Impact of Annexin A 7 Deficiency on FGF23 Plasma Concentrations
Conclusion: Annexin A7 deficiency upregulates FGF23 plasma levels, an effect paralleled by increased corticosterone plasma levels, as well as decreased 1,25(OH)2 D3 and PTH plasma levels.Kidney Blood Press Res 2016;41:828-836 (Source: Kidney and Blood Pressure Research)
Source: Kidney and Blood Pressure Research - November 21, 2016 Category: Urology & Nephrology Source Type: research

Triptolide Attenuates Inflammatory Response in Membranous Glomerulo-Nephritis Rat via Downregulation of NF- & #x03BA;B Signaling Pathway
This study aims to investigate the potential anti-inflammatory effect of TPL in rats with membranous glomerulonephritis (MGN).Results: Our data showed that the pathological kidney damage was significantly alleviated by TPL treatment in MGN rats. We also found that MGN rats exhibited significantly higher (p (Source: Kidney and Blood Pressure Research)
Source: Kidney and Blood Pressure Research - November 21, 2016 Category: Urology & Nephrology Source Type: research

< b > < i > Monascus Adlay < /i > < /b > and Monacolin K Attenuates Arterial Thrombosis in Rats through the Inhibition of ICAM-1 and Oxidative Stress
Conclusions:We suggest MA is better than MK to improve FeCl3-induced arterial thrombosis.Kidney Blood Press Res 2016;41:815-827 (Source: Kidney and Blood Pressure Research)
Source: Kidney and Blood Pressure Research - November 11, 2016 Category: Urology & Nephrology Source Type: research

Gulo Acts as a < b > < i > de novo < /i > < /b > Marker for Pronephric Tubules in < b > < i > Xenopus laevis < /i > < /b >
Conclusion:Gulo is a novel specific marker for pronephros tubules inX. laevis, and may be used as a potential marker for kidney development studies and disease diagnosis in mammals.Kidney Blood Press Res 2016;41:794-801 (Source: Kidney and Blood Pressure Research)
Source: Kidney and Blood Pressure Research - November 10, 2016 Category: Urology & Nephrology Source Type: research

Extracellular Volume Overload and Increased Vasoconstriction in Patients With Recurrent Intradialytic Hypertension
Conclusions:Recurrent intradialytic hypertension is associated with higher post-dialysis extracellular volume and TPRI. Intradialytic TPRI surges account for the vasoconstrictive state post-dialysis, but intradialytic fluid shifts may contribute to post-hemodialysis volume expansion.Kidney Blood Press Res 2016;41:802-814 (Source: Kidney and Blood Pressure Research)
Source: Kidney and Blood Pressure Research - November 10, 2016 Category: Urology & Nephrology Source Type: research

Expression of BMP-2 in Vascular Endothelial Cells of Recipient May Predict Delayed Graft Function After Renal Transplantation
Background/Aims:Delayed graft function (DGF) is associated with adverse outcomes after renal transplantation. Bone morphogenetic protein-2 (BMP-2) is involved in both endothelial function and immunological events. We compared expression of BMP-2 in epigastric artery of renal transplant recipients with immediate graft function (IGF) and DGF.Methods:79 patients were included in this prospective study. Patients were divided in IGF group (64 patients) and DGF group (15 patients). BMP-2 expression in intima media (BMP2m) and endothelium (BMP2e) of epigastric artery was assessed by immunohistochemistry.Results:Lower intensity of...
Source: Kidney and Blood Pressure Research - November 10, 2016 Category: Urology & Nephrology Source Type: research

Global Overexpression of ET-1 Decreases Blood Pressure - A Systematic Review and Meta-Analysis of ET-1 Transgenic Mice
Conclusion:This meta-analysis provides robust evidence that global ET-1 overexpression in mice lowers blood pressure in an age-dependent manner. Older ET-1+/+ mice have a somewhat more pronounced reduction of blood pressure.Kidney Blood Press Res 2016;41:770-780 (Source: Kidney and Blood Pressure Research)
Source: Kidney and Blood Pressure Research - November 10, 2016 Category: Urology & Nephrology Source Type: research

Roles of Non-Coding RNAs in Acute Kidney Injury
Acute kidney injury (AKI) is a complex kidney disorder that leads to numerous complications, such as elevated nitrogenous wastes, metabolic acidosis, high potassium levels and even death. The pathogenesis of AKI is very complicated, and its causes are commonly categorized as prerenal, intrinsic or postrenal. In the past few years, evidence has accumulated showing that non-coding RNAs (ncRNAs), such as microRNAs (miRNAs) and long non-coding RNAs (lncRNAs), have significant potential to aid the development of diagnostic and therapeutic strategies of AKI. In this review, we briefly summarize the current understanding of the m...
Source: Kidney and Blood Pressure Research - November 10, 2016 Category: Urology & Nephrology Source Type: research

Overexpression of Intrarenal Renin-Angiotensin System in Human Acute Tubular Necrosis
Conclusions:We demonstrate that the intrarenal RAS is upregulated in patients with ATN and is associated with the severity of ATN. Urinary angiotensinogen reflects intrarenal RAS status, and is of value to assess the severity of ATN.Kidney Blood Press Res 2016;41:746-756 (Source: Kidney and Blood Pressure Research)
Source: Kidney and Blood Pressure Research - October 27, 2016 Category: Urology & Nephrology Source Type: research

Blood Pressure Reduction is Associated With the Changes in Oxidative Stress and Endothelial Activation in Hypertension, Regardless of Antihypertensive Therapy
Conclusions:Present study suggests that observed oxidative stress is a consequence of hypertension. BP reduction is associated with the observed decrease in oxidative stress and changes in endothelial activation regardless of antihypertensive therapy.Kidney Blood Press Res 2016;41:721-735 (Source: Kidney and Blood Pressure Research)
Source: Kidney and Blood Pressure Research - October 27, 2016 Category: Urology & Nephrology Source Type: research

Frailty in Chinese Peritoneal Dialysis Patients: Prevalence and Prognostic Significance
Background/Aims:Previous studies showed that frailty is prevalent in both pre-dialysis and dialysis patients. However, the prevalence and prognostic implication of frailty in Chinese peritoneal dialysis (PD) patients remain unknown.Methods:We used a validated questionnaire to determine the Frailty Score of 193 unselected prevalent PD patients. All patients were then followed for 2 years for their need of hospitalization and mortality.Results:Amongst the 193 patients, 134 (69.4%) met the criteria of being frail. Frailty Score significantly correlated with Charlson's comorbidity score (r = 0.40, p (Source: Kidney and Blood Pressure Research)
Source: Kidney and Blood Pressure Research - October 21, 2016 Category: Urology & Nephrology Source Type: research

Causes and Consequences of Interdialytic weight gain
Conclusion:The most important associations of %IDWG are age, height, weight, diuresis, and postdialysis sodium. Patients with the highest IDWG have significantly higher diastolic blood pressures.Kidney Blood Press Res 2016;41:710-720 (Source: Kidney and Blood Pressure Research)
Source: Kidney and Blood Pressure Research - October 14, 2016 Category: Urology & Nephrology Source Type: research

Improved Left Ventricular Structure and Function After Successful Kidney Transplantation
Conclusion:LV hypertrophy reversed after successful KTX and was accompanied by an improvement in longitudinal LV function as assessed by STE. Diastolic function and STE-derived LA function parameters did not change significantly after KTX.Kidney Blood Press Res 2016;41:701-709 (Source: Kidney and Blood Pressure Research)
Source: Kidney and Blood Pressure Research - October 7, 2016 Category: Urology & Nephrology Source Type: research

Early Predictors of Acute Kidney Injury: A Narrative Review
Accompanied with the broad application of interventional therapy, the incidence of acute kidney injury (AKI) has been recently increasing in clinical renal medicine. The pathogenesis of AKI is diverse and complex. In the context of the requirements for the diagnosis and treatment of a renal disorder, a large number of studies have explored biological markers and their usefulness to the early diagnosis and treatment of AKI, including glomerular injury, renal tubular injury, and others. These biomarkers provide an important basis for early monitoring of AKI, but are still not quite sufficient. More ideal biomarkers are neede...
Source: Kidney and Blood Pressure Research - September 27, 2016 Category: Urology & Nephrology Source Type: research

Risk Factors and Prognosis of Cardiorenal Syndrome Type 1 in Elderly Chinese Patients: A Retrospective Observational Cohort Study
Background/Aims: Cardiorenal syndrome type 1 (CRS1) is a syndrome characterized by a rapid worsening of cardiac function leading to acute kidney injury (AKI). The aims of this study were to investigate the risk factors and the prognosis of CRS1 in elderly patients.Methods: A total of 312 elderly patients ( ≥60 years old) with acute heart failure (AHF) were studied. They were assigned as CRS1 (suffered from in-hospital AKI) or NCRS1 (without AKI) group. Clinical and laboratory data were recorded. Univariate and multivariate analysis were performed to clarify the risk factors for occurrence and mortal ity of CRS1 in this ...
Source: Kidney and Blood Pressure Research - September 27, 2016 Category: Urology & Nephrology Source Type: research

Circulating CXCL16 in Diabetic Kidney Disease
Conclusion:In diabetic kidney disease patients, GFR and serum albumin independently predicted plasma CXCL16 levels.Kidney Blood Press Res 2016;41:663-671 (Source: Kidney and Blood Pressure Research)
Source: Kidney and Blood Pressure Research - September 24, 2016 Category: Urology & Nephrology Source Type: research

Cardio-Renal Syndrome Type 4: The Correlation Between Cardiorenal Ultrasound Parameters
Bakground/Aims:Cardiovascular diseases represent the leading causes of morbidity and mortality in patients with cronich kidney disease (CKD). The pathogenesis includes a complex, bidirectional interaction between heart and kidney termed cardiorenal syndrome type 4. The aim of study was to evaluate the association between renal and cardiovascular ultrasonographic parameters and identify early markers of cardiovascular risk.Methods:A total of 35 patients with CKD and 25 healthy controls, were enrolled and we have evaluated inflammatory indexes, mineral metabolism, renal function, renal and cardiovascular ultrasonographic par...
Source: Kidney and Blood Pressure Research - September 24, 2016 Category: Urology & Nephrology Source Type: research

Role and Association of Inflammatory and Apoptotic Caspases in Renal Tubulointerstitial Fibrosis
Conclusions:Our study associated inflammatory and apoptotic caspases in TIF for the first time and we further confirmed that caspase-1 activation is an upstream event of apoptotic caspase-7 induction in TIF triggered by UUO and in TECs mediated by TGF- β1 induced transdifferentiation.Kidney Blood Press Res 2016;41:643-653 (Source: Kidney and Blood Pressure Research)
Source: Kidney and Blood Pressure Research - September 19, 2016 Category: Urology & Nephrology Source Type: research

Interferon (IFN)-Induced Protein 35 (IFI35), a Type I Interferon-Dependent Transcript, Upregulates Inflammatory Signaling Pathways by Activating Toll-Like Receptor 3 in Human Mesangial Cells
Conclusion:Regional expression of IFI35 and its dysregulation may be involved in the pathogenesis of glomerular inflammation in CKD.Kidney Blood Press Res 2016;41:635-642 (Source: Kidney and Blood Pressure Research)
Source: Kidney and Blood Pressure Research - September 16, 2016 Category: Urology & Nephrology Source Type: research

The Association Between Adiponectin, Serum Uric Acid and Urinary Markers of Renal Damage in the General Population: Cross-Sectional Data from the Troms ø Study
Conclusions:Unexpectedly, adiponectin was positively associated with both urinary markers of renal damage. SUA was positively associated with albuminuria only. SUA and adiponectin added little beyond traditional cardiovascular risk factors to predict renal damage and did not interact in their associations with the urinary biomarkers. Longitudinal studies are needed before firm conclusions can be made.Kidney Blood Press Res 2016;41:623-634 (Source: Kidney and Blood Pressure Research)
Source: Kidney and Blood Pressure Research - September 13, 2016 Category: Urology & Nephrology Source Type: research

Effect of Denosumab on Peripheral Compartmental Bone Density, Microarchitecture and Estimated Bone Strength in < b > < i > De Novo < /i > < /b > Kidney Transplant Recipients
Background/Aims:In a randomized controlled clinical trial in kidney transplant recipients (NCT01377467) we have recently shown that RANKL inhibition with denosumab significantly improved areal bone mineral density (aBMD) when given during the first year after transplantation. The effect of denosumab on skeletal microstructure and bone strength in kidney transplant recipients is not known.Methods:The purpose of the present bone microarchitecture ancillary study was to investigate high-resolution peripheral quantitative computed tomography (HRpQCT) data from the distal tibia and distal radius in 24 study patients that had be...
Source: Kidney and Blood Pressure Research - September 13, 2016 Category: Urology & Nephrology Source Type: research

The Influence of Thyroid Function, Inflammation, and Obesity on Risk Prediction of Acute Kidney Injury by Cystatin C in the Emergency Department
Conclusions:CysC is known to be influenced by thyroid function, inflammation and obesity, but in our large ED population there was no significant impact of these factors on the diagnostic accuracy of CysC to detect AKI in ED patients.Kidney Blood Press Res 2016;41:604-613 (Source: Kidney and Blood Pressure Research)
Source: Kidney and Blood Pressure Research - August 31, 2016 Category: Urology & Nephrology Source Type: research

Renalase Secreted by Human Kidney HEK293T Cells Lacks its N-Terminal Peptide: Implications for Putative Mechanisms of Renalase Action
Conclusions:Lack of the N-terminal peptide, the structural precondition for FAD binding, suggests that extracellular (circulating) renalase acts in a FAD-independent manner and mechanisms of its action are not associated with FAD.Kidney Blood Press Res 2016;41:593-603 (Source: Kidney and Blood Pressure Research)
Source: Kidney and Blood Pressure Research - August 31, 2016 Category: Urology & Nephrology Source Type: research

Hyponatremia with Persistent Elevated Urinary Fractional Uric Acid Excretion: Evidence for Proximal Tubular Injury?
Background/Aims:Hyponatremia associated with high urinary fractional excretion of uric acid which persists after serum sodium is corrected is the cardinal feature of salt losing nephropathy (SLN). We hypothesize that low grade proximal tubular injury is present in SLN because the proximal tubule is the main site of uric acid and sodium transport.Methods:Five subjects with SLN were compared to four subjects with recurrent hyponatremia and three healthy individuals. Urinary NGAL (neutrophil gelatinase associated lipocalin, a marker of tubular injury) and fasting urinary fructose levels (a marker of proximal tubular injury) w...
Source: Kidney and Blood Pressure Research - August 25, 2016 Category: Urology & Nephrology Source Type: research

L-Carnitine Protects Renal Tubular Cells Against Calcium Oxalate Monohydrate Crystals Adhesion Through Preventing Cells From Dedifferentiation
Conclusions:COM attachment promotes subsequent COM crystals adhesion, by inducing cell dedifferentiation via Akt/GSK-3 β/Snail signaling. L-carnitine partially abolishes cell dedifferentiation and resists COM crystals adhesion. L-carnitine, may be used as a potential therapeutic strategy against recurrence of urolithiasis.Kidney Blood Press Res 2016;41:582-592 (Source: Kidney and Blood Pressure Research)
Source: Kidney and Blood Pressure Research - August 24, 2016 Category: Urology & Nephrology Source Type: research

Empirically Derived Dietary Patterns and Hypertension Likelihood: A Meta-Analysis
Conclusions:Our results of this systematic review and meta-analysis suggest that dietary pattern may be associated with the likelihood of hypertension.Kidney Blood Press Res 2016;41:570-581 (Source: Kidney and Blood Pressure Research)
Source: Kidney and Blood Pressure Research - August 24, 2016 Category: Urology & Nephrology Source Type: research

Direct Renin Inhibitor is Better than Angiotensin II Receptor Blocker for Intrarenal Arterioles
Conclusion:The long-term DRI administration increases tissue and circulatory renin; however, afferent arteriolar proliferative changes as shown in ARBs were not induced.Kidney Blood Press Res 2016;41:561-569 (Source: Kidney and Blood Pressure Research)
Source: Kidney and Blood Pressure Research - August 24, 2016 Category: Urology & Nephrology Source Type: research

Serum Anti-M üllerian Hormone Concentration in Young Women with Chronic Kidney Disease on Hemodialysis, and After Successful Kidney Transplantation
Conclusions:1. Significantly lower serum AMH concentration was found in the regularly menstruating CKD women on hemodialysis in comparison with the healthy controls. 2. Serum AMH decreased significantly after successful KTx.Kidney Blood Press Res 2016;41:552-560 (Source: Kidney and Blood Pressure Research)
Source: Kidney and Blood Pressure Research - August 24, 2016 Category: Urology & Nephrology Source Type: research

Serum Potassium Profile and Associated Factors in Incident Peritoneal Dialysis Patients
Conclusion:Hyperkalemia and blood BUN and Cr levels were significantly associated in incident PD patients.Kidney Blood Press Res 2016;41:545-551 (Source: Kidney and Blood Pressure Research)
Source: Kidney and Blood Pressure Research - August 24, 2016 Category: Urology & Nephrology Source Type: research

C-Terminal to Intact Fibroblast Growth Factor 23 Ratio in Relation to Estimated Glomerular Filtration Rate in Elderly Population
Conclusions:Our results suggest impairment in the cleavage of the C-terminal FGF23 fragments with the deterioration of kidney excretory function and age in the elderly population. Inflammation and low serum iron level seems to diminish degradation capacity of FGF23 fragments.Kidney Blood Press Res 2016;41:519-526 (Source: Kidney and Blood Pressure Research)
Source: Kidney and Blood Pressure Research - August 16, 2016 Category: Urology & Nephrology Source Type: research

Pharmacokinetic and Pharmacodynamic Characteristics of Subcutaneously Applied PTH-1-37
Conclusions:PTH-1-37 is rapidly absorbed after s.c. injection, has a short plasma elimination half-life, and does not accumulate during multiple dosing. Biological activity was demonstrated by rising serum calcium and decreasing endogenous PTH-1-84 in blood plasma. The study drugs were well tolerated and safe. Our investigation presents data that PTH-1-37 is an excellent drug candidate for intervening with syndromes of dysregulation of calcium metabolism.Kidney Blood Press Res 2016;41:507-518 (Source: Kidney and Blood Pressure Research)
Source: Kidney and Blood Pressure Research - August 3, 2016 Category: Urology & Nephrology Source Type: research

Serum Alkaline Phosphatase Levels are Not Associated with Increased Death Risk in Prevalent Hemodialysis Patients: 5-Year Experience in a Single Hemodialysis Center
Conclusion: Our study demonstrated that serum ALP levels were not associated with increased death risk in prevalent HD patients over a 5-year interval. Kidney Blood Press Res 2016;41:498-506 (Source: Kidney and Blood Pressure Research)
Source: Kidney and Blood Pressure Research - July 28, 2016 Category: Urology & Nephrology Source Type: research

Early Biomarkers of Renal Damage in Relation to Arterial Stiffness and Inflammation in Male Coronary Artery Disease Patients
Background/Aims: Plasma neutrophil gelatinase-associated lipocalin (NGAL), urinary liver-type fatty acid-binding protein (L-FABP) and urinary kidney injury molecule-1 (KIM-1) have emerged as promising biomarkers for both acute and chronic kidney injury that also provide prognostic value for cardiovascular morbidity and mortality. Our aim was to evaluate their relationships with arterial stiffness and inflammation in coronary artery disease (CAD) patients and in clinically healthy controls. Methods: We studied 52 patients with CAD (age 63.2 ± 9.2 years) and 41 healthy controls (age 60.1 ± 7.2 years). Urinary L...
Source: Kidney and Blood Pressure Research - July 19, 2016 Category: Urology & Nephrology Source Type: research

Mortality and Associated Risk Factors in Dialysis Patients with Cardiovascular Disease
Background/Aims: Although dialysis patients have a higher risk of morbidity and mortality related to cardiovascular disease (CVD) than the general population, the mortality and associated risk factors in Asian dialysis patients with CVD have not been well examined. Methods: In this prospective cohort study, mortality and risk factors were investigated in 591 dialysis patients who were recruited from two dialysis centers from May 1, 2009 to May 1, 2014. The Cox proportional hazards regression assessed adjusted differences in mortality risk. A multivariate analysis was also performed, comparing the CVD and non-CVD groups. Re...
Source: Kidney and Blood Pressure Research - July 19, 2016 Category: Urology & Nephrology Source Type: research

Risk of Cerebral Infarction in Japanese Hemodialysis Patients: Miyazaki Dialysis Cohort Study (MID study)
Conclusions: The incidence of CI was higher in dialysis patients with a previous history of CI and AF; however, the preventive effects of antiplatelet/anticoagulant drugs on the development of CI were not evident.Kidney Blood Press Res 2016;41:471-478 (Source: Kidney and Blood Pressure Research)
Source: Kidney and Blood Pressure Research - July 14, 2016 Category: Urology & Nephrology Source Type: research

Evaluation of Vitamin C Supplementation on Kidney Function and Vascular Reactivity Following Renal Ischemic Injury in Mice
Conclusion: Vitamin C protects kidney function and renal arterial reactivity against IRI. The protective role of vitamin C is linked to ROS, SOD, GSH and NO levels in renal ischemic injury.Kidney Blood Press Res 2016;41:460-470 (Source: Kidney and Blood Pressure Research)
Source: Kidney and Blood Pressure Research - July 14, 2016 Category: Urology & Nephrology Source Type: research

Co-inhibition of Angiotensin II Receptor and Endothelin-1 Attenuates Renal Injury in Unilateral Ureteral Obstructed Mice
Conclusions: Bosentan and valsartan acted complementarily, and co-treatment with both drugs had an additive protective effect against renal fibrosis.Kidney Blood Press Res 2016;41:450-459 (Source: Kidney and Blood Pressure Research)
Source: Kidney and Blood Pressure Research - July 14, 2016 Category: Urology & Nephrology Source Type: research

Urotensin II Induces ER Stress and EMT and Increase Extracellular Matrix Production in Renal Tubular Epithelial Cell in Early Diabetic Mice
Conclusions: We are the first to verify UII induces ER stress and EMT and increase extracellular matrix production in renal tubular epithelial cell in early diabetic mice. Moreover, UII may induce renal tubular epithelial EMT via triggering ER stress pathway in vitro, which might be the new pathogenic pathway for the development of renal fibrosis in DN.Kidney Blood Press Res 2016;41:434-449 (Source: Kidney and Blood Pressure Research)
Source: Kidney and Blood Pressure Research - July 12, 2016 Category: Urology & Nephrology Source Type: research

Renal Function Predicts Outcomes in Patients with Ischaemic Stroke and Haemorrhagic Stroke
Conclusions: Patients with haemorrhagic stroke, in particular with acute kidney injury during hospitalisation had significantly worse outcomes than patients with ischaemic stroke. Assessment of kidney function is prerequisite to employ the necessary measures to decrease the risk of in-hospital mortality among patients with acute stroke. Appropriate approach to patients with renal dysfunction (adequate hydration, avoidance of nephrotoxic drugs, drug dose adjustment etc) should be considered as preventive and therapeutic strategies in the management of acute stroke.Kidney Blood Press Res 2016;41:424-433 (Source: Kidney and B...
Source: Kidney and Blood Pressure Research - July 12, 2016 Category: Urology & Nephrology Source Type: research

Combined Association of Serum Uric Acid and Metabolic Syndrome with Chronic Kidney Disease in Hypertensive Patients
Background/Aims: Chronic kidney disease (CKD) is one of the major complications of hypertension. It is not only associated with the future burden of end-stage renal disease but also affects mortality and cardiovascular outcomes caused by hypertension. To help understand the pathogenesis and early prevention of progressive CKD, this large-scale study is designed to determine the complex association between serum uric acid (SUA), metabolic syndrome and the prevalence of CKD in hypertensive patients. Methods: A total of 19,848 hypertensive subjects were enrolled in this cross-sectional study. Patients with proteinuria and/or ...
Source: Kidney and Blood Pressure Research - June 29, 2016 Category: Urology & Nephrology Source Type: research

Plasma Mitochondrial DNA Level is a Prognostic Marker in Peritoneal Dialysis Patients
Background/Aims: Circulating bacterial DNA fragment is related to systemic inflammatory state in peritoneal dialysis (PD) patients. We hypothesize that circulating mitochondrial DNA, which has a similar structure with bacterial DNA, correlates with systemic inflammatory state and predicts cardiovascular event in new PD patients. Methods: We measured plasma mitochondrial DNA level by quantitative polymerase chain reaction (PCR) in 197 new PD patients and 150 patients with chronic kidney disease. PD patients were followed for 24 months for the development of cardiovascular event, hospitalization, and patient survival. Result...
Source: Kidney and Blood Pressure Research - June 29, 2016 Category: Urology & Nephrology Source Type: research

Home- or Institutional Hemodialysis? - a Matched Pair-Cohort Study Comparing Survival and Some Modifiable Factors Related to Survival
Background/Aims: Survival for dialysis patients is poor. Earlier studies have shown better survival in home-hemodialysis (HHD). The aims of this study are to compare survival for matched patients with HHD and institutional hemodialysis (IHD) and to elucidate the effect on factors related to survival such as hyperphosphatemia, fluid overload and anemia. Methods: In this retrospective, observational study, incident patients starting HHD and IHD were matched according to sex, age, comorbidity and date of start. Survival analysis was performed both as ”intention to treat” including renal transplantation and ”...
Source: Kidney and Blood Pressure Research - June 24, 2016 Category: Urology & Nephrology Source Type: research

Association Between Serum Cortisol and Chronic Kidney Disease in Patients with Essential Hypertension
Conclusion: Serum cortisol level was negatively correlated with eGFRcr-cys in subjects with essential hypertension. Further studies are needed to investigate whether cortisol plays a role in hypertensive nephropathy development.Kidney Blood Press Res 2016;41:384-391 (Source: Kidney and Blood Pressure Research)
Source: Kidney and Blood Pressure Research - June 24, 2016 Category: Urology & Nephrology Source Type: research

Salt Sensitivity Determined From Capillary Blood
Conclusions: SS can be estimated derived from the individual RBC sodium buffer capacity as measured by the SBT-mini. About one third of a healthy test cohort exhibits a high sensitivity to salt. Reduction of sodium consumption to at least two grams per day (equals five grams of NaCl per day as suggested by the WHO) is recommended, particularly for individuals with high salt sensitivity.Kidney Blood Press Res 2016;41:355-364 (Source: Kidney and Blood Pressure Research)
Source: Kidney and Blood Pressure Research - June 22, 2016 Category: Urology & Nephrology Source Type: research

Relationship Between Type of Hypertension and Renal Arteriolosclerosis in Chronic Glomerular Disease
Conclusions: Our findings suggest that renal AH was severe not only in the SHT group, but also in the MHT group. Careful ABP monitoring should be recommended in patients with CGD.Kidney Blood Press Res 2016;41:374-383 (Source: Kidney and Blood Pressure Research)
Source: Kidney and Blood Pressure Research - June 22, 2016 Category: Urology & Nephrology Source Type: research

Osteoporosis and Impaired Trabecular Bone Score in Hemodialysis Patients
Background/Aims: Small attention is paid to other types of bone diseases then chronic kidney disease-mineral and bone disorder in dialysis patients. The aim of our study was to assess the occurrence of osteoporosis and bone microarchitecture by trabecular bone score in this population. Methods: 59 patients (67.6 ± 13.1 years, 43 males) treated with hemodiafIltration underwent densitometry (Lunar Prodigy, TBS software 2.1.2) and laboratory assessment. Results: Osteoporosis was observed in 34% patients, high bone turnover was found in 80% of them, with SHPT (PTH> 300 ng/l) present in 69%. TBS was significantly decr...
Source: Kidney and Blood Pressure Research - June 22, 2016 Category: Urology & Nephrology Source Type: research

Association Between Prescription Opioid Use and Biomarkers of Kidney Disease in US Adults
We examined relationships between use of analgesics with biomarkers of chronic kidney disease (CKD) in a representative sample of adults in the United States (US). Methods: Participants (n=3980) were from the National Health and Nutrition Examination Survey (NHANES) 2009-2010. Use of any analgesic, prescription opioids, and NSAIDs were compared to referent groups with use of non-analgesic prescription medication or use of no prescription medication. CKD biomarkers including urine albumin-to-creatinine ratio (UACR) and serum-creatinine-based estimated glomerular filtration rate (eGFR; CKD Epidemiology Collaboration: CKD-EPI...
Source: Kidney and Blood Pressure Research - June 17, 2016 Category: Urology & Nephrology Source Type: research

Effect of Intervention in Mast Cell Function Before Reperfusion on Renal Ischemia-Reperfusion Injury in Rats
Conclusion: Intervention in mast cell activity prior to reperfusionhas a strong effect on RI/RI.Kidney Blood Press Res 2016;41:335-344 (Source: Kidney and Blood Pressure Research)
Source: Kidney and Blood Pressure Research - June 15, 2016 Category: Urology & Nephrology Source Type: research

Three Decades of Atherosclerotic Reno-vascular Disease Management - Changing Outcomes in an Observational Study
Background/Aims: Optimized medical therapy has improved cardiovascular outcomes in the general population. To investigate whether changes in the management of atherosclerotic renovascular disease (ARVD) have had an impact on clinical outcomes. Methods: Recruitment into this single-center prospective cohort study started in 1986. Data was analyzed retrospectively. Patients were divided into four groups based on relationship of diagnosis year to landmark randomized controlled trials (RCT); group 1 - pre-large RCT data (1986-2000); group 2 - post-early RCT (2001-2004); group 3 - ASTRAL study recruitment era (2004-2009); group...
Source: Kidney and Blood Pressure Research - May 25, 2016 Category: Urology & Nephrology Source Type: research

Chronic Administration of Visfatin Ameliorated Diabetic Nephropathy in Type 2 Diabetic Mice
Conclusion: Visfatin might have a protective effect in diabetic nephropathy without the hypoglycemic effect.Kidney Blood Press Res 2016;41:311-324 (Source: Kidney and Blood Pressure Research)
Source: Kidney and Blood Pressure Research - May 25, 2016 Category: Urology & Nephrology Source Type: research