A cross-sectional study design was applied using a sample of 400 postmenopausal women who attended health centers in the south of Tehran, Iran. The menopausal symptoms were assessed by a Menopaus...
Source: Menopause - March 29, 2019 Category: OBGYN Tags: Original Articles Source Type: research

Sleep disturbance in women who undergo surgical menopause compared with women who experience natural menopause
Objective: Women who undergo surgical menopause (SM) experience a relatively more acute and precipitous drop of estrogen compared with women who experience natural menopause (NM). Few studies, however, have compared sleep quality in women who experience natural versus SM. Methods: Participants were 526 postmenopausal women (mean age 60.2 ± 7.64). All participants completed self-report questionnaires about insomnia symptoms, sleep-interfering behaviors, depression, sleep quality, and gynecological history. Analysis of covariance was conducted to compare women who experienced NM versus SM on sleep variables. ...
Source: Menopause - March 29, 2019 Category: OBGYN Tags: Original Articles Source Type: research

A pooled analysis of three studies of nonpharmacological interventions for menopausal hot flashes
Conclusion: Acupuncture, yoga, and health and wellness education classes all demonstrated statistically similar effectiveness in reduction of hot flash frequency compared with controls. (Source: Menopause)
Source: Menopause - March 29, 2019 Category: OBGYN Tags: Original Articles Source Type: research

Women's experience of vulvovaginal symptoms associated with menopause
Conclusions: Women's own words methodically recorded and analyzed during qualitative interviews and cognitive debriefing focus groups illuminate the subjective experience of women with GSM. It is hoped that the PROM currently in development will provide an effective tool for increasing our understanding of the prevalence, predictors, and impact of GSM in menopausal women's lives. (Source: Menopause)
Source: Menopause - March 29, 2019 Category: OBGYN Tags: Original Articles Source Type: research

Women harmed by vaginal laser for treatment of GSM—the latest casualties of fear and confusion surrounding hormone therapy
No abstract available (Source: Menopause)
Source: Menopause - March 29, 2019 Category: OBGYN Tags: Editorials Source Type: research

Yoga and acupuncture versus “sham” treatments for menopausal hot flashes: how do they compare?
No abstract available (Source: Menopause)
Source: Menopause - March 29, 2019 Category: OBGYN Tags: Editorials Source Type: research

Genitourinary syndrome of menopause: in their own words—development of a new patient-reported outcome measure
No abstract available (Source: Menopause)
Source: Menopause - March 29, 2019 Category: OBGYN Tags: Editorials Source Type: research

Menopausal symptoms in different substages of perimenopause and their relationships with social support and resilience
This study is designed to measure the prevalence and severity of menopausal symptoms at different substages of perimenopause, as well as the relationships of these symptoms with social support and resilience in perimenopausal women. Methods: A convenience sample of 732 perimenopausal women was recruited from 3 communities of Jinan City, Shandong Province, China, between March 2015 and March 2017. The participants completed the Menopause Rating Scale, the 10-item Connor-Davidson Resilience Scale, the Perceived Social Support Scale, and a questionnaire regarding sociodemographic information. Results: Of all perimenopau...
Source: Menopause - March 1, 2019 Category: OBGYN Tags: Original Articles Source Type: research

Polycystic ovary syndrome: is the cardiometabolic risk increased after menopause?
Although more commonly known for its fertility sequelae, dermatologic, metabolic, and psychological morbidities associated with polycystic ovary syndrome (PCOS) are not well recognized. This Practice Pearl reviews the effect of PCOS on cardiometabolic risk during the reproductive years and the consequence of these findings in middle-aged women. Current screening and management recommendations are reviewed. (Source: Menopause)
Source: Menopause - February 26, 2019 Category: OBGYN Tags: Clinical Corner: NAMS Practice Pearl Source Type: research

Association of menopause and type 2 diabetes mellitus
Objective: Limited information is available on the direct effect of menopause and risk of type 2 diabetes mellitus (T2DM) among women with different metabolic types. We aimed to investigate whether menopause is a direct risk factor for T2DM. Methods: In this population-based cross-sectional study, women were recruited from a rural area of China from July to August 2013 and July to August 2014. Multivariate logistic regression analysis yielded adjusted odds ratios (ORs) and 95% CIs. Mediation analysis was performed to examine the contribution of age to menopause status-related T2DM. Results: We included 8,191 women ...
Source: Menopause - February 26, 2019 Category: OBGYN Tags: Original Articles Source Type: research

Age and leptinemia association with anxiety and depression symptoms in overweight middle-aged women
Conclusions: Postmenopausal women presented impaired body composition, energy expenditure, insulin sensitivity, and mental symptoms, in comparison to similarly overweight premenopausal women. Among all the overweight midlife women, these symptoms were more strongly associated with age and leptin levels than with reproductive aging itself. The data indicate that, among overweight middle-aged women with abdominal obesity, the aging process and the development of leptin resistance are associated with impairment of mental health. (Source: Menopause)
Source: Menopause - February 26, 2019 Category: OBGYN Tags: Original Articles Source Type: research

Adaptation and translation of the menopause-specific Utian Quality of Life (UQOL) scale to Yoruba language using middle-aged women attending a clinic in Nigeria
Conclusions: This study has validated the YUQOL as a psychometrically sound research instrument for measuring menopause-specific QOL among women undergoing menopausal transition. Its sexual subscale would, however, need to be further tested, preferably in sexually active menopausal women to fully confirm its true psychometric property. (Source: Menopause)
Source: Menopause - February 26, 2019 Category: OBGYN Tags: Original Articles Source Type: research

Amenorrhea after lung cancer treatment
Conclusions: Chemotherapy for lung cancer patients appears to increase risk of early loss of menses in survivors. (Source: Menopause)
Source: Menopause - February 26, 2019 Category: OBGYN Tags: Original Articles Source Type: research

The association of an alpha2C adrenoreceptor gene polymorphism with vasomotor symptoms in African American women
Objective: The alpha2C adrenoreceptor deletion 322-325 (ADRA2C del 322-325) polymorphism has been associated with autonomic activity and thermoregulation, which are implicated in the vasomotor symptom (VMS) mechanism. The ADRA2C del (322-325) has higher prevalence in African American women, a group known to experience more frequent and bothersome VMS. We assessed whether the ADRA2C del (322-325) genotype is associated with increased frequency of VMS in African American women. Methods: DNA samples from African American (N = 400) women participating in the Study of Women's Health Across the Nation (SWAN) were genoty...
Source: Menopause - February 26, 2019 Category: OBGYN Tags: Original Articles Source Type: research

Low pretreatment serum concentration of vitamin D at breast cancer diagnosis in postmenopausal women
Objective: The aim of the study was to evaluate the rate of and risk factors for low pretreatment vitamin D (VitD) levels in postmenopausal breast cancer (BC) women, compared with postmenopausal women without BC. Methods: A cross-sectional clinical study was conducted to compare 209 women with BC (case group) to 418 women without BC (control group), age range: 45 to 75 years. The case group consisted of women diagnosed with BC, amenorrhea ≥12 months, aged ≥45 years, without use of medication or clinical conditions that might interfere with VitD levels. The control group consisted of women with amenorrhea ≥12 ...
Source: Menopause - February 26, 2019 Category: OBGYN Tags: Original Articles Source Type: research

Epidemiology of low-energy fracture in Chinese postmenopausal women: changing trend of incidence since menopause and associated risk factors, a national population-based survey
Objective: The aim of the study was to report the incidence of low-energy fracture since menopause in postmenopausal women ≤70 years and to explore associated risk factors Methods: This was a part of the Chinese National Fracture Survey (CNFS), which was carried out in eight provinces of China mainland between January and May 2015. Data on 68,783 postmenopausal women ≤70 years were extracted from the CNFS database for calculations and analyses. Results: A total of 309 women were confirmed to have low-energy fractures in 2014, indicating the incidence of 449.2 (95% CI, 399.3-499.2) per 100,000 women. There wer...
Source: Menopause - February 26, 2019 Category: OBGYN Tags: Original Articles Source Type: research

Inter-relationship between diet, lifestyle habits, gut microflora, and the equol-producer phenotype: baseline findings from a placebo-controlled intervention trial
Conclusion: Equol production might not depend on the quantity, but on the quality of equol-producing bacteria. High microbial diversity might enhance equol production. Increasing microbial diversity through healthy lifestyle habits and habitual consumption of a wide variety of foods might be useful to maintain a healthy gut environment for equol production. (Source: Menopause)
Source: Menopause - February 26, 2019 Category: OBGYN Tags: Original Articles Source Type: research

Clinician knowledge, attitudes, and barriers to management of vulvovaginal atrophy: variations in primary care and gynecology
Conclusions: Primary care and gynecology clinicians differ in their knowledge and confidence in managing vulvovaginal atrophy but report similar practice barriers. Addressing identified knowledge deficits and practice barriers may lead to improved management of vulvovaginal atrophy. (Source: Menopause)
Source: Menopause - February 26, 2019 Category: OBGYN Tags: Original Articles Source Type: research

Effect of high-intensity interval training on body composition and inflammatory markers in obese postmenopausal women: a randomized controlled trial
This study tested whether high-intensity interval training is a time-efficient strategy for improving visceral adiposity tissue and inflammatory markers in obese postmenopausal women when compared with combined training. Moreover, we tested whether change in visceral adiposity tissue is associated with alterations in these inflammatory markers. Methods: Postmenopausal women were randomized in two groups: combined training (n = 13) and high-intensity interval training (n = 13). The combined training group performed 60 minutes of walking at 70% of maximum heart rate and resistance exercises at 70% of one repetitio...
Source: Menopause - February 26, 2019 Category: OBGYN Tags: Original Articles Source Type: research

Microablative fractional CO2 laser for the genitourinary syndrome of menopause: up to 12-month results
Objective: The aim of this study is to assess the efficacy of microablative fractional CO2 laser therapy for genitourinary syndrome of menopause (GSM) management, when three, four, or five laser therapies were applied in a follow-up period of 12 months. Methods: Retrospective study evaluating GSM symptoms at baseline, and 1, 3, 6, and 12 months after last laser therapy. Visual analog scale, International Consultation on Incontinence Questionnaires- Female Urinary Tract Symptoms, International Consultation on Incontinence Questionnaires-Urinary Incontinence Short Form, Urogenital Distress Inventory-6, and Female Sexual...
Source: Menopause - February 26, 2019 Category: OBGYN Tags: Original Articles Source Type: research

Assessment of NAMS members’ prescription patterns of hormone therapy before and after the 2016 NAMS Annual Meeting
Conclusions: NAMS members’ prescribing patterns of HT vary in complex clinical scenarios. After the 2016 NAMS Annual Meeting where a draft of the 2017 NAMS HT Position Statement was presented and discussed, in four challenging and complex clinical situations a significant number of practitioners changed their prescription patterns toward prescribing HT which was consistent with the new guideline. (Source: Menopause)
Source: Menopause - February 26, 2019 Category: OBGYN Tags: Original Articles Source Type: research

Menopausal symptoms in different substages of perimenopause and their relationships with social support and resilience
This study is designed to measure the prevalence and severity of menopausal symptoms at different substages of perimenopause, as well as the relationships of these symptoms with social support and resilience in perimenopausal women. Methods: A convenience sample of 732 perimenopausal women was recruited from 3 communities of Jinan City, Shandong Province, China, between March 2015 and March 2017. The participants completed the Menopause Rating Scale, the 10-item Connor-Davidson Resilience Scale, the Perceived Social Support Scale, and a questionnaire regarding sociodemographic information. Results: Of all perimenopau...
Source: Menopause - February 26, 2019 Category: OBGYN Tags: Original Articles Source Type: research

Small study, big questions!
No abstract available (Source: Menopause)
Source: Menopause - February 26, 2019 Category: OBGYN Tags: Editorials Source Type: research

Menopausal symptoms: not just estrogen deficiency
No abstract available (Source: Menopause)
Source: Menopause - February 26, 2019 Category: OBGYN Tags: Editorials Source Type: research

In Reply
No abstract available (Source: Menopause)
Source: Menopause - January 29, 2019 Category: OBGYN Tags: Letters to the Editor Source Type: research

To the Editor
No abstract available (Source: Menopause)
Source: Menopause - January 29, 2019 Category: OBGYN Tags: Letters to the Editor Source Type: research

In Reply
No abstract available (Source: Menopause)
Source: Menopause - January 29, 2019 Category: OBGYN Tags: Letters to the Editor Source Type: research

To the Editor
No abstract available (Source: Menopause)
Source: Menopause - January 29, 2019 Category: OBGYN Tags: Letters to the Editor Source Type: research

In Reply
No abstract available (Source: Menopause)
Source: Menopause - January 29, 2019 Category: OBGYN Tags: Letters to the Editor Source Type: research

To the Editor
No abstract available (Source: Menopause)
Source: Menopause - January 29, 2019 Category: OBGYN Tags: Letters to the Editor Source Type: research

Intracrinology and menopause: the science describing the cell-specific intracellular formation of estrogens and androgens from DHEA and their strictly local action and inactivation in peripheral tissues
The secretion of estrogens by the ovaries stops at menopause. Afterward, dehydroepiandrosterone (DHEA) becomes the only source of both estrogens and androgens during all the postmenopausal years. To maintain very low and biologically inactive concentrations of estrogens and androgens in the circulation, DHEA is transformed intracellularly into cell-specific small amounts of estrogens and androgens (except in the endometrium) which then act and are inactivated locally in the same cells, thus avoiding biologically significant systemic exposure to active sex steroids. The secretion of DHEA, however, mainly of adrenal origin, ...
Source: Menopause - January 29, 2019 Category: OBGYN Tags: Personal Perspective Source Type: research

Clinical management of hypoactive sexual desire disorder
Although a woman's healthcare provider has the best opportunity to address hypoactive sexual desire disorder (HSDD), most women are reluctant to discuss their loss of sexual desire. The feeling is often mutual, because limited education and misunderstanding persist, leaving few providers feeling competent to assess and treat this condition. The purpose of this Practice Pearl is to improve the clinician's understanding of and confidence in discussing HSDD, including symptoms, etiology, burden, diagnosis, and treatment. (Source: Menopause)
Source: Menopause - January 29, 2019 Category: OBGYN Tags: Clinical Corner: NAMS Practice Pearl Source Type: research

Factors associated with age at natural menopause among elderly women in São Paulo, Brazil
Conclusions: We found significant associations of age at natural menopause with reproductive and lifestyle factors similar to some studies of women from developed countries. (Source: Menopause)
Source: Menopause - January 29, 2019 Category: OBGYN Tags: Original Articles Source Type: research

Validation of the 10-item Cervantes Scale in middle-aged Portuguese women: paper-and-pencil and online format assessment of menopause-related symptoms
Conclusions: The Portuguese language version of the CS-10 rendered data with good psychometric properties in a sample of middle-aged Portuguese women. Therefore, it can be used in both clinical and community settings. The weak association between both instruments (UQoLS and CS-10) might be due to the different conceptualization of the quality of life construct: the CS-10 focuses on symptom severity, whereas the UQoLS assesses domains such as work-related or health-related behaviors. (Source: Menopause)
Source: Menopause - January 29, 2019 Category: OBGYN Tags: Original Articles Source Type: research

Hormone therapy in postmenopausal women associated with risk of stroke and venous thromboembolism: a population-based cohort study in Taiwan
Conclusions: In postmenopausal Taiwanese women, HT may be associated with an increased risk of cardiovascular disease. Although the women in our population receiving HT were near menopausal age, their risk of cardiovascular disease was still higher than in the non-HT group. (Source: Menopause)
Source: Menopause - January 29, 2019 Category: OBGYN Tags: Original Articles Source Type: research

Demands for perimenopausal health care in women aged 40 to 60 years—a hospital-based cross-sectional study in Shanghai, China
Objectives: The aim of the study was to describe the major complaints of menopausal symptoms among middle-aged women who initiated healthcare seeking for menopausal symptoms and to understand the factors influencing women's decisions to seek perimenopausal health care in Shanghai, China. Methods: A cross-sectional study was performed in five hospitals in Shanghai. Women aged 40 to 60 years at their first visit to the perimenopausal outpatient departments/clinics were investigated in person over a 3-month period. Information on sociodemographics, menopausal symptoms, and experiences in seeking perimenopausal health car...
Source: Menopause - January 29, 2019 Category: OBGYN Tags: Original Articles Source Type: research

Status of bone strength and factors associated with vertebral fracture in postmenopausal women with type 2 diabetes
Conclusions: Low bone mass and deteriorated TBS were noted in approximately two-thirds of T2DM women and was also associated with vertebral fracture. In addition to aging, poor glycemic control may play an important role in bone remodeling, which may be associated with changes in bone strength in T2DM women. Bone strength together with clinical risk factors has the strongest association with fracture, and may potentially be useful to identify women with T2DM at risk. (Source: Menopause)
Source: Menopause - January 29, 2019 Category: OBGYN Tags: Original Articles Source Type: research

Bazedoxifene-induced vasodilation and inhibition of vasoconstriction is significantly greater than estradiol
Conclusion: Bazedoxifene and bazedoxifene + estradiol relaxed mesenteric arteries and opposed vasoconstriction to a greater degree than estradiol or medroxyprogesterone + estradiol. These effects were independent of sex and G-protein-coupled estrogen receptor expression. We conclude that bazedoxifene may provide vascular benefits over estrogen alone or estrogen plus progestogen combinations in postmenopausal women. (Source: Menopause)
Source: Menopause - January 29, 2019 Category: OBGYN Tags: Original Articles Source Type: research

Changes in adiposity and other factors in relation to age at natural menopause: analyses from the coronary artery risk development (CARDIA) study
Conclusion: These findings show that age at natural menopause is partly determined by modifiable factors such as premenopausal hypertension and baseline adiposity. These results highlight the importance of both control and prevention of cardiovascular risk factors such as excess weight in early to mid-adulthood before menopause onset. (Source: Menopause)
Source: Menopause - January 29, 2019 Category: OBGYN Tags: Original Articles Source Type: research

Decreasing sleep-related symptoms through increasing physical activity among Asian American midlife women
Conclusions: The WPAPP is potentially beneficial in decreasing Asian American midlife women's sleep-related symptoms and promoting their lifestyle physical activity. (Source: Menopause)
Source: Menopause - January 29, 2019 Category: OBGYN Tags: Original Articles Source Type: research

Successful long-term use of Gellhorn pessary and the effect on symptoms and quality of life in women with symptomatic pelvic organ prolapse
Conclusions: More than half of the patients continued long-term use of the pessary. The Gellhorn pessary can resolve prolapse and voiding difficulty symptoms effectively. In addition, the Gellhorn pessary can significantly improve the QOL of women via long-term use. However, the Gellhorn pessary has a limited effect on defecatory symptoms. (Source: Menopause)
Source: Menopause - January 29, 2019 Category: OBGYN Tags: Original Articles Source Type: research

Postmenopausal hormone therapy is accompanied by elevated risk for uterine prolapse
Objective: Receptors for estrogen and progesterone are present in the pelvic floor, and therefore, postmenopausal hormone therapy may affect its function. We compared the former use of estradiol-progestogen postmenopausal hormone therapy in nonhysterectomized women with a uterine prolapse surgery (N = 12,072) and control women (N = 33,704). Methods: The women with a history of uterine prolapse operation were identified from the Finnish National Hospital Discharge Register, and the control women from the Finnish Central Population Register. The use of hormone therapy was traced from the national drug reimbursem...
Source: Menopause - January 29, 2019 Category: OBGYN Tags: Original Articles Source Type: research

Risk factors for sexual dysfunction in BRCA mutation carriers after risk-reducing salpingo-oophorectomy
Objective: The aim of the study was to identify risk factors for sexual dysfunction in BRCA mutation carriers who have undergone risk-reducing salpingo-oophorectomy (RRSO). Methods: A cross-sectional study was performed. BRCA1/2 mutation carriers with and without RRSO were surveyed to determine sexual function (Female Sex Function Index [FSFI]), demographics, medical history, sleep quality, depression, and anxiety scores. Characteristics of patients with the lowest quartile of FSFI scores ( (Source: Menopause)
Source: Menopause - January 29, 2019 Category: OBGYN Tags: Original Articles Source Type: research

WISDOM survey: attitudes and behaviors of physicians toward vulvar and vaginal atrophy (VVA) treatment in women including those with breast cancer history
Conclusions: More OB/GYNs than PCPs prescribed VVA treatment, especially vaginal estrogens, for menopausal women, but both groups generally had similar attitudes and behaviors regarding VVA treatment. Physician comfort was low when prescribing to women with a history of breast cancer, despite women's health medical societies supporting vaginal estrogen use in women with a history of estrogen-dependent breast cancer who were unresponsive to nonhormonal therapies when offered in consultation with their oncologist. (Source: Menopause)
Source: Menopause - January 29, 2019 Category: OBGYN Tags: Original Articles Source Type: research

Sleep: suicide's tipping point? Time for menopausal practitioners to act
No abstract available (Source: Menopause)
Source: Menopause - January 29, 2019 Category: OBGYN Tags: Editorials Source Type: research