Symptoms and effects of physical factors in Japanese middle-aged women
Conclusions: The prevalence and severities of shoulder stiffness, considered a characteristic symptom in Japanese women, were high. Increased BMI was shown to be associated with a higher severity of vasomotor symptoms, joint pain, nervousness, and urinary symptoms. (Source: Menopause)
Source: Menopause - August 26, 2016 Category: OBGYN Tags: Original Articles Source Type: research

Effectiveness of a flamenco and sevillanas program to enhance mobility, balance, physical activity, blood pressure, body mass, and quality of life in postmenopausal women living in the community in Spain: a randomized clinical trial
This study aimed to test the effectiveness of a dance therapy program in improving mobility, balance, physical activity, blood pressure (BP), body mass, and quality of life in postmenopausal women in Spain. Methods: Fifty-two sedentary postmenopausal women (mean age 69.27 ± 3.85 y) were randomly assigned to receive either dance therapy (n = 27) or self-care treatment advice (n = 25). The intervention group participated in 2 months of dance therapy, three sessions weekly, based on Spanish folk dance (flamenco and sevillanas). The control group was provided a booklet containing physical activity recommend...
Source: Menopause - August 26, 2016 Category: OBGYN Tags: Original Articles Source Type: research

Ospemifene's effect on vasomotor symptoms: a post hoc analysis of phase 2 and 3 clinical data
Objective: To examine the effect of ospemifene 60 mg/d on vasomotor symptoms in postmenopausal women using clinical safety and efficacy data from five phase 2 and 3 studies. Methods: The incidence of hot flush treatment-emergent adverse events (TEAEs) was compiled from five randomized, placebo-controlled clinical studies; baseline parameters associated with hot flush incidence were also identified. Ospemifene's effects on the frequency and severity of hot flushes were evaluated in a previously unpublished, 6-week, placebo-controlled study. Results: Analysis of pooled hot flush TEAE data for 2,166 women showed an incide...
Source: Menopause - August 26, 2016 Category: OBGYN Tags: Original Articles Source Type: research

Longtime napping is associated with cardiovascular risk estimation according to Framingham risk score in postmenopausal women
Objective: Menopause can affect the physiological timing system, which could result in circadian rhythm changes and development of napping habits. Whether longtime napping in postmenopausal women is associated with cardiovascular disease is, however, still debated. The present study aims to investigate this association. Methods: We conducted a population-based study in 4,616 postmenopausal Chinese women. Information on sleep duration was self-reported. The Framingham General Cardiovascular Risk Score was calculated and used to identify participants at high risk of coronary heart disease (CHD). Results: Increased daytime ...
Source: Menopause - August 26, 2016 Category: OBGYN Tags: Original Articles Source Type: research

Anxiety as a risk factor for menopausal hot flashes: evidence from the Penn Ovarian Aging cohort
Objective: The aim of this study was to identify temporal associations of anxiety dimensions with menopausal hot flashes in women progressing through the menopausal transition. We hypothesized that associations of both somatic and affective dimensions of anxiety with hot flashes increased in the menopausal transition, and that somatic anxiety was an independent risk factor for menopausal hot flashes. Methods: Hot flashes, anxiety symptoms, hormone levels, and other psychosocial variables were assessed annually for 14 years of follow-up. The 233 women were premenopausal at baseline and continued through 1 year or more afte...
Source: Menopause - August 26, 2016 Category: OBGYN Tags: Original Articles Source Type: research

Are nappers unhealthy?
No abstract available (Source: Menopause)
Source: Menopause - August 26, 2016 Category: OBGYN Tags: Editorials Source Type: research

Somatic, more than affective, anxiety increases the risk for menopausal hot flashes
No abstract available (Source: Menopause)
Source: Menopause - August 26, 2016 Category: OBGYN Tags: Editorials Source Type: research

Effects of walking on body composition in perimenopausal and postmenopausal women: a systematic review and meta-analysis
Conclusions: Walking interventions improved body composition in perimenopausal and postmenopausal women, which underscores the central role of walking as a physical activity for health promotion. (Source: Menopause)
Source: Menopause - July 28, 2016 Category: OBGYN Tags: Review Article Source Type: research

Media and education of the consumer
Abstract: The landscape has changed in how consumers get their health information. A shift to the Internet and social media are now the way many consumers obtain their health and medical information. In addition, the highly complex information in medicine and science separates health journalism from other forms of journalism. In this article, the question of the role of media in educating consumers is examined. It is clear that knowledge translation is complex and begs the cooperation of scientists and journalists alike. (Source: Menopause)
Source: Menopause - July 28, 2016 Category: OBGYN Tags: Clinical Corner: Invited Review Source Type: research

Concurrent and lagged relations between momentary affect and sedentary behavior in middle-aged women
Objective: The purpose of this study was to investigate the reciprocal relationship between sedentary behavior (SB) and momentary affect in the context of daily experiences. Methods: Community-dwelling midlife women (N = 121; age 40-60 y) were recruited for a 15-day daily diary study. The women rated their positive and negative affect when prompted on a personal digital assistant device four times per day and wore an accelerometer for objective assessment of SB. Multilevel models were estimated to test concurrent and lagged associations between momentary estimates of SB and affect. Results: In models that controlled ...
Source: Menopause - July 28, 2016 Category: OBGYN Tags: Brief Report Source Type: research

The relationship between phytoestrogens and speed of processing
This study examined the cross-sectional association between phytoestrogens and speed of processing. We hypothesized that higher levels of phytoestrogens would be related to better cognitive performance among older women. Methods: Participants were from the National Health and Nutrition Examination Survey and consisted of 200 older women (M = 74.4 y). Stepwise regressions examined indicators of speed of processing, measured by the Digit Symbol Substitution Test. Isoflavones, lignans, and individual phytoestrogens were added to the regression after including covariates of age, education, race, smoking, and creatinine. I...
Source: Menopause - July 28, 2016 Category: OBGYN Tags: Original Articles Source Type: research

Do BRCA1/2 mutation carriers have an earlier onset of natural menopause?
Conclusions: Various types of selection bias hamper the comparison of ANM between BRCA1/2 mutation carriers and noncarriers, genetically tested in the clinic. (Source: Menopause)
Source: Menopause - July 28, 2016 Category: OBGYN Tags: Original Articles Source Type: research

Estrogen and DPP4 inhibitor, but not metformin, exert cardioprotection via attenuating cardiac mitochondrial dysfunction in obese insulin-resistant and estrogen-deprived female rats
Conclusions: Treatment with estrogen and vildagliptin provided more beneficial effects in the inhibition of oxidative stress, apoptosis, and cardiac mitochondrial dysfunction, and preserved cardiac contractile performance in estrogen-deprived insulin-resistant female rats. (Source: Menopause)
Source: Menopause - July 28, 2016 Category: OBGYN Tags: Original Articles Source Type: research

Relationship between sociodemographic, reproductive, and lifestyle factors and the severity of menopausal symptoms among Egyptian women in Alexandria
Conclusions: Participant-related information such as working status, which was shown to increase the frequency of psychological symptoms in our ethnic group, should be noted by the physician, and a suitable approach should be adopted to achieve better therapy outcomes. Counseling about the importance of maintaining an ideal body weight and exercise should be emphasized to reduce menopausal symptoms. Appropriate advice and support in improving the overall state of the postmenopausal women is essential. (Source: Menopause)
Source: Menopause - July 28, 2016 Category: OBGYN Tags: Original Articles Source Type: research

The prevalence of endometrial cancer in pre- and postmenopausal Chinese women
Conclusions: Our data demonstrate that although both type 1 and type 2 endometrial cancers are more likely to occur in Chinese women after menopause than before, the total prevalence of endometrial cancer is lower in our study population than in previous reports from white women (80%). The age at diagnosis did not differ between type 1 and type 2 endometrial cancers regardless of the menopause status in our study population. Our results caution clinicians to be more aware of the importance of abnormal uterine bleeding in premenopausal Chinese women. (Source: Menopause)
Source: Menopause - July 28, 2016 Category: OBGYN Tags: Original Articles Source Type: research

Randomized clinical trial: benefits of aerobic physical activity for 24 weeks in postmenopausal women with nonalcoholic fatty liver disease
Objective: The aim of the study was to evaluate the effectiveness of aerobic physical activity in reducing the frequency of hepatic steatosis and metabolic and cardiovascular risk in postmenopausal women with nonalcoholic fatty liver disease (NAFLD). Methods: Forty sedentary postmenopausal women (mean age 55.3 ± 8.0 y) with biopsy-proven NAFLD were randomly divided into two groups: an exercising group (19 participants) and a control group (nonexercising, 21 participants). The exercise group underwent a supervised aerobic physical activity program of 120 min/wk for 24 weeks. The anthropometric parameters; body...
Source: Menopause - July 28, 2016 Category: OBGYN Tags: Original Articles Source Type: research

Whole-body vibration improves neuromuscular parameters and functional capacity in osteopenic postmenopausal women
Conclusions: Low-intensity vibration improved balance, motility, and muscle strength in the upper and lower limbs in postmenopausal women. (Source: Menopause)
Source: Menopause - July 28, 2016 Category: OBGYN Tags: Original Articles Source Type: research

Influence of SULT1A1 genetic variation on age at menopause, estrogen levels, and response to hormone therapy in recently postmenopausal white women
Conclusions: Interindividual variability in onset of menopause and symptoms before initiation of HT is explained in part by genetic variation in SULT1A1 and may represent a step toward individualizing HT treatment decisions. (Source: Menopause)
Source: Menopause - July 28, 2016 Category: OBGYN Tags: Original Articles Source Type: research

The usability of a WeChat-based electronic questionnaire for collecting participant-reported data in female pelvic floor disorders: a comparison with the traditional paper-administered format
Conclusions: WeChat-based questionnaires were well accepted by women with pelvic floor disorders and had good data quality and reliability. (Source: Menopause)
Source: Menopause - July 28, 2016 Category: OBGYN Tags: Original Articles Source Type: research

Hot flashes: emerging cardiovascular risk factors in recent and late postmenopause and their association with higher blood pressure
Objective: The aim of the study was to compare the endothelial function of symptomatic (self-reported hot flashes>3 on a scale of 0-10) versus asymptomatic (≤3) women in different postmenopause stages, and to examine if the association between hot flashes and endothelial function was independent of classical cardiovascular risk factors observed during the analysis. Methods: Noninvasive venous occlusion plethysmography within two groups: recent (recent postmenopause [RPM], (Source: Menopause)
Source: Menopause - July 28, 2016 Category: OBGYN Tags: Original Articles Source Type: research

Individualized predictions of time to menopause using multiple measurements of antimüllerian hormone
Objective: The ability of antimüllerian hormone (AMH) to predict age at menopause has been reported in several studies, and a decrease in AMH level has been found to increase the probability of menopause. The rate of decline varies among women, and there is also a variability of decline between women's cycles. As a result, individualized evaluation is required to accurately predict time of menopause. To this end, we have used the AMH trajectories of individual women to predict each one's age at menopause. Methods: From a cohort study, 266 women (ages 20-50 y) who had regular and predictable menstrual cycles at the in...
Source: Menopause - July 28, 2016 Category: OBGYN Tags: Original Articles Source Type: research

Focal depth measurements of the vaginal wall: a new method to noninvasively quantify vaginal wall thickness in the diagnosis and treatment of vaginal atrophy
Objective: The aim of the study was to evaluate if vaginal focal depth measurement could be a noninvasive method to quantify vaginal wall thickness. Methods: Postmenopausal women undergoing topical estrogen therapy because of vaginal atrophy (VA) were recruited. VA was diagnosed based on the presence of symptoms and vaginal pH at least 5.5. The control group consisted of women above 40 years without VA. Focal depth measurements were performed before and after treatment using the Cytocam-Incident Dark Field device assessing the distance between the subepithelial microcirculation and the epithelial surface. Measurements wer...
Source: Menopause - July 28, 2016 Category: OBGYN Tags: Original Articles Source Type: research

Effects of stretching on menopausal and depressive symptoms in middle-aged women: a randomized controlled trial
Conclusions: These findings suggest that 10 minutes of stretching before bedtime decreases menopausal and depressive symptoms in middle-aged, Japanese women. (Source: Menopause)
Source: Menopause - July 28, 2016 Category: OBGYN Tags: Original Articles Source Type: research

Within-day associations between sedentary behavior and affect in middle-aged women
No abstract available (Source: Menopause)
Source: Menopause - July 28, 2016 Category: OBGYN Tags: Editorials Source Type: research

Quantification of vaginal atrophy: several decades of advances
No abstract available (Source: Menopause)
Source: Menopause - July 28, 2016 Category: OBGYN Tags: Editorials Source Type: research

Stretch it and lose it: the potential benefits of a stretching intervention for the reduction of menopausal symptoms
No abstract available (Source: Menopause)
Source: Menopause - July 28, 2016 Category: OBGYN Tags: Editorials Source Type: research

Pelvic floor muscles training to reduce symptoms and signs of vulvovaginal atrophy: a case study
Conclusions: Pelvic floor muscle training may improve some VVA symptoms and signs in women taking local ET. Further study is needed to investigate and confirm the present case findings and to explore mechanisms of action of this intervention for VVA. (Source: Menopause)
Source: Menopause - June 28, 2016 Category: OBGYN Tags: Case Report Source Type: research

Primary ovarian insufficiency associated with autosomal abnormalities: from chromosome to genome-wide and beyond
Conclusions: The considerably complex process of POI is still not well understood. Further research is needed for gene functional validation studies to confirm the contribution of genes in POI, or additional genome-wide association studies using novel clustered regularly interspaced short palindromic repeat/Cas9 technique might make these mechanisms more comprehensible. (Source: Menopause)
Source: Menopause - June 28, 2016 Category: OBGYN Tags: Review Article Source Type: research

Cognition and the menopause transition
Complaints about forgetfulness, “brain fog,” and difficulty concentrating are common in women transitioning through menopause. Women with these cognitive complaints often express concern about whether these problems are normal, related to menopause, or represent a symptom of Alzheimer disease or another serious cognitive disorder. In this Practice Pearl, we provide a brief summary of the scientific literature on the frequency of cognitive complaints in midlife women, the validity of complaints in relation to performance on standardized cognitive tests, and the influence of menopause on cognitive performance. We...
Source: Menopause - June 28, 2016 Category: OBGYN Tags: Clinical Corner: NAMS Practice Pearl Source Type: research

Menopausal women requesting egg/embryo donation: examining health screening guidelines for assisted reproductive technology
Conclusions: Because maternal and fetal morbidity and mortality increase in postmenopausal women who become pregnant through ART, practitioners caring for this cohort should provide input into developing standardized, comprehensive guidelines for this population so that screening is consistent for all older women seeking this intervention and risks are objectively outlined and considered. (Source: Menopause)
Source: Menopause - June 28, 2016 Category: OBGYN Tags: Brief Report Source Type: research

Efficacy of vaginally applied estrogen, testosterone, or polyacrylic acid on vaginal atrophy: a randomized controlled trial
Conclusions: After a 12-week treatment with testosterone and estrogen compared with placebo lubrication, there was a significant improvement in vaginal trophism in postmenopausal women with vaginal atrophy. (Source: Menopause)
Source: Menopause - June 28, 2016 Category: OBGYN Tags: Original Articles Source Type: research

A cross-cultural comparison of climacteric symptoms, self-esteem, and perceived social support between Mosuo women and Han Chinese women
Objective: This cross-cultural study aimed to compare climacteric symptoms, self-esteem, and perceived social support between Mosuo and Han Chinese women, and to explore the interaction between culture and climacteric symptoms. Mosuo is a Chinese minority group with a matriarchal structure, and Han Chinese is the majority ethnic group in China with a patriarchal structure. Methods: Through convenience sampling, 54 Mosuo women and 52 Han Chinese women between 40 and 60 years of age completed the sociodemographic questionnaire, the Menopause Rating Scale, the Self-Esteem Scale, and the Perceived Social Support Scale. Resul...
Source: Menopause - June 28, 2016 Category: OBGYN Tags: Original Articles Source Type: research

Estrogen therapy may counterbalance eutrophic remodeling of coronary arteries and increase bradykinin relaxation in a rat model of menopausal hypertension
Conclusions: Estrogen may therefore be considered to counterbalance some of the adverse changes seen in the wall of intramural coronaries in the early stages of chronic hypertension. (Source: Menopause)
Source: Menopause - June 28, 2016 Category: OBGYN Tags: Original Articles Source Type: research

Efficacy and tolerability of bazedoxifene in Mexican women with osteoporosis: a subgroup analysis of a randomized phase 3 trial
Objective: Bazedoxifene (BZA) is a selective estrogen receptor modulator that reduces fracture risk and bone turnover in postmenopausal women with osteoporosis. This analysis evaluated BZA's effects on bone mineral density (BMD) and bone turnover in Mexican women with osteoporosis from the global pivotal trial (Study Evaluating Bazedoxifene Acetate in Osteoporosis in Postmenopausal Women). Methods: In this 3-year, phase 3, randomized, double-blind trial, healthy postmenopausal women with osteoporosis (N = 7,492) received BZA 20 or 40 mg/d, raloxifene 60 mg/d, or placebo. The subanalyses of Mexican women assessed s...
Source: Menopause - June 28, 2016 Category: OBGYN Tags: Original Articles Source Type: research

Long-term outcomes of modified laparoscopic sacrocolpopexy for advanced pelvic organ prolapse: a 3-year prospective study
Objective: The aim of the study was to evaluate the anatomical and functional outcomes of modified laparoscopic sacrocolpopexy (MLSC) for the treatment of advanced pelvic organ prolapse (POP). Methods: From May 2009 to September 2012, a consecutive prospective observational study of 30 participants was conducted to evaluate MLSC as a treatment for symptomatic advanced POP at Peking Union Medical College Hospital. The Pelvic Organ Prolapse Quantification (POP-Q) classification was used to determine the POP stage. Validated tools were used to evaluate symptoms (Pelvic Floor Distress Inventory, PFDI-20) and sexual function (...
Source: Menopause - June 28, 2016 Category: OBGYN Tags: Original Articles Source Type: research

Metabolic syndrome as a predictor of endometrial polyps in postmenopausal women
Objective: The aim of the study was to evaluate clinical predictive factors for endometrial polyps in postmenopausal women compared with postmenopausal women without polyps. Methods: In this cross-sectional study, 132 Brazilian women with a histopathological diagnosis of endometrial polyps were compared with 264 women without endometrial alterations (control). The study group included women aged at least 45 years with amenorrhea for at least 12 months, who underwent hysteroscopic polypectomy. The control group consisted of women aged at least 45 years with amenorrhea for at least 12 months, without postmenopausal bleeding...
Source: Menopause - June 28, 2016 Category: OBGYN Tags: Original Articles Source Type: research

Profiling of plasma metabolites in postmenopausal women with metabolic syndrome
Conclusions: Our large-scale metabolomic profiling indicates that Japanese postmenopausal women with MetS have abnormal polar metabolites, suggesting altered catabolic pathways. These results may help to understand metabolic disturbance, including in persons with normal body mass index and relatively high levels of high-density lipoprotein cholesterol, and may have clinical utility based on further studies. (Source: Menopause)
Source: Menopause - June 28, 2016 Category: OBGYN Tags: Original Articles Source Type: research

Effects of preoperative vaginal estrogen therapy for the incidence of mesh complication after pelvic organ prolapse surgery in postmenopausal women: is it helpful or a myth? A 1-year randomized controlled trial
Conclusions: In postmenopausal women with severe POP who underwent transvaginal PRS with mesh, non-VE therapy before surgery was noninferior to VE therapy regarding mesh exposure rate within 1 year of follow-up. (Source: Menopause)
Source: Menopause - June 28, 2016 Category: OBGYN Tags: Original Articles Source Type: research

Prevalence and severity of vasomotor symptoms and joint pain in women at midlife in Bangladesh: a population-based survey
Objective: The aim of the study was to document the prevalence of menopausal symptoms and the extent to which women are bothered by vasomotor symptoms (VMS) and joint pain in Bangladesh. Methods: A total of 1,590 women, aged 30 to 59 years, participated in a cross-sectional, questionnaire-based study between September 2013 and March 2014. The main outcome measures were moderate to severely bothersome VMS and joint pain, measured by the Menopause-Specific Quality of Life questionnaire. Results: Of participants, 59.4% were premenopausal, 8.4% perimenopausal, and 32.3% postmenopausal. Approximately all women reached menopau...
Source: Menopause - June 28, 2016 Category: OBGYN Tags: Original Articles Source Type: research

Effects of ospemifene, a novel selective estrogen-receptor modulator, on human breast tissue ex vivo
Objective: Ospemifene (Osp) is a novel selective estrogen-receptor modulator (SERM) accepted for the treatment of dyspareunia, a symptom of postmenopausal vulvovaginal atrophy. We aimed to analyze the effects of Osp on human breast tissue (HBT), in comparison with the clinically established SERMs raloxifene (Ral) and tamoxifen (Tam), using ex vivo explant cultures. Methods: HBT samples were obtained from postmenopausal women undergoing mammoplasty and cultured with or without Osp, Ral, Tam, or 17β-estradiol (E2) for 7 and 14 days, and studied for morphology, proliferation, and apoptosis. The expression of epithelial ...
Source: Menopause - June 28, 2016 Category: OBGYN Tags: Original Articles Source Type: research

Exercise training reduces the frequency of menopausal hot flushes by improving thermoregulatory control
Objective: Postmenopausal hot flushes occur due to a reduction in estrogen production causing thermoregulatory and vascular dysfunction. Exercise training enhances thermoregulatory control of sweating, skin and brain blood flow. We aimed to determine if improving thermoregulatory control and vascular function with exercise training alleviated hot flushes. Methods: Twenty-one symptomatic women completed a 7-day hot flush questionnaire and underwent brachial artery flow-mediated dilation and a cardiorespiratory fitness test. Sweat rate and skin blood flow temperature thresholds and sensitivities, and middle cerebral artery ...
Source: Menopause - June 28, 2016 Category: OBGYN Tags: Original Articles Source Type: research

Menopausal symptoms in Bangladeshi women in midlife
No abstract available (Source: Menopause)
Source: Menopause - June 28, 2016 Category: OBGYN Tags: Editorials Source Type: research

The response to ospemifene in normal human breast tissue cultures
No abstract available (Source: Menopause)
Source: Menopause - June 28, 2016 Category: OBGYN Tags: Editorials Source Type: research

Is exercise an effective therapy for menopause and hot flashes?
No abstract available (Source: Menopause)
Source: Menopause - June 28, 2016 Category: OBGYN Tags: Editorials Source Type: research

Confirmatory factor analysis for assessment of the menopausal representation questionnaire: Retraction
No abstract available (Source: Menopause)
Source: Menopause - May 21, 2016 Category: OBGYN Tags: Retraction Source Type: research

Palmiwon attenuates hepatic lipid accumulation and hyperlipidemia in a menopausal rat model: Erratum
No abstract available (Source: Menopause)
Source: Menopause - May 21, 2016 Category: OBGYN Tags: Erratum Source Type: research

In Reply
No abstract available (Source: Menopause)
Source: Menopause - May 21, 2016 Category: OBGYN Tags: Letters to the Editor Source Type: research

To the Editor
No abstract available (Source: Menopause)
Source: Menopause - May 21, 2016 Category: OBGYN Tags: Letters to the Editor Source Type: research

Systemic hypertension and diabetes mellitus as predictors of malignancy among women with endometrial polyps: a meta-analysis of observational studies
Conclusions: Physicians should increase their awareness among women with endometrial polyps who suffer from DM and/or SH. Further studies are needed to corroborate our findings and elucidate the underlying mechanisms of this relation. (Source: Menopause)
Source: Menopause - May 21, 2016 Category: OBGYN Tags: Review Article Source Type: research

Menopause status is associated with circadian- and sleep-related alterations
Objective: The aim of the study was to investigate whether postmenopausal women show differences in circadian-related variables and sleep characteristics compared with premenopausal women, and to analyze potential associations between these circadian-related variables and abdominal fat distribution or metabolic syndrome (MetS) components. Methods: A total of 177 women were studied (127 premenopausal, 50 postmenopausal). Sixty percent of the total population was overweight/obese, with no significant differences between premenopausal (60%) and postmenopausal women (62%) (P = 0.865). Wrist temperature (WT) and rest-activ...
Source: Menopause - May 21, 2016 Category: OBGYN Tags: Original Articles Source Type: research