Correlates of sexual function among multi-ethnic middle-aged women: results from the Study of Women's Health Across the Nation (SWAN)
Objective: To examine sexual function in a cohort of Baby Boomer women of diverse racial/ethnic backgrounds; to compare differences between pre-and early perimenopausal women; and to identify sociodemographic, health-related, and psychosocial (including psychological, behavioral, and relationship) factors related to sexual function. Design: Six domains of sexual function were studied in 3,167 women in the baseline cohort of the Study of Women's Health Across the Nation (SWAN). Participants were 42 to 52 years old, pre-or early perimenopausal, and not using hormones. The study sample included non-Hispanic white, Africa...
Source: Menopause - October 25, 2018 Category: OBGYN Tags: Commemorative Papers Source Type: research

Predictors of decreased libido in women during the late reproductive years
Conclusions: Decreased libido in the late reproductive years is associated with a pronounced fluctuation in total testosterone over time. Other independent risk factors for decreased libido include vaginal dryness, depression, and living with children. Sexual dysfunction is a complex disorder, related to physiological and psychosocial factors, requiring further investigation. (Source: Menopause)
Source: Menopause - October 25, 2018 Category: OBGYN Tags: Commemorative Papers Source Type: research

Caloric restriction reduces age at menopause: the effect of the 1944-1945 Dutch famine
Conclusions: Our findings suggest that caloric restriction decreases age at natural menopause. Early childhood seems to be a particularly sensitive age period for this effect. (Source: Menopause)
Source: Menopause - October 25, 2018 Category: OBGYN Tags: Commemorative Papers Source Type: research

The Utian Quality of Life (UQOL) Scale: development and validation of an instrument to quantify quality of life through and beyond menopause
Conclusion: We are reporting on the process of validating an instrument for quantifying sense of well-being in a perimenopausal population. Substantial reliability and validity estimates for the scale and its subscales support the UQOL as a valuable new tool for use in clinical research and practice. (Source: Menopause)
Source: Menopause - October 25, 2018 Category: OBGYN Tags: Commemorative Papers Source Type: research

Comparison of the antioxidant effects of equine estrogens, red wine components, vitamin E, and probucol on low-density lipoprotein oxidation in postmenopausal women
Objective: Oxidized low-density lipoprotein (LDL) seems to play an important role in the etiology of atherosclerosis. To further study this, we performed two studies: (1) we determined the ability of 10 estrogen components of the drug, conjugated equine estrogen (CEE), trans-resveratrol (t-resveratrol) and quercetin (red wine components), trolox (vitamin E analog), and probucol (a serum cholesterol-lowering drug) to delay or prevent the oxidation of plasma LDL isolated from untreated postmenopausal women, and (2) we assessed the effect of long-term (>1 year) estrogen replacement therapy and hormone replacement therapy...
Source: Menopause - October 25, 2018 Category: OBGYN Tags: Commemorative Papers Source Type: research

17β-estradiol vaginal tablet versus conjugated equine estrogen vaginal cream to relieve menopausal atrophic vaginitis
Objectives: The efficacy and safety of 25-μg 17β-estradiol vaginal tablets (Vagifem) were assessed and compared with 1.25-mg conjugated equine estrogen vaginal cream (Premarin Vaginal Cream) for the relief of menopausal-derived atrophic vaginitis, resulting from estrogen deficiency. Design: In a multicenter, open-label, randomized, parallel-group study, 159 menopausal women were treated for 24 weeks with either vaginal tablets or vaginal cream. Efficacy was evaluated by relief of vaginal symptoms and concentrations of serum estradiol and follicle-stimulating hormone. Safety was monitored by the incidence of ad...
Source: Menopause - October 25, 2018 Category: OBGYN Tags: Commemorative Papers Source Type: research

Aromatase and estrogen receptor immunoreactivity in the coronary arteries of monkeys and human subjects
Conclusion: The present results provide the first evidence for the local formation of estrogen in the coronary arteries. In addition to complementing the evidence of a cardioprotective effect of estrogen on the coronary circulation, our results highlight the potential importance of local regulation of estrogen formation and the role of available precursor androgens in maintaining the cardiovascular system. (Source: Menopause)
Source: Menopause - October 25, 2018 Category: OBGYN Tags: Commemorative Papers Source Type: research

Breast cancer risk among women under 55 years of age by joint effects of usage of oral contraceptives and hormone replacement therapy
Conclusions: Although our results must be cautiously interpreted given small numbers within subgroups, they raise concern and emphasize the need for further evaluation on breast cancer risk of the increasingly common exposure to both oral contraceptives and hormone replacement therapy. (Source: Menopause)
Source: Menopause - October 25, 2018 Category: OBGYN Tags: Commemorative Papers Source Type: research

Long-term postmenopausal estrogen therapy may be associated with increased risk of breast cancer: a cohort study
Reports of a role of postmenopausal estrogen replacement therapy in the development of breast cancer have been inconsistent. Although many epidemiologic studies have failed to show an association between short-term use of estrogen and breast cancer, there are indications that long-term use may present an increased risk. We undertook a long-term, retrospective cohort study of the incidence of breast cancer in women who had taken long-term estrogen (average 17.2 years), compared to women who had not taken estrogen. Subjects were 454 women born between 1900 and 1915, who were members of a large health maintenance organization...
Source: Menopause - October 25, 2018 Category: OBGYN Tags: Commemorative Papers Source Type: research

Continuation of postmenopausal hormone replacement therapy: comparison of cyclic versus continuous combined schedules
Discontinuation of hormone replacement therapy (HRT) is much more common than what is reported in randomized, double-blind clinical trials. Our purpose in this retrospective study, using a prescription database, was to compare the continuation rate among women who took cyclic combination therapy adding progesterone to estrogen (CYC-PERT) or continuous combined estrogen progestin therapy (CC-PERT). The study subjects were 1,532 women, ≥45 years old, who initially filled index prescriptions for 0.625 mg conjugated estrogens. They were divided into two groups (CYC-PERT = 644, CC-PERT = 888) on the basis of copres...
Source: Menopause - October 25, 2018 Category: OBGYN Tags: Commemorative Papers Source Type: research

Progestin enhances vasoconstrictor responses in postmenopausal women receiving estrogen replacement therapy
Clinical and experimental evidence suggests that the cardioprotective effect of estrogen replacement is due to effects both on scrum lipids and on blood vessels. Current practice includes the use of a progestin in combination with estrogen if the patient still has her uterus: however, little is known about the effects of combination therapy on vascular reactivity. We therefore studied the effects of estrogen alone and with added progestin on forearm vascular resistance at rest, during reactive hyperemia, and after cold pressor stimulation using plethysmography in six healthy, postmenopausal women. Measurements were made be...
Source: Menopause - October 25, 2018 Category: OBGYN Tags: Commemorative Papers Source Type: research

NAMS-gallup survey on women's knowledge, information sources, and attitudes to menopause and hormone replacement therapy
The North American Menopause Society (NAMS) sponsored a Gallup Organization survey of 833 women aged 45-60 to determine attitudes and experience with menopause and various forms of hormone replacement therapy (HRT). The results of this survey are presented herein. (Source: Menopause)
Source: Menopause - October 25, 2018 Category: OBGYN Tags: Commemorative Papers Source Type: research

Menopause 25th Anniversary Commemorative Issue
No abstract available (Source: Menopause)
Source: Menopause - October 25, 2018 Category: OBGYN Tags: Editorial Source Type: research

Fractional microablative CO2 laser in breast cancer survivors affected by iatrogenic vulvovaginal atrophy after failure of nonestrogenic local treatments: a retrospective study Erratum
No abstract available (Source: Menopause)
Source: Menopause - September 14, 2018 Category: OBGYN Tags: Erratum Source Type: research

In Reply
No abstract available (Source: Menopause)
Source: Menopause - September 14, 2018 Category: OBGYN Tags: Letters to the Editor Source Type: research

To the Editor
No abstract available (Source: Menopause)
Source: Menopause - September 14, 2018 Category: OBGYN Tags: Letters to the Editor Source Type: research

In Reply
No abstract available (Source: Menopause)
Source: Menopause - September 14, 2018 Category: OBGYN Tags: Letters to the Editor Source Type: research

To the Editor
No abstract available (Source: Menopause)
Source: Menopause - September 14, 2018 Category: OBGYN Tags: Letters to the Editor Source Type: research

Metabolic syndrome and its components in premenopausal and postmenopausal women: a comprehensive systematic review and meta-analysis on observational studies
Conclusions: The prevalence of MetS is relatively high in postmenopausal women and was more prevalent among postmenopausal than premenopausal women. Menopausal hormone therapy should be used with caution in patients with MetS, as its safety has not yet been evaluated among MetS patients and meticulous evaluation of each individual patient before starting MHT is needed. (Source: Menopause)
Source: Menopause - September 14, 2018 Category: OBGYN Tags: Review Article Source Type: research

Drug holidays in women treated for postmenopausal osteoporosis
In this Practice Pearl, the experience with long-term treatment of osteoporosis with bisphosphonates and denosumab will be reviewed as well as the effects of discontinuing therapy, providing the platform for recommendations about “drug holidays” for these medications. (Source: Menopause)
Source: Menopause - September 14, 2018 Category: OBGYN Tags: Clinical Corner: NAMS Practice Pearl Source Type: research

Therapeutic progestin segesterone acetate promotes neurogenesis: implications for sustaining regeneration in female brain
Conclusion: These findings provide preclinical evidence and mechanistic insights for the development of ST-1435 as a neuroregenerative therapy to promote intrinsic regenerative capacity in female brains against aging and neurodegenerative disorders. (Source: Menopause)
Source: Menopause - September 14, 2018 Category: OBGYN Tags: Original Articles Source Type: research

Physical activity modifies genetic susceptibility to obesity in postmenopausal women
Conclusion: Our study suggests that physical activity attenuates the influence of genetic predisposition to obesity, and this effect is more profound in the oldest age group. (Source: Menopause)
Source: Menopause - September 14, 2018 Category: OBGYN Tags: Original Articles Source Type: research

Efficacy of injecting platelet concentrate combined with hyaluronic acid for the treatment of vulvovaginal atrophy in postmenopausal women with history of breast cancer: a phase 2 pilot study
Objective: Approximately 50% to 70% of breast cancer survivors are affected by one or more symptoms of vulvovaginal atrophy (VVA). For those who cannot take hormone therapy, autologous platelet-rich plasma combined with hyaluronic acid (A-PRP-HA) may provide a new alternative therapy for the treatment of VVA in postmenopausal women with history of breast cancer. Methods: We enrolled 20 postmenopausal breast cancers survivors with VVA and a score of (Source: Menopause)
Source: Menopause - September 14, 2018 Category: OBGYN Tags: Original Articles Source Type: research

Sex hormone levels and risk of primary open-angle glaucoma in postmenopausal women
Conclusions: Overall, plasma sex hormone levels in postmenopausal women were not associated with POAG risk; however, a trend of higher testosterone levels being associated with higher POAG risk and higher IOP at diagnosis was observed and needs confirmation. (Source: Menopause)
Source: Menopause - September 14, 2018 Category: OBGYN Tags: Original Articles Source Type: research

Anxiety levels predict fracture risk in postmenopausal women assessed for osteoporosis
This study aimed at investigating the role of severity of anxiety in bone health. Methods: Multiple clinical risk factors for fractures, the Fracture Risk Assessment Tool score, the bone mineral density (BMD) at the lumbar spine and femoral neck, Hamilton Anxiety Rating Scale (HAMA) scores, Beck Depression Inventory scores, and the 36-Item Short Form Health Survey (SF-36) scores for evaluation of the quality of life were determined, and x-ray vertebral morphometry was carried out in postmenopausal women referred for osteoporosis. Results: Of the 192 women recruited (mean age 67.5 ± 9.5 years), participants...
Source: Menopause - September 14, 2018 Category: OBGYN Tags: Original Articles Source Type: research

Vasomotor symptoms in women over 60: results from the Data Registry on Experiences of Aging, Menopause, and Sexuality (DREAMS)
Objective: Frequency of vasomotor symptoms (VMS) in older women and the contributing factors are largely undefined. We measured the frequency of moderate-to-severe vasomotor symptoms (msVMS) in women ≥60 years of age and examined their characteristics to determine factors that may associate with VMS in older women. Methods: A cross-sectional survey was completed using the Menopause Health Questionnaire from the Data Registry on Experiences of Aging, Menopause, and Sexuality. Data were collected from women presenting for menopause consultation to Mayo Clinic, Rochester, MN, from January 1, 2006 to October 7, 2014. W...
Source: Menopause - September 14, 2018 Category: OBGYN Tags: Original Articles Source Type: research

Factors associated with developing vaginal dryness symptoms in women transitioning through menopause: a longitudinal study
Conclusion: In these longitudinal analyses, our data support many clinical observations about the relationship between vaginal dryness, menopause, and pain during intercourse, and suggest that reporting of vaginal dryness is not related to androgen level or sexual intercourse frequency. (Source: Menopause)
Source: Menopause - September 14, 2018 Category: OBGYN Tags: Original Articles Source Type: research

Effects of vaginal estradiol tablets and moisturizer on menopause-specific quality of life and mood in healthy postmenopausal women with vaginal symptoms: a randomized clinical trial
Conclusions: Treatment with low-dose vaginal estradiol, but not vaginal moisturizer, modestly improved menopause-related quality of life and sexual function domain scores in postmenopausal women with moderate–severe vulvovaginal symptoms. (Source: Menopause)
Source: Menopause - September 14, 2018 Category: OBGYN Tags: Original Articles Source Type: research

Guidelines for the evaluation and treatment of perimenopausal depression: summary and recommendations
There is a new appreciation of the perimenopause – defined as the early and late menopause transition stages as well as the early postmenopause - as a window of vulnerability for the development of both depressive symptoms and major depressive episodes. However, clinical recommendations on how to identify, characterize and treat clinical depression are lacking. To address this gap, an expert panel was convened to systematically review the published literature and develop guidelines on the evaluation and management of perimenopausal depression. The areas addressed included: 1) epidemiology; 2) clinical presentation; 3...
Source: Menopause - September 14, 2018 Category: OBGYN Tags: Consensus Recommendations Source Type: research

Time to advocate for better science, and better treatments for women
No abstract available (Source: Menopause)
Source: Menopause - September 14, 2018 Category: OBGYN Tags: Editorials Source Type: research

Do current treatment options fall short for persistent vasomotor symptom bother in women over 60?
No abstract available (Source: Menopause)
Source: Menopause - September 14, 2018 Category: OBGYN Tags: Editorials Source Type: research

Clinician practice: bridging what we clinically know about genitourinary syndrome of menopause and what research data report to us
No abstract available (Source: Menopause)
Source: Menopause - September 14, 2018 Category: OBGYN Tags: Editorials Source Type: research

25 years and sex is still hot
No abstract available (Source: Menopause)
Source: Menopause - September 14, 2018 Category: OBGYN Tags: Editorials Source Type: research

In Reply
No abstract available (Source: Menopause)
Source: Menopause - August 21, 2018 Category: OBGYN Tags: Letters to the Editor Source Type: research

To the Editor
No abstract available (Source: Menopause)
Source: Menopause - August 21, 2018 Category: OBGYN Tags: Letters to the Editor Source Type: research

Is ovarian reserve associated with body mass index and obesity in reproductive aged women? A meta-analysis
Conclusion: Ovarian reserve markers of AMH and FSH are significantly lower in obese than in nonobese women, and BMI is negatively correlated with AMH in all study populations, and with FSH in fertile non-PCOS subgroups. PCOS and fertility status do not appear to affect the associations. (Source: Menopause)
Source: Menopause - August 21, 2018 Category: OBGYN Tags: Review Article Source Type: research

Tissue selective estrogen complex (TSEC): a review
Conclusions: Choice of SERM, selection of doses, and clinical trial data evaluating safety and efficacy are key to ensuring safety and adequate therapeutic effect of TSECs for addressing menopausal symptoms. (Source: Menopause)
Source: Menopause - August 21, 2018 Category: OBGYN Tags: Clinical Corner: Invited Review Source Type: research

Design and protocol of Estrogenic Regulation of Muscle Apoptosis (ERMA) study with 47 to 55-year-old women's cohort: novel results show menopause-related differences in blood count
Conclusions: The ERMA study was successful in recruiting and characterizing the menopausal status of a cohort sample of middle-aged women. The significant group differences found in the blood count variables and their associations with E2 and FSH verifies menopause-associated changes in WBC composition potentially being an early sign of low-grade inflammation that may develop later in life. (Source: Menopause)
Source: Menopause - August 21, 2018 Category: OBGYN Tags: Original Articles Source Type: research

Vascular dysfunction across the stages of the menopausal transition is associated with menopausal symptoms and quality of life
Objective: The menopausal transition is associated with somatic symptoms and increased rates of depression, which can impair quality of life (QOL) and increase cardiovascular disease (CVD) risk. This period is also associated with accelerated vascular aging (arterial stiffening and endothelial dysfunction), an antecedent to CVD. This secondary analysis sought to explore associations between depression, menopausal symptoms and QOL, and vascular aging across menopause stages. Methods: Arterial stiffness (carotid artery compliance), endothelial function (brachial artery flow-mediated dilation [FMD]), menopausal symptoms ...
Source: Menopause - August 21, 2018 Category: OBGYN Tags: Original Articles Source Type: research

Effect of a 1-year elastic band resistance exercise program on cardiovascular risk profile in postmenopausal women
Conclusion: One year of progressive resistance training with elastic bands has beneficial effects on anti-inflammatory and anthropometric cardiovascular risk factors in menopausal women, including changes in lipid profile. (Source: Menopause)
Source: Menopause - August 21, 2018 Category: OBGYN Tags: Original Articles Source Type: research

The effects of mindfulness and relaxation training for insomnia (MRTI) on postmenopausal women: a pilot study
Conclusions: Eight weeks mindfulness meditation training improved sleep quality, quality of life, attention levels, and reduced vasomotor symptoms in postmenopausal women with insomnia. (Source: Menopause)
Source: Menopause - August 21, 2018 Category: OBGYN Tags: Original Articles Source Type: research

Estrogen-alone therapy and invasive breast cancer incidence by dose, formulation, and route of delivery: findings from the WHI observational study
This study directly compared different estrogen doses, formulations, and route of delivery of estrogen alone among women with a hysterectomy in relation to invasive breast cancer incidence. Methods: The Women's Health Initiative Observational Study is a large multicenter prospective cohort study conducted at 40 US sites. Analyses included 26,525 postmenopausal women with a hysterectomy, aged 50 to 79 years, at study entry, recruited between September, 1993 and December, 1998, with annual follow-up through September 12, 2005. Results: Average follow-up was 8.2 years. For conjugated equine estrogen (CEE) users, no diff...
Source: Menopause - August 21, 2018 Category: OBGYN Tags: Original Articles Source Type: research

Negative beliefs about back pain are associated with persistent, high levels of low back disability in community-based women
This study examined the association between beliefs about back pain and the development and progression of low back pain and disability over a 2-year period in community-dwelling women. Methods: A total of 506 women were recruited at baseline to participate in a 2-year cohort study. Beliefs about back pain were measured at baseline using the Back Beliefs Questionnaire, and low back pain and disability were assessed at baseline and 2 years using the Chronic Pain Grade Questionnaire (CPG). Participants were categorized into the following groups based on their CPG scores: no, developing, resolving, and persistent high-inte...
Source: Menopause - August 21, 2018 Category: OBGYN Tags: Original Articles Source Type: research

Endometrial cancer in the elderly: does age influence surgical treatments, outcomes, and prognosis?
Objective: To compare clinicopathological characteristics, surgical outcomes, and survival rates for nonelderly ( (Source: Menopause)
Source: Menopause - August 21, 2018 Category: OBGYN Tags: Original Articles Source Type: research

Multifactorial: pain in the menopause transition
No abstract available (Source: Menopause)
Source: Menopause - August 21, 2018 Category: OBGYN Tags: Editorials Source Type: research

Endometrial cancer in the elderly: does patient age influence the choice of treatment interventions and do age-related treatment choices impact survival?
No abstract available (Source: Menopause)
Source: Menopause - August 21, 2018 Category: OBGYN Tags: Editorials Source Type: research

Deciphering the complex relationship between menopause and heart disease: 25 years and counting
No abstract available (Source: Menopause)
Source: Menopause - August 21, 2018 Category: OBGYN Tags: Editorials Source Type: research

In Reply
No abstract available (Source: Menopause)
Source: Menopause - July 26, 2018 Category: OBGYN Tags: Letters to the Editor Source Type: research

To the Editor
No abstract available (Source: Menopause)
Source: Menopause - July 26, 2018 Category: OBGYN Tags: Letters to the Editor Source Type: research

In Reply
No abstract available (Source: Menopause)
Source: Menopause - July 26, 2018 Category: OBGYN Tags: Letters to the Editor Source Type: research