Angiotensin II, RAS activation and RAS blockers in COVID-19: unambiguous evidence
N/A (Source: Kidney and Blood Pressure Research)
Source: Kidney and Blood Pressure Research - September 5, 2022 Category: Urology & Nephrology Source Type: research
Retraction Statement
Kidney Blood Press Res (Source: Kidney and Blood Pressure Research)
Source: Kidney and Blood Pressure Research - September 5, 2022 Category: Urology & Nephrology Source Type: research
The proportion of memory CD8+ T cell predict infection event in patients with peritoneal dialysis
Conclusion: High level of EM CD8+ T cell could be a significant predictor of infection event in patients on PD. (Source: Kidney and Blood Pressure Research)
Source: Kidney and Blood Pressure Research - August 29, 2022 Category: Urology & Nephrology Source Type: research
Associations of urinary and dietary sodium-to-potassium ratios with albuminuria in community-dwelling Japanese adults: a cross-sectional study
Conclusions: Both spot urinary and dietary sodium-to-potassium ratios were associated with elevated albuminuria in community -dwelling Japanese adults. Our findings further support the potential usefulness of the spot urinary sodium-to-potassium ratio as an indicator of sodium intake and suggest a link between sodium intake and kidney damage. (Source: Kidney and Blood Pressure Research)
Source: Kidney and Blood Pressure Research - August 5, 2022 Category: Urology & Nephrology Source Type: research
Impact of Salt Intake and Renin-Angiotensin-Aldosterone System Blockade on Lung Severe Acute Respiratory Syndrome Coronavirus 2 Host Factors
Conclusions: These findings offer biological support regarding the safety of these drugs that are often prescribed to COVID-19 patients with cardiovascular comorbidity. High salt intake, on the other hand, might adversely affect COVID-19 outcome. Our preclinical data should stimulate clinical studies addressing this point of concern. (Source: Kidney and Blood Pressure Research)
Source: Kidney and Blood Pressure Research - July 25, 2022 Category: Urology & Nephrology Source Type: research
Impact of Salt Intake and RAAS blockade on lung SARS CoV-2 Host Factors
Conclusions: These findings offer biological support regarding the safety of these drugs that are often prescribed to COVID-19 patients with cardiovascular co-morbidity. High salt intake on the other hand might adversely affect COVID-19 outcome. Our preclinical data should stimulate clinical studies addressing this point of concern. (Source: Kidney and Blood Pressure Research)
Source: Kidney and Blood Pressure Research - July 25, 2022 Category: Urology & Nephrology Source Type: research
Relationship between proton pump inhibitors and adverse effects in hemodialysis patients: a systematic review and meta-analysis
Background ：Currently, the interaction between proton pump inhibitors (PPI) and their effects on hemodialysis (HD) patients has not been clarified. Here, we aimed to explore the association between PPI and adverse outcomes in HD patients.
Methods：A search was performed on the PubMed, Embase, Cochrane Libra ry, and Web of Science databases for relevant articles published up to April 10, 2022. Studies examining the association (odds ratio [OR]) between PPI and side effects were identified. The study followed guidelines prescribed in the Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA), and was ...
Source: Kidney and Blood Pressure Research - July 25, 2022 Category: Urology & Nephrology Source Type: research
Gitelman ’s and Bartter’s syndromes: from genetics to the molecular basis of hypertension and more
Background: Gitelman ’s and Bartter’s syndromes (GS/BS) are rare genetic tubulopathies characterized by electrolyte imbalance and activation of the renin angiotensin aldosterone system (RAAS). These syndromes have intriguing biochemical and hormonal abnormalities that leads them to be protected from hypertension, ca rdiovascular and renal remodeling.
Summary: In this review we explore the biochemical/molecular mechanisms induced by the activation of the RAAS and its counterregulatory arm which is particularly activated in GS/BS patients, in the context of blood pressure regulation. In addition, we report our fi ndings ...
Source: Kidney and Blood Pressure Research - July 20, 2022 Category: Urology & Nephrology Source Type: research
Retraction Statement
Kidney Blood Press Res (Source: Kidney and Blood Pressure Research)
Source: Kidney and Blood Pressure Research - June 23, 2022 Category: Urology & Nephrology Source Type: research
Pterostilbene, a resveratrol derivative, improves ectopic lipid deposition in the kidneys of mice induced by a high-fat diet
Conclusion: Pterostilbene alleviates renal fibrosis and ectopic lipid deposition in the kidneys of diabetic mice induced by high fat diet by inhibiting the TGF-β1/smad3 signaling. (Source: Kidney and Blood Pressure Research)
Source: Kidney and Blood Pressure Research - June 17, 2022 Category: Urology & Nephrology Source Type: research
Identification of hub gene and transcription factor related to chronic allograft nephropathy based on WGCNA analysis
Conclusion This study updates information and provides a new perspective for understanding the pathogenesis of CAN by bioinformatics means. More research is needed to validate and explore the results we have found to reveal the mechanisms underlying CAN. (Source: Kidney and Blood Pressure Research)
Source: Kidney and Blood Pressure Research - June 15, 2022 Category: Urology & Nephrology Source Type: research
Bioelectrical impedance vector analysis and brain natriuretic peptide in the evaluation of patients with chronic kidney disease in hemodialitic treatment
Conclusion: We suggest to carry out BIVA with PhA combined with BNP to assess an adequate DW and evaluate a correct nutritional status in HD patients. (Source: Kidney and Blood Pressure Research)
Source: Kidney and Blood Pressure Research - June 7, 2022 Category: Urology & Nephrology Source Type: research
How the Availability of Anti-C5a Agents Could Change the Management of Antineutrophil Cytoplasmic Antibody-Associated Vasculitis
Background: Antineutrophil cytoplasmic antibody-associated vasculitis (AAV) is a cluster of potentially life-threatening disorders, often involving the kidney with a necrotizing crescentic glomerulonephritis with scanty deposition of immunoglobulins and complement. Historically the role of complement has been considered ancillary. Recently, an anti-myeloperoxidase (MPO) AAV model in complement-deficient mice has shown an involvement for the complement cascade in the development of the renal injuries. Further animal studies showing that in contrast to mice deficient for factor B and C5 animals deficient for C4 were suscepti...
Source: Kidney and Blood Pressure Research - June 3, 2022 Category: Urology & Nephrology Source Type: research
How the availability of anti-C5a agents could change the management of ANCA-associated Vasculitis
Background: Anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) is a cluster of potentially life-threatening disorders often involving the kidney with a necrotizing crescentic glomerulonephritis with scanty deposition of immunoglobulins and complement. Historically the role of complement has been considered ancillary. Recently, an anti-myeloperoxidase (MPO) AAV model in complement-deficient mice has shown an involvement for the complement cascade in the development of the renal injuries. Further animal studies showing that in contrast to mice deficient for factor B and C5 animals deficient for C4 were s...
Source: Kidney and Blood Pressure Research - June 3, 2022 Category: Urology & Nephrology Source Type: research
Improvement in Kidney Function After Discontinuation of Fenofibrate in Outpatient Nephrology Consultation for Chronic Kidney Disease
We examined the effect of discontinuation of fenofibrate on kidney function, change in sCr and estimated glomerular filtration (eGFR) at 3, 6 and 12 months.
Results: A total of 22 patients (59% women, 86% white, 59% with type 2 diabetes, 18% with peripheral arterial disease) were captured over 2.5 years. Median sCr at the time of fenofibrate discontinuation was 1.9 (1.1–3.3) mg/dL and eGFR 32 (17 –57) ml/min; proteinuria was absent in 17 (77%). Upon discontinuation of fenofibrate, median sCr decreased to 1.5 (0.9–2.4), 1.4 (1.0–2.5) and 1.4 (1.0–2.3) mg/dL at 3, 6, and 12 months respectively (p (Source: Kidney...
Source: Kidney and Blood Pressure Research - May 24, 2022 Category: Urology & Nephrology Source Type: research
