Activation of TRPV1 Prevents Salt-Induced Kidney Damage and Hypertension After Renal Ischemia-Reperfusion Injury in Rats
Conclusion: Activation of TRPV1 plays an anti-inflammatory and anti-oxidative stress role in preventing renal tissue damage and salt-induced hypertension after I/R injury, indicating that TRPV1 conveys preconditioning protection that may have therapeutic implication.Kidney Blood Press Res 2018;43:1285 –1296 (Source: Kidney and Blood Pressure Research)
Source: Kidney and Blood Pressure Research - August 3, 2018 Category: Urology & Nephrology Source Type: research

Metabonomic Profiling Reveals Difference in Altered Metabolic Pathways Between Chronic Kidney Disease and High-Fat-Induced Insulin Resistance in Rats
Conclusion: Alterations in metabolites and relevant pathways were significantly different between the CKD- and HFD-induced IR rats. These findings may offer important information regarding the pathogenesis specific to IR caused by the decline in the renal function.Kidney Blood Press Res 2018;43:1199 –1211 (Source: Kidney and Blood Pressure Research)
Source: Kidney and Blood Pressure Research - August 2, 2018 Category: Urology & Nephrology Source Type: research

Role of Cytosolic Serine Hydroxymethyl Transferase 1 (SHMT1) in Phosphate-Induced Vascular Smooth Muscle Cell Calcification
Conclusion: Silencing of SHMT1 promotes osteo-/chondrogenic signaling in VSMCs, at least in part, by inducing cellular oxidative stress. It thus aggravates phosphate-induced calcification of VSMCs. The present findings support a regulatory role of SHMT1 in vascular calcification during conditions of hyperphosphatemia such as chronic kidney disease.Kidney Blood Press Res 2018;43:1212 –1221 (Source: Kidney and Blood Pressure Research)
Source: Kidney and Blood Pressure Research - August 2, 2018 Category: Urology & Nephrology Source Type: research

Bone Biopsy Results in Chronic Kidney Disease: a Single-Center Experience
Conclusion: In CKD 5D patients, high-turnover ROD was associated with elevated iPTH at a low cutoff but not with BAP. The same diagnosis in CKD NOD was associated both with iPTH and BAP.Kidney Blood Press Res 2018;43:1222 –1230 (Source: Kidney and Blood Pressure Research)
Source: Kidney and Blood Pressure Research - August 2, 2018 Category: Urology & Nephrology Source Type: research

The Association of Fibroblast Growth Factor 23 with Arterial Stiffness and Atherosclerosis in Patients with Autosomal Dominant Polycystic Kidney Disease
Conclusion: In patients with ADPKD, as the disease stage advanced, serum FGF-23 levels increased while s-KL decreased. In ADPKD patients, AS and atherosclerosis development increased as compared to healthy subjects, and as CKD advanced. In ADPKD patients, the effect of serum FGF-23 on the development of AS and atherosclerosis in peripheral vessels is independent of s-KL.Kidney Blood Press Res 2018;43:1160 –1173 (Source: Kidney and Blood Pressure Research)
Source: Kidney and Blood Pressure Research - July 31, 2018 Category: Urology & Nephrology Source Type: research

Circulating α-Klotho Levels in Hemodialysis Patients and Their Relationship to Atherosclerosis
Conclusion: Serum sKlotho was related to systolic pressure, pulse pressure, ultrafiltration volume, hemoglobin, serum phosphorus, corrected serum calcium ×phosphorus, Hs-CRP, increased cIMT, carotid atherosclerotic plaque quantity and atherosclerosis. Age, dry weight, Hs-CRP, and serum sKlotho were risk factors for atherosclerosis in MHD patients. Serum sKlotho may be a novel risk factor for atherosclerosis in MHD patients.Kidney Blood Press Res 2018;43:1174 –1182 (Source: Kidney and Blood Pressure Research)
Source: Kidney and Blood Pressure Research - July 31, 2018 Category: Urology & Nephrology Source Type: research

Efficacies of Various Surgical Regimens in the Treatment of Renal Calculi Patients: a Network Meta-Analysis in 25 Enrolled Controlled Clinical Trials
Conclusion: This meta-analysis demonstrated that the URS + RIRS surgical procedure has the best stone-free rate and the lowest number of auxiliary procedures. The RIRS and Microperc both have the shortest hospital stay and operative time.Kidney Blood Press Res 2018;43:1183 –1198 (Source: Kidney and Blood Pressure Research)
Source: Kidney and Blood Pressure Research - July 31, 2018 Category: Urology & Nephrology Source Type: research

RANK Deficiency Ameliorates Podocyte Injury by Suppressing Calcium/Calcineurin/ NFATc1 Signaling
Conclusion: Our findings demonstrated that RANK deficiency ameliorates podocyte injury by suppressing calcium/calcineurin/NFATc1 signaling, which may present a promising target for therapeutic intervention.Kidney Blood Press Res 2018;43:1149 –1159 (Source: Kidney and Blood Pressure Research)
Source: Kidney and Blood Pressure Research - July 23, 2018 Category: Urology & Nephrology Source Type: research

Derivation and Validation of Risk Scores to Predict Cerebrovascular Mortality Among Incident Peritoneal Dialysis Patients
Conclusion: The new risk score, developed and validated using clinical measurements that are accessible on entry into PD, could be used clinically to screen for patients at high risk of CeVD mortality. Such patients might benefit from therapies reducing the incidence of CeVD related events.Kidney Blood Press Res 2018;43:1141 –1148 (Source: Kidney and Blood Pressure Research)
Source: Kidney and Blood Pressure Research - July 23, 2018 Category: Urology & Nephrology Source Type: research

The Unexpected Effects of L-Carnitine Supplementation on Lipid Metabolism in Hemodialysis Patients
Conclusion: Our results show significant effects of L-carnitine supplementation on lipid metabolism. Further clinical trials, as well as experimental research are needed to define the role of lipid metabolism in CKD population. Significant benefits of L-carnitine supplementation in patients with better initial serum albumin levels suggest that this therapy should not be restricted to patients with the worst nutritional and overall status.Kidney Blood Press Res 2018;43:1113 –1120 (Source: Kidney and Blood Pressure Research)
Source: Kidney and Blood Pressure Research - July 17, 2018 Category: Urology & Nephrology Source Type: research

Association Between Thyroid-Stimulating Hormone and Renal Function: a Mendelian Randomization Study
Conclusion: By a genetic approach that limits residual confounding and reverse causation in observational conventional epidemiological studies, TSH and eGFR are not causally associated, which suggests genetically elevated TSH concentrations may not affect the renal function.Kidney Blood Press Res 2018;43:1121 –1130 (Source: Kidney and Blood Pressure Research)
Source: Kidney and Blood Pressure Research - July 17, 2018 Category: Urology & Nephrology Source Type: research

Clinicopathological Characteristics, Role of Immunosuppressive Therapy and Progression in IgA Nephropathy with Hyperuricemia
Conclusion: Hyperuricemic IgAN patients presented more severe clinical features. Tubulointerstitial injury could be a pathological feature closely related to hyperuricemia in IgAN. Immunosuppressive therapy and RAS blockade could reduce proteinuria and improve renal outcome in IgAN patients with hyperuricemia.Kidney Blood Press Res 2018;43:1131 –1140 (Source: Kidney and Blood Pressure Research)
Source: Kidney and Blood Pressure Research - July 17, 2018 Category: Urology & Nephrology Source Type: research

Lentivirus-Mediated Silencing of Src Homology 2 Domain-Containing Protein Tyrosine Phosphatase 2 Inhibits Release of Inflammatory Cytokines and Apoptosis in Renal Tubular Epithelial Cells Via Inhibition of the TLR4/NF-kB Pathway in Renal Ischemia-Reperfusion Injury
Conclusion: The results indicated that lentivirus-mediated silencing of SHP-2 inhibited the release of inflammatory cytokines and the apoptosis of renal tubular epithelial cells, and promoted the proliferation of these cells by inhibiting the TLR4/NF- κB signaling pathway in rats with renal I/R injury.Kidney Blood Press Res 2018;43:1084 –1103 (Source: Kidney and Blood Pressure Research)
Source: Kidney and Blood Pressure Research - July 10, 2018 Category: Urology & Nephrology Source Type: research

Clinical Outcome of Twice-Weekly Hemodialysis Patients with Long-Term Dialysis Vintage
Conclusion: The similar survival between twice-weekly HD and thrice-weekly HD in patients with long-term dialysis vintage is likely relating to patient selection, individualized treatment for dialysis patients based on clinical features and socioeconomic factors remains a tough task for the clinicians.Kidney Blood Press Res 2018;43:1104 –1112 (Source: Kidney and Blood Pressure Research)
Source: Kidney and Blood Pressure Research - July 10, 2018 Category: Urology & Nephrology Source Type: research

Association of Thyroid Function With the Estimated Glomerular Filtration Rate in a Large Chinese Euthyroid Population
Conclusion: Our findings suggest that TSH is associated with eGFR in euthyroid individuals and that higher FT4 is associated with an increased risk of CKD. More cohort studies are warranted to confirm whether the association is causal.Kidney Blood Press Res 2018;43:1075 –1083 (Source: Kidney and Blood Pressure Research)
Source: Kidney and Blood Pressure Research - July 5, 2018 Category: Urology & Nephrology Source Type: research

Adenine-Induced Chronic Renal Failure in Rats: A Model of Chronic Renocardiac Syndrome with Left Ventricular Diastolic Dysfunction but Preserved Ejection Fraction
Conclusion: Rats with ACRF develop LV hypertrophy and diastolic dysfunction while systolic performance was preserved. There was an increased hypertrophy and apoptosis of cardiomyocytes in the LV of ACRF rats. The cardiac abnormalities in ACRF rats resemble those in patients with CKD in which heart failure with preserved ejection fraction is common. Hence, this experimental model is well suited for studying pathophysiological mechanisms in chronic renocardiac syndromes.Kidney Blood Press Res 2018;43:1053 –1064 (Source: Kidney and Blood Pressure Research)
Source: Kidney and Blood Pressure Research - July 3, 2018 Category: Urology & Nephrology Source Type: research

Applying Regional Citrate Anticoagulation in Continuous Renal Replacement Therapy for Acute Kidney Injury Patients with Acute Liver Dysfunction: a Retrospective Observational Study
Conclusion: The present study demonstrated that, with proper monitoring and adjustment of citrates and calcium infusion, applying RCA in CRRT is reasonably safe for AKI patients with acute liver dysfunction, as long as circuit time stays below roughly 50 hours.Kidney Blood Press Res 2018;43:1065 –1074 (Source: Kidney and Blood Pressure Research)
Source: Kidney and Blood Pressure Research - July 3, 2018 Category: Urology & Nephrology Source Type: research

Effect of Home Blood Pressure Monitoring on Patient ’s Awareness and Goal Attainment Under Antihypertensive Therapy: The Factors Influencing Results in Anti-HypertenSive Treatment (FIRST) Study
Conclusion: In a large Swiss cohort of patients with arterial hypertension, information and training on BP self-measurement and direct involvement of patients by using HBPM led to improvement in BP control. Treatment with irbesartan alone or in combination with hydrochlorothiazide was well tolerated and markedly reduced BP.Kidney Blood Press Res 2018;43:979 –986 (Source: Kidney and Blood Pressure Research)
Source: Kidney and Blood Pressure Research - June 25, 2018 Category: Urology & Nephrology Source Type: research

Multiple Primary Malignancies in Renal Transplant Recipients: a Single Centre Retrospective Cohort Study
Conclusion: MPM are more frequent in renal transplant recipients than in the general population. It is associated with a high mortality rate, especially in the metachronous group. An increased awareness and frequent screening tests are necessary when managing this condition.Kidney Blood Press Res 2018;43:1034 –1041 (Source: Kidney and Blood Pressure Research)
Source: Kidney and Blood Pressure Research - June 25, 2018 Category: Urology & Nephrology Source Type: research

A Prospective Cohort Study Showing No Association Between Serum Sclerostin Level and Mortality in Maintenance Hemodialysis Patients
Conclusion: Serum sclerostin level was not an independent predictor of mortality in MHD patients after adjustment for several confounders. However, whether clinical interventions to modulate serum sclerostin levels in MHD patients would improve their survival remains to be determined.Kidney Blood Press Res 2018;43:1023 –1033 (Source: Kidney and Blood Pressure Research)
Source: Kidney and Blood Pressure Research - June 25, 2018 Category: Urology & Nephrology Source Type: research

Assessment of Peritoneal Membrane Arteriolar Structure in Conjunction with Traditional Cardiovascular System Evaluation in Chronic Kidney Disease (CKD) Stage 5 Patients
Conclusion: Peritoneal membrane arteriolar damage seems to be an integrated part of cardiovascular system damage in CKD stage 5 patients.Kidney Blood Press Res 2018;43:1042 –1052 (Source: Kidney and Blood Pressure Research)
Source: Kidney and Blood Pressure Research - June 25, 2018 Category: Urology & Nephrology Source Type: research

Exosomes: The New Mediator of Peritoneal Membrane Function
Fibrosis and angiogenesis are the most common processes that result in progressive peritoneal tissue remodeling and, eventually, peritoneal membrane dysfunction. The role of exosomes, which contributes to intercellular communication, in these processes has been neglected. Various biomolecules, including DNA, mRNA, proteins, lipids, and particular certain miRNAs, can be transferred by exosomes to local, neighboring and distal cells. Upon stimulation by cytokines or other microenvironment stimuli, donor cells release a mass of exosomes to peritoneal mesothelial cells, further affecting fibrosis and angiogenesis. This importa...
Source: Kidney and Blood Pressure Research - June 25, 2018 Category: Urology & Nephrology Source Type: research

Uremic Pruritus is Associated with Two-Year Cardiovascular Mortality in Long Term Hemodialysis Patients
Conclusion: Uremic pruritus is one of the predictor of 24-month cardiovascular mortality in MHD patients.Kidney Blood Press Res 2018;43:1000 –1009 (Source: Kidney and Blood Pressure Research)
Source: Kidney and Blood Pressure Research - June 18, 2018 Category: Urology & Nephrology Source Type: research

Anti-Inflammatory Action of Sitagliptin and Linagliptin in Doxorubicin Nephropathy
Conclusion: NLRP3 inflammasome activation was shown in our rat model of doxorubicin nephropathy. DPP4 inhibitors can suppress the activity of NLRP3, with or without relieving NADPH oxidase 2-related oxidative stress.Kidney Blood Press Res 2018;43:987 –999 (Source: Kidney and Blood Pressure Research)
Source: Kidney and Blood Pressure Research - June 18, 2018 Category: Urology & Nephrology Source Type: research

Progression of Chronic Kidney Disease Affects HDL Impact on Lipoprotein Lipase (LPL)-Mediated VLDL Lipolysis Efficiency
Conclusion: The progression of CKD affects lipoprotein composition and properties, and modulates the positive impact of HDL on VLDL lipolysis efficiency. In CKD patients, HDL deficiency and dysfunction can directly affect hypertriglyceridaemia development.Kidney Blood Press Res 2018;43:970 –978 (Source: Kidney and Blood Pressure Research)
Source: Kidney and Blood Pressure Research - June 18, 2018 Category: Urology & Nephrology Source Type: research

Diagnosis and Treatment of Metabolic Acidosis in Patients with Chronic Kidney Disease – Position Statement of the Working Group of the Polish Society of Nephrology
Metabolic acidosis is commonly found in patients with chronic kidney disease (CKD), and its causes are: impaired ammonia excretion, reduced tubular bicarbonate reabsorption and insufficient renal bicarbonate production in relation to the amount of acids synthesised by the body and ingested with food. As the consequence, numerous metabolic abnormalities develop, which may lead to dysfunction of several organs. In observational studies, it has been found that CKD patients with metabolic acidosis are characterised by faster progression of kidney disease towards end stage kidney failure, and by increased mortality. Results of ...
Source: Kidney and Blood Pressure Research - June 12, 2018 Category: Urology & Nephrology Source Type: research

Trace Urine Albumin and Mortality: Kangbuk Samsung Health Study
Conclusion: Trace albumin with low SG in urine dipstick test was associated with higher all-cause mortality in Korean adults. We should not neglect the significance of trace albumin and SG when interpreting urinalysis results.Kidney Blood Press Res 2018;43:951 –958 (Source: Kidney and Blood Pressure Research)
Source: Kidney and Blood Pressure Research - June 12, 2018 Category: Urology & Nephrology Source Type: research

Continuous Blood Purification Ameliorates Multiple Organ Failure Through Inhibiting the Activation of the P38 MAPK Signaling Pathway in a Rat Model
Conclusion: Our study proved that CBP could downregulate the p38 MAPK signaling pathway, suppress iNOS expression, reduced the serum levels of nitric oxide and TNF- α, thus ameliorate symptom of MOF.Kidney Blood Press Res 2018;43:938 –950 (Source: Kidney and Blood Pressure Research)
Source: Kidney and Blood Pressure Research - June 12, 2018 Category: Urology & Nephrology Source Type: research

Different Doses of < b > < i > Tripterygium < /i > < /b > Glycosides in the Treatment of Diabetic Nephropathy: Effects on Blood Lipids
Conclusion: The double dose of TG has improved clinical efficacy, compared with the low dose, and the same safety profile.Kidney Blood Press Res 2018;43:931 –937 (Source: Kidney and Blood Pressure Research)
Source: Kidney and Blood Pressure Research - June 12, 2018 Category: Urology & Nephrology Source Type: research

Investigation of the Oxidative Stress and DIO1 Expression in CRF Patients Accompanied With and Without Euthyroid Sick Syndrome
Conclusions: CRF patients showed elevated oxidative stress. The CRF patients without ESS showed higher expression of DIO1 than patients with ESS and the control group. The concentration of serum 8-Isoprostane was not correlated with FT3 and DIO1 levels.Kidney Blood Press Res 2018;43:924 –930 (Source: Kidney and Blood Pressure Research)
Source: Kidney and Blood Pressure Research - June 12, 2018 Category: Urology & Nephrology Source Type: research

Depression and Physical Frailty Have Additive Effect on the Nutritional Status and Clinical Outcome of Chinese Peritoneal Dialysis
Conclusion: Physical frailty and depressive symptoms are both common in Chinese PD patients, and they have additive adverse effect on the nutritional status and clinical outcome.Kidney Blood Press Res 2018;43:914 –923 (Source: Kidney and Blood Pressure Research)
Source: Kidney and Blood Pressure Research - June 12, 2018 Category: Urology & Nephrology Source Type: research

Tempol Protects Against Acute Renal Injury by Regulating PI3K/Akt/mTOR and GSK3 β Signaling Cascades and Afferent Arteriolar Activity
Conclusion: Tempol attenuates renal I/R injury. The protective mechanisms seem to relate with activation of PI3K/Akt/mTOR and GSK3 β pathways, inhibition of cellular damage markers and inflammation factors, as well as improvement of afferent arteriolar activity.Kidney Blood Press Res 2018;43:904 –913 (Source: Kidney and Blood Pressure Research)
Source: Kidney and Blood Pressure Research - June 5, 2018 Category: Urology & Nephrology Source Type: research

New Factors Predicting Delayed Graft Function: a Multi-Center Cohort Study of Kidney Donation After Brain Death Followed by Circulatory Death
Conclusion: The novel factors, confirmed for the first time in our study, will help to improve risk prediction of DGF and to determine optimal interventions to prevent DGF in clinical practice.Kidney Blood Press Res 2018;43:893 –903 (Source: Kidney and Blood Pressure Research)
Source: Kidney and Blood Pressure Research - June 5, 2018 Category: Urology & Nephrology Source Type: research

Association of Intradialytic Hypertension with Left Ventricular Mass in Hypertensive Hemodialysis Patients Enrolled in the Blood Pressure in Dialysis (BID) Study
Conclusion: IDH is independently associated with higher LVMI in hypertensive HD patients and may contribute to increased cardiovascular events.Kidney Blood Press Res 2018;43:882 –892 (Source: Kidney and Blood Pressure Research)
Source: Kidney and Blood Pressure Research - June 5, 2018 Category: Urology & Nephrology Source Type: research

A Prospective Observational Study on the Predictive Value of Serum Cystatin C for Successful Weaning from Continuous Renal Replacement Therapy
Conclusion: Serum CysC, at the time of CRRT cessation, is an independent predictor of the successful weaning from CRRT in critically ill patients with acute kidney injury.Kidney Blood Press Res 2018;43:872 –881 (Source: Kidney and Blood Pressure Research)
Source: Kidney and Blood Pressure Research - June 5, 2018 Category: Urology & Nephrology Source Type: research

Enhanced Renal Afferent Arteriolar Reactive Oxygen Species and Contractility to Endothelin-1 Are Associated with Canonical Wnt Signaling in Diabetic Mice
Conclusion: Increased ROS, notably H2O2 contributes to enhanced afferent arteriolar responses to ET-1 in diabetes, which is closely associated with Wnt signaling. Antioxidant pharmacological strategies targeting Wnt signaling may improve vascular function in diabetic nephropathy.Kidney Blood Press Res 2018;43:860 –871 (Source: Kidney and Blood Pressure Research)
Source: Kidney and Blood Pressure Research - June 5, 2018 Category: Urology & Nephrology Source Type: research

Assessment of Renal Pathological Changes in Lupus Nephritis Using Diffusion Weighted Imaging: A Multiple Correspondence Analysis
Conclusion: DWI is a noninvasive technique that may be used to detect renal pathophysiological changes. Renal cell proliferation and intestinal fibrosis may impact the movement of water in certain microenvironments. Enhanced perfusion may be a compensatory mechanism that is associated with renal pathological injuries.Kidney Blood Press Res 2018;43:847 –859 (Source: Kidney and Blood Pressure Research)
Source: Kidney and Blood Pressure Research - June 5, 2018 Category: Urology & Nephrology Source Type: research

Impaired Microcirculation in Children After Kidney Transplantation: Everolimus Versus Mycophenolate Based Immunosuppression Regimen
Conclusion: Endothelial dysfunction seems more frequent in KTx patients on EVR-based immunosuppressive regimen compared to standard immunosuppression.Kidney Blood Press Res 2018;43:793 –806 (Source: Kidney and Blood Pressure Research)
Source: Kidney and Blood Pressure Research - May 29, 2018 Category: Urology & Nephrology Source Type: research

Add-On Effect of Angiotensin Receptor Blockade (Candesartan) on Clinical Remission in Active IgA Nephropathy Patients Treated with Steroid Pulse Therapy and Tonsillectomy: a Randomized, Parallel-Group Comparison Trial
Conclusion: Early candesartan treatment combined with TSP may not benefit clinical remission regardless of the blood pressure. ARB titration later during the treatment might provide benefit for patients with active IgA nephropathy.Kidney Blood Press Res 2018;43:780 –792 (Source: Kidney and Blood Pressure Research)
Source: Kidney and Blood Pressure Research - May 29, 2018 Category: Urology & Nephrology Source Type: research

Effects of Angiotensin-Converting Enzyme Inhibitors and Angiotensin II Receptor Blockers on All-Cause Mortality and Renal Outcomes in Patients with Diabetes and Albuminuria: a Systematic Review and Meta-Analysis
Conclusion: In patients with diabetes and albuminuria, ARBs reduced risks of ESRD and doubling of the serum creatinine level. ACE inhibitors and ARBs failed to reduce all-cause mortality and CV. Based on the renoprotective effects, ARBs may be preferred for diabetic patients with albuminuria.Kidney Blood Press Res 2018;43:768 –779 (Source: Kidney and Blood Pressure Research)
Source: Kidney and Blood Pressure Research - May 29, 2018 Category: Urology & Nephrology Source Type: research

Metabolite Profiling of Feces and Serum in Hemodialysis Patients and the Effect of Medicinal Charcoal Tablets
Conclusion: Parallel fecal and serum metabolomics uncovered the systematic metabolic variations of HD patients, especially disturbances in amino acid metabolism in the colon. Medicinal charcoal tablets had an impact on the serum and fecal metabolomes of HD patients, but their exact effects still need to be studied further.Kidney Blood Press Res 2018;43:755 –767 (Source: Kidney and Blood Pressure Research)
Source: Kidney and Blood Pressure Research - May 29, 2018 Category: Urology & Nephrology Source Type: research

Serum Fas Ligand, Serum Myostatin and Urine TGF- β1 Are Elevated in Autosomal Dominant Polycystic Kidney Disease Patients with Impaired and Preserved Renal Function
Conclusions: ADPKD patients with moderately preserved renal function have higher levels of FasL, myostatin and urine TGF- β1 than controls. These results indicate that an interplay between endothelial dysfunction and renal ischemia with mechanisms linked to apoptosis and fibrosis may be present even in early stages of ADPKD.Kidney Blood Press Res 2018;43:744 –754 (Source: Kidney and Blood Pressure Research)
Source: Kidney and Blood Pressure Research - May 29, 2018 Category: Urology & Nephrology Source Type: research

Circulating α-Klotho is Related to Plasma Aldosterone and Its Follow-Up Change Predicts CKD Progression
Conclusion: The change in concentration of soluble α-klotho during the 1.5-years follow-up was an indicator of CKD progression. Renal damage associated with a reduction of α-klotho may involve the upregulation of plasma aldosterone. Future studies are needed to validate our findings, and to investigate the underlying mechanism by which α-klotho a nd aldosterone may cause renal damage.Kidney Blood Press Res 2018;43:836 –846 (Source: Kidney and Blood Pressure Research)
Source: Kidney and Blood Pressure Research - May 29, 2018 Category: Urology & Nephrology Source Type: research

Mucin 4 Gene Silencing Reduces Oxidative Stress and Calcium Oxalate Crystal Formation in Renal Tubular Epithelial Cells Through the Extracellular Signal-Regulated Kinase Signaling Pathway in Nephrolithiasis Rat Model
Conclusion: Taken together, silencing of MUC4 can inactivate the ERK signaling pathway and further restrain oxidative stress and CaOx crystal formation in RTEC. Thus, MUC4 represents a potential investigative focus target in nephrolithiasis.Kidney Blood Press Res 2018;43:820 –835 (Source: Kidney and Blood Pressure Research)
Source: Kidney and Blood Pressure Research - May 29, 2018 Category: Urology & Nephrology Source Type: research

Erythropoietin Protects the Kidney by Regulating the Effect of TNF- α in L-NAME-Induced Hypertensive Rats
Conclusion: Erythropoietin protects kidney tissue against hypertension by preventing the apoptotic effects of TNF- α by blocking macrophage accumulation, decreasing TNF-α levels, and switching the TNF-α receptors from the apoptotic receptor TNFR1 to the proliferative receptor TNFR2.Kidney Blood Press Res 2018;43:807 –819 (Source: Kidney and Blood Pressure Research)
Source: Kidney and Blood Pressure Research - May 29, 2018 Category: Urology & Nephrology Source Type: research

Different Relevance of Peripheral, Central or Nighttime Blood Pressure Measurements in the Prediction of Chronic Kidney Disease Progression in Patients with Mild or No-Proteinuria
Conclusion: 1. In patients with CKD stages 3 or 4 and mild or no- proteinuria, peripheral and central blood pressure did not change significantly during a one-year observation period despite the significant decline of eGFR and seems not to participate in the CKD progression. 2. Reduced magnitude of the diastolic dipping, which reflects the increase of diastolic blood pressure load during the nighttime, may play an important role in the pathogenesis of deterioration of kidney function in these patients.Kidney Blood Press Res 2018;43:735 –743 (Source: Kidney and Blood Pressure Research)
Source: Kidney and Blood Pressure Research - May 15, 2018 Category: Urology & Nephrology Source Type: research

The Calcium-Sensing Receptor Gene Polymorphism rs1801725 and Calcium-Related Phenotypes in Hemodialysis Patients
Conclusion: The variant allele ofCASR rs1801725 solely and together with the variant allele of rs7652589 increases risk of more advanced sHPT. Homozygosity of the rs1801725 variant allele contributes to infection-related mortality in HD patients.Kidney Blood Press Res 2018;43:719 –734 (Source: Kidney and Blood Pressure Research)
Source: Kidney and Blood Pressure Research - May 15, 2018 Category: Urology & Nephrology Source Type: research

Endothelial Progenitor Cells and Kidney Diseases
Endothelial progenitor cells (EPC) are bone marrow derived or tissue-resident cells that play major roles in the maintenance of vascular integrity and repair of endothelial damage. Although EPCs may be capable of directly engrafting and regenerating the endothelium, the most important effects of EPCs seem to be depended on paracrine effects. In recent studies, specific microvesicles and mRNAs have been found to mediate the pro-angiogenic and regenerative effects of EPCs on endothelium. EPC counts have important prognostic implications in cardiovascular diseases (CVD). Uremia and inflammation are associated with lower EPC c...
Source: Kidney and Blood Pressure Research - May 15, 2018 Category: Urology & Nephrology Source Type: research

Clinical Correlates of Ambulatory Blood Pressure Phenotypes at a Tertiary Care Hospital in Turkey
Conclusion: Potential usages of ABPM in Turkey may include screening of high risk individuals who have traditional cardiovascular risk factors. It also provides clinicians valuable information on abnormal ABP phenotypes. Future studies are needed to clarify the risk factors of different ABP phenotypes and to evaluate the role of ABPM on detection and control of hypertension.Kidney Blood Press Res 2018;43:690 –700 (Source: Kidney and Blood Pressure Research)
Source: Kidney and Blood Pressure Research - May 15, 2018 Category: Urology & Nephrology Source Type: research

Prognostic Factors of Renal Involvement in Systemic Sclerosis
Conclusion: In SSc patients, renal function was normal for 4.1 years despite the presence of increased intrarenal arterial stiffness. SRC was observed in 4.9% of SSc patients. In SSc patients, a periodic follow-up based on clinical and laboratory evaluation, colorDoppler ultrasound and, in some cases, renal biopsy is required to evaluate renal involvement.Kidney Blood Press Res 2018;43:682 –689 (Source: Kidney and Blood Pressure Research)
Source: Kidney and Blood Pressure Research - May 15, 2018 Category: Urology & Nephrology Source Type: research