Comparing estrogen-based hormonal contraceptives and hormone therapy on bone mineral density in women with premature ovarian insufficiency: a systematic review
Importance:
Premature ovarian insufficiency (POI) is a condition associated with estrogen deficiency which leads to decreased bone mineral density and an increased risk of osteoporosis and fractures. Estrogen-based hormone therapy is an integral component of treatment; however, to date the ideal hormone formulation for optimizing bone health has not been established.
Objective:
To assess the effects of estrogen-based oral contraceptives (OCP) versus hormone therapy (HT) on bone mineral density (BMD) in women with POI.
Evidence Review:
A systematic review of Ovid MEDLINE, EMBASE, Cochrane Library, and Web ...
Source: Menopause - February 27, 2022 Category: OBGYN Tags: Review Articles Source Type: research
Cosmetic dermatology in menopause
Skin changes that accompany aging lead many to seek treatments that restore a more youthful appearance. Common issues of concern include skin tone, wrinkles, skin thinning, sagging, laxity and decreased elasticity, and hollowing of the face. This work discusses these concerns and their anatomic bases and highlights evidence for a causal role played by menopause-associated hormonal changes where such evidence exists. In addition, treatment options are discussed, with an emphasis on minimally invasive approaches. A variety of modalities are discussed, including botulinum toxins, fillers, multiple types of lasers, radiofreque...
Source: Menopause - February 27, 2022 Category: OBGYN Tags: Clinical Corner: Invited Review Source Type: research
Declining serum bone turnover markers are associated with the short-term positive change of lumbar spine bone mineral density in postmenopausal women
Objective:
While serum bone turnover markers (BTMs) and bone mineral density (BMD) have been confirmed as useable risk assessment tools for postmenopausal osteoporosis, the associations between BTMs and BMD changes are still ambiguous. The aim of this study was to explore the underlying associations between BTMs and BMD changes in postmenopausal women.
Methods:
Between January 2015 and October 2020, 135 postmenopausal women were retrospectively enrolled. They were divided into two groups according to lumbar spine (LS) 1-4 BMD change (1 y T-score minus baseline T-score, Group 1 [n = 36] (Source: Menopause)
Source: Menopause - February 27, 2022 Category: OBGYN Tags: Original Studies Source Type: research
Validation of the Vulvovaginal Symptom Questionnaire in Turkish women with genitourinary syndrome of menopause
Conclusions:
Our study shows successful cross-cultural adaptation and validation with sufficient psychometric properties for VSQ to be used in Turkish postmenopausal women with GSM. (Source: Menopause)
Source: Menopause - February 27, 2022 Category: OBGYN Tags: Original Studies Source Type: research
Low sexual function is associated with menopausal status in mid-aged women with human immunodeficiency virus infection
Conclusions:
HIV-infected postmenopausal women have a higher prevalence of LSF than those non-postmenopausal ones, even when adjusting for multiple potential confounders. (Source: Menopause)
Source: Menopause - February 27, 2022 Category: OBGYN Tags: Original Studies Source Type: research
NT-pro B-type natriuretic peptide, early menopause, and incident heart failure in postmenopausal women of the ARIC study
Conclusions:
The association of NT-proBNP with incident HFpEF is similar irrespective of early menopause status. However, the association of NT-proBNP with incident HFrEF is greater among women with early menopause when compared to those without early menopause.
Video Summary:http://links.lww.com/MENO/A893. (Source: Menopause)
Source: Menopause - February 27, 2022 Category: OBGYN Tags: Original Studies Source Type: research
Effects of E2/P4 oral capsules on bone turnover in women with vasomotor symptoms
Objective:
To evaluate bone turnover markers (BTM) in the REPLENISH trial (NCT01942668).
Methods:
REPLENISH evaluated oral estradiol/progesterone (E2/P4) for the treatment of moderate to severe vasomotor symptoms (VMS) in postmenopausal women with a uterus. Eligible women for this analysis had ≥50 moderate to severe VMS/wk, were (Source: Menopause)
Source: Menopause - February 27, 2022 Category: OBGYN Tags: Original Studies Source Type: research
Oral postmenopausal hormone therapy and genetic risk on venous thromboembolism: gene-hormone interaction results from a large prospective cohort study
Conclusion:
The VTE GRS might inform clinical guidance regarding the balance of risks and benefits of HT use, especially among younger women. (Source: Menopause)
Source: Menopause - February 27, 2022 Category: OBGYN Tags: Original Studies Source Type: research
Association between intergenerational violence exposure and maternal age of menopause
Objective:
To investigate whether maternal violence exposure personally and through her child is associated with an earlier age of menopause, controlling for covariates.
Methods:
Analyses used merged data from two related sources. Although mothers (n = 1,466) were interviewed in 1995 and then 20 years later (2015-17), their children were interviewed in the National Longitudinal Study of Adolescent to Adult Health repeatedly (Waves 1-4, 1994/5 to 2008-2009). Mothers reported their own age of menopause, and mothers and adolescents each reported their own exposure to violence as children and adults.
Results:...
Source: Menopause - February 27, 2022 Category: OBGYN Tags: Original Studies Source Type: research
The long-term association between bilateral oophorectomy and depression: a prospective cohort study
This study aimed to investigate the associations between unilateral and bilateral oophorectomy and depression over a 25-year period (1993-2018) and whether this varied by age at oophorectomy or use of menopausal hormone therapy.
Methods:
Twenty-five thousand one hundred eighty-eight nurses aged ≥45 years from the Danish Nurse Cohort were included. Nurses with depression prior to baseline were excluded. Poisson regression models, with log-transformed person-years as offset, were used to assess the associations between oophorectomy and incident depression. Nurses who retained their ovaries were the reference group...
Source: Menopause - February 27, 2022 Category: OBGYN Tags: Original Studies Source Type: research
Duodenal microbiome changes in postmenopausal women: effects of hormone therapy and implications for cardiovascular risk
Conclusions:
These findings support previous studies suggesting that HT may have beneficial effects following menopause, and although preliminary, may also support a beneficial effect of HT on the duodenal microbiome. (Source: Menopause)
Source: Menopause - February 27, 2022 Category: OBGYN Tags: Original Studies Source Type: research
Association of sleep disturbance with Parkinson disease: evidence from the Women's Health Initiative
Objective:
To examine the association of sleep disturbance with Parkinson disease (PD) during 10+ years of follow-up among postmenopausal women, 50 to 79 years of age at baseline.
Methods:
Longitudinal data on 130,502 study-eligible women (mean ± standard deviation baseline age = 63.16 ± 7.20 y) from the Women's Health Initiative Clinical Trials and Women's Health Initiative Observational Study were analyzed. The cohort was followed for 15.88 ± 6.50 years, yielding 2,829 (2.17%) PD cases. Sleep disturbance (habitual sleep duration, insomnia symptoms, obstructive sleep apnea risk factors, sle...
Source: Menopause - February 27, 2022 Category: OBGYN Tags: Original Studies Source Type: research
The impact of postmenopausal hormone therapy on the duodenal microbiome
No abstract available (Source: Menopause)
Source: Menopause - February 27, 2022 Category: OBGYN Tags: Editorials Source Type: research
Sleep duration, insomnia, and Parkinson disease
No abstract available (Source: Menopause)
Source: Menopause - February 27, 2022 Category: OBGYN Tags: Editorials Source Type: research
Monckeberg's arteriosclerosis: a case report of chronic endometritis presenting as postmenopausal bleeding
Conclusions:
The lack of reviews of chronic endometritis in postmenopausal women reveals a gap in the literature. Further studies are necessary to review MocA and decreased uterine perfusion in the context of a possible predisposition to chronic endometrial infection and/or inflammation. (Source: Menopause)
Source: Menopause - February 1, 2022 Category: OBGYN Tags: Case Report Source Type: research
