Identification of hub genes correlated with the initiation and development in chronic kidney disease via bioinformatics analysis
Conclusion: Our study reveals the coordination of genes during UUO, and provides a promising gene panel CKD treatment. GNG2 and PF4 were identified as potential targets for developing CKD drugs. (Source: Kidney and Blood Pressure Research)
Source: Kidney and Blood Pressure Research - January 5, 2023 Category: Urology & Nephrology Source Type: research
Protective effects of Xanthohumol against diabetic nephropathy in a mouse model
Conclusion: Xanthohumol could ameliorate DN-related impairments via Nrf2 signaling pathway, which might serve as a promising drug candidate for treatment of DN. (Source: Kidney and Blood Pressure Research)
Source: Kidney and Blood Pressure Research - January 2, 2023 Category: Urology & Nephrology Source Type: research
Acknowledgement to the Reviewers
Kidney Blood Press Res 2022;47:742 –743 (Source: Kidney and Blood Pressure Research)
Source: Kidney and Blood Pressure Research - December 22, 2022 Category: Urology & Nephrology Source Type: research
Expression of Wilms ’ Tumor 1 Antigen, Vimentin, and Corticotropin-Releasing Factor in the Human Kidney with Focal Segmental Glomerulosclerosis and Effect of Oxidative Stress on These Markers in HEK 293 Cells
Discussion: Our observations on kidney biopsy samples support that the reduction of WT1 and vimentin could be characteristic for FSGS. Our results on HEK cells suggest that meta- and ortho-Tyr may play a role in the development of FSGS. (Source: Kidney and Blood Pressure Research)
Source: Kidney and Blood Pressure Research - December 16, 2022 Category: Urology & Nephrology Source Type: research
Expression of Wilms-tumor 1 antigen, vimentin and corticotropin releasing factor in human kidney with focal segmental glomerulosclerosis and effect of oxidative stress on these markers in HEK 293 cells
Discussion: Our observations on kidney biopsy samples support that the reduction of WT1 and vimentin could be characteristic for FSGS. Our results on HEK cells suggest that meta- and ortho-tyrosine may play a role in the development of FSGS. (Source: Kidney and Blood Pressure Research)
Source: Kidney and Blood Pressure Research - December 16, 2022 Category: Urology & Nephrology Source Type: research
Therapeutic Plasmapheresis: A Revision of Literature
Background: Therapeutic plasmapheresis (TP) is an extracorporeal therapy that allows the removal of pathogens from plasma. The role of TP in immuno-mediated diseases and toxic conditions has been of interest for decades.Summary: We reviewed the recent literature on the application and the optimal choice of TP technique ranging from plasma exchange, double filtration plasmapheresis, rheopheresis, immunoadsorptions, plasma adsorption perfusion and lipidoapheresis. In addition, we report our experience in the application of TP for various diseases ranging in different medical specialties, following the American Society for Ap...
Source: Kidney and Blood Pressure Research - December 8, 2022 Category: Urology & Nephrology Source Type: research
Therapeutic Plasmapheresis: a revision of literature.
Background: Therapeutic Plasmapheresis (TP) is an extracorporeal therapy that allows the removal of pathogens from plasma. The role of TP in immuno-mediated diseases and toxic conditions has been of interest for decades.
Summary: We reviewed the recent literature on the application and the optimal choice of TP technique ranging from Plasma Exchange, Double Filtration Plasmapheresis, Rheopheresis, Immunoadsorptions and Lipidoapheresis. In addition, we report our experience in the application of TP for various diseases ranging in different medical specialties, following the American Society for Apheresis (ASFA) recommendati...
Source: Kidney and Blood Pressure Research - December 8, 2022 Category: Urology & Nephrology Source Type: research
Upregulated MicroRNA-185-3p Inhibits the Development of Hyperlipidemia in Rats
Conclusion: Upregulated miR-185-3p represses hyperlipidemia development via modulating MAML1 expression. This research provides novel therapeutic candidates for the treatment of hyperlipidemia. (Source: Kidney and Blood Pressure Research)
Source: Kidney and Blood Pressure Research - December 8, 2022 Category: Urology & Nephrology Source Type: research
Up-regulated microRNA-185-3p inhibits the development of hyperlipidemia in rats
Conclusion: Up-regulated miR-185-3p represses hyperlipidemia development via modulating MAML1 expression. This research provides novel therapeutic candidates for the treatment of hyperlipidemia. (Source: Kidney and Blood Pressure Research)
Source: Kidney and Blood Pressure Research - December 8, 2022 Category: Urology & Nephrology Source Type: research
The relationship of uremic toxin indoxyl sulfate and intestinal elimination mechanisms in hemodialysis patients
Conclusion: No evidence of bowel elimination pathway via ABCC2 and ABCG2 transporters was found in renal replacement therapy patients. (Source: Kidney and Blood Pressure Research)
Source: Kidney and Blood Pressure Research - November 24, 2022 Category: Urology & Nephrology Source Type: research
Severe hypophosphatemia as the initial presentation of renal Fanconi ’s syndrome and distal renal tubular acidosis related to zoledronic acid: A case report and literature review
Conclusion: Progressive electrolyte disorders and CKD were the long-term renal outcome of the current patient. We would like to arouse more attention to electrolytes imbalance related to early ZA-induced kid ney injury and emphasize the significance of close monitoring. (Source: Kidney and Blood Pressure Research)
Source: Kidney and Blood Pressure Research - November 21, 2022 Category: Urology & Nephrology Source Type: research
Long Noncoding RNA HOXA-AS2 Facilitates Prostate Cancer Progression by Inhibiting miR-885-5p to Upregulate KDM5B
Conclusion: This study revealed a potential ceRNA regulatory pathway in which HOXA-AS2 affects KDM5B expression levels by sponging miR-885-5p to promote PCa development and progression. (Source: Kidney and Blood Pressure Research)
Source: Kidney and Blood Pressure Research - November 18, 2022 Category: Urology & Nephrology Source Type: research
LncRNA HOXA-AS2 facilitates prostate cancer progression by inhibiting miR-885-5p to upregulate KDM5B
Conclusions: This study revealed a potential ceRNA regulatory pathway in which HOXA-AS2 affects KDM5B expression levels by sponging miR-885-5p to promote PCa development and progression. (Source: Kidney and Blood Pressure Research)
Source: Kidney and Blood Pressure Research - November 18, 2022 Category: Urology & Nephrology Source Type: research
Development and validation of a cardiovascular disease risk prediction model for patients with non-dialysis-dependent chronic kidney diseases based on the nomogram
This study enrolled 1138 participants with non-dialysis-dependent chronic kidney disease (NDD-CKD). Following a proportion of 7:3, patients were randomly assigned to training and validation cohorts. The relevant predictors of cardiovascular events were screened using the least absolute shrinkage and selection operator (Lasso) regression. The area under the receiver operating characteristic curve (AUC) and the calibration curve with 1000 bootstraps resamples were used to assess the nomogram's performance. Tests on the discrimination of the prediction model used Kaplan-Meier (KM) curve.
Results
After screening all the pred...
Source: Kidney and Blood Pressure Research - November 8, 2022 Category: Urology & Nephrology Source Type: research
Association between plasma xanthine oxidoreductase activity and the renal function in a general Japanese population: The Tohoku Medical Megabank community-based cohort study
This study investigated the association between XOR and renal function in a general Japanese population.
Methods: The Iwate Tohoku Medical Megabank Organization pooled individual participant data from a community-based cohort study in Iwate prefecture. Chronic kidney disease (CKD) was estimated using the estimated glomerular filtration rate of cystatin C (eGFRcys). Individuals with a history of hyperuricemia or severe renal dysfunction (eGFRcys (Source: Kidney and Blood Pressure Research)
Source: Kidney and Blood Pressure Research - November 1, 2022 Category: Urology & Nephrology Source Type: research
