MicroRNA-26a: An Emerging Regulator of Renal Biology and Disease
MicroRNAs (miRNAs) are short, single-stranded, noncoding RNAs that modulate many key biological processes by simultaneously suppressing multiple target genes. Among them, miR-26a, a conserved miRNA among vertebrates, is highly expressed in various tissues. Accumulating evidence demonstrates that miR-26a plays pivotal roles in cellular differentiation, cell growth, apoptosis, and metastasis, thereby participating in the initiation and development of various human diseases, such as metabolic disease and cancer. More recently, miR-26a was found as a versatile regulator of renal biology and disease. miR-26a is intensively invo...
Source: Kidney and Blood Pressure Research - June 4, 2019 Category: Urology & Nephrology Source Type: research
Association between Plasma Levels of Growth Differentiation Factor-15 and Renal Function in the Elderly: Korean Frailty and Aging Cohort Study
Conclusion: Plasma GDF-15 levels were negatively associated with eGFR and were significantly increased in the elderly with CKD. Our results suggested that plasma GDF-15 might be a useful marker for discriminating renal impairment in the elderly. Further large and prospective outcome studies of extended duration are needed.Kidney Blood Press Res (Source: Kidney and Blood Pressure Research)
Source: Kidney and Blood Pressure Research - June 4, 2019 Category: Urology & Nephrology Source Type: research
Arterial Stiffness as a Risk Factor for Subclinical Coronary Artery Calcification in Predialysis Chronic Kidney Disease: From the KNOW-CKD Study
Conclusion: Increased arterial stiffness measured by high baPWV was associated with CAC in a predialysis CKD cohort. Longitudinal studies are needed to determine the effect of arterial stiffness on the development or progression of CAC in CKD.Kidney Blood Press Res (Source: Kidney and Blood Pressure Research)
Source: Kidney and Blood Pressure Research - May 27, 2019 Category: Urology & Nephrology Source Type: research
Relationship of Serum Soluble Klotho Levels and Echocardiographic Parameters in Patients on Maintenance Hemodialysis
Conclusions: The present study showed that patients with lower circulating s-Klotho levels were more often associated with larger IVST and greater ratios of IVST and PWT. There was an independent association between s-Klotho and IVST, and lower s-Klotho levels seem to be a potential risk factor of uremic cardiomyopathy in MHD patients.Kidney Blood Press Res (Source: Kidney and Blood Pressure Research)
Source: Kidney and Blood Pressure Research - May 10, 2019 Category: Urology & Nephrology Source Type: research
Intensive versus Usual Control of Hypertension in the Prevention of Cardiovascular and Renal Outcomes: A Cumulative Meta-Analysis of Randomized Controlled Trials
Conclusion: The findings of this study suggest that IBP control plays a beneficial role in the prevention of some major cardiovascular events, including myocardial infarction, stroke, and albuminuria.Kidney Blood Press Res (Source: Kidney and Blood Pressure Research)
Source: Kidney and Blood Pressure Research - May 10, 2019 Category: Urology & Nephrology Source Type: research
