Effect of high-dose glucocorticoids on markers of inflammation and bone metabolism in patients with primary glomerular disease
Conclusions:
Plasma SIRT-1 increase during high-dose corticosteroid therapy is negatively related to the change of plasma sclerostin that may suggest a protective role of SIRT-1 against the negative effects of steroid therapy on bone. (Source: Kidney and Blood Pressure Research)
Source: Kidney and Blood Pressure Research - May 24, 2022 Category: Urology & Nephrology Source Type: research
The correlation between ferroptosis and m6A methylation in patients with acute kidney injury
Objective: The present research analyzed the correlation between m6A methylation and ferroptosis associated genes (FAGs) in acute kidney injury (AKI) patients.
Methods: Bioinformatics analysis of microarray profiles (GSE30718) were performed to select differential expression genes (DEGs). FAGs are derived from systematic analysis of the aberrances and functional implications. The m6A methylation related genes were derived from the molecular characterization and clinical significance of m6A modulators. The multi-gene correlation of ferroptosis and M6A methylation modification were displayed. Then, the CIBERSORT algorithm w...
Source: Kidney and Blood Pressure Research - May 13, 2022 Category: Urology & Nephrology Source Type: research
Physical Activity in Renal Disease and the Effect on Hypertension: A Randomized Controlled Trial
Conclusions: Despite an improvement in peak aerobic capacity and body composition, we did not detect a change in 24-h ambulatory SBP in people with moderate-to-severe CKD.Kidney Blood Press Res (Source: Kidney and Blood Pressure Research)
Source: Kidney and Blood Pressure Research - April 21, 2022 Category: Urology & Nephrology Source Type: research
Physical Activity in Renal Disease (PAIRED) and the effect on hypertension: a randomized controlled trial
Conclusions: Despite an improvement in VO2peak and body comp osition, we did not detect a change in 24-hour ambulatory systolic BP in people with moderate to severe chronic kidney disease. (Source: Kidney and Blood Pressure Research)
Source: Kidney and Blood Pressure Research - April 21, 2022 Category: Urology & Nephrology Source Type: research
Cognitive Impairment and Kidney Transplantation: Underestimated, Underrecognized but Clinically Relevant Problem
Background: Chronic kidney disease (CKD) affects the crosstalk between organs in the body and vast majority of studies were devoted to the interactions between the kidneys and the cardiovascular system. As of today, there is more evidence of the kidney and the central nervous system connections.Summary: Indeed, CKD and in particular dialysis therapy is linked to the increased prevalence of neurological complications, such as cerebrovascular disorders, movement disorders, cognitive impairment, and depression. Both traditional cardiovascular risk factors (such as diabetes, hypertension, and lipid disorders), nontraditional r...
Source: Kidney and Blood Pressure Research - April 21, 2022 Category: Urology & Nephrology Source Type: research
Cognitive impairment and kidney transplantation- underestimated, underrecognized but clinically relevant problem
Background: Chronic kidney disease (CKD) affects the crosstalk between organs in the body and vast majority of studies were devoted to the interactions between the kidneys and the cardiovascular system. As of today, there is more evidence of the kidney and the central nervous system connections.
Summary: Indeed, CKD and in particular dialysis therapy is linked to the increased prevalence of neurological complications, such as cerebrovascular disorders, movement disorders, cognitive impairment, and depression. Both traditional cardiovascular risk factors (such as diabetes, hypertension, and lipid disorders), non-traditiona...
Source: Kidney and Blood Pressure Research - April 21, 2022 Category: Urology & Nephrology Source Type: research
Dosing of Aminoglycosides in Chronic Kidney Disease and End-Stage Renal Disease Patients Treated with Intermittent Hemodialysis
(Source: Kidney and Blood Pressure Research)
Source: Kidney and Blood Pressure Research - April 20, 2022 Category: Urology & Nephrology Source Type: research
Specific alterations of Gut microbiota in Chinese patients with Hypertension: A systematic review and meta-analysis
Conclusions: Variation in gut microbial parameters is likely associated with Chinese patients with HTN. Further investigations should distinguish geographical and ethnic characteristics to develop in-depth knowledge of the underlying mechanisms by which gut dysbiosis contributes to HTN. (Source: Kidney and Blood Pressure Research)
Source: Kidney and Blood Pressure Research - April 8, 2022 Category: Urology & Nephrology Source Type: research
Intravascular Renal Denervation Reduces Ambulatory and Office Blood Pressure in Patients with Essential Hypertension: A Meta-Analysis of Randomized Sham-Controlled Trials
Background: This meta-analysis was designed to evaluate the antihypertensive efficacy of intravascular renal denervation (RDN) in patients with essential hypertension, especially to determine the magnitude of blood pressure (BP) reduction with RDN therapy using second-generation catheters. Methods: PubMed was searched to identify randomized sham-controlled trials from inception through August 2021. The endpoints were changes in 24-hours (24-h) ambulatory BP or office BP (OBP). This meta-analysis was performed by calculating the weighted mean difference (WMD) with 95% confidence interval (CI) using the random-effects model ...
Source: Kidney and Blood Pressure Research - April 6, 2022 Category: Urology & Nephrology Source Type: research
Long-Term Impact of the COVID-19 Associated AKI: The Relationship between Kidney Recovery and Mortality in a 10-Month Follow-Up Cohort Study
Conclusion: Overall, it was shown that patients with COVID-19 who develop AKI, mainly stage 2 and 3, and patients with unresolved kidney injury at the time of discharge, were at an increased risk of mortality, even after hospitalization for an extended period of time. (Source: Kidney and Blood Pressure Research)
Source: Kidney and Blood Pressure Research - April 4, 2022 Category: Urology & Nephrology Source Type: research
Long term impact of the COVID-19 associated AKI: the relationship between kidney recovery and mortality in a 10-month follow-up cohort study
Abstract
Introduction: Corona Virus-2019 (COVID-19) associated acute kidney injury (AKI) and its short and mid-term effect on kidney has been well established in the previous literature, indicating a high number of AKI in hospitalized patients associated with high rates of mortality, followed by high rates of unresolved kidney injury at the time of discharge. However, the long-term impact of AKI and its resulting lack of recovery at discharge has not been investigated. Herein, we sought to explore the possible relationship between AKI and unresolved kidney injury and post-discharge mortality.
Method: In this cohort study...
Source: Kidney and Blood Pressure Research - April 4, 2022 Category: Urology & Nephrology Source Type: research
The dopamine system: insights between kidney and brain
BACKGROUND: Chronic kidney disease (CKD) is one of the most common diseases in adult age and it is typical of older adults. Recent data suggest that almost half of the elders have CKD. It is now clear that CKD is accompanied, in the early stages, by cognitive impairment, together with depression and subtle abnormalities in motor control (such as gait and balance alterations).
SUMMARY: Several data suggest a link between brain dopamine and kidney diseases. Metabolic syndrome and diabetes can affect dopamine neuron survival (leading to Parkinson ’s Disease). Several uremic toxins in CKD (uric acid, indoxyl sulphate) and t...
Source: Kidney and Blood Pressure Research - April 4, 2022 Category: Urology & Nephrology Source Type: research
Naringenin Protects against Hypertension by Regulating Lipid Disorder and Oxidative Stress in a Rat Model
Conclusion: Naringenin ameliorates obesity-associated hypertension by regulating lipid disorder and oxidative stress. (Source: Kidney and Blood Pressure Research)
Source: Kidney and Blood Pressure Research - March 30, 2022 Category: Urology & Nephrology Source Type: research
Naringenin alleviates obesity-associated hypertension by reducing hyperlipidemia and oxidative stress
Conclusion: Naringenin ameliorates obesity-associated hypertension by regulating lipid disorder and oxidative stress. (Source: Kidney and Blood Pressure Research)
Source: Kidney and Blood Pressure Research - March 30, 2022 Category: Urology & Nephrology Source Type: research
Requirement of Na < sup > + < /sup > /H < sup > + < /sup > Exchanger NHE1 for Vasopressin-Induced Osteogenic Signaling and Calcification in Human Aortic Smooth Muscle Cells
Conclusion: Vasopressin stimulates NHE1 expression and ROS generation, an effect dependent on SGK1 and required for vasopressin-induced stimulation of osteogenic signaling and calcification of VSMCs. (Source: Kidney and Blood Pressure Research)
Source: Kidney and Blood Pressure Research - March 25, 2022 Category: Urology & Nephrology Source Type: research
