Identification of Key Genes and Pathways in Renal Cell Carcinoma Through Expression Profiling Data
Conclusion: Our study suggests that several crucial genes including CAV1,CAV2, GNAI1, GPSM2, and GNAO1 and pathways may play key roles in RCC progression.Kidney Blood Press Res 2015;40:288-297 (Source: Kidney and Blood Pressure Research)
Source: Kidney and Blood Pressure Research - May 30, 2015 Category: Urology & Nephrology Source Type: research

Early Peritonitis is an Independent Risk Factor for Mortality in Elderly Peritoneal Dialysis Patients
Conclusions: Early peritonitis is an independent risk factor for mortality in elderly peritoneal dialysis patients.Kidney Blood Press Res 2015;40:298-305 (Source: Kidney and Blood Pressure Research)
Source: Kidney and Blood Pressure Research - May 30, 2015 Category: Urology & Nephrology Source Type: research

The Missing Link - Likely Pathogenetic Role of GM3 and Other Gangliosides in the Development of Diabetic Nephropathy
Despite scientific advances, diabetic nephropathy remains both a therapeutical challenge, and one of the major diabetic complications. Chemical structure of gangliosides, the most complex of glycosphingolipids, is characterised by one or more sialic acids and carbohydrate groups linked to a ceramide structure. Their potential pathogenetic role in a number of disorders linked to diabetes mellitus has recently been conjectured, due to evidence of their negative modulation of the insulin-mediated signaling and general effects on key cell functions like proliferation, differentiation, apoptosis, cellular signaling and adhesion...
Source: Kidney and Blood Pressure Research - May 30, 2015 Category: Urology & Nephrology Source Type: research

Diameter of Parathyroid Glands Measured by Computed Tomography as a Predictive Indicator for Response to Cinacalcet in Dialysis Patients with Secondary Hyperparathyroidism
Conclusions: The diameter of PTGs on CT could predict the response to cinacalcet in dialysis patients with SHPT.Kidney Blood Press Res 2015;40:277-287 (Source: Kidney and Blood Pressure Research)
Source: Kidney and Blood Pressure Research - May 21, 2015 Category: Urology & Nephrology Source Type: research

Sclerostin Quo Vadis? - Is This a Useful Long-Term Mortality Parameter in Prevalent Hemodialysis Patients?
Conclusion: Higher FGF23, PTH, AP and lower 25(OH)vitamin D but not sclerostin predict long-term mortality. Sclerostin was negatively associated with FGF23, PTH and AP and lower in females than in males.Kidney Blood Press Res 2015;40:266-276 (Source: Kidney and Blood Pressure Research)
Source: Kidney and Blood Pressure Research - May 20, 2015 Category: Urology & Nephrology Source Type: research

Pegylated Interferon (Alone or With Ribavirin) for Chronic Hepatitis C in Haemodialysis Population
Conclusions: Results from this study showed that pegylated interferon alone or with ribavirin is unsatisfactory in terms of efficacy and safety. Prospective trials based on interferon-free regimens (i.e., sofosbuvir plus ribavirin or sofosbuvir plus daclatasvir) are under way in patients with hepatitis C receiving long-term hemodialysis.Kidney Blood Press Res 2015;40:258-265 (Source: Kidney and Blood Pressure Research)
Source: Kidney and Blood Pressure Research - May 14, 2015 Category: Urology & Nephrology Source Type: research

Molecular Patterns of Subclinical and Clinical Rejection of Kidney Allograft: Quantity Matters
Background/Aims: Subclinical rejection diagnosed from protocol biopsies is thought to be a risk factor of long- term allograft dysfunction. The reason why in some patients subclinical rejection does not represent risk for progression is not fully understood. Methods: The intragraft expression of 376 target genes involved in chemokine defense, apoptosis, inflammation, tolerance and TGF-β signalling pathways was measured using quantitative real-time RT-PCR (2-#x2206;#x2206;Ct) method in subclinical inflammation (SCI, n=10), clinical inflammation in acute T-cell mediated rejection (CI, n=10) and no rejection samples (n=9...
Source: Kidney and Blood Pressure Research - May 12, 2015 Category: Urology & Nephrology Source Type: research

Association of Visceral Fat Area with Chronic Kidney Disease and Metabolic Syndrome Risk in the General Population: Analysis Using Multi-Frequency Bioimpedance
Background/Aims: Advances in bioimpedance analysis (BIA) technologies now enable visceral fat area (VFA) to be assessed using this method. The aim of this study was to evaluate the clinical relevance and usefulness of VFA as a predictor of chronic kidney disease (CKD) and metabolic syndrome (MS), using BIA. Methods: We identified 24,791 adults who underwent voluntary routine health checkups at Yeungnam University Hospital. In total 22,480 patients were recruited into our study. Participants were divided into 3 tertiles based on their VFA: low, middle, and high tertiles. CKD was defined as an estimated glomerular filtration...
Source: Kidney and Blood Pressure Research - May 5, 2015 Category: Urology & Nephrology Source Type: research

Regional Variation of Chronic Kidney Disease in Germany: Results From Two Population-Based Surveys
Background/Aims: Due to the increasing prevalence of risk factors for chronic kidney disease (CKD), kidney dysfunction becomes a major public health problem. We investigated the CKD prevalence and determined to what extent the variation of risk factors explains the different CKD prevalence in Germany. Methods: We analyzed data from 6,054 participants, aged 31 to 82 years, from the Study of Health in Pomerania (SHIP-1) in Northeast Germany and the Cooperative Health Research in the Region of Augsburg (KORA F4) Study in Southern Germany. Regional differences in selected percentiles corresponding to the cutpoints for estimate...
Source: Kidney and Blood Pressure Research - May 5, 2015 Category: Urology & Nephrology Source Type: research

Renalase Protects the Cardiomyocytes of Sprague-Dawley Rats Against Ischemia and Reperfusion Injury by Reducing Myocardial Cell Necrosis and Apoptosis
Background/Aims: Renalase, a novel flavoprotein expressed in the kidney and heart, reduces renal tubular necrosis and apoptosis, which suggests that it might protect against necrosis and/or apoptosis in myocardial ischemia reperfusion injury (MIRI). The present study thus explored the effects of renalase on Sprague-Dawley (SD) rats subjected to MIRI. Methods: We used Lentivirus-mediated RNA interference (RNAi) to inhibit the renalase gene expression in the heart tissue via pericardial cavity injection. The MIRI animal modal was established by blocking the left anterior descending artery for 45mins followed by 4h of reperfu...
Source: Kidney and Blood Pressure Research - May 5, 2015 Category: Urology & Nephrology Source Type: research

Continuous Lead Exposure Increases Blood Pressure but Does Not Alter Kidney Function in Adults 20-44 Years of Age in a Lead-Polluted Region of China
Conclusion: Continuous lead exposure causes increased blood lead levels among local residents. Blood lead levels are positively associated with both SBP and DBP increases among adults aged 20-44 years. The relationships between blood lead levels and SBP and DBP are most pronounced in young women. Chronic saturnism does not increase blood pressure by altering kidney function. These results provide support for continued efforts to control blood pressure in the population living in a lead-polluted region of China, particularly in young women.Kidney Blood Press Res 2015;40:207-214 (Source: Kidney and Blood Pressure Research)
Source: Kidney and Blood Pressure Research - April 20, 2015 Category: Urology & Nephrology Source Type: research

Clinicopathological Features and Outcomes of IgA Nephropathy with Hematuria and/or Minimal Proteinuria
Conclusions: Severe renal histological injury may be observed in some IgAN patients with benign clinical characteristics. Proteinuria is an independent predictor of severe renal pathological injury in IgAN patients with mild proteinuria. More severe pathological injury (> Grade II, Hass classification) are predictors of poor prognosis.Kidney Blood Press Res 2015;40:200-206 (Source: Kidney and Blood Pressure Research)
Source: Kidney and Blood Pressure Research - April 17, 2015 Category: Urology & Nephrology Source Type: research

Plasma Lipoprotein(a) Levels and Atherosclerotic Renal Artery Stenosis in Hypertensive Patients
Conclusion: Lipoprotein(a) might contribute to the development of ARAS and detection of elevated levels of this lipoprotein could raise the suspicion of renovascular disease in patients with high blood pressure.Kidney Blood Press Res 2015;40:166-175 (Source: Kidney and Blood Pressure Research)
Source: Kidney and Blood Pressure Research - April 3, 2015 Category: Urology & Nephrology Source Type: research

Impact of Phosphorus Restriction and Vitamin D-Substitution on Secondary Hyperparathyroidism in a Proteinuric Mouse Model
Conclusions: The development of SHPT resulted from phosphate retention in this proteinuric model and could completely be suppressed with a low-phosphorus diet.Kidney Blood Press Res 2015;40:153-165 (Source: Kidney and Blood Pressure Research)
Source: Kidney and Blood Pressure Research - April 3, 2015 Category: Urology & Nephrology Source Type: research

Glomerular Damage in Experimental Proliferative Glomerulonephritis Under Glomerular Capillary Hypertension
Conclusions: Our results demonstrate that glomerular hypertension aggravate glomerular damage and glomerulosclerosis in this model of Thy 1 nephritis.Kidney Blood Press Res 2015;40:188-199 (Source: Kidney and Blood Pressure Research)
Source: Kidney and Blood Pressure Research - April 3, 2015 Category: Urology & Nephrology Source Type: research

Rheological Influence Upon the Glomerular Podocyte and Resultant Mechanotransduction
The glomerular podocyte is exposed to numerous mechanical forces as a constituent of the glomerular filtration apparatus. This includes fluid shear stress (FSS) displaced upon the podocytic foot process's apical, lateral, and basal surfaces. Even in the face of continuous flow the podocyte is capable of contributing to physiologic filtration, however with pathologic levels of hyperfiltration there is increased FSS placed upon the cell. The mechanisms by which the podocyte detects and responds to FSS are topics of recent investigations, with the aim to clarify the way these cells are injured and/or adapt in times of hyperfi...
Source: Kidney and Blood Pressure Research - April 3, 2015 Category: Urology & Nephrology Source Type: research

Indoxyl Sulfate, Not P-Cresyl Sulfate, is Associated with Advanced Glycation end Products in Patients on Long-Term Hemodialysis
This study was a cross-sectional study that recruited 129 stable patients on maintenance HD in a single medical center from July 1 to July 15, 2011. Serum levels of total and free IS, PCS and AGEs were measured concurrently. General laboratory results and patient background were also investigated. Results: Serum levels of AGEs were associated with total IS (r = 2.7, p
Source: Kidney and Blood Pressure Research - March 27, 2015 Category: Urology & Nephrology Source Type: research

Renal Effects of Coronary Artery Bypass Graft Surgery in Diabetic and Non-Diabetic Patients: A Study with Urinary Neutrophil Gelatinase-Associated Lipocalin and Serum Cystatin C
Conclusions: Measurement of cystatin C level in both diabetic and non-diabetic patients may reveal AKI earlier than NGAL and BUN. In diabetic patients, measurement of urinary NGAL and serum cystatin C levels may indicate AKI signs earlier than BUN and Cre.Kidney Blood Press Res 2015;40:141-152 (Source: Kidney and Blood Pressure Research)
Source: Kidney and Blood Pressure Research - March 27, 2015 Category: Urology & Nephrology Source Type: research

Interventional Decentralized Telemonitoring: Bridging the Gap Between Patient's Device and Physician's Needs in Well Selected Indications
Telemedicine comprises different concepts aiming to close a spatial distance between practitioner, medical staff and patient. It's functionality can include mere data transmission but extend as well to triggering alarms or enable consultation and therapy suggestions. A special form of telemedicinal application is interventional decentralized telemonitoring. Here practitioner-patient communication is characterized by telemedicinial data collection driven therapy-control and -optimization. To identify feasible indications for the employment of telemonitoring a detailed definition of communicated parameters, alarm rules and a...
Source: Kidney and Blood Pressure Research - March 27, 2015 Category: Urology & Nephrology Source Type: research

Fluorofenidone Attenuates Oxidative Stress and Renal Fibrosis in Obstructive Nephropathy via Blocking NOX2 (gp91phox) Expression and Inhibiting ERK/MAPK Signaling Pathway
Conclusion: AKF-PD treatment inhibits the progression of renal interstitial fibrosis by suppressing oxidative stress and ERK/MAPK signaling pathway.Kidney Blood Press Res 2015;40:89-99 (Source: Kidney and Blood Pressure Research)
Source: Kidney and Blood Pressure Research - March 17, 2015 Category: Urology & Nephrology Source Type: research

Urinary Angiotensin Converting Enzyme 2 Increases in Patients With Type 2 Diabetic Mellitus
Conclusions: UACE2 increased in type 2 diabetic patients with various degrees of albuminuria and RAS inhibitors suppresses UACE2 excretion. UACE2 might potentially function as a marker for monitoring the metabolic status and therapeutic response of RAS inhibitors in diabetes.Kidney Blood Press Res 2015;40:101-110 (Source: Kidney and Blood Pressure Research)
Source: Kidney and Blood Pressure Research - March 17, 2015 Category: Urology & Nephrology Source Type: research

hTERT, BICD1 and Chromosome 18 Polymorphisms Associated with Telomere Length Affect Kidney Allograft Function After Transplantation
Conclusions: Graft rs2735940 hTERT and rs2630578 BICD1 gene polymorphisms and rs7235755/rs2162440 chromosome 18 polymorphisms, apart from the association with TL, affect early kidney function after transplantation. Relative TL correlated negatively with creatinine concentrations, allowing the use of TL as a predictor of long-term kidney function.Kidney Blood Press Res 2015;40:111-120 (Source: Kidney and Blood Pressure Research)
Source: Kidney and Blood Pressure Research - March 17, 2015 Category: Urology & Nephrology Source Type: research

Depression and Quality of Life in Relation to Decreased Glomerular Filtration Rate Among Adults with Hypertension in Rural Northeast China
Background/Aims: We aim to investigate the extent to which depression and quality of life might be associated with decreased glomerular filtration rate (GFR) in a large hypertensive population in rural Northeast China. Methods: A total of 5566 hypertensive participants aged 35 years and older were screened with a stratified cluster multistage sampling scheme in rural areas of Liaoning Province during 2012-2013. Decreased GFR was defined as estimated GFR (Source: Kidney and Blood Pressure Research)
Source: Kidney and Blood Pressure Research - March 10, 2015 Category: Urology & Nephrology Source Type: research

Induction of Apoptosis by Hypertension Via Endoplasmic Reticulum Stress
Conclusions: These results suggest that ER stress can contribute to myocardial apoptosis during hypertensive disease.Kidney Blood Press Res 2015;40:41-51 (Source: Kidney and Blood Pressure Research)
Source: Kidney and Blood Pressure Research - March 10, 2015 Category: Urology & Nephrology Source Type: research

The Enhancement of Cx45 Expression and Function in Renal Interlobar Artery of Spontaneously Hypertensive Rats at Different Age
This study was designed to investigate the expression and function of gap junction protein connexin 45 (Cx45) in renal interlobar artery (RIA) of spontaneously hypertensive rats (SHR), and the association between hypertension and enhanced vasoconstrictive response in SHR. Methods: Western blot analysis and pressure myography were used to examine the differences in expression and function of Cx45 in vascular smooth muscle cells (VSMCs) of RIA between SHR and normotensive Wistar-Kyoto (WKY) rats. Results: Our results demonstrated that 1) whole-cell patch clamp measurements showed that the membrane capacitance and conductance...
Source: Kidney and Blood Pressure Research - March 10, 2015 Category: Urology & Nephrology Source Type: research

Drug Resistant Hypertension - No SIMPLE Way Out
Hypertension poses growing challenge for health policy-makers and doctors worldwide. Recently published results of Symplicity-III trial (HTN-3), the first blinded, randomized, multicenter study on the efficacy of renal denervation for the treatment of resistant hypertension did not show a significant reduction of BP in patients with resistant hypertension 6 months after renal-artery denervation, as compared with controls. In this paper we review clinical and experimental studies on renal denervation. In order to identify causes of inconsistent results in renal denervation studies we look at basic science support for renal ...
Source: Kidney and Blood Pressure Research - March 10, 2015 Category: Urology & Nephrology Source Type: research

Relaxin-2 Does Not Ameliorate Nephropathy in an Experimental Model of Type-1 Diabetes
Conclusions: We investigated a model showing early DN without overt tubulo-interstitial fibrosis and activation of the TGF-β-Smad-2/3 pathway. In this model, Rlx proved ineffective; however, the same may not apply to other models and types of diabetes.Kidney Blood Press Res 2015;40:77-88 (Source: Kidney and Blood Pressure Research)
Source: Kidney and Blood Pressure Research - March 10, 2015 Category: Urology & Nephrology Source Type: research

Protective Activity of Dendropanax Morbifera Against Cisplatin-Induced Acute Kidney Injury
Conclusion: We demonstrated that DP extracts decreased cisplatin-induced renal toxicity, indicating its potential to ameliorate drug-associated acute kidney damage.Kidney Blood Press Res 2015;40:1-12 (Source: Kidney and Blood Pressure Research)
Source: Kidney and Blood Pressure Research - February 6, 2015 Category: Urology & Nephrology Source Type: research

Determination of Procalcitonin Levels in Patients with Nephropathia Epidemica - A Useful Tool or an Unnecessary Diagnostic Procedure?
Background/Aims: Puumala virus causes nephropathia epidemica (NE), a milder form of hemorrhagic fever with renal syndrome that occurs in Central and Northern Europe. Several studies have sought to identify risk factors for severe NE. However, elevated procalcitonin (PCT) levels have not previously been investigated as a predictive marker for a severe course of NE. Methods: A cross-sectional prospective survey of 456 adults with serologically confirmed NE was performed. Results: PCT levels at the time of diagnosis were available for 43 out of 456 patients, and in 24 of these patients (56%) PCT levels were elevated (“P...
Source: Kidney and Blood Pressure Research - February 6, 2015 Category: Urology & Nephrology Source Type: research

Changes of Serum Calcium, Magnesium and Parathyroid Hormone Induced by Hemodialysis with Citrate-Enriched Dialysis Solution
Conclusion: Our study clearly shows that the substitution of part of acetate with citrate in dialysis solution significantly influences changes of serum calcium, magnesium and parathyroid hormone concentrations during hemodialysis and hemodiafiltration procedures.Kidney Blood Press Res 2015;40:13-21 (Source: Kidney and Blood Pressure Research)
Source: Kidney and Blood Pressure Research - February 6, 2015 Category: Urology & Nephrology Source Type: research

Blood Pressure and Intracranial Aneurysms in Autosomal Dominant Polycystic Kidney Disease
Conclusions: Development of ICANs in hypertensive ADPKD patients is accompanied with higher values of some BP parameters measured by ABPM. Hypertensive ADPKD patients with substantial fluctuations in BP assessed by ABPM, especially those after 45 years-of-age, should become candidates for screening for ICANs.Kidney Blood Press Res 2014;39:630-635 (Source: Kidney and Blood Pressure Research)
Source: Kidney and Blood Pressure Research - January 10, 2015 Category: Urology & Nephrology Source Type: research

Regulation of the Voltage Gated K+ Channel Kv1.3 by Recombinant Human Klotho Protein
Conclusion: Alpha Klotho protein enhances Kv1.3 channel abundance and Kv1.3 currents in the plasma membrane, an effect depending on its β-glucuronidase activity.Kidney Blood Press Res 2014;39:609-622 (Source: Kidney and Blood Pressure Research)
Source: Kidney and Blood Pressure Research - December 30, 2014 Category: Urology & Nephrology Source Type: research

Diagnostic and Prognostic Utility of Neutrophil Gelatinase-Associated Lipocalin (NGAL) in Patients with Cardiovascular Diseases - Review
NGAL (neutrophil gelatinase-associated lipocalin) is an acute phase protein, participating in antibacterial immunity. NGAL forms a complex with metalloproteinase 9 (MMP-9), thereby increasing its activity and preventing its degradation. NGAL is freely filtered through the glomerular membrane and reabsorbed by endocytosis in the proximal tubule. NGAL detected in urine is produced mainly in the distal nephron. Elevated serum and urine NGAL allows diagnosis of acute kidney injury approximately 24 hours earlier than plasma creatinine concentration. Increased levels of NGAL were detected in patients with acute myocardial infarc...
Source: Kidney and Blood Pressure Research - December 24, 2014 Category: Urology & Nephrology Source Type: research

Is There Association Between Changes in eGFR Value and the Risk of Permanent Type of Atrial Fibrillation? - Analysis of Valvular and Non-Valvular Atrial Fibrillation Population
Background/Aims: There are no data concerning renal function in population with valvular and non-valvular atrial fibrillation (AF). To assess renal function in patients with AF, the association between eGFR and AF perpetuation, in-hospital mortality. Methods: We studied 1523 patients with AF. Patients with chronic kidney disease (CKD) were compared to population with preserved renal function. Results: CKD was more frequently observed in patients with valvular AF(p=0.009). In non-valvular AF patients eGFR (Source: Kidney and Blood Pressure Research)
Source: Kidney and Blood Pressure Research - December 24, 2014 Category: Urology & Nephrology Source Type: research

Downregulation of Peptide Transporters PEPT1 and PEPT2 by Oxidative Stress Responsive Kinase OSR1
Conclusion: OSR1 has the capacity to downregulate the peptide transporters PEPT1 and PEPT2 by decreasing the carrier protein abundance in the cell membrane.Kidney Blood Press Res 2014;39:591-599 (Source: Kidney and Blood Pressure Research)
Source: Kidney and Blood Pressure Research - December 24, 2014 Category: Urology & Nephrology Source Type: research

Effects of Paricalcitol and Aliskiren Combination Therapy on Experimental Diabetic Nephropathy Model in Rats
Background/Aims: The aim of the present study was to investigate the effect of combination of aliskiren with paricalcitol on experimental diabetic nephropathy (DN) model in rats. Methods: Forty male Sprague Dawley rats were divided into 5 groups of 8 rats each, namely the control (Group C), diabetes (Group D), aliskiren (Group A), paricalcitol (Group P), and aliskiren plus paricalcitol (Group A+P) groups. Aliskiren was given by oral-gavage at a dose of 50 mg/kg/day once daily for 12 weeks. Paricalcitol was given by intraperitoneally at a dose of 0,4 µg/kg/three day of week for 12 weeks. Renal function parameters, oxi...
Source: Kidney and Blood Pressure Research - December 24, 2014 Category: Urology & Nephrology Source Type: research

Effects of Spironolactone in Combination with Angiotensin-Converting Enzyme Inhibitors or Angiotensin Receptor Blockers in Patients with Proteinuria
This study aimed to investigate the potential beneficial anti-proteinuric effect of an add-on aldosterone blockade and the impact of the aldosterone escape phenomenon. Methods: We retrospectively analyzed data of 304 patients with persistent proteinuria, who were administered spironolactone (25 mg/day) after treatment with angiotensin-converting enzyme inhibitors (ACEIs) or angiotensin II receptor blockers (ARBs) for>3 months. Patients were divided according to their aldosterone levels during ACEI/ARB treatment into an escape group (plasma aldosterone>80 pg/mL, N=95, 31.5%) and a non-escape group (plasma aldosterone ...
Source: Kidney and Blood Pressure Research - December 24, 2014 Category: Urology & Nephrology Source Type: research

Mortality Prediction Using Modern Peptide Biomarkers in Hemodialysis Patients - A Comparative Analysis
Conclusions: Among peptide biomarkers high sensitive troponins and to a lesser extent natriuretic peptides are strong predictors of mortality in asymptomatic hemodialysis patients, followed by markers of mineral-bone disease and inflammation.Kidney Blood Press Res 2014;39:563-572 (Source: Kidney and Blood Pressure Research)
Source: Kidney and Blood Pressure Research - December 24, 2014 Category: Urology & Nephrology Source Type: research

Aortic Arch Calcification Predicts Cardiovascular and All-Cause Mortality in Maintenance Hemodialysis Patients
Conclusions: The presence and progression of AoAC assessed by chest X-ray were independently associated with mortality in MHD patients. Regular follow-up by chest X-ray could be a simple and useful method to stratify mortality risk in MHD patients.Kidney Blood Press Res 2014;39:658-667 (Source: Kidney and Blood Pressure Research)
Source: Kidney and Blood Pressure Research - December 24, 2014 Category: Urology & Nephrology Source Type: research

Cysteinyl 1 Receptor Antagonist Montelukast, Does Not Prevent Peritoneal Membrane Damage in Experimental Chronic Peritoneal Dialysis Model in Rats
Conclusion: This study suggests that montelukast treatment does not prevent the peritoneal membrane from deleterious effects of hyperosmolar PDF in the uremic environment.Kidney Blood Press Res 2014;39:648-657 (Source: Kidney and Blood Pressure Research)
Source: Kidney and Blood Pressure Research - December 24, 2014 Category: Urology & Nephrology Source Type: research

Superior Predictive Value for NTproBNP Compared with High Sensitivity cTnT in Dialysis Patients: A Pilot Prospective Observational Study
Conclusion: NT-pro-BNP is a strong predictor of overall mortality in asymptomatic hemodialysis patients. The addition of hs-cTnT did not improve the prognostic accuracy compared with NT proBNP alone.Kidney Blood Press Res 2014;39:636-647 (Source: Kidney and Blood Pressure Research)
Source: Kidney and Blood Pressure Research - December 24, 2014 Category: Urology & Nephrology Source Type: research

Cross-Sectional Evaluation of Kidney Function in Hospitalized Patients: Estimated GFR Versus Renal Scintigraphy
Background/Aims: Accurate staging of chronic kidney disease (CKD) is very important. We tried to identify difference in GFR evaluation between CKD-EPI and Gates method with renal scintigraphy and which variables are associated with these differences. Methods: We retrospectively reviewed the records of 341 patients who underwent dynamic renal scintigraphy in the last 5 years. Patients were categorized according to KDIGO staging I to V, using the eGFR calculated with the CKD-EPI equation. Secondarily, we stratified patients according to treatment with renin-angiotensin system (RAS) inhibitors. Results: Gates method tends to ...
Source: Kidney and Blood Pressure Research - December 24, 2014 Category: Urology & Nephrology Source Type: research

Pathogenesis and Treatment of Chronic Kidney Disease: A Review of Our Recent Basic and Clinical Data
Chronic kidney disease (CKD) is a worldwide public health problem that affects millions of people from all racial and ethnic groups. At end of 2013, over 300,000 Japanese patients had maintenance dialysis therapy (JSDT). In Japan, the major causes of end stage kidney disease (ESKD) are chronic glomerulonephritis (particularly IgA nephropathy), type 2 diabetic nephropathy, and hypertensive nephrosclerosis. Hypertension is a major factor driving the progression of CKD to ESKD. Since many features of the pathogenesis of IgA nephropathy are still obscure, specific treatment is not yet available. However, efforts by investigato...
Source: Kidney and Blood Pressure Research - December 4, 2014 Category: Urology & Nephrology Source Type: research

Evening -Versus Morning- Dosing Drug Therapy for Chronic Kidney Disease Patients with Hypertension: A Systematic Review
Background/Aims: There is a strong correlation between non-dipping status and cardiovascular events in chronic kidney disease (CKD) patients. Our study is designed to identify the effect of evening administration of antihypertensive drugs to hypertensive CKD patients. Methods: A comprehensive search of Medline, Embase, the Chinese Biomedical Literature Database, Wanfang Data, Chinese National Knowledge Infrastructure, and the Cochrane Central Register of Controlled Trials was performed in July 2014. Concurrent controlled or crossover trials (including randomized and non-randomized experimental trials) designed to evaluate ...
Source: Kidney and Blood Pressure Research - November 26, 2014 Category: Urology & Nephrology Source Type: research

Down-Regulation of Renal Klotho Expression by Shiga Toxin 2
Conclusion: Shiga toxin 2 treatment stimulated Tnfα transcription, down-regulated renal klotho expression and increased FGF23 formation, effects presumably contributing to renal tissue injury.Kidney Blood Press Res 2014;39:441-449 (Source: Kidney and Blood Pressure Research)
Source: Kidney and Blood Pressure Research - November 26, 2014 Category: Urology & Nephrology Source Type: research

Aristolochic Acid Induced Suicidal Erythrocyte Death
Conclusions: Aristolochic Acid triggers eryptosis, an effect at least in part due to entry of extracellular Ca2+ and ceramide formation.Kidney Blood Press Res 2014;39:408-419 (Source: Kidney and Blood Pressure Research)
Source: Kidney and Blood Pressure Research - November 18, 2014 Category: Urology & Nephrology Source Type: research

Correlation Between Endothelial Dysfunction and Left Ventricular Remodeling in Patients with Chronic Kidney Disease
Conclusions: The results showed that there was a higher incidence of left ventricular hypertrophy in patients with chronic kidney disease. Endothelin-1 and nitric oxide played an important role on the development of left ventricular hypertrophy.Kidney Blood Press Res 2014;39:420-426 (Source: Kidney and Blood Pressure Research)
Source: Kidney and Blood Pressure Research - November 18, 2014 Category: Urology & Nephrology Source Type: research

The Intron 4 Polymorphism in the Calcium-Sensing Receptor Gene in Diabetes Mellitus and its Chronic Complications, Diabetic Nephropathy and Non-Diabetic Renal Disease
Conclusion: We conclude that CaSR is a general factor in pancreas and kidney pathologies.Kidney Blood Press Res 2014;39:399-407 (Source: Kidney and Blood Pressure Research)
Source: Kidney and Blood Pressure Research - November 8, 2014 Category: Urology & Nephrology Source Type: research

Significant Association Between Bone-Specific Alkaline Phosphatase and Vascular Calcification of the Hand Arteries in Male Hemodialysis Patients
We examined association between serum BAP and vascular calcification of male hemodialysis patients. Methods: Hand roentgenography of 167 male maintenance hemodialysis patients was conducted, and visible vascular calcification of the hand arteries was evaluated. Serum levels of 3 bone formation markers (BAP, osteocalcin, and N-terminal propeptide of type I collagen) and 2 bone resorption markers (C-terminal telopeptide of type I collagen, and cross-linked N-telopeptide of type I collagen) were measured, along with serum intact parathyroid hormone (PTH). Results: Of 167 patients, visible vascular calcification was seen in 37...
Source: Kidney and Blood Pressure Research - November 7, 2014 Category: Urology & Nephrology Source Type: research

Cardiac and Renal Effects of Atrasentan in Combination with Enalapril and Paricalcitol in Uremic Rats
Conclusions: We found distinct cardiac and renal effects of atrasentan. Combination treatment with atrasentan, enalapril and paricalcitol provided positive effects on cardiac remodeling in uremic rats, whereas combination treatment did not offer further protective effects on blood pressure, proteinuria or renal histology.Kidney Blood Press Res 2014;39:340-352 (Source: Kidney and Blood Pressure Research)
Source: Kidney and Blood Pressure Research - November 7, 2014 Category: Urology & Nephrology Source Type: research