Association of very Low-density Lipoprotein Cholesterol with All-cause and Cardiovascular Mortality in Peritoneal Dialysis
Conclusions: An elevated VLDL-C level is an independent risk factor for all-cause and cardiovascular mortality in peritoneal dialysis (PD) patients.Kidney Blood Press Res 2017;42:52 –61 (Source: Kidney and Blood Pressure Research)
Source: Kidney and Blood Pressure Research - March 17, 2017 Category: Urology & Nephrology Source Type: research

Dexamethasone Modifies Cystatin C-Based Diagnosis of Acute Kidney Injury During Cisplatin-Based Chemotherapy
Conclusions: In the presence of dexamethasone, elevation of pCysC does not reliably diagnose AKI after cisplatin-based chemotherapy.Kidney Blood Press Res 2017;42:62 –75 (Source: Kidney and Blood Pressure Research)
Source: Kidney and Blood Pressure Research - March 17, 2017 Category: Urology & Nephrology Source Type: research

Heart Rate Variability Predicts Major Adverse Cardiovascular Events and Hospitalization in Maintenance Hemodialysis Patients
Conclusions: Reduced VLF power is linked to an increased risk of MACEs and hospitalization in maintenance HD patients. Assessing cardiac autonomic function through HRV is of pivotal prognostic significance for this patient population.Kidney Blood Press Res 2017;42:76 –88 (Source: Kidney and Blood Pressure Research)
Source: Kidney and Blood Pressure Research - March 17, 2017 Category: Urology & Nephrology Source Type: research

Magnesium Replacement Improves the Metabolic Profile in Obese and Pre-Diabetic Patients with Mild-to-Moderate Chronic Kidney Disease: A 3-Month, Randomised, Double-Blind, Placebo-Controlled Study
Conclusion: Our data support the argument that magnesium supplementation improves the metabolic status in hypomagnesemic CKD patients with pre-diabetes and obesity.Kidney Blood Press Res 2017;42:33 –42 (Source: Kidney and Blood Pressure Research)
Source: Kidney and Blood Pressure Research - March 15, 2017 Category: Urology & Nephrology Source Type: research

Pulse Pressure, Instead of Brachium-Ankle Pulse Wave Velocity, is Associated with Reduced Kidney Function in a Chinese Han Population
Conclusion: PP but not baPWV is a predictor of declined renal function. Smokers have worse arterial stiffness and worse renal function.Kidney Blood Press Res 2017;42:43 –51 (Source: Kidney and Blood Pressure Research)
Source: Kidney and Blood Pressure Research - March 14, 2017 Category: Urology & Nephrology Source Type: research

Disease Progression Modeling to Evaluate the Effects of Enzyme Replacement Therapy on Kidney Function in Adult Patients with the Classic Phenotype of Fabry Disease
Conclusion: Mathematical disease progression modeling indicates that there is no clear therapeutic effect of ERT on kidney function in adult patients with Classic Phenotype of FD. Interpretation of these findings should take into account that the study is not randomized and lacks a placebo controlled group. Further investigations are warranted to clarify whether earlier ERT initiation before 18 years of age, higher ERT dose or more intensive therapies can preserve kidney function.Kidney Blood Press Res 2017;42:1 –15 (Source: Kidney and Blood Pressure Research)
Source: Kidney and Blood Pressure Research - March 2, 2017 Category: Urology & Nephrology Source Type: research

Microarray Analysis Reveals Increased Expression of Matrix Metalloproteases and Cytokines of Interleukin-20 Subfamily in the Kidneys of Neonate Rats Underwent Unilateral Ureteral Obstruction: A Potential Role of IL-24 in the Regulation of Inflammation and Tissue Remodeling
Conclusions: This study provides an extensive view of UUO induced changes in the gene expression profile of the developing kidney and describes novel molecules, which may play significant role in the pathomechanism of CON.Kidney Blood Press Res 2017;42:16 –32 (Source: Kidney and Blood Pressure Research)
Source: Kidney and Blood Pressure Research - March 2, 2017 Category: Urology & Nephrology Source Type: research

Risk Factors and Prognosis of Cardiorenal Syndrome Type 1 in Elderly Chinese Patients: A Retrospective Observational Cohort Study
Kidney Blood Press Res 2016;41:1037-1037 (Source: Kidney and Blood Pressure Research)
Source: Kidney and Blood Pressure Research - December 23, 2016 Category: Urology & Nephrology Source Type: research

Indoxyl Sulfate Impairs Endothelial Progenitor Cells and Might Contribute to Vascular Dysfunction in Patients with Chronic Kidney Disease
Conclusions:In humans, IS impairs early EPCs and was strongly correlated with vascular dysfunction. Thus, we speculate that this adverse effect of IS may partly result from the inhibition of early EPCs.Kidney Blood Press Res 2016;41:1025-1036 (Source: Kidney and Blood Pressure Research)
Source: Kidney and Blood Pressure Research - December 23, 2016 Category: Urology & Nephrology Source Type: research

The Prevalence of Fabry Disease in Patients with Chronic Kidney Disease in Turkey: The TURKFAB Study
Conclusions:The prevalence of Fabry disease in selected CKD patients is in the range found among renal replacement therapy patients, but the disease is diagnosed at an earlier, treatable stage. These data support the ERBP recommendation to screen for Fabry disease in patients with CKD of unknown origin.Kidney Blood Press Res 2016;41:1016-1024 (Source: Kidney and Blood Pressure Research)
Source: Kidney and Blood Pressure Research - December 23, 2016 Category: Urology & Nephrology Source Type: research

Cardiorenal Syndrome Type 5 in Sepsis: Role of Endotoxin in Cell Death Pathways and Inflammation
Conclusion:Our data suggest a possible relationship between endotoxin levels and renal cell death in septic patients with CRS Type 5. Furthermore, this study highlights the presence of renal apoptosis, the immune deregulation and the strong inflammation in CRS Type 5 patients, especially in those with high endotoxin activity.Kidney Blood Press Res 2016;41:1008-1015 (Source: Kidney and Blood Pressure Research)
Source: Kidney and Blood Pressure Research - December 23, 2016 Category: Urology & Nephrology Source Type: research

Urine Epidermal Growth Factor, Monocyte Chemoattractant Protein-1 or Their Ratio as Biomarkers for Interstitial Fibrosis and Tubular Atrophy in Primary Glomerulonephritis
Conclusion: EGF/MCP-1 ratio is independently associated IFTA severity in primary glomerulonephritis, but the ability of EGF/MCP-1 ratio to discriminate moderate to severe IFTA may not be much better than EGF alone.Kidney Blood Press Res 2016;41:997-1007 (Source: Kidney and Blood Pressure Research)
Source: Kidney and Blood Pressure Research - December 17, 2016 Category: Urology & Nephrology Source Type: research

Cognitive Impairment and Structural Neuroimaging Abnormalities Among Patients with Chronic Kidney Disease
Conclusion: Dialysis modality showed no association with cognitive impairment, although hemodialysis patients had more severe neuroimaging abnormalities. For the whole group, white matter hyperintensity, and ventricular and hippocampal atrophy, were independently associated with global cognitive impairment in chronic kidney disease patients.Kidney Blood Press Res 2016;41:986-996 (Source: Kidney and Blood Pressure Research)
Source: Kidney and Blood Pressure Research - December 17, 2016 Category: Urology & Nephrology Source Type: research

High Dialysate Calcium Concentration May Cause More Sympathetic Stimulus During Hemodialysis
Conclusion: Although higher DCa is associated with better hemodynamic tolerability during hemodialysis, this occurs at the expense of increased sympathetic activity. Higher sympathetic activity was associated with a decrease of ABI during hemodialysis.Kidney Blood Press Res 2016;41:978-985 (Source: Kidney and Blood Pressure Research)
Source: Kidney and Blood Pressure Research - December 16, 2016 Category: Urology & Nephrology Source Type: research

Reduced Erythrocyte Survival in Uremic Patients Under Hemodialysis or Peritoneal Dialysis
Conclusions: Similar to HD patients, PD patients suffer from enhanced eryptosis, which is paralleled by oxidative stress and enhanced ceramide abundance contributing to the anemia of uremic patients.Kidney Blood Press Res 2016;41:966-977 (Source: Kidney and Blood Pressure Research)
Source: Kidney and Blood Pressure Research - December 9, 2016 Category: Urology & Nephrology Source Type: research

Association of MYH9 Polymorphisms with Hypertension in Patients with Chronic Kidney Disease in China
This study explored the correlation between hypertension and non-muscle myosin heavy chain 9 (MYH9) gene polymorphisms in Chinese chronic kidney disease (CKD) patients.Methods: This case-control study included 301 patients with CKD and 293 healthy controls. The E1 haplotype single nucleotide polymorphisms (SNPs) rs3752462 and rs4821480 were genotyped by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) analysis. The association betweenMYH9 polymorphisms and high systolic blood pressure (SBP ≥ 140 mmHg) susceptibility in CKD patients was analysed.Results: The cases and controls had similar gen...
Source: Kidney and Blood Pressure Research - December 7, 2016 Category: Urology & Nephrology Source Type: research

Clinical Course of Acute Kidney Injury in Elderly Individuals Above 80 Years
Conclusion: The prognosis of AKI in elderly patients is not necessarily worse than in middle aged individuals. Nevertheless, older patients may be particularly vulnerable to circulatory or ischemic insults of the kidneys.Kidney Blood Press Res 2016;41:947-955 (Source: Kidney and Blood Pressure Research)
Source: Kidney and Blood Pressure Research - December 7, 2016 Category: Urology & Nephrology Source Type: research

GSK-3beta Inhibitor Induces Expression of Nrf2/TrxR2 Signaling Pathway to Protect against Renal Ischemia/Reperfusion Injury in Diabetic Rats
Conclusion: TDZD-8 may exert its protective effect against RI/RI by regulating the Nrf2/TrxR2 signaling pathway in the kidney tissue in DM.Kidney Blood Press Res 2016;41:937-946 (Source: Kidney and Blood Pressure Research)
Source: Kidney and Blood Pressure Research - December 7, 2016 Category: Urology & Nephrology Source Type: research

Intrarenal Vascular Resistance is Associated With a Prothrombotic State in Hypertensive Patients
Conclusions: A prothrombotic state is associated with increased intrarenal vascular resistance in nondiabetic hypertensive patients and might contribute to the early stages of hypertensive renal disease.Kidney Blood Press Res 2016;41:929-936 (Source: Kidney and Blood Pressure Research)
Source: Kidney and Blood Pressure Research - November 28, 2016 Category: Urology & Nephrology Source Type: research

Clinical Utility of Serum Cystatin C in Predicting Diabetic Nephropathy Among Patients with Diabetes Mellitus: a Meta-Analysis
Conclusion: Serum cystatin C is an early predictor of DN among patients with DM.Kidney Blood Press Res 2016;41:919-928 (Source: Kidney and Blood Pressure Research)
Source: Kidney and Blood Pressure Research - November 25, 2016 Category: Urology & Nephrology Source Type: research

Evaluation of KIM-1 and NGAL as Early Indicators for Assessment of Gentamycin-Induced Nephrotoxicity < b > < i > In Vivo < /i > < /b > and < b > < i > In Vitro < /i > < /b >
Conclusions: In contrast, no significant increase in the expression of the biomarker genes and proteins were evident in HK-2 cells after treated by Gentamycin for up to 48h, suggesting that they may not be suitable endpoints for sensitive detection of nephrotoxic effects in vitro.Kidney Blood Press Res 2016;41:911-918 (Source: Kidney and Blood Pressure Research)
Source: Kidney and Blood Pressure Research - November 25, 2016 Category: Urology & Nephrology Source Type: research

Plasma Renalase is Not Associated with Blood Pressure and Brachial-Ankle Pulse Wave Velocity in Chinese Adults With Normal Renal Function
This study aimed to investigate the association of renalase with blood pressure (BP) and brachial-ankle pulse wave velocity (baPWV) in order to better understand the role of renalase in the pathogenesis of hypertension and atherosclerosis.Methods: A total of 344 subjects with normal kidney function were recruited from our previously established cohort in Shaanxi Province, China. They were divided into the normotensive (NT) and hypertensive (HT) groups or high baPWV and normal baPWV on the basis of BP levels or baPWV measured with an automatic waveform analyzer. Plasma renalase was determined through an enzyme-linked immuno...
Source: Kidney and Blood Pressure Research - November 21, 2016 Category: Urology & Nephrology Source Type: research

Self-Reported Physical Activity, Quality of Life, and Psychological Status in Relation to Plasma 25-Hydroxyvitamin D Concentration in Patients Treated with Hemodialysis
Conclusions: Vitamin D status is independently positively associated with physical activity in HD patients. Quality of life and mental health do not seem to be associated with circulating 25(OH)D under condition of its suboptimal levels.Kidney Blood Press Res 2016;41:886-900 (Source: Kidney and Blood Pressure Research)
Source: Kidney and Blood Pressure Research - November 21, 2016 Category: Urology & Nephrology Source Type: research

Comparative Effectiveness of Renin-Angiotensin System Antagonists in Maintenance Dialysis Patients
Conclusions: Patients initiating maintenance dialysis who received an ACEI faced an increased risk for mortality and a trend towards an increased risk for CV-endpoints when compared to patients who received an ARB. Validation of these results in a rigorous clinical trial is warranted.Kidney Blood Press Res 2016;41:873-885 (Source: Kidney and Blood Pressure Research)
Source: Kidney and Blood Pressure Research - November 21, 2016 Category: Urology & Nephrology Source Type: research

Renal Complications in Patients with Renal Infarction: Prevalence and Risk Factors
This study aimed to investigate the incidence and risk factors for acute kidney injury (AKI) and chronic kidney disease (CKD) in patients with renal infarction.Methods: A single-center retrospective study was conducted from January 2005 to December 2013. Baseline and clinical characteristics of the enrolled patients with renal infarction were evaluated and analyzed according to the presence of AKI and CKD. In particular, predictors for AKI and CKD were determined using logistic regression analysis.Results: Of the 105 patients included in present study, 41 (39.0%) patients had AKI. A total of 80 patients were followed up fo...
Source: Kidney and Blood Pressure Research - November 21, 2016 Category: Urology & Nephrology Source Type: research

Olmesartan Prevents Microalbuminuria in db/db Diabetic Mice Through Inhibition of Angiotensin II/p38/SIRT1-Induced Podocyte Apoptosis
Conclusions: Olmesartan reduced albuminuria in diabetic nephropathy through inhibiting angiotensin II/p38/SIRT1 triggered podocyte apoptosis.Kidney Blood Press Res 2016;41:848-864 (Source: Kidney and Blood Pressure Research)
Source: Kidney and Blood Pressure Research - November 21, 2016 Category: Urology & Nephrology Source Type: research

Impact of Annexin A 7 Deficiency on FGF23 Plasma Concentrations
Conclusion: Annexin A7 deficiency upregulates FGF23 plasma levels, an effect paralleled by increased corticosterone plasma levels, as well as decreased 1,25(OH)2 D3 and PTH plasma levels.Kidney Blood Press Res 2016;41:828-836 (Source: Kidney and Blood Pressure Research)
Source: Kidney and Blood Pressure Research - November 21, 2016 Category: Urology & Nephrology Source Type: research

Triptolide Attenuates Inflammatory Response in Membranous Glomerulo-Nephritis Rat via Downregulation of NF- & #x03BA;B Signaling Pathway
This study aims to investigate the potential anti-inflammatory effect of TPL in rats with membranous glomerulonephritis (MGN).Results: Our data showed that the pathological kidney damage was significantly alleviated by TPL treatment in MGN rats. We also found that MGN rats exhibited significantly higher (p (Source: Kidney and Blood Pressure Research)
Source: Kidney and Blood Pressure Research - November 21, 2016 Category: Urology & Nephrology Source Type: research

< b > < i > Monascus Adlay < /i > < /b > and Monacolin K Attenuates Arterial Thrombosis in Rats through the Inhibition of ICAM-1 and Oxidative Stress
Conclusions:We suggest MA is better than MK to improve FeCl3-induced arterial thrombosis.Kidney Blood Press Res 2016;41:815-827 (Source: Kidney and Blood Pressure Research)
Source: Kidney and Blood Pressure Research - November 11, 2016 Category: Urology & Nephrology Source Type: research

Gulo Acts as a < b > < i > de novo < /i > < /b > Marker for Pronephric Tubules in < b > < i > Xenopus laevis < /i > < /b >
Conclusion:Gulo is a novel specific marker for pronephros tubules inX. laevis, and may be used as a potential marker for kidney development studies and disease diagnosis in mammals.Kidney Blood Press Res 2016;41:794-801 (Source: Kidney and Blood Pressure Research)
Source: Kidney and Blood Pressure Research - November 10, 2016 Category: Urology & Nephrology Source Type: research

Extracellular Volume Overload and Increased Vasoconstriction in Patients With Recurrent Intradialytic Hypertension
Conclusions:Recurrent intradialytic hypertension is associated with higher post-dialysis extracellular volume and TPRI. Intradialytic TPRI surges account for the vasoconstrictive state post-dialysis, but intradialytic fluid shifts may contribute to post-hemodialysis volume expansion.Kidney Blood Press Res 2016;41:802-814 (Source: Kidney and Blood Pressure Research)
Source: Kidney and Blood Pressure Research - November 10, 2016 Category: Urology & Nephrology Source Type: research

Expression of BMP-2 in Vascular Endothelial Cells of Recipient May Predict Delayed Graft Function After Renal Transplantation
Background/Aims:Delayed graft function (DGF) is associated with adverse outcomes after renal transplantation. Bone morphogenetic protein-2 (BMP-2) is involved in both endothelial function and immunological events. We compared expression of BMP-2 in epigastric artery of renal transplant recipients with immediate graft function (IGF) and DGF.Methods:79 patients were included in this prospective study. Patients were divided in IGF group (64 patients) and DGF group (15 patients). BMP-2 expression in intima media (BMP2m) and endothelium (BMP2e) of epigastric artery was assessed by immunohistochemistry.Results:Lower intensity of...
Source: Kidney and Blood Pressure Research - November 10, 2016 Category: Urology & Nephrology Source Type: research

Global Overexpression of ET-1 Decreases Blood Pressure - A Systematic Review and Meta-Analysis of ET-1 Transgenic Mice
Conclusion:This meta-analysis provides robust evidence that global ET-1 overexpression in mice lowers blood pressure in an age-dependent manner. Older ET-1+/+ mice have a somewhat more pronounced reduction of blood pressure.Kidney Blood Press Res 2016;41:770-780 (Source: Kidney and Blood Pressure Research)
Source: Kidney and Blood Pressure Research - November 10, 2016 Category: Urology & Nephrology Source Type: research

Roles of Non-Coding RNAs in Acute Kidney Injury
Acute kidney injury (AKI) is a complex kidney disorder that leads to numerous complications, such as elevated nitrogenous wastes, metabolic acidosis, high potassium levels and even death. The pathogenesis of AKI is very complicated, and its causes are commonly categorized as prerenal, intrinsic or postrenal. In the past few years, evidence has accumulated showing that non-coding RNAs (ncRNAs), such as microRNAs (miRNAs) and long non-coding RNAs (lncRNAs), have significant potential to aid the development of diagnostic and therapeutic strategies of AKI. In this review, we briefly summarize the current understanding of the m...
Source: Kidney and Blood Pressure Research - November 10, 2016 Category: Urology & Nephrology Source Type: research

Overexpression of Intrarenal Renin-Angiotensin System in Human Acute Tubular Necrosis
Conclusions:We demonstrate that the intrarenal RAS is upregulated in patients with ATN and is associated with the severity of ATN. Urinary angiotensinogen reflects intrarenal RAS status, and is of value to assess the severity of ATN.Kidney Blood Press Res 2016;41:746-756 (Source: Kidney and Blood Pressure Research)
Source: Kidney and Blood Pressure Research - October 27, 2016 Category: Urology & Nephrology Source Type: research

Blood Pressure Reduction is Associated With the Changes in Oxidative Stress and Endothelial Activation in Hypertension, Regardless of Antihypertensive Therapy
Conclusions:Present study suggests that observed oxidative stress is a consequence of hypertension. BP reduction is associated with the observed decrease in oxidative stress and changes in endothelial activation regardless of antihypertensive therapy.Kidney Blood Press Res 2016;41:721-735 (Source: Kidney and Blood Pressure Research)
Source: Kidney and Blood Pressure Research - October 27, 2016 Category: Urology & Nephrology Source Type: research

Frailty in Chinese Peritoneal Dialysis Patients: Prevalence and Prognostic Significance
Background/Aims:Previous studies showed that frailty is prevalent in both pre-dialysis and dialysis patients. However, the prevalence and prognostic implication of frailty in Chinese peritoneal dialysis (PD) patients remain unknown.Methods:We used a validated questionnaire to determine the Frailty Score of 193 unselected prevalent PD patients. All patients were then followed for 2 years for their need of hospitalization and mortality.Results:Amongst the 193 patients, 134 (69.4%) met the criteria of being frail. Frailty Score significantly correlated with Charlson's comorbidity score (r = 0.40, p (Source: Kidney and Blood Pressure Research)
Source: Kidney and Blood Pressure Research - October 21, 2016 Category: Urology & Nephrology Source Type: research

Causes and Consequences of Interdialytic weight gain
Conclusion:The most important associations of %IDWG are age, height, weight, diuresis, and postdialysis sodium. Patients with the highest IDWG have significantly higher diastolic blood pressures.Kidney Blood Press Res 2016;41:710-720 (Source: Kidney and Blood Pressure Research)
Source: Kidney and Blood Pressure Research - October 14, 2016 Category: Urology & Nephrology Source Type: research

Improved Left Ventricular Structure and Function After Successful Kidney Transplantation
Conclusion:LV hypertrophy reversed after successful KTX and was accompanied by an improvement in longitudinal LV function as assessed by STE. Diastolic function and STE-derived LA function parameters did not change significantly after KTX.Kidney Blood Press Res 2016;41:701-709 (Source: Kidney and Blood Pressure Research)
Source: Kidney and Blood Pressure Research - October 7, 2016 Category: Urology & Nephrology Source Type: research

Early Predictors of Acute Kidney Injury: A Narrative Review
Accompanied with the broad application of interventional therapy, the incidence of acute kidney injury (AKI) has been recently increasing in clinical renal medicine. The pathogenesis of AKI is diverse and complex. In the context of the requirements for the diagnosis and treatment of a renal disorder, a large number of studies have explored biological markers and their usefulness to the early diagnosis and treatment of AKI, including glomerular injury, renal tubular injury, and others. These biomarkers provide an important basis for early monitoring of AKI, but are still not quite sufficient. More ideal biomarkers are neede...
Source: Kidney and Blood Pressure Research - September 27, 2016 Category: Urology & Nephrology Source Type: research

Risk Factors and Prognosis of Cardiorenal Syndrome Type 1 in Elderly Chinese Patients: A Retrospective Observational Cohort Study
Background/Aims: Cardiorenal syndrome type 1 (CRS1) is a syndrome characterized by a rapid worsening of cardiac function leading to acute kidney injury (AKI). The aims of this study were to investigate the risk factors and the prognosis of CRS1 in elderly patients.Methods: A total of 312 elderly patients ( ≥60 years old) with acute heart failure (AHF) were studied. They were assigned as CRS1 (suffered from in-hospital AKI) or NCRS1 (without AKI) group. Clinical and laboratory data were recorded. Univariate and multivariate analysis were performed to clarify the risk factors for occurrence and mortal ity of CRS1 in this ...
Source: Kidney and Blood Pressure Research - September 27, 2016 Category: Urology & Nephrology Source Type: research

Circulating CXCL16 in Diabetic Kidney Disease
Conclusion:In diabetic kidney disease patients, GFR and serum albumin independently predicted plasma CXCL16 levels.Kidney Blood Press Res 2016;41:663-671 (Source: Kidney and Blood Pressure Research)
Source: Kidney and Blood Pressure Research - September 24, 2016 Category: Urology & Nephrology Source Type: research

Cardio-Renal Syndrome Type 4: The Correlation Between Cardiorenal Ultrasound Parameters
Bakground/Aims:Cardiovascular diseases represent the leading causes of morbidity and mortality in patients with cronich kidney disease (CKD). The pathogenesis includes a complex, bidirectional interaction between heart and kidney termed cardiorenal syndrome type 4. The aim of study was to evaluate the association between renal and cardiovascular ultrasonographic parameters and identify early markers of cardiovascular risk.Methods:A total of 35 patients with CKD and 25 healthy controls, were enrolled and we have evaluated inflammatory indexes, mineral metabolism, renal function, renal and cardiovascular ultrasonographic par...
Source: Kidney and Blood Pressure Research - September 24, 2016 Category: Urology & Nephrology Source Type: research

Role and Association of Inflammatory and Apoptotic Caspases in Renal Tubulointerstitial Fibrosis
Conclusions:Our study associated inflammatory and apoptotic caspases in TIF for the first time and we further confirmed that caspase-1 activation is an upstream event of apoptotic caspase-7 induction in TIF triggered by UUO and in TECs mediated by TGF- β1 induced transdifferentiation.Kidney Blood Press Res 2016;41:643-653 (Source: Kidney and Blood Pressure Research)
Source: Kidney and Blood Pressure Research - September 19, 2016 Category: Urology & Nephrology Source Type: research

Interferon (IFN)-Induced Protein 35 (IFI35), a Type I Interferon-Dependent Transcript, Upregulates Inflammatory Signaling Pathways by Activating Toll-Like Receptor 3 in Human Mesangial Cells
Conclusion:Regional expression of IFI35 and its dysregulation may be involved in the pathogenesis of glomerular inflammation in CKD.Kidney Blood Press Res 2016;41:635-642 (Source: Kidney and Blood Pressure Research)
Source: Kidney and Blood Pressure Research - September 16, 2016 Category: Urology & Nephrology Source Type: research

The Association Between Adiponectin, Serum Uric Acid and Urinary Markers of Renal Damage in the General Population: Cross-Sectional Data from the Troms ΓΈ Study
Conclusions:Unexpectedly, adiponectin was positively associated with both urinary markers of renal damage. SUA was positively associated with albuminuria only. SUA and adiponectin added little beyond traditional cardiovascular risk factors to predict renal damage and did not interact in their associations with the urinary biomarkers. Longitudinal studies are needed before firm conclusions can be made.Kidney Blood Press Res 2016;41:623-634 (Source: Kidney and Blood Pressure Research)
Source: Kidney and Blood Pressure Research - September 13, 2016 Category: Urology & Nephrology Source Type: research

Effect of Denosumab on Peripheral Compartmental Bone Density, Microarchitecture and Estimated Bone Strength in < b > < i > De Novo < /i > < /b > Kidney Transplant Recipients
Background/Aims:In a randomized controlled clinical trial in kidney transplant recipients (NCT01377467) we have recently shown that RANKL inhibition with denosumab significantly improved areal bone mineral density (aBMD) when given during the first year after transplantation. The effect of denosumab on skeletal microstructure and bone strength in kidney transplant recipients is not known.Methods:The purpose of the present bone microarchitecture ancillary study was to investigate high-resolution peripheral quantitative computed tomography (HRpQCT) data from the distal tibia and distal radius in 24 study patients that had be...
Source: Kidney and Blood Pressure Research - September 13, 2016 Category: Urology & Nephrology Source Type: research

The Influence of Thyroid Function, Inflammation, and Obesity on Risk Prediction of Acute Kidney Injury by Cystatin C in the Emergency Department
Conclusions:CysC is known to be influenced by thyroid function, inflammation and obesity, but in our large ED population there was no significant impact of these factors on the diagnostic accuracy of CysC to detect AKI in ED patients.Kidney Blood Press Res 2016;41:604-613 (Source: Kidney and Blood Pressure Research)
Source: Kidney and Blood Pressure Research - August 31, 2016 Category: Urology & Nephrology Source Type: research

Renalase Secreted by Human Kidney HEK293T Cells Lacks its N-Terminal Peptide: Implications for Putative Mechanisms of Renalase Action
Conclusions:Lack of the N-terminal peptide, the structural precondition for FAD binding, suggests that extracellular (circulating) renalase acts in a FAD-independent manner and mechanisms of its action are not associated with FAD.Kidney Blood Press Res 2016;41:593-603 (Source: Kidney and Blood Pressure Research)
Source: Kidney and Blood Pressure Research - August 31, 2016 Category: Urology & Nephrology Source Type: research

Hyponatremia with Persistent Elevated Urinary Fractional Uric Acid Excretion: Evidence for Proximal Tubular Injury?
Background/Aims:Hyponatremia associated with high urinary fractional excretion of uric acid which persists after serum sodium is corrected is the cardinal feature of salt losing nephropathy (SLN). We hypothesize that low grade proximal tubular injury is present in SLN because the proximal tubule is the main site of uric acid and sodium transport.Methods:Five subjects with SLN were compared to four subjects with recurrent hyponatremia and three healthy individuals. Urinary NGAL (neutrophil gelatinase associated lipocalin, a marker of tubular injury) and fasting urinary fructose levels (a marker of proximal tubular injury) w...
Source: Kidney and Blood Pressure Research - August 25, 2016 Category: Urology & Nephrology Source Type: research