Corticosteroid therapy in IgA Nephropathy: A friend or foe?
Background: The administration of corticosteroids in addition to supportive care to delay progressive Immunoglobulin A nephropathy (IgAN), the most common primary glomerulonephritis worldwide, remains controversial. This is partly due to the paucity of well-designed randomized controlled trials and well-known corticosteroid-related side effects. As a result, clinical equipoise in corticosteroid therapy exists depending on geographical regions and the clinician ’s preference. Summary: Better understanding around the pathogenesis of IgAN has prompted several clinical trials exploring the effects of immunosuppressive agents...
Source: Kidney and Blood Pressure Research - March 27, 2023 Category: Urology & Nephrology Source Type: research
Urea reduction in acute kidney injury and mortality risk
Conclusions
In our retrospective cohort of AKI patients, the percent decrease in UXR from admission was associated with a stratified risk of death. Patients with a UXR>25% had the best associated outcomes. Overall, a greater magnitude in UXR was associated with improved patient survival. (Source: Kidney and Blood Pressure Research)
Source: Kidney and Blood Pressure Research - March 27, 2023 Category: Urology & Nephrology Source Type: research
Prevalence of cognitive impairment in peritoneal dialysis patients and associated factors
Background. Cognitive impairment (CI) in patients with chronic kidney disease, including those treated with renal replacement therapy (RRT) is a growing problem worldwide. The study aimed to assess the prevalence of CI and associated factors in patients undergoing peritoneal dialysis (PD).
Methods. In this cross-sectional study, 18 consecutive patients with PD therapy and 15 controls were evaluated for CI using the Addenbrooke's Cognitive Examination III (ACE III) test.
Results. The prevalence of CI was 33% in patients and 27% in the control group and was not statistically significant. A higher prevalence of CI was found...
Source: Kidney and Blood Pressure Research - March 20, 2023 Category: Urology & Nephrology Source Type: research
Optimal renal artery-aorta angulation revealed by flow simulation
Discussion
Renal transplant patients receiving a right donor kidney to the right side showed faster adaptation and higher eGFR values than those receiving a left donor ki dney to the right side (eGFR: 65±7 vs 56±6 ml/min/1.73 m2; P (Source: Kidney and Blood Pressure Research)
Source: Kidney and Blood Pressure Research - March 20, 2023 Category: Urology & Nephrology Source Type: research
Intra-renal and urinary glycogen synthase kinase 3 beta levels in diabetic and non-diabetic chronic kidney disease
Background Renal glycogen synthase kinase-3 beta (GSK3 β) over-activity has been associated with a diverse range of kidney diseases. GSK3β activity in urinary exfoliated cells was reported to predict the progression of diabetic kidney disease (DKD). We compared the prognostic value of urinary and intra-renal GSK3β levels in DKD and non-diabetic chron ic kidney disease (CKD). Methods We recruited 118 consecutive biopsy-proved DKD patients and 115 non-diabetic CKD patients. Their urinary and intra-renal GSK3β levels were measured. They were then followed for dialysis-free survival and rate of renal function decline. Resu...
Source: Kidney and Blood Pressure Research - March 20, 2023 Category: Urology & Nephrology Source Type: research
Measurement of complement activation via plasma soluble C5b-9 comparison with terminal complement complex staining in a series of kidney biopsies
Conclusion: Plasma sC5b-9 as a marker of total complement activation does not correlate with TCC kidney staining. This discordance s uggests that plasma sC5b-9 and TCC staining are distinct markers of disease. TCC staining reflects chronicity and tissue deposition of complement over time. Conversely, plasma sC5b-9 concentrations change rapidly and reflect systemic complement activation. Complement activation was present in a hete rogeneous group of kidney disease, indicating the underlying role of complement in many disorders. (Source: Kidney and Blood Pressure Research)
Source: Kidney and Blood Pressure Research - March 14, 2023 Category: Urology & Nephrology Source Type: research
Serum 25(OH)D level is negatively associated with fatigue in elderly maintenance hemodialysis patients
Introduction: Chronic kidney disease-mineral and bone disorder (CKD-MBD) is frequently observed in maintenance hemodialysis (MHD) patients, and is associated with fracture, muscle weakness, malnutrition, etc.; however, relationships of CKD-MBD markers and fatigue are not well established.
Methods: This was a cross-sectional study included 244 MHD patients (89 elders) from July to September 2021 in The First Affiliated Hospital of Shandong First Medical University. CKD-MBD markers and other clinical data were collected from medical records. Fatigue in the past week was measure by Standardized Outcomes in Nephrology-Hemodia...
Source: Kidney and Blood Pressure Research - March 7, 2023 Category: Urology & Nephrology Source Type: research
Aberrant Gut Microbiome Contributes to Barrier Dysfunction, Inflammation and Local Immune Responses in IgA Nephropathy
Conclusions The urine Gd-IgA1 level may be as a bi omarker for the early screening of potential IgAN, and Gut microbiota dysbiosis was demonstrated in IgAN, which might be involved the dysfunction of the mucosal barrier, inflammation and local Immune responses. (Source: Kidney and Blood Pressure Research)
Source: Kidney and Blood Pressure Research - March 6, 2023 Category: Urology & Nephrology Source Type: research
Clear Cell Renal Cell Carcinoma: A Comprehensive in Silico Study in Searching for Therapeutic Targets
Introduction: Clear cell renal cell carcinoma is recognized as one of the leading causes of illness and death worldwide. Understanding the molecular mechanisms in clear cell renal cell carcinoma pathogenesis is crucial for discovering novel therapeutic targets and developing efficient drugs. With the application of a comprehensive in silico analysis of the clear cell renal cell carcinoma-related array sets, the main objective of this study was to discover the top molecules and pathways in the pathogenesis of this cancer.
Methods: Clear cell renal cell carcinoma microarray datasets were downloaded from the Gene Expression ...
Source: Kidney and Blood Pressure Research - February 28, 2023 Category: Urology & Nephrology Source Type: research
AST-120 to target protein-bound uremic toxins improves cardiac output and kidney oxygenation in experimental chronic kidney disease.
In this study, we investigated the effect of reducing plasma levels of protein bound uremic toxins in a rat model of CKD, challenged with high salt intake and compared the effects to that of conventional treatment using an angiotensin converting enzyme inhibitor (ACEI).
Methods
In rats, the right kidney and 2/3 of the left kidney were surgically removed (5/6 nephrectomy). Animals were fed a normal salt diet and randomized to either no treatment (control) or chronic treatment with either the oral absorbent AST-120 to reduce plasma levels of protein bound uremic to xins; or the ACEI enalapril to inhibit angiotensin II sign...
Source: Kidney and Blood Pressure Research - February 15, 2023 Category: Urology & Nephrology Source Type: research
Correlation of renal oxygenation with renal function in chronic kidney disease: a preliminary prospective study
This study aimed to explore the correlation of renal oxygenation evaluated by BOLD-MRI with renal function. Methods: 97 non-dialysis patients with CKD stages 1-5 and healthy volunteers (HVs) were recruited in the study. Based on their estimated glomerular filtration rate (eGFR), the patients were divided into two groups: CKD stages 1-3 (CKD 1-3) and CKD stages 4-5 (CKD 4-5) . We measured cortical and medullary T2* (COT2* and MET2*) values in all participants by BOLD-MRI. Physiological indices were also recorded and compared among three groups. Correlation of T2* values with clinical characteristics were determined. Results...
Source: Kidney and Blood Pressure Research - February 15, 2023 Category: Urology & Nephrology Source Type: research
GDF11 improves ischemia-reperfusion-induced acute kidney injury via regulating macrophage M1/M2 polarization
Conclusion: GDF11 can promote the repair of acute kidney injury caused by ischemia-reperfusion by regulating the balance of M1/M2 polarization in macrophages and oxidative stress. (Source: Kidney and Blood Pressure Research)
Source: Kidney and Blood Pressure Research - February 13, 2023 Category: Urology & Nephrology Source Type: research
The Swiss Kidney Stone Cohort (SKSC), a longitudinal, multi-centric, observational cohort to study course and causes of kidney stone disease in Switzerland
Conclusion: SKSC provides an unique opportunity and resource to further study cause and course of kidney disease in a large population with data and samples collected of a homogenous collective of patients throughout the whole Swiss population. (Source: Kidney and Blood Pressure Research)
Source: Kidney and Blood Pressure Research - February 13, 2023 Category: Urology & Nephrology Source Type: research
Biomarker-based prediction of survival and recovery of kidney function in acute kidney injury
Background
Acute kidney injury (AKI) affects increasing numbers of hospitalized patients, the prog-nosis remains poor. The diagnosis is still based on the 2012 published KDIGO criteria. Numerous new AKI biomarkers have been identified in recent years, they either reflect impaired excretory function or structural damage. The majority of markers are useful for AKI recognition under certain circumstances. Fewer data are available on the role of biomarkers in the prediction of in-hospital survival and renal recovery post-AKI. The current article is intended to provide information about these two aspects.
Summary
The followi...
Source: Kidney and Blood Pressure Research - February 9, 2023 Category: Urology & Nephrology Source Type: research
Phospholipase A2 receptor antibodies and clinical prognosis in patients with idiopathic membranous nephropathy: an updated systematic review and meta-analysis
Conclusion: In contrast to previous meta-analyses, our results verified that PLA2R-ab can likely predict CR and spontaneous remission in IMN patients, instead of PR and relapse. Race, immunosuppressive agents and duration of treatment may affect the prognostic value of PLA2R-ab. Considering that the remission rate of IMN patients with a middle level of PLA2R-ab was not different from that of patients with the lowest level, a proper cut-off value of PLA2R-ab for prognosis should be clarified. (Source: Kidney and Blood Pressure Research)
Source: Kidney and Blood Pressure Research - January 31, 2023 Category: Urology & Nephrology Source Type: research
