Effects of Paricalcitol and Aliskiren Combination Therapy on Experimental Diabetic Nephropathy Model in Rats
Background/Aims: The aim of the present study was to investigate the effect of combination of aliskiren with paricalcitol on experimental diabetic nephropathy (DN) model in rats. Methods: Forty male Sprague Dawley rats were divided into 5 groups of 8 rats each, namely the control (Group C), diabetes (Group D), aliskiren (Group A), paricalcitol (Group P), and aliskiren plus paricalcitol (Group A+P) groups. Aliskiren was given by oral-gavage at a dose of 50 mg/kg/day once daily for 12 weeks. Paricalcitol was given by intraperitoneally at a dose of 0,4 µg/kg/three day of week for 12 weeks. Renal function parameters, oxi...
Source: Kidney and Blood Pressure Research - December 24, 2014 Category: Urology & Nephrology Source Type: research

Effects of Spironolactone in Combination with Angiotensin-Converting Enzyme Inhibitors or Angiotensin Receptor Blockers in Patients with Proteinuria
This study aimed to investigate the potential beneficial anti-proteinuric effect of an add-on aldosterone blockade and the impact of the aldosterone escape phenomenon. Methods: We retrospectively analyzed data of 304 patients with persistent proteinuria, who were administered spironolactone (25 mg/day) after treatment with angiotensin-converting enzyme inhibitors (ACEIs) or angiotensin II receptor blockers (ARBs) for>3 months. Patients were divided according to their aldosterone levels during ACEI/ARB treatment into an escape group (plasma aldosterone>80 pg/mL, N=95, 31.5%) and a non-escape group (plasma aldosterone ...
Source: Kidney and Blood Pressure Research - December 24, 2014 Category: Urology & Nephrology Source Type: research

Mortality Prediction Using Modern Peptide Biomarkers in Hemodialysis Patients - A Comparative Analysis
Conclusions: Among peptide biomarkers high sensitive troponins and to a lesser extent natriuretic peptides are strong predictors of mortality in asymptomatic hemodialysis patients, followed by markers of mineral-bone disease and inflammation.Kidney Blood Press Res 2014;39:563-572 (Source: Kidney and Blood Pressure Research)
Source: Kidney and Blood Pressure Research - December 24, 2014 Category: Urology & Nephrology Source Type: research

Aortic Arch Calcification Predicts Cardiovascular and All-Cause Mortality in Maintenance Hemodialysis Patients
Conclusions: The presence and progression of AoAC assessed by chest X-ray were independently associated with mortality in MHD patients. Regular follow-up by chest X-ray could be a simple and useful method to stratify mortality risk in MHD patients.Kidney Blood Press Res 2014;39:658-667 (Source: Kidney and Blood Pressure Research)
Source: Kidney and Blood Pressure Research - December 24, 2014 Category: Urology & Nephrology Source Type: research

Cysteinyl 1 Receptor Antagonist Montelukast, Does Not Prevent Peritoneal Membrane Damage in Experimental Chronic Peritoneal Dialysis Model in Rats
Conclusion: This study suggests that montelukast treatment does not prevent the peritoneal membrane from deleterious effects of hyperosmolar PDF in the uremic environment.Kidney Blood Press Res 2014;39:648-657 (Source: Kidney and Blood Pressure Research)
Source: Kidney and Blood Pressure Research - December 24, 2014 Category: Urology & Nephrology Source Type: research

Superior Predictive Value for NTproBNP Compared with High Sensitivity cTnT in Dialysis Patients: A Pilot Prospective Observational Study
Conclusion: NT-pro-BNP is a strong predictor of overall mortality in asymptomatic hemodialysis patients. The addition of hs-cTnT did not improve the prognostic accuracy compared with NT proBNP alone.Kidney Blood Press Res 2014;39:636-647 (Source: Kidney and Blood Pressure Research)
Source: Kidney and Blood Pressure Research - December 24, 2014 Category: Urology & Nephrology Source Type: research

Cross-Sectional Evaluation of Kidney Function in Hospitalized Patients: Estimated GFR Versus Renal Scintigraphy
Background/Aims: Accurate staging of chronic kidney disease (CKD) is very important. We tried to identify difference in GFR evaluation between CKD-EPI and Gates method with renal scintigraphy and which variables are associated with these differences. Methods: We retrospectively reviewed the records of 341 patients who underwent dynamic renal scintigraphy in the last 5 years. Patients were categorized according to KDIGO staging I to V, using the eGFR calculated with the CKD-EPI equation. Secondarily, we stratified patients according to treatment with renin-angiotensin system (RAS) inhibitors. Results: Gates method tends to ...
Source: Kidney and Blood Pressure Research - December 24, 2014 Category: Urology & Nephrology Source Type: research

Pathogenesis and Treatment of Chronic Kidney Disease: A Review of Our Recent Basic and Clinical Data
Chronic kidney disease (CKD) is a worldwide public health problem that affects millions of people from all racial and ethnic groups. At end of 2013, over 300,000 Japanese patients had maintenance dialysis therapy (JSDT). In Japan, the major causes of end stage kidney disease (ESKD) are chronic glomerulonephritis (particularly IgA nephropathy), type 2 diabetic nephropathy, and hypertensive nephrosclerosis. Hypertension is a major factor driving the progression of CKD to ESKD. Since many features of the pathogenesis of IgA nephropathy are still obscure, specific treatment is not yet available. However, efforts by investigato...
Source: Kidney and Blood Pressure Research - December 4, 2014 Category: Urology & Nephrology Source Type: research

Evening -Versus Morning- Dosing Drug Therapy for Chronic Kidney Disease Patients with Hypertension: A Systematic Review
Background/Aims: There is a strong correlation between non-dipping status and cardiovascular events in chronic kidney disease (CKD) patients. Our study is designed to identify the effect of evening administration of antihypertensive drugs to hypertensive CKD patients. Methods: A comprehensive search of Medline, Embase, the Chinese Biomedical Literature Database, Wanfang Data, Chinese National Knowledge Infrastructure, and the Cochrane Central Register of Controlled Trials was performed in July 2014. Concurrent controlled or crossover trials (including randomized and non-randomized experimental trials) designed to evaluate ...
Source: Kidney and Blood Pressure Research - November 26, 2014 Category: Urology & Nephrology Source Type: research

Down-Regulation of Renal Klotho Expression by Shiga Toxin 2
Conclusion: Shiga toxin 2 treatment stimulated Tnfα transcription, down-regulated renal klotho expression and increased FGF23 formation, effects presumably contributing to renal tissue injury.Kidney Blood Press Res 2014;39:441-449 (Source: Kidney and Blood Pressure Research)
Source: Kidney and Blood Pressure Research - November 26, 2014 Category: Urology & Nephrology Source Type: research

Aristolochic Acid Induced Suicidal Erythrocyte Death
Conclusions: Aristolochic Acid triggers eryptosis, an effect at least in part due to entry of extracellular Ca2+ and ceramide formation.Kidney Blood Press Res 2014;39:408-419 (Source: Kidney and Blood Pressure Research)
Source: Kidney and Blood Pressure Research - November 18, 2014 Category: Urology & Nephrology Source Type: research

Correlation Between Endothelial Dysfunction and Left Ventricular Remodeling in Patients with Chronic Kidney Disease
Conclusions: The results showed that there was a higher incidence of left ventricular hypertrophy in patients with chronic kidney disease. Endothelin-1 and nitric oxide played an important role on the development of left ventricular hypertrophy.Kidney Blood Press Res 2014;39:420-426 (Source: Kidney and Blood Pressure Research)
Source: Kidney and Blood Pressure Research - November 18, 2014 Category: Urology & Nephrology Source Type: research

The Intron 4 Polymorphism in the Calcium-Sensing Receptor Gene in Diabetes Mellitus and its Chronic Complications, Diabetic Nephropathy and Non-Diabetic Renal Disease
Conclusion: We conclude that CaSR is a general factor in pancreas and kidney pathologies.Kidney Blood Press Res 2014;39:399-407 (Source: Kidney and Blood Pressure Research)
Source: Kidney and Blood Pressure Research - November 8, 2014 Category: Urology & Nephrology Source Type: research

Significant Association Between Bone-Specific Alkaline Phosphatase and Vascular Calcification of the Hand Arteries in Male Hemodialysis Patients
We examined association between serum BAP and vascular calcification of male hemodialysis patients. Methods: Hand roentgenography of 167 male maintenance hemodialysis patients was conducted, and visible vascular calcification of the hand arteries was evaluated. Serum levels of 3 bone formation markers (BAP, osteocalcin, and N-terminal propeptide of type I collagen) and 2 bone resorption markers (C-terminal telopeptide of type I collagen, and cross-linked N-telopeptide of type I collagen) were measured, along with serum intact parathyroid hormone (PTH). Results: Of 167 patients, visible vascular calcification was seen in 37...
Source: Kidney and Blood Pressure Research - November 7, 2014 Category: Urology & Nephrology Source Type: research

Cardiac and Renal Effects of Atrasentan in Combination with Enalapril and Paricalcitol in Uremic Rats
Conclusions: We found distinct cardiac and renal effects of atrasentan. Combination treatment with atrasentan, enalapril and paricalcitol provided positive effects on cardiac remodeling in uremic rats, whereas combination treatment did not offer further protective effects on blood pressure, proteinuria or renal histology.Kidney Blood Press Res 2014;39:340-352 (Source: Kidney and Blood Pressure Research)
Source: Kidney and Blood Pressure Research - November 7, 2014 Category: Urology & Nephrology Source Type: research

Apolipoprotein E Mutation and Double Filtration Plasmapheresis Therapy on a New Chinese Patient with Lipoprotein Glomerulopathy
Conclusion: APOE Kyoto mutation was found in a new Chinese patient with LPG, accompanied by Cys112Arg. More cases and further functional experiments are needed to investigate the role of these two mutations together in LPG. DFPP is an effective therapeutic modality for improving NS in patients with LPG.Kidney Blood Press Res 2014;39:330-339 (Source: Kidney and Blood Pressure Research)
Source: Kidney and Blood Pressure Research - November 7, 2014 Category: Urology & Nephrology Source Type: research

Maternal Vitamin D Deficiency and Fetal Programming - Lessons Learned from Humans and Mice
Conclusions: Our study demonstrates an association between maternal 25OHD and offspring birth weight. The effect of 25OHD on birth weight seems to be mediated by vitamin D controlling gestational age. Results from an animal experiment suggest that gestational 25OHD insufficiency is causally linked to adverse pregnancy outcomes. Since birth weight and prematurity are associated with an adverse cardiovascular outcome in later life, this study emphasizes the need for novel monitoring and treatment guidelines of vitamin D deficiency during pregnancy.Kidney Blood Press Res 2014;39:315-329 (Source: Kidney and Blood Pressure Research)
Source: Kidney and Blood Pressure Research - November 7, 2014 Category: Urology & Nephrology Source Type: research

Nonalcoholic Fatty Liver Disease (NAFLD) And Cardiovascular Risk In Renal Transplant Recipients
We examined whether transient elastography (TE) defined NAFLD was associated with atherosclerosis in RTRs, as measured by ultrasound in the carotid arteries. Methods: Carotid atherosclerosis was assesses in 71 RTRs with a TE proven NAFLD. With the help of TE liver stiffness was used to assess liver fibrosis and Controlled Attenuation Parameter (CAP) was used to detect and quantify liver steatosis. NAFLD was defined by the presence of steatosis with CAP values ≥238 dB.m-1. Results: RTRs with NAFLD showed more carotid atherosclerosis than RTRs without NAFLD. RTRs-NAFLD patients had the mean intima-media measurements (ITM)...
Source: Kidney and Blood Pressure Research - November 7, 2014 Category: Urology & Nephrology Source Type: research

SPAK and OSR1 Dependent Down-Regulation of Murine Renal Outer Medullary K+ Channel ROMK1
Conclusion: ROMK1 protein abundance and activity are down-regulated by SPAK and OSR1.Kidney Blood Press Res 2014;39:353-360 (Source: Kidney and Blood Pressure Research)
Source: Kidney and Blood Pressure Research - November 7, 2014 Category: Urology & Nephrology Source Type: research

Gene Expression Analysis in Tubule Interstitial Compartments Reveals Candidate Agents for IgA Nephropathy
Conclusion: Our work provided a systematic insight in understanding the mechanism of IgA nephropathy. Small molecules such as thapsigargin might be potential candidate agents for the treatment of IgA nephropathy.Kidney Blood Press Res 2014;39:361-368 (Source: Kidney and Blood Pressure Research)
Source: Kidney and Blood Pressure Research - November 7, 2014 Category: Urology & Nephrology Source Type: research

The Impact of Umbilical Blood Flow Regulation on Fetal Development Differs in Diabetic and Non-Diabetic Pregnancy
Conclusions: The impact of umbilical blood flow on fetal growth is time dependent in human gestational diabetes mellitus and non-gestational diabetes mellitus pregnancy. In gestational diabetes mellitus pregnancy umbilical blood flow is critical for organ development in much earlier stages of pregnancy as compared to non-gestational diabetes mellitus pregnancy. The physiological and molecular pathways why there is a catch up growth in later times of gestational diabetes mellitus pregnancy resulting in larger gestational diabetes mellitus babies at birth needs to be addressed in further studies.Kidney Blood Press Res 2014;3...
Source: Kidney and Blood Pressure Research - November 7, 2014 Category: Urology & Nephrology Source Type: research

Regulation of ClC-2 Activity by SPAK and OSR1
Conclusion: SPAK and OSR1 are powerful negative regulators of the cell volume regulatory Cl- channel ClC-2.Kidney Blood Press Res 2014;39:378-387 (Source: Kidney and Blood Pressure Research)
Source: Kidney and Blood Pressure Research - November 7, 2014 Category: Urology & Nephrology Source Type: research

SPAK Dependent Regulation of Peptide Transporters PEPT1 and PEPT2
Conclusion: SPAK is a powerful regulator of peptide transporters PEPT1 and PEPT2.Kidney Blood Press Res 2014;39:388-398 (Source: Kidney and Blood Pressure Research)
Source: Kidney and Blood Pressure Research - November 7, 2014 Category: Urology & Nephrology Source Type: research

Investigating the Effect of CoCl2 Administration on Diabetic Nephropathy and Associated Aortic Dysfunction
Kidney Blood Press Res 2012;35:694–697 (DOI:10.1159/000343888) (Source: Kidney and Blood Pressure Research)
Source: Kidney and Blood Pressure Research - January 8, 2013 Category: Urology & Nephrology Source Type: research

Antiviral Therapy for HCV-Associated Cryoglobulinemic Glomerulonephritis: Case Report and Review of the Literature
Kidney Blood Press Res 2012;35:687–693 (DOI:10.1159/000345515) (Source: Kidney and Blood Pressure Research)
Source: Kidney and Blood Pressure Research - January 7, 2013 Category: Urology & Nephrology Source Type: research

Effect of Nutritional Status on Human Paraoxonase-1 Activity in Patients with Chronic Kidney Disease
Kidney Blood Press Res 2012;36:310-319 (DOI:10.1159/000343383) (Source: Kidney and Blood Pressure Research)
Source: Kidney and Blood Pressure Research - December 11, 2012 Category: Urology & Nephrology Source Type: research

Fructose Acutely Stimulates NHE3 Activity in Kidney Proximal Tubule
Kidney Blood Press Res 2012;36:320-334 (DOI:10.1159/000343390) (Source: Kidney and Blood Pressure Research)
Source: Kidney and Blood Pressure Research - December 11, 2012 Category: Urology & Nephrology Source Type: research

The Enhanced Renin-Angiotensin-Aldosteron System Pharmacological Blockade - Which is the Best?
Kidney Blood Press Res 2012;36:335-343 (DOI:10.1159/000343391) (Source: Kidney and Blood Pressure Research)
Source: Kidney and Blood Pressure Research - December 11, 2012 Category: Urology & Nephrology Source Type: research

Neutrophil Gelatinase-Associated Lipocalin (NGAL) in Chronic Cardiorenal Failure is Correlated with Endogenous Erythropoietin Levels and Decreases in Response to Low-Dose Erythropoietin Treatment
Kidney Blood Press Res 2012;36:344-354 (DOI:10.1159/000343392) (Source: Kidney and Blood Pressure Research)
Source: Kidney and Blood Pressure Research - December 11, 2012 Category: Urology & Nephrology Source Type: research

Enhanced FGF23 Serum Concentrations and Phosphaturia in Gene Targeted Mice Expressing WNK-Resistant Spak
Kidney Blood Press Res 2012;36:355-364 (DOI:10.1159/000343393) (Source: Kidney and Blood Pressure Research)
Source: Kidney and Blood Pressure Research - December 11, 2012 Category: Urology & Nephrology Source Type: research

Determining the Optimal Cut-Off Value of the Urinary Albumin-To-Creatinine Ratio to Detect Atherosclerotic Vascular Diseases
Kidney Blood Press Res 2012;36:290-300 (DOI:10.1159/000343418) (Source: Kidney and Blood Pressure Research)
Source: Kidney and Blood Pressure Research - December 11, 2012 Category: Urology & Nephrology Source Type: research

Autosomal Dominant Polycystic Kidney Disease and Hypertension are Associated with Left Ventricular Mass in a Gender-Dependent Manner
Kidney Blood Press Res 2012;36:301-309 (DOI:10.1159/000343419) (Source: Kidney and Blood Pressure Research)
Source: Kidney and Blood Pressure Research - December 11, 2012 Category: Urology & Nephrology Source Type: research

Does Proteinuria-Inducing Physical Activity Increase Biomarkers of Acute Kidney Injury?
Kidney Blood Press Res 2012;36:278-289 (DOI:10.1159/000343417) (Source: Kidney and Blood Pressure Research)
Source: Kidney and Blood Pressure Research - November 27, 2012 Category: Urology & Nephrology Source Type: research

Effects of Endothelin Receptor Antagonists on Renal Hemodynamics in Angiotensin II-Infused Rats on High NaCl Intake
Kidney Blood Press Res 2012;36:258-267 (DOI:10.1159/000343415) (Source: Kidney and Blood Pressure Research)
Source: Kidney and Blood Pressure Research - November 25, 2012 Category: Urology & Nephrology Source Type: research

Can Aortic Elastic Parameters be Used for the Diagnosis of Volume Overload in Patients with End Stage Renal Disease
Kidney Blood Press Res 2012;36:268-277 (DOI:10.1159/000343416) (Source: Kidney and Blood Pressure Research)
Source: Kidney and Blood Pressure Research - November 25, 2012 Category: Urology & Nephrology Source Type: research

Renoprotective Effects of Sildenafil in DOCA-Salt Hypertensive Rats
Kidney Blood Press Res 2012;36:248-257 (DOI:10.1159/000343414) (Source: Kidney and Blood Pressure Research)
Source: Kidney and Blood Pressure Research - November 20, 2012 Category: Urology & Nephrology Source Type: research

Associations of Proteinuria, Fluid Volume Imbalance, and Body Mass Index with Circadian Ambulatory Blood Pressure in Chronic Kidney Disease Patients
Kidney Blood Press Res 2012;36:231-241 (DOI:10.1159/000343412) (Source: Kidney and Blood Pressure Research)
Source: Kidney and Blood Pressure Research - November 18, 2012 Category: Urology & Nephrology Source Type: research

VAP-1, a Novel Molecule Linked to Endothelial Damage and Kidney Function in Kidney Allograft Recipients
Kidney Blood Press Res 2012;36:242-247 (DOI:10.1159/000343413) (Source: Kidney and Blood Pressure Research)
Source: Kidney and Blood Pressure Research - November 18, 2012 Category: Urology & Nephrology Source Type: research

Protective Effect of Dexpanthenol on Ischemia-Reperfusion-Induced Renal Injury in Rats
Kidney Blood Press Res 2012;36:220-230 (DOI:10.1159/000343411) (Source: Kidney and Blood Pressure Research)
Source: Kidney and Blood Pressure Research - November 14, 2012 Category: Urology & Nephrology Source Type: research

Netrin-1 Attenuates the Progression of Renal Dysfunction by Inhibiting Peritubular Capillary Loss and Hypoxia in 5/6 Nephrectomized Rats
Kidney Blood Press Res 2012;36:209-219 (DOI:10.1159/000343410) (Source: Kidney and Blood Pressure Research)
Source: Kidney and Blood Pressure Research - November 11, 2012 Category: Urology & Nephrology Source Type: research

Effects of AA Amyloidosis on Survival in Peritoneal Dialysis
Kidney Blood Press Res 2012;36:182-190 (DOI:10.1159/000343407) (Source: Kidney and Blood Pressure Research)
Source: Kidney and Blood Pressure Research - November 10, 2012 Category: Urology & Nephrology Source Type: research

The Association of Klotho Polymorphism with Disease Progression and Mortality in IgA Nephropathy
Kidney Blood Press Res 2012;36:191-199 (DOI:10.1159/000343408) (Source: Kidney and Blood Pressure Research)
Source: Kidney and Blood Pressure Research - November 10, 2012 Category: Urology & Nephrology Source Type: research

ADMA, SDMA and L-arginine/ADMA Ratio but not DDAH Genetic Polymorphisms are Reliable Predictors of Diabetic Nephropathy Progression as Identified by Competing Risk Analysis
Kidney Blood Press Res 2012;36:200-208 (DOI:10.1159/000343409) (Source: Kidney and Blood Pressure Research)
Source: Kidney and Blood Pressure Research - November 10, 2012 Category: Urology & Nephrology Source Type: research