The Hot Flash Related Daily Interference Scale: cutoffs, minimally important differences, and a revised short version
No abstract available (Source: Menopause)
Source: Menopause - July 27, 2017 Category: OBGYN Tags: Editorials Source Type: research

Fredi Kronenberg, PhD (March 7, 1950–April 20, 2017)
No abstract available (Source: Menopause)
Source: Menopause - July 27, 2017 Category: OBGYN Tags: In Memoriam Source Type: research

In Reply
No abstract available (Source: Menopause)
Source: Menopause - June 27, 2017 Category: OBGYN Tags: Letters to the Editor Source Type: research

To the Editor
No abstract available (Source: Menopause)
Source: Menopause - June 27, 2017 Category: OBGYN Tags: Letters to the Editor Source Type: research

Subcutaneous testosterone-letrozole therapy before and concurrent with neoadjuvant breast chemotherapy: clinical response and therapeutic implications
Conclusions: Subcutaneous testosterone-letrozole was an effective treatment for this patient's breast cancer and did not interfere with chemotherapy. This novel combination implant has the potential to prevent side effects from chemotherapy, improve quality of life, and warrants further investigation. (Source: Menopause)
Source: Menopause - June 27, 2017 Category: OBGYN Tags: Case Report Source Type: research

Estrogen and DPP-4 inhibitor share similar efficacy in reducing brain pathology caused by cardiac ischemia-reperfusion injury in both lean and obese estrogen-deprived rats
Conclusions: Cardiac I/R aggravates brain toxicity in estrogen-deprived lean rats, but not in the estrogen-deprived obese rats. Estrogen and DPP-4 inhibitor treatments attenuate those effects in all groups. (Source: Menopause)
Source: Menopause - June 27, 2017 Category: OBGYN Tags: Original Articles Source Type: research

Vaginal estrogen: a dual-edged sword in postoperative healing of the vaginal wall
Conclusions: Collectively, these data indicate that, in contrast to the reported positive effects of preoperative estrogen on the uninjured vagina, acute administration of postoperative vaginal estrogen has adverse effects on the early phase of healing of the stromal layer. In contrast, postoperative estrogen plays a positive role in healing of the vaginal epithelium after injury. (Source: Menopause)
Source: Menopause - June 27, 2017 Category: OBGYN Tags: Original Articles Source Type: research

Parity and increased risk of insulin resistance in postmenopausal women: the 2010 Korean National Health and Nutrition Examination Survey
The objective of this study was to assess the association between parity and insulin resistance in nondiabetic, postmenopausal women. Methods: This cross-sectional study was conducted using data from the 2010 Korean National Health and Nutrition Examination Survey administered by the Korean Ministry of Health and Welfare. A total of 1,243 nondiabetic postmenopausal women were included in this study and subdivided into three groups according to parity (1-2, 3-4, and ≥5 live births). Insulin resistance was measured using the homeostasis model assessment of insulin resistance (HOMA-IR) index. The relationship between pari...
Source: Menopause - June 27, 2017 Category: OBGYN Tags: Original Articles Source Type: research

Psychometric properties of the medical outcomes study sleep scale in Spanish postmenopausal women
This study aimed to analyze the reliability and validity of the Spanish version of the Medical Outcomes Study Sleep Scale (MOS-SS), and its ability to discriminate between poor and good sleepers among a Spanish population with vestibular disorders. Methods: In all, 121 women (50-76 years old) completed the Spanish version of the MOS-SS. Internal consistency, test-retest reliability, and construct validity (exploratory factor analysis) were analyzed. Concurrent validity was evaluated using the Pittsburgh Sleep Quality Index and the 36-item Short Form Health Survey. To analyze the ability of the MOS-SS scores to discriminat...
Source: Menopause - June 27, 2017 Category: OBGYN Tags: Original Articles Source Type: research

Time since menopause and skeletal muscle estrogen receptors, PGC-1α, and AMPK
Objective: Short-term administration of estradiol (E2) improves insulin-stimulated glucose disposal rate in early postmenopausal (EPM) women compared with a reduction in late postmenopausal (LPM) women. The underlying mechanisms by which E2 action on glucose disposal rate reversed from beneficial early to harmful late in menopause is unknown, but might include adverse changes in estrogen receptors (ERs) or other biomarkers of cellular energy metabolism with age or duration of estrogen deficiency. Methods: We retrospectively analyzed skeletal muscle samples from 27 postmenopausal women who were 6 years or less past menopau...
Source: Menopause - June 27, 2017 Category: OBGYN Tags: Original Articles Source Type: research

Use of a novel fractional CO2 laser for the treatment of genitourinary syndrome of menopause: 1-year outcomes
Objectives: To assess safety and efficacy of a fractional CO2 laser therapy for the treatment of genitourinary syndrome of menopause (GSM) with follow-up to 1 year posttreatment. Methods: Women presenting with GSM and meeting inclusion criterion were enrolled. Visual Analog Scales were used to grade vaginal pain, burning, itching, dryness, dyspareunia, and dysuria. Dilators were used to rate vaginal elasticity at baseline and at each follow-up visit. Before each treatment and at follow-up, Vaginal Health Index scoring and Female Sexual Function Index questionnaires were completed. Women received three vaginal laser treatm...
Source: Menopause - June 27, 2017 Category: OBGYN Tags: Original Articles Source Type: research

Polycystic ovarian syndrome and the risk of subsequent primary ovarian insufficiency: a nationwide population-based study
Objective: To evaluate the risk of subsequent primary ovarian insufficiency (POI) amongst patients with a history of polycystic ovarian syndrome (PCOS). Methods: This nationwide, population-based study is an inspection and review of data from the 1998 to 2012 Taiwan National Health Insurance Research Database. In a sample of 1,000,000 randomly sampled individuals, women with PCOS (exposure group; n = 7,049) and women without PCOS (contrast group; n = 70,490) were compared. Women initially diagnosed with PCOS at less than 15 or more than 35 years of age were excluded. Each woman with PCOS was age-matched to 10 wome...
Source: Menopause - June 27, 2017 Category: OBGYN Tags: Original Articles Source Type: research

Association of follicle-stimulating hormone levels and risk of type 2 diabetes in older postmenopausal women
Objective: Recent studies of perimenopausal women have observed associations of follicle-stimulating hormone (FSH) levels with markers of insulin resistance, independent of estradiol. Whether FSH is related to type 2 diabetes (T2D) in older women who have completed the menopause transition remains unknown. We assessed the association of FSH levels with diabetes and measures of insulin resistance among 588 postmenopausal Finnish women. Methods: Study participants were aged 53 to 73 years and not using hormone therapy at baseline (1998-2001) when FSH was measured. Prevalence of T2D was assessed at baseline, along with fasti...
Source: Menopause - June 27, 2017 Category: OBGYN Tags: Original Articles Source Type: research

Association between osteoporosis treatment and severe periodontitis in postmenopausal women
Conclusions: The results suggest that women treated with estrogen for postmenopausal osteoporosis have a lower prevalence of severe periodontitis than women not receiving treatment. (Source: Menopause)
Source: Menopause - June 27, 2017 Category: OBGYN Tags: Original Articles Source Type: research

Menopause and big data: Word Adjacency Graph modeling of menopause-related ChaCha data
Conclusions: We modeled menopause-related queries posed by ChaCha users between 2009 and 2012. ChaCha data may be used on its own or in combination with other Big Data sources to identify patient-driven educational needs and create patient-centered interventions. (Source: Menopause)
Source: Menopause - June 27, 2017 Category: OBGYN Tags: Original Articles Source Type: research

Efficacy of a biobehavioral intervention for hot flashes: a randomized controlled pilot study
Conclusions: Hypnosis alone reduced hot flashes equal to venlafaxine alone, but the combination of hypnosis and venlafaxine did not reduce hot flashes more than either treatment alone. More research is needed to clarify whether combining hypnosis with a different antidepressant would provide synergistic benefits. (Source: Menopause)
Source: Menopause - June 27, 2017 Category: OBGYN Tags: Original Articles Source Type: research

Effects of a dance-based aquatic exercise program in obese postmenopausal women with knee osteoarthritis: a randomized controlled trial
Conclusions: An 8-week dance-based exercise program significantly improved function and cardiorespiratory capacity, and decreased postexercise heart rate and fatigue. Most of these improvements were maintained at 3-month follow-up in obese postmenopausal women. (Source: Menopause)
Source: Menopause - June 27, 2017 Category: OBGYN Tags: Original Articles Source Type: research

An Internet-based cognitive behavioral therapy for treatment-induced menopausal symptoms in breast cancer survivors: results of a pilot study
Conclusions: These findings suggest that an Internet-based CBT program for women with treatment-induced menopausal symptoms is feasible and promising in terms of efficacy. The efficacy of the CBT program is currently being investigated in a larger randomized controlled trial. (Source: Menopause)
Source: Menopause - June 27, 2017 Category: OBGYN Tags: Original Articles Source Type: research

Cardiac autonomic function and hot flashes among perimenopausal and postmenopausal women
Conclusions: Among perimenopausal and postmenopausal women with hot flashes, variations in hot flash frequency and severity were not explained by variations in resting sympathetic activation. Greater parasympathetic activation was associated with more frequent moderate-to-severe hot flashes, which may reflect increased sensitivity to perceiving hot flashes. (Source: Menopause)
Source: Menopause - June 27, 2017 Category: OBGYN Tags: Original Articles Source Type: research

NAMS CME activity self-assessment examination
No abstract available (Source: Menopause)
Source: Menopause - June 27, 2017 Category: OBGYN Tags: CME Exam Source Type: research

The 2017 hormone therapy position statement of The North American Menopause Society
Abstract: The 2017 Hormone Therapy Position Statement of The North American Menopause Society (NAMS) updates the 2012 Hormone Therapy Position Statement of The North American Menopause Society and identifies future research needs. An Advisory Panel of clinicians and researchers expert in the field of women's health and menopause was recruited by NAMS to review the 2012 Position Statement, evaluate new literature, assess the evidence, and reach consensus on recommendations, using the level of evidence to identify the strength of recommendations and the quality of the evidence. The Panel's recommendations were reviewed and a...
Source: Menopause - June 27, 2017 Category: OBGYN Tags: Position Statement Source Type: research

The North American Menopause Society (NAMS) Continuing Medical Education Activity
No abstract available (Source: Menopause)
Source: Menopause - June 27, 2017 Category: OBGYN Tags: CME Activity Source Type: research

Can dance-based aquatic exercise improve functionality in obese women with knee osteoarthritis?
No abstract available (Source: Menopause)
Source: Menopause - June 27, 2017 Category: OBGYN Tags: Editorials Source Type: research

An eHealth approach to treating vasomotor symptoms
No abstract available (Source: Menopause)
Source: Menopause - June 27, 2017 Category: OBGYN Tags: Editorials Source Type: research

Cardiac autonomic function and vasomotor symptoms: too much break and not enough accelerator?
No abstract available (Source: Menopause)
Source: Menopause - June 27, 2017 Category: OBGYN Tags: Editorials Source Type: research

Is there a SERM in your menopause toolkit?: Erratum
No abstract available (Source: Menopause)
Source: Menopause - May 26, 2017 Category: OBGYN Tags: Erratum Source Type: research

In Reply
No abstract available (Source: Menopause)
Source: Menopause - May 26, 2017 Category: OBGYN Tags: Letters to the Editor Source Type: research

To the Editor
No abstract available (Source: Menopause)
Source: Menopause - May 26, 2017 Category: OBGYN Tags: Letters to the Editor Source Type: research

In Reply
No abstract available (Source: Menopause)
Source: Menopause - May 26, 2017 Category: OBGYN Tags: Letters to the Editor Source Type: research

To the Editor
No abstract available (Source: Menopause)
Source: Menopause - May 26, 2017 Category: OBGYN Tags: Letters to the Editor Source Type: research

In Reply
No abstract available (Source: Menopause)
Source: Menopause - May 26, 2017 Category: OBGYN Tags: Letters to the Editor Source Type: research

To the Editor
No abstract available (Source: Menopause)
Source: Menopause - May 26, 2017 Category: OBGYN Tags: Letters to the Editor Source Type: research

Science of intracrinology in postmenopausal women
Conclusions: The symptoms and signs of vulvovaginal atrophy (genitourinary syndrome of menopause) can be successfully treated by the intravaginal administration of DHEA without safety concerns. This strategy exclusively replaces in the vagina the missing cell-specific intracellular estrogens and androgens. This approach avoids systemic exposure and the potential risks of estrogen exposure for the tissues other than the vagina. (Source: Menopause)
Source: Menopause - May 26, 2017 Category: OBGYN Tags: Review Article Source Type: research

Tailoring strategies for the management of depression in midlife years
Abstract: Depression affects one in every five adults in North America. Women are more affected than men, possibly because of genetics, coping strategies, and hormone variations. The concept of a menopause-associated depression, however, remains a complex and controversial topic. Although hormone therapy is not recommended as first-line therapy for depression in midlife women, estrogen-based hormone therapy may minimize the need for or enhance the response to antidepressant or behavior-based therapies in select perimenopausal women. (Source: Menopause)
Source: Menopause - May 26, 2017 Category: OBGYN Tags: Clinical Corner: NAMS Practice Pearl Source Type: research

Dried and free flowing granules of Spinacia oleracea accelerate bone regeneration and alleviate postmenopausal osteoporosis
Conclusions: SOE treatment effectively prevents ovariectomy-induced bone loss and stimulated fracture healing in adult rats. The dried granular form of the extract of Spinaceae oleracea was effective in fracture healing at the same dose. (Source: Menopause)
Source: Menopause - May 26, 2017 Category: OBGYN Tags: Original Articles Source Type: research

Pharmacodynamic effects of the fetal estrogen estetrol in postmenopausal women: results from a multiple-rising-dose study
Conclusions: In this study, estetrol treatment showed dose-dependent estrogenic effects on endocrine parameters, bone turnover markers, and lipids and lipoproteins. The effect on triglycerides was small as were the effects on hemostatic variables. These results support the further investigation of estetrol as a candidate for hormone therapy. Quantitatively, the effects of 10 mg estetrol were similar to the study comparator 2 mg estradiol valerate. (Source: Menopause)
Source: Menopause - May 26, 2017 Category: OBGYN Tags: Original Articles Source Type: research

Sexual activity and function assessment in middle-aged Chinese women using the female sexual function index
Objective: To assess sexual activity, sexual function, and their correlation with vaginal maturation status among middle-aged Chinese women. Methods: A cross-sectional study with comparisons across age groups was carried out. In all, 120 women aged 45 to 60 years were recruited into three groups: 45 to 50 (youngest group), 51 to 55 (intermediate group), and 56 to 60 years old (eldest group). Sexual function was assessed through the Female Sexual Function Index (FSFI); vaginal maturation status was determined through the Vaginal Maturation Index (VMI) and pH value. Sexual activity was recorded with self-administered questi...
Source: Menopause - May 26, 2017 Category: OBGYN Tags: Original Articles Source Type: research

Genetic variants of age at menopause are not related to timing of ovarian failure in breast cancer survivors
Conclusions: Thirteen previously identified genetic variants associated with time to natural menopause were not related to timing of ovarian failure in breast cancer survivors. (Source: Menopause)
Source: Menopause - May 26, 2017 Category: OBGYN Tags: Original Articles Source Type: research

Improving menopausal symptoms through promoting physical activity: a pilot Web-based intervention study among Asian Americans
Objective: Based on previous studies, a Web-based physical activity promotion program with educational modules on menopausal symptoms and physical activity has been developed for Asian American midlife women to reduce their menopausal symptoms through increasing their physical activity. The purpose of this pilot randomized intervention study was to determine the efficacy of the Web-based program in improving menopausal symptom experience of Asian American midlife women. Methods: This was a randomized repeated measures pretest/posttest (pretest, post 1 month, and post 3 months) control group study among 29 Asian American m...
Source: Menopause - May 26, 2017 Category: OBGYN Tags: Original Articles Source Type: research

Association between anxiety and severe quality-of-life impairment in postmenopausal women: analysis of a multicenter Latin American cross-sectional study
Conclusions: In this postmenopausal Latin American sample, anxiety was independently associated with severe QoL impairment. Hence, screening for anxiety in this population is important. (Source: Menopause)
Source: Menopause - May 26, 2017 Category: OBGYN Tags: Original Articles Source Type: research

Free androgen index as a determinant of arterial stiffness in menopause: a mediation analysis
Objective: Associations of endogenous androgens in menopause with blood pressure (BP) and indices of arterial stiffness are reported, but directional relationships are not clear. Structural equation modeling is a contemporary statistical method, which allows assessment of such relationships and improves pathway understanding. Methods: We recruited 411 consecutive apparently healthy postmenopausal women who underwent noninvasive vascular evaluation. This included pulse wave analysis (aortic pressures and arterial wave reflections [augmentation index]), measurement of aortic stiffness by pulse wave velocity (PWV), stiffness...
Source: Menopause - May 26, 2017 Category: OBGYN Tags: Original Articles Source Type: research

Menopausal symptom clusters and their correlates in women with and without a history of breast cancer: a pooled data analysis from the Women's Wellness Research Program
Objectives: This analysis examined climacteric symptoms clusters in women with and without breast cancer, and explored how sociodemographic, health, and modifiable lifestyle factors predicted symptom clusters. Methods: This pooled analysis of four Women's Wellness Research Program (WWRP) studies comprised individual-level data from 969 Australian women aged 40 to 63 years, 293 of whom had been previously treated for breast cancer and 678 without a breast cancer history. Climacteric symptoms, menopausal status, sociodemographic characteristics, and health and lifestyle factors were assessed. Principal component analysis wa...
Source: Menopause - May 26, 2017 Category: OBGYN Tags: Original Articles Source Type: research

Exercise training ameliorates glucosamine-induced insulin resistance in ovariectomized rats
Conclusions: Exercise training can alleviate IR in OVX rats treated with GlcN. Islet hyperplasia was subsequently prevented. Preserving GLUT-4 expression may be one of the mechanisms by which exercise prevents IR. (Source: Menopause)
Source: Menopause - May 26, 2017 Category: OBGYN Tags: Original Articles Source Type: research

Malignancy risk of sonographically benign appearing purely solid adnexal masses in asymptomatic postmenopausal women
Conclusions: The risk of malignancy of benign appearing purely solid adnexal masses in asymptomatic postmenopausal women is low. Conservative management of these lesions might be an option. (Source: Menopause)
Source: Menopause - May 26, 2017 Category: OBGYN Tags: Original Articles Source Type: research

Association of sleep disturbance and sexual function in postmenopausal women
Objective: Sleep disturbance and sexual dysfunction are common in menopause; however, the nature of their association is unclear. The present study aimed to determine whether sleep characteristics were associated with sexual activity and sexual satisfaction. Methods: Sexual function in the last year and sleep characteristics (past 4 wk) were assessed by self-report at baseline for 93,668 women age 50 to 79 years enrolled in the Women's Health Initiative (WHI) Observational Study (OS). Insomnia was measured using the validated WHI Insomnia Rating Scale. Sleep-disordered breathing (SDB) risk was assessed using questions ada...
Source: Menopause - May 26, 2017 Category: OBGYN Tags: Original Articles Source Type: research

Another link between exercise and relief from postmenopausal decline
No abstract available (Source: Menopause)
Source: Menopause - May 26, 2017 Category: OBGYN Tags: Editorials Source Type: research

Pelvic ultrasound: a powerful tool in managing the patient with an adnexal mass
No abstract available (Source: Menopause)
Source: Menopause - May 26, 2017 Category: OBGYN Tags: Editorials Source Type: research

Postmenopausal sleep disturbance and sexual dysfunction
No abstract available (Source: Menopause)
Source: Menopause - May 26, 2017 Category: OBGYN Tags: Editorials Source Type: research

Use of cardiovascular age for assessing risks and benefits of menopausal hormone therapy
Abstract: The Women's Health Initiative studies and others have suggested that menopausal hormone therapy may enhance the risk of new cardiovascular (CV) events in older women and diminish the development of coronary atherosclerosis in younger women. The underlying mechanisms to explain these findings are encapsulated in the term “Timing Hypothesis.” Extensive pathophysiologic studies have provided mechanistic evidence for the dichotomous effects of estrogen on coronary artery vasculature. Early in the atherosclerotic disease process, estrogen exerts protective effects on the endothelium and retards plaque form...
Source: Menopause - April 27, 2017 Category: OBGYN Tags: Personal Perspective Source Type: research

Treating schizophrenia during menopause
Conclusions: Both HT and changes in antipsychotic management should be considered for women with schizophrenia at menopause. The question about differences in response between early- and late-onset women cannot yet be answered. (Source: Menopause)
Source: Menopause - April 27, 2017 Category: OBGYN Tags: Review Article Source Type: research