SIS3 alleviates cisplatin-induced acute kidney injury by regulating the lncRNA Arid2-IR-transferrin receptor pathway
Conclusion：Smad3 regulated lncRNA Arid2-IR via TFRC, thereby regulating the cell cycle, protecting against cell apoptosis and promoting cell regeneration. (Source: Kidney and Blood Pressure Research)
Source: Kidney and Blood Pressure Research - October 31, 2022 Category: Urology & Nephrology Source Type: research
Proteomics Insights into Medullary Sponge Kidney Disease: Review of the Recent Results of an Italian Research Collaborative Network
Background: Medullary sponge kidney (MSK) disease is a rare and neglected congenital condition typically associated with nephrocalcinosis/nephrolithiasis, urinary concentration defects, and cystic anomalies in the precalyceal ducts that, although sporadic in the general population, is relatively frequent in renal stone formers. The physiopathologic mechanism associated with this disease is not fully understood, and omics technologies may help address this gap.Summary: The aim of this review was to provide an overview of the current state of the application of proteomics in the study of this rare disease. In particular, we ...
Source: Kidney and Blood Pressure Research - October 20, 2022 Category: Urology & Nephrology Source Type: research
Proteomics insights into medullary sponge kidney (MSK) disease: review of the recent results of an Italian research collaborative network.
Background: Medullary sponge kidney (MSK) disease is a rare and neglected congenital condition typically associated with nephrocalcinosis/nephrolithiasis, urinary concentration defects and cystic anomalies in the precalyceal ducts that, although sporadic in the general population, is relatively frequent in renal stone formers. The physiopathologic mechanism associated with this disease is not fully understood and omics technologies may help to address this gap. Summary: The aim of this review is to provide an overview of the current state of the application of proteomics in the study of this rare disease. In particular, we...
Source: Kidney and Blood Pressure Research - October 20, 2022 Category: Urology & Nephrology Source Type: research
Diagnosis and course of membranous nephropathy in adults: comparison by age group
The objective of this study was to compare younger and older patients with membranous nephropathy, in terms of the clinical, etiological, remission, and survival data.
Method
This was a retrospective study of patients with membranous nephropathy who underwent renal biopsy between 2009 and 2017.
Results
We included 214 patients with membranous nephropathy. At diagnosis, 169 (79%) of those patients were (Source: Kidney and Blood Pressure Research)
Source: Kidney and Blood Pressure Research - October 20, 2022 Category: Urology & Nephrology Source Type: research
KLK4 silencing inhibits the growth of chromophobe renal cell carcinoma through ERK/AKT signaling pathway
Conclusion: KLK4 accelerated KICH progression via ERK/AKT signaling pathway, providing a novel regulatory mechanism for KICH pathogenesis. (Source: Kidney and Blood Pressure Research)
Source: Kidney and Blood Pressure Research - October 19, 2022 Category: Urology & Nephrology Source Type: research
The Impact of Malnutrition, Inflammation on Cognitive Impairment in Hemodialysis Patients: A Multicenter Study
Conclusions: MIS was independently associated with cognitive impairment in HD patients. (Source: Kidney and Blood Pressure Research)
Source: Kidney and Blood Pressure Research - October 19, 2022 Category: Urology & Nephrology Source Type: research
The impact of malnutrition, inflammation on cognitive impairment in hemodialysis patients-A multicenter study
Introduction: Cognitive impairment is prevalent in patients undergoing hemodialysis (HD), which is related to the nutritional and inflammatory status of this population. Malnutrition-inflammation score (MIS) has been identified as a useful tool to evaluate nutrition and inflammation status. The aim of this study is to investigate the association between MIS and cognitive impairment in HD patients. Methods: This was a multicenter observational cohort study with 1591 patients undergoing HD. Nutritional and inflammatory status was evaluated with MIS, anthropometric measurements, and body composition assessments. Cognitive fun...
Source: Kidney and Blood Pressure Research - October 19, 2022 Category: Urology & Nephrology Source Type: research
Contrast-Enhanced Ultrasound and Protein Shakes Are No Alternatives for Inulin Clearance and Meat to Assess Renal Functional Reserve in Humans
Conclusions: CEUS is not a valuable alternative for inulin clearance to measure RFR. Meat ingestion leads to modest changes in renal Doppler parameters and to glomerular hyperfiltration in both women and men, while protein shakes and L-arginine do not. (Source: Kidney and Blood Pressure Research)
Source: Kidney and Blood Pressure Research - October 3, 2022 Category: Urology & Nephrology Source Type: research
Contrast enhanced ultrasound and protein shakes are no alternatives for inulin clearance and meat to assess renal functional reserve in humans
In this study we assessed whether contrast-enhanced ultrasound (CEUS) is a valuable alternative to the gold standard inulin-clearance, and whether L-arginine or protein shakes lead to similar changes in glomerular filtration rate (GFR) as animal proteins in men and women.
Methods: Changes in GFR and renal microperfusion were studied in 25 healthy subjects (8 men, 17 women) by simultaneously performing inulin clearance and CEUS (perfusion index, PI) before and 1 and 2 hours after different protein loads (L-arginine, protein shake or meat). Doppler parameters - renal resistive index (RRI) and pulsatility index (PuI) - were ...
Source: Kidney and Blood Pressure Research - October 3, 2022 Category: Urology & Nephrology Source Type: research
Should the CKD EPI Equation Be Used for Estimation of the Glomerular Filtration Rate in Obese Subjects?
Conclusions: The prevalence of CKD is overestimated, and the prevalence of GHF is underestimated in obese subjects using the CKD EPI equation, i.e., the CKD EPI equation is unreliable in one-third of the population. De-indexed equations should be recommended instead of the CKD EPI equation in epidemiological studies until direct measurement of the glomerular filtration rate becomes more available. (Source: Kidney and Blood Pressure Research)
Source: Kidney and Blood Pressure Research - September 28, 2022 Category: Urology & Nephrology Source Type: research
Should CKD EPI equation be used for estimation of glomerular filtration rate in obese subjects?
Introduction: Pandemic of obesity is strongly related to increase of chronic kidney disease (CKD) prevalence. Currently recommended CKD EPI equation has several serious limitations particularly in obese subjects who have high body surface area (BSA). The aim of our study was to analyze differences in the prevalence of CKD between CKD EPI and de-indexed equations where individual BSA was used.
Methods: In total of 2058 subjects (random sample from general rural population, 29.65% obese) BSA was estimated using DuboisDubois and Moesteller equations and included into the de-indexed equations (CKD Di, CKD Mi). CKD was classif...
Source: Kidney and Blood Pressure Research - September 28, 2022 Category: Urology & Nephrology Source Type: research
Inhibition of Phosphoinositide 3-Kinase Gamma protects endothelial cells via the Akt signaling pathway in sepsis-induced acute kidney injury
Conclusions: In this study, endothelial cell dysfunction plays an important role in sepsis-induced AKI, and the inhibition of PI3Kγ alleviates endothelial cell injury in sepsis-induced AKI through the PI3Kγ/Akt pathway, providing novel targets for treating sepsis and related kidney injury. (Source: Kidney and Blood Pressure Research)
Source: Kidney and Blood Pressure Research - September 21, 2022 Category: Urology & Nephrology Source Type: research
Risk factors for arteriovenous fistula thrombus development: a systematic review and meta-analysis
Background: Risk factors like femal sex, fistula location, hypertension, albumin, diabetes, age and other factors are related to arteriovenous fistula thrombus (AVFT), but the consistency and magnitude of their associations have not been confirmed by meta-analysis.
Objectives ：The purpose of this study was to provide a comprehensive and up-to-date synthesis of evidence on the association between potential risk factors and AVFT.
Methods: In this systematic review and meta-analysis, PubMed, Embase, Cochrane Library, and Web of Science databases were searched for articles published up to April 20th, 2022, and cohort, cross...
Source: Kidney and Blood Pressure Research - September 16, 2022 Category: Urology & Nephrology Source Type: research
Characteristics and survival results of peritoneal dialysis patients suffering from covid-19 in turkey: a multicenter national study
Background: We aimed to study the characteristics of peritoneal dialysis (PD) patients with Coronavirus disease-19 (COVID-19), determine the short-term mortality and other medical complications, and delineate the factors associated with COVID-19 outcome.
Methods: In this multicenter national study, we included PD patients with confirmed COVID-19 from 27 centers. The baseline demographic, clinical, laboratory, and radiological data and outcomes at the end of the first month were recorded.
Results: We enrolled 142 COVID-19 patients (median age:52 years). 58.2% of patients had mild disease at diagnosis. Lung involvement was...
Source: Kidney and Blood Pressure Research - September 13, 2022 Category: Urology & Nephrology Source Type: research
MicroRNA-204-5p hampers the malignant progression of clear cell renal cell carcinoma through GXYLT2 down-regulation
Conclusion: These findings revealed the vital role of microRNA-204-5p and GXYLT2 in ccRCC progression, as wel l as the possibility of microRNA-204-5p in improving ccRCC prognosis and treatment. (Source: Kidney and Blood Pressure Research)
Source: Kidney and Blood Pressure Research - September 5, 2022 Category: Urology & Nephrology Source Type: research
