Vaginal erbium laser as second-generation thermotherapy for the genitourinary syndrome of menopause: a pilot study in breast cancer survivors
Objective: The aim of this study was to evaluate the efficacy and acceptability of a second generation of vaginal laser treatment, the vaginal erbium laser, as a nonablative photothermal therapy for the management of genitourinary syndrome of menopause in postmenopausal breast cancer survivors. Methods: The study was performed using an erbium laser crystal yttrium-aluminum-garnet (XS Fotona Smooth, Fotona, Ljubljana, Slovenia) with a wavelength of 2,940 nm. Forty-three postmenopausal breast cancer survivors were treated with three laser applications every 30 days. Symptoms were assessed before the treatment and after 1,...
Source: Menopause - February 28, 2017 Category: OBGYN Tags: Brief Report Source Type: research

Cultural issues in menopause: an exploratory qualitative study of Macedonian women in Australia
Conclusions: Culturally determined attitudes appear to affect the perception and experience of menopause. Other influencing factors include migration, women's roles, marital status, religion, use of herbal and traditional remedies, social situation, access to information, knowledge and experience of menopausal symptoms. (Source: Menopause)
Source: Menopause - February 28, 2017 Category: OBGYN Tags: Original Articles Source Type: research

Effect of Gua sha therapy on perimenopausal syndrome: a randomized controlled trial
This study aims to evaluate the effectiveness and safety of Gua sha therapy on perimenopausal symptoms, quality of life, and serum female hormones in participants with perimenopausal syndrome. Methods: A prospective, randomized, controlled clinical trial was conducted at the First Affiliated Hospital of Nanjing University of Chinese Medicine in China. Eighty women with perimenopausal syndrome were recruited and randomized into an intervention group or a control group. Participants in the intervention group received 15-minute Gua sha treatment sessions once a week plus conventional treatment for 8 weeks, whereas participan...
Source: Menopause - February 28, 2017 Category: OBGYN Tags: Original Articles Source Type: research

Bioavailable insulin-like growth factor-I as mediator of racial disparity in obesity-relevant breast and colorectal cancer risk among postmenopausal women
Objective: Bioavailable insulin-like growth factor-I (IGF-I) interacts with obesity and exogenous estrogen (E) in a racial disparity in obesity-related cancer risk, yet their interconnected pathways are not fully characterized. We investigated whether circulating bioavailable IGF-I acted as a mediator of the racial disparity in obesity-related cancers such as breast and colorectal (CR) cancers and how obesity and E use regulate this relationship. Methods: A total of 2,425 white and 164 African American (AA) postmenopausal women from the Women's Health Initiative Observational Study were followed from October 1, 1993 throu...
Source: Menopause - February 28, 2017 Category: OBGYN Tags: Original Articles Source Type: research

Altered nocturnal blood pressure profiles in women with insomnia disorder in the menopausal transition
Objective: Insomnia disorder is a risk factor for cardiovascular (CV) pathology. It is unknown whether insomnia that develops in the context of the menopausal transition (MT) impacts the CV system. We assessed nocturnal blood pressure (BP) and heart rate (HR) profiles in women with insomnia disorder in the MT. Methods: Twelve women meeting DSM-IV criteria for insomnia in the MT (age, mean ± SD: 50.5 ± 3.6 y) and 11 controls (age, mean ± SD: 49.0 ± 3.0 y) had polysomnographic recordings on one or two nights during which beat-to-beat BP and HR were assessed and analyzed hourly fro...
Source: Menopause - February 28, 2017 Category: OBGYN Tags: Original Articles Source Type: research

Effects of aerobic exercise training on ACE and ADRB2 gene expression, plasma angiotensin II level, and flow-mediated dilation: a study on obese postmenopausal women with prehypertension
Objective: The purpose of this study is to determine the effect of 10 weeks of moderate-intensity aerobic exercise training (MIET) on blood pressure (BP), angiotensin-converting enzyme (ACE) and β2-adrenergic receptor (ADRB2) gene expression in leukocytes, plasma angiotensin II (Ang II), and flow-mediated dilation (FMD) in obese postmenopausal women (PMW) with prehypertension. Methods: Twenty-four obese prehypertensive PMW (aged 50-70 y; body mass index ≥30 kg/m2) randomly assigned to control (n = 12) and exercise (n = 12) groups. Exercise group performed MIET (25-40 min/d, 3 d/wk at 50%-70% of heart...
Source: Menopause - February 28, 2017 Category: OBGYN Tags: Original Articles Source Type: research

Combined exercise reduces arterial stiffness, blood pressure, and blood markers for cardiovascular risk in postmenopausal women with hypertension
Objective: Postmenopausal women exhibit elevated brachial-ankle pulse wave velocity (baPWV), an indicator of arterial stiffness, which is associated with an increased risk of cardiovascular events and mortality. The purpose of this study is to examine the impact of combined resistance and aerobic exercise training on baPWV, blood pressure (BP), and cardiovascular fitness in postmenopausal women with stage 1 hypertension. Methods: Twenty postmenopausal women (age, 75 ± 2 y; systolic BP, 152 ± 2 mm Hg, diastolic BP, 95 ± 3 mm Hg) were randomly assigned to a “no-exercise” (CON, n...
Source: Menopause - February 28, 2017 Category: OBGYN Tags: Original Articles Source Type: research

Association of genetic variation in the tachykinin receptor 3 locus with hot flashes and night sweats in the Women's Health Initiative Study
We examined genetic variation in relation to VMS (yes/no) in each study and using trans-ethnic inverse variance fixed-effects meta-analysis. A total of 11,078,977 single-nucleotide polymorphisms (SNPs) met the quality criteria. Results: After adjustment for covariates and population structure, three SNPs (on chromosomes 3 and 11) were associated with VMS at the genome-wide threshold of 5 × 10−8 in the African American SHARe GWAS, but were not associated in the other cohorts. In the meta-analysis, 14 SNPs, all located on chromosome 4 in the tachykinin receptor 3 (TACR3) locus, however, had P (Source: Menopause)
Source: Menopause - February 28, 2017 Category: OBGYN Tags: Original Articles Source Type: research

Employment conditions and work-related stressors are associated with menopausal symptom reporting among perimenopausal and postmenopausal women
Conclusions: These findings may help inform the development of tailored occupational health policies and programs that cater for the needs of older women as they transition through menopause in the workplace. (Source: Menopause)
Source: Menopause - February 28, 2017 Category: OBGYN Tags: Original Articles Source Type: research

Longitudinal changes in menopausal symptoms comparing women randomized to low-dose oral conjugated estrogens or transdermal estradiol plus micronized progesterone versus placebo: the Kronos Early Estrogen Prevention Study
The objective of the present study was to compare the efficacy of two forms of menopausal hormone therapy in alleviating vasomotor symptoms, insomnia, and irritability in early postmenopausal women during 4 years. Methods: A total of 727 women, aged 42 to 58, within 3 years of their final menstrual period, were randomized to receive oral conjugated estrogens (o-CEE) 0.45 mg (n = 230) or transdermal estradiol (t-E2) 50 μg (n = 225; both with micronized progesterone 200 mg for 12 d each mo), or placebos (PBOs; n = 275). Menopausal symptoms were recorded at screening and at 6, 12, 24, 36, and 48 months p...
Source: Menopause - February 28, 2017 Category: OBGYN Tags: Original Articles Source Type: research

Work stress and menopausal symptoms
No abstract available (Source: Menopause)
Source: Menopause - February 28, 2017 Category: OBGYN Tags: Editorials Source Type: research

Low-dose hormone therapy and menopausal symptoms: the ongoing quest for relief
No abstract available (Source: Menopause)
Source: Menopause - February 28, 2017 Category: OBGYN Tags: Editorials Source Type: research

In Reply
No abstract available (Source: Menopause)
Source: Menopause - January 28, 2017 Category: OBGYN Tags: Letters to the Editor Source Type: research

To the Editor
No abstract available (Source: Menopause)
Source: Menopause - January 28, 2017 Category: OBGYN Tags: Letters to the Editor Source Type: research

The effect of whole-body vibration training on lean mass in postmenopausal women: a systematic review and meta-analysis
Conclusions: This meta-analysis demonstrated that WBVT alone may not be a sufficient stimulus to increase lean mass in postmenopausal women. Thus, additional complimentary training methods with WBVT are needed to increase muscle size in women with lower hormonal responses. (Source: Menopause)
Source: Menopause - January 28, 2017 Category: OBGYN Tags: Review Article Source Type: research

Relationship between equol producer status and metabolic parameters in 743 Japanese women: equol producer status is associated with antiatherosclerotic conditions in women around menopause and early postmenopause
Conclusions: Equol producer status was associated with favorable metabolic parameters, in women in the early phase postmenopause, with the transitional periods noted with declining intrinsic estrogen levels. (Source: Menopause)
Source: Menopause - January 28, 2017 Category: OBGYN Tags: Original Articles Source Type: research

Comparison of Pueraria mirifica gel and conjugated equine estrogen cream effects on vaginal health in postmenopausal women
Objectives: To compare the effects of a 12-week treatment with Pueraria mirifica (PM) gel or a conjugated estrogen cream on vaginal maturation index, vaginal symptom score, vaginal health assessment score, and vaginal flora in postmenopausal women. Methods: In a prospective, noninferiority, randomized controlled study, 82 postmenopausal women with at least one vulvovaginal symptom, that is, dryness, soreness, irritation, dyspareunia, or discharge, were recruited. Participants were randomly assigned into two groups for treatment with either PM gel or conjugated estrogen cream (CEE). The treatment regimen consisted of appli...
Source: Menopause - January 28, 2017 Category: OBGYN Tags: Original Articles Source Type: research

Increased expression of progesterone receptor membrane component 1 is associated with aggressive phenotype and poor prognosis in ER-positive and negative breast cancer
Conclusions: Our findings suggest that the expression of PGRMC1 might be useful for predicting prognosis in patients with breast cancer. (Source: Menopause)
Source: Menopause - January 28, 2017 Category: OBGYN Tags: Original Articles Source Type: research

Association between maternal age at childbirth and metabolic syndrome in postmenopausal women: Korea National Health and Nutrition Examination Survey 2010 to 2012
Objective: The aim of this study was to evaluate the relationship between maternal age at childbirth and metabolic syndrome in postmenopausal women. Methods: We carried out a cross-sectional study on 3,956 Korean postmenopausal women who participated in the Korea National Health and Nutrition Examination Survey from 2010 to 2012. Multivariate logistic regression was used to evaluate the association between maternal age at first and last childbirth and metabolic syndrome, with adjustment for potential confounding variables. Results: Women with metabolic syndrome had younger age at first delivery (23.3 ± 0.1 vs ...
Source: Menopause - January 28, 2017 Category: OBGYN Tags: Original Articles Source Type: research

In-hospital complications of bilateral salpingo-oophorectomy at benign hysterectomy: a population-based cohort study
Conclusions: Bilateral salpingo-oophorectomy at hysterectomy for benign conditions is not associated with an increased risk of in-hospital complications. (Source: Menopause)
Source: Menopause - January 28, 2017 Category: OBGYN Tags: Original Articles Source Type: research

Association of life events and depressive symptoms among early postmenopausal Chinese women in Hong Kong
Conclusions: Hong Kong Chinese women encounter many SLEs at midlife. Multiple episodes of SLE had a cumulative effect on the onset of depressive symptoms. Our findings have important implications for the identification and management of midlife women with high depressive symptoms. (Source: Menopause)
Source: Menopause - January 28, 2017 Category: OBGYN Tags: Original Articles Source Type: research

Trajectories of response to acupuncture for menopausal vasomotor symptoms: the Acupuncture in Menopause study
Conclusions: Approximately half of the treated sample reported a decline in VMS frequency, but identifying clear predictors of clinical response to acupuncture treatment of menopausal VMS remains challenging. (Source: Menopause)
Source: Menopause - January 28, 2017 Category: OBGYN Tags: Original Articles Source Type: research

Dopaminergic contributions to working memory-related brain activation in postmenopausal women
Conclusions: Patterns of increased blood-oxygen-level dependent signal activation after dopaminergic stimulation were found in this study in posterior brain regions with no effect on working memory performance. Further studies should examine specific dopaminergic contributions to brain functioning in healthy postmenopausal women to determine the effects of the increased brain activation on cognition and behavior. (Source: Menopause)
Source: Menopause - January 28, 2017 Category: OBGYN Tags: Original Articles Source Type: research

Sleep-disordered breathing and the menopausal transition among participants in the Sleep in Midlife Women Study
Conclusions: Progression through menopause is associated with greater sleep-disordered breathing severity. This association is independent of aging and changes in body habitus. (Source: Menopause)
Source: Menopause - January 28, 2017 Category: OBGYN Tags: Original Articles Source Type: research

Age at natural menopause genetic risk score in relation to age at natural menopause and primary open-angle glaucoma in a US-based sample
Conclusions: A genetic risk score predicting 4.8% of ANM variation was not related to POAG; thus, genetic determinants of ANM are unlikely to explain the previously reported association between the two phenotypes. (Source: Menopause)
Source: Menopause - January 28, 2017 Category: OBGYN Tags: Original Articles Source Type: research

Duration of the menopausal transition is longer in women with young age at onset: the multiethnic Study of Women's Health Across the Nation
Objective: The menopausal transition (MT) is a critical period associated with physiologic changes that influence women's long-term health and longevity. Information is, however, limited regarding factors that influence age at the onset of the MT and its duration (ie, time from MT onset to the final menstrual period). Methods: We analyzed data for 1,145 women from four sites of the Study of Women's Health Across the Nation who participated in the menstrual calendar substudy, had the start of the MT identified, and had no missing covariate information. Participants included from four racial/ethnic groups: African American,...
Source: Menopause - January 28, 2017 Category: OBGYN Tags: Original Articles Source Type: research

Estrogen alone and health outcomes in black women by African ancestry: a secondary analyses of a randomized controlled trial
Conclusions: In black postmenopausal women with prior hysterectomy, estrogen alone significantly reduced breast cancer incidence with no adverse influence on CHD, venous thromboembolism, or all-cause mortality. Favorable estrogen-alone global index effects in younger black women warrant further study. (Source: Menopause)
Source: Menopause - January 28, 2017 Category: OBGYN Tags: Original Articles Source Type: research

Menopausal symptoms and cardiovascular disease mortality in the Women's Ischemia Syndrome Evaluation (WISE)
We examined associations between VMS and cardiovascular events and endothelial function, considering age of symptom onset. Methods: The Women's Ischemia Syndrome Evaluation enrolled women referred for coronary angiography for suspected myocardial ischemia. A total of 254 women aged more than 50 years, postmenopausal, with both ovaries, not taking hormone therapy underwent a baseline evaluation, were followed annually (median = 6.0 y), and the National Death Index was searched to ascertain CVD mortality (median = 9.3 y). A subset of participants underwent brachial artery ultrasound for flow-mediated dilation (FMD)....
Source: Menopause - January 28, 2017 Category: OBGYN Tags: Original Articles Source Type: research

The impact of estrogen alone hormone therapy on breast cancer risk and health outcomes: reassurance for the treatment of climacteric symptoms in black women?
No abstract available (Source: Menopause)
Source: Menopause - January 28, 2017 Category: OBGYN Tags: Editorials Source Type: research

Is it WISE to link vasomotor symptoms with cardiovascular disease?
No abstract available (Source: Menopause)
Source: Menopause - January 28, 2017 Category: OBGYN Tags: Editorials Source Type: research

In Reply
No abstract available (Source: Menopause)
Source: Menopause - December 24, 2016 Category: OBGYN Tags: Letters to the Editor Source Type: research

To the Editor
No abstract available (Source: Menopause)
Source: Menopause - December 24, 2016 Category: OBGYN Tags: Letters to the Editor Source Type: research

Association of estradiol with sleep apnea in depressed perimenopausal and postmenopausal women: a preliminary study
Conclusions: These preliminary results suggest that, in addition to higher BMI and age, lower estradiol may be associated with increased OSA risk in depressed women during the peri- and postmenopause, raising the possibility that estradiol withdrawal associated with menopause influences upper-airway patency in women. (Source: Menopause)
Source: Menopause - December 24, 2016 Category: OBGYN Tags: Brief Report Source Type: research

To assess differential features of marrow adiposity between postmenopausal women with osteoarthritis and osteoporosis using water/fat MRI
Objective: To assess the differential features of marrow adiposity between osteoarthritis (OA) and osteoporosis (OP) in postmenopausal women using water/fat MRI. Methods: This cross-sectional study included 97 postmenopausal women (OA [n = 25], OA + osteopenia [n = 27], OA + OP [n = 23], and OP groups [n = 22]). Water/fat MRI, dual-energy x-ray absorptiometry and biochemical analysis were performed to assess vertebral marrow fat fraction, bone mineral density, and bone biomarkers, respectively. Harris Hip Score was recorded to evaluate hip function. Results: There were significant differences in m...
Source: Menopause - December 24, 2016 Category: OBGYN Tags: Original Articles Source Type: research

Frequent nocturia episodes, a suboptimal response to treatment, and small bladder capacity predict the need for persistent antimuscarinic therapy or re-treatment after discontinuation of antimuscarinics in female overactive bladder
Conclusions: Frequent nocturia episodes, a suboptimal response, and small bladder capacity may predict PR after solifenacin treatment. These findings may serve as an initial guide in consultation regarding the treatment of OAB. (Source: Menopause)
Source: Menopause - December 24, 2016 Category: OBGYN Tags: Original Articles Source Type: research

Clinical investigation of RAD1901, a novel estrogen receptor ligand, for the treatment of postmenopausal vasomotor symptoms: a phase 2 randomized, placebo-controlled, double-blind, dose-ranging, proof-of-concept trial
Conclusions: Daily treatment with 10 mg RAD1901 over 4 weeks resulted in a statistically significant reduction in the frequency of moderate-to-severe hot flashes compared with placebo, with an acceptable safety profile. Further clinical trials are warranted to investigate RAD1901's utility as a potential treatment for vasomotor symptoms. (Source: Menopause)
Source: Menopause - December 24, 2016 Category: OBGYN Tags: Original Articles Source Type: research

Bone health assessment by quantitative ultrasound and dual-energy x-ray absorptiometry in postmenopausal women with breast cancer receiving aromatase inhibitors
Objective: Phalangeal quantitative ultrasound (QUS) measurements provide surrogate information on bone quality. The aim of the present study was to assess bone status by phalangeal QUS and by dual-energy x-ray absorptiometry (DXA), and to evaluate bone turnover in breast cancer (BC) women receiving aromatase inhibitors (AIs). Methods: Sixty postmenopausal BC women and 42 matched controls were recruited (mean age 61.64 ± 8.33 y). Amplitude-dependent speed of sound (AD-SoS), bone transmission time (BTT), Ultrasound Bone Profile Index, as QUS parameters, L1-L4 and femoral neck BMD by DXA were assessed at baseline ...
Source: Menopause - December 24, 2016 Category: OBGYN Tags: Original Articles Source Type: research

Association between urinary incontinence and climacteric symptoms in postmenopausal women
Objective: The aim of the study was to evaluate whether climacteric symptoms are related to urinary incontinence (UI) in postmenopausal women. Methods: A cross-sectional investigation was performed on 1,502 postmenopausal women attending the outpatient service for menopause at a University Hospital. Data regarding climacteric symptoms, evaluated by the Greene Climacteric Scale, objective pelvic floor defects, and UI of any type, were retrieved from an electronic database. Additional information retrieved were age, anthropometric measures, personal and reproductive history, use of medication or drugs, smoking, state of anx...
Source: Menopause - December 24, 2016 Category: OBGYN Tags: Original Articles Source Type: research

Compliance to vaginal treatment—tablets versus cream: a retrospective 9 years study
Objective: Local estrogens are used for the treatment of genitourinary symptoms of menopause. The efficacy and adverse effects of both estrogen-containing vaginal tablets (VT) and estrogen-containing vaginal creams (VC)/gels are comparable. Our objective was to assess the compliance and adherence to treatment in a large population. Methods: A retrospective study on women aged 40 to 89 was performed in the Central District of the “Clalit” Health Services between 2006 and 2014. Demographic data on all women and usage details were electronically recorded. Patients eligible for analysis used VT or VC for at least ...
Source: Menopause - December 24, 2016 Category: OBGYN Tags: Original Articles Source Type: research

Reproductive history and risk of type 2 diabetes mellitus in postmenopausal women: findings from the Women's Health Initiative
Objective: The aim of the study was to understand the association between women's reproductive history and their risk of developing type 2 diabetes. We hypothesized that characteristics signifying lower cumulative endogenous estrogen exposure would be associated with increased risk. Methods: Prospective cohort analysis of 124,379 postmenopausal women aged 50 to 79 years from the Women's Health Initiative (WHI). We determined age of menarche and final menstrual period, and history of irregular menses from questionnaires at baseline, and calculated reproductive length from age of menarche and final menstrual period. Presenc...
Source: Menopause - December 24, 2016 Category: OBGYN Tags: Original Articles Source Type: research

An investigation of life circumstances associated with the experience of hot flashes in Campeche, Mexico
Conclusions: Hot flash questionnaires can elicit different symptom frequencies depending on the language used and the sociocultural context of women's lives. Qualitative findings suggest that the themes most likely to influence the perception and experience of hot flashes in Campeche are biomedicine, social support, marriage, and stress. (Source: Menopause)
Source: Menopause - December 24, 2016 Category: OBGYN Tags: Original Articles Source Type: research

Long-term effects of exercise in postmenopausal women: 16-year results of the Erlangen Fitness and Osteoporosis Prevention Study (EFOPS)
Objective: Multimorbidity related to menopause and/or increased age will put healthcare systems in western nations under ever-greater strain. Effective strategies to prevent diseases are thus of high priority and should be started earlier in life. The purpose of the study was to evaluate the long-term effect of exercise on different important health parameters in initially early postmenopausal women over a 16-year period. Methods: In 1998, 137 early postmenopausal women with osteopenia living in Erlangen-Nürnberg were included in the study. Eighty-six women joined the exercise group (EG) and conducted two supervised ...
Source: Menopause - December 24, 2016 Category: OBGYN Tags: Original Articles Source Type: research

Ages at menarche and menopause and reproductive lifespan as predictors of exceptional longevity in women: the Women's Health Initiative
Conclusions: Reproductive characteristics were associated with late-age survival in older women. (Source: Menopause)
Source: Menopause - December 24, 2016 Category: OBGYN Tags: Original Articles Source Type: research

Knowledge of clinical trials regarding hormone therapy and likelihood of prescribing hormone therapy
Objective: The aim of the study was to examine whether physicians who are better informed about large, published hormone therapy (HT) trials (eg, the Women's Health Initiative) are more likely to prescribe HT for menopausal symptoms. Methods: US obstetricians/gynecologists and primary care physicians completed a 15- to 20-minute Internet-based survey. Knowledge was assessed via nine true-false statements about HT trials (range: 0-9). Prescribing practices were assessed via six case studies with a seven-point response scale of “extremely unlikely” to “extremely likely” in relation to treatment optio...
Source: Menopause - December 24, 2016 Category: OBGYN Tags: Original Articles Source Type: research

Longitudinal analysis of changes in weight and waist circumference in relation to incident vasomotor symptoms: the Study of Women's Health Across the Nation (SWAN)
Conclusions: Concurrent BMI and waist circumference were positively related to incident VMS in early menopause and negatively related in late menopause. Maintaining healthy weight in early menopause may help prevent VMS. (Source: Menopause)
Source: Menopause - December 24, 2016 Category: OBGYN Tags: Original Articles Source Type: research

Exercise: a comprehensive tool for ageing women to take care of their health
No abstract available (Source: Menopause)
Source: Menopause - December 24, 2016 Category: OBGYN Tags: Editorials Source Type: research

Links between reproductive factors and general health
No abstract available (Source: Menopause)
Source: Menopause - December 24, 2016 Category: OBGYN Tags: Editorials Source Type: research

We still have a long way to go
No abstract available (Source: Menopause)
Source: Menopause - December 24, 2016 Category: OBGYN Tags: Editorials Source Type: research

Feed a hot flash, starve a hot flash?
No abstract available (Source: Menopause)
Source: Menopause - December 24, 2016 Category: OBGYN Tags: Editorials Source Type: research