The Role of β-Adrenergic Overstimulation in the Early Stages of Renal Injury
Conclusion: These findings support relevant information regarding the contribution of specific β-adrenergic hyperactivity in early stage of renal injury, indicating the reactive oxygen species, ER stress and intrarenal RAS as important factors in this process.Kidney Blood Press Res 2017;42:1277 –1289 (Source: Kidney and Blood Pressure Research)
Source: Kidney and Blood Pressure Research - December 21, 2017 Category: Urology & Nephrology Source Type: research

Early Markers of Cardiovascular Risk in Autosomal Dominant Polycystic Kidney Disease
Conclusion: In our study, ADPKD patients, in the early stages of disease, showed a greater insulin resistance, endothelial dysfunction, inflammation and mineral metabolism disorders, respect to control group. Moreover, these patients presented reduced tolerance to stress, and decreased anaerobic threshold to CPET. Our results indicate a major and early cardiovascular risk in ADPKD patients. Therefore early and noninvasive markers of cardiovascular risk and CPET should be carried out, in ADPKD patients, in the early stages of disease, despite the cost implication.Kidney Blood Press Res 2017;42:1290 –1302 (Source: Kidn...
Source: Kidney and Blood Pressure Research - December 21, 2017 Category: Urology & Nephrology Source Type: research

Association Between Plasma Homocysteine and Microalbuminuria in Untreated Patients with Essential Hypertension: a Case-Control Study
Conclusion: This matched case-control study indicates that Hcy may increase the susceptibility of essential hypertensive subjects to MAU.Kidney Blood Press Res 2017;42:1303 –1311 (Source: Kidney and Blood Pressure Research)
Source: Kidney and Blood Pressure Research - December 21, 2017 Category: Urology & Nephrology Source Type: research

The Impact of Osteocalcin, Osteoprotegerin and Osteopontin on Arterial Stiffness in Chronic Renal Failure Patients on Hemodialysis
Conclusion: Except for OC, our results failed to document direct association of vascular lesion with OP and OPG, therefore their high circulating levels may be an epiphenomenon or they may have counter-regulatory role to attenuate the uremic calcification process.Kidney Blood Press Res 2017;42:1312 –1321 (Source: Kidney and Blood Pressure Research)
Source: Kidney and Blood Pressure Research - December 19, 2017 Category: Urology & Nephrology Source Type: research

MiRNA and mRNA Profiling in Systemic Lupus Reveals a Novel Set of Cytokine - Related miRNAs and their Target Genes in Cases With and Without Renal Involvement
Conclusions: We reported some human miRNAs which were differentially expressed in SLE patients according to disease activity and renal involvement. Larger studies are necessary to confirm our findings and detect further biomarkers.Kidney Blood Press Res 2017;42:1322 –1337 (Source: Kidney and Blood Pressure Research)
Source: Kidney and Blood Pressure Research - December 19, 2017 Category: Urology & Nephrology Source Type: research

Irisin and Volume Overload are Associated with Protein Energy Wasting in Peritoneal Dialysis Patients
Conclusion: Our results are the first to provide clinical evidence of the association between serum irisin, volume overload, and PEW in PD patients. PEW may inhibit the release or synthesis of irisin from skeletal muscles, and volume overload may aggravate PEW in PD patients.Kidney Blood Press Res 2017;42:1216 –1224 (Source: Kidney and Blood Pressure Research)
Source: Kidney and Blood Pressure Research - December 15, 2017 Category: Urology & Nephrology Source Type: research

Association Between Comprehensive Nutritional Scoring System (CNSS) and Outcomes of Continuous Ambulatory Peritoneal Dialysis Patients
Conclusion: CNSS provides an integrated scoring system with significant associations with hospitalization and mortality in PD patients. The CNSS grade differentiates patients with malnutritional risk and independently predicts high risk of morbidity and mortality.Kidney Blood Press Res 2017;42:1225 –1237 (Source: Kidney and Blood Pressure Research)
Source: Kidney and Blood Pressure Research - December 15, 2017 Category: Urology & Nephrology Source Type: research

Relationship Between Short-Term Blood Pressure Variability and Incidence of Acute Kidney Injury in Critically Ill Patients
Conclusion: BP variability is correlated with the incidence of AKI in critically ill patients.Kidney Blood Press Res 2017;42:1238 –1246 (Source: Kidney and Blood Pressure Research)
Source: Kidney and Blood Pressure Research - December 15, 2017 Category: Urology & Nephrology Source Type: research

Whole-Genome Analysis of an Extensive Drug-Resistant < b > < i > Acinetobacter Baumannii < /i > < /b > ST195 Isolate from a Recipient After DCD Renal Transplantation in China
Conclusion: Understanding the genetic characteristics associated with drug resistance mechanism and antimicrobial profiles of pathogen is important in controlling infection outbreak and preventing serious complications and gives a new insight into the development of antimicrobial agents.Kidney Blood Press Res 2017;42:1247 –1257 (Source: Kidney and Blood Pressure Research)
Source: Kidney and Blood Pressure Research - December 15, 2017 Category: Urology & Nephrology Source Type: research

Screening for Fabry Disease in Kidney Disease: a Cross-Sectional Study in Males and Females
Conclusion: The prevalence was higher in women, and the most prevalent symptom was heart diseases.Kidney Blood Press Res 2017;42:1258 –1265 (Source: Kidney and Blood Pressure Research)
Source: Kidney and Blood Pressure Research - December 15, 2017 Category: Urology & Nephrology Source Type: research

Risk Factors and Outcomes of Early-Onset Peritonitis in Chinese Peritoneal Dialysis Patients
Conclusion: Male gender and a low serum albumin level before PD were strongly associated with EOP. Additionally, EOP patients had a higher risk of poor clinical outcomes. More importantly, an early peritonitis onset was associated with a high peritonitis rate.Kidney Blood Press Res 2017;42:1266 –1276 (Source: Kidney and Blood Pressure Research)
Source: Kidney and Blood Pressure Research - December 15, 2017 Category: Urology & Nephrology Source Type: research

Association of –1082A & #x3e;G Polymorphism in the Interleukin-10 Gene with Estimated Glomerular Filtration Rate in Type 2 Diabetes
Conclusion: Our findings support the hypothesis that the -1082A#x3e;G polymorphism in theIL10 gene might be associated with DKD in white Brazilians with type 2 diabetes.Kidney Blood Press Res 2017;42:1164 –1174 (Source: Kidney and Blood Pressure Research)
Source: Kidney and Blood Pressure Research - December 11, 2017 Category: Urology & Nephrology Source Type: research

Higher Serum Hepatocyte Growth Factor Concentration is Associated with Better Preservation of GFR in Hemodialysis Patients
Conclusions: We found that a higher HGF serum level during hemodialysis treatment is associated with a slower loss of residual renal function.Kidney Blood Press Res 2017;42:1175 –1182 (Source: Kidney and Blood Pressure Research)
Source: Kidney and Blood Pressure Research - December 11, 2017 Category: Urology & Nephrology Source Type: research

Serum Hepcidin and Iron Indices Affect Anemia Status Differently According to the Kidney Function of Non-Dialysis Chronic Kidney Disease Patients: Korean Cohort Study For Outcome in Patients with Chronic Kidney Disease (KNOW-CKD)
Conclusions: TSAT was associated with less severe anemia in early CKD patients. Serum hepcidin was associated with more severe anemia in advanced CKD patients.Kidney Blood Press Res 2017;42:1183 –1192 (Source: Kidney and Blood Pressure Research)
Source: Kidney and Blood Pressure Research - December 11, 2017 Category: Urology & Nephrology Source Type: research

Red Blood Cell Distribution Width is an Independent Predictor of AKI and Mortality in Patients in the Coronary Care Unit
Conclusion: RDW is an independent predictor of AKI and mortality in patients in the CCU.Kidney Blood Press Res 2017;42:1193 –1204 (Source: Kidney and Blood Pressure Research)
Source: Kidney and Blood Pressure Research - December 11, 2017 Category: Urology & Nephrology Source Type: research

High Phosphate-Induced Calcification of Vascular Smooth Muscle Cells is Associated with the TLR4/NF- κb Signaling Pathway
Conclusion: These data suggest that high-phospha te conditions directly induce vascular calcification via the activation of TLR4/NF-κB signaling in VSMCs. Moreover, inhibition of the TLR4/NF-κB signaling pathway might be a key intervention to prevent vascular calcification in patients with CKD.Kidney Blood Press Res 2017;42:1205 –1215 (Source: Kidney and Blood Pressure Research)
Source: Kidney and Blood Pressure Research - December 11, 2017 Category: Urology & Nephrology Source Type: research

Response of Renal Podocytes to Excessive Hydrostatic Pressure: a Pathophysiologic Cascade in a Malignant Hypertension Model
Conclusions: Hypertension induces podocyte detachment by autocrine and paracrine effects. In a direct response to pressure, podocytes increase Angiotensin-II levels. This leads, via AT1 receptors, to structural changes in adhesion proteins, culminating in viable podocyte detachment. Paracrine effects of hypertension, mediated by mesangial cells, lead to higher levels of both Angiotensin-II and TGF- β1, culminating in apoptosis and detachment of non-viable podocytes.Kidney Blood Press Res 2017;42:1104 –1118 (Source: Kidney and Blood Pressure Research)
Source: Kidney and Blood Pressure Research - December 8, 2017 Category: Urology & Nephrology Source Type: research

Comparison of Muscle Mass Indices Using Computed Tomography or Dual X-Ray Absorptiometry for Predicting Physical Performance in Hemodialysis Patients
Conclusion: TMA indices using CT may be more valuable in predicting physical performance or strength in HD patients.Kidney Blood Press Res 2017;42:1119 –1127 (Source: Kidney and Blood Pressure Research)
Source: Kidney and Blood Pressure Research - December 8, 2017 Category: Urology & Nephrology Source Type: research

Renal Resistive Index as a Novel Indicator for Renal Complications in High-Fat Diet-Fed Mice
Conclusion: This study seems to confirm the utility of a noninvasive and repeatable ultrasound parameter to rapidly evaluate renal fibrosis in a HFD-induced type 2 diabetic mouse modelin vivo. This highly sensitive and comparable renal RI measurement could monitor the whole procedure of disease development in real-time. RI measurement of the renal artery is capable of differentiating responses to standard therapy with lovastatin in HFD-fed mice from the CHD group.Kidney Blood Press Res 2017;42:1128 –1140 (Source: Kidney and Blood Pressure Research)
Source: Kidney and Blood Pressure Research - December 8, 2017 Category: Urology & Nephrology Source Type: research

Association of the TG/HDL-C and Non-HDL-C/HDL-C Ratios with Chronic Kidney Disease in an Adult Chinese Population
Conclusion: In this relatively healthy adult Chinese population, the CKD-EPI equation determined that the TG/HDL-c and non-HDL-c/HDL-c ratios as well as TG and HDL-c correlate with the prevalence of CKD.Kidney Blood Press Res 2017;42:1141 –1154 (Source: Kidney and Blood Pressure Research)
Source: Kidney and Blood Pressure Research - December 8, 2017 Category: Urology & Nephrology Source Type: research

Association Between GLCCI1 Promoter Polymorphism (Rs37972) and Post-Transplant Hypertension in Renal Transplant Recipients
Conclusion: GLCCI1 promoter polymorphism rs37972 may be associated with post-transplant hypertension.Kidney Blood Press Res 2017;42:1155 –1163 (Source: Kidney and Blood Pressure Research)
Source: Kidney and Blood Pressure Research - December 8, 2017 Category: Urology & Nephrology Source Type: research

Plasma ET-1 Concentrations Are Elevated in Pregnant Women with Hypertension -Meta-Analysis of Clinical Studies
Conclusion: Plasma ET-1 concentrations are elevated in hypertensive disorders during human pregnancy. In particular women with preeclampsia (hypertensive pregnant women with proteinuria) have substantially elevated plasma ET-1 concentration as compared to pregnant women with normal blood pressure.Kidney Blood Press Res 2017;42:654 –663 (Source: Kidney and Blood Pressure Research)
Source: Kidney and Blood Pressure Research - December 6, 2017 Category: Urology & Nephrology Source Type: research

In Patients with Chronic Kidney Disease Short Term Blood Pressure Variability is Associated with the Presence and Severity of Sleep Disorders
Conclusions: In CKD patients impaired sleep quality increases BPV, might contribute to their disease progression and worsen prognosis. Searching for sleep problems in CKD patients could help planning their treatment of sleep problems contributing to CV risk reduction. Our data provide the rationale working hypothesis for the need of studies with larger number of patients aimed to demonstrate improved outcome of CKD progression and CV risk with the treatment also of sleep disorders.Kidney Blood Press Res 2017;42:804 –815 (Source: Kidney and Blood Pressure Research)
Source: Kidney and Blood Pressure Research - December 6, 2017 Category: Urology & Nephrology Source Type: research

Clinical Evaluation of Continuous Renal Replacement Therapy in Combination with Ultrasound-Guided Percutaneous Transhepatic Gallbladder Drainage for Acute Severe Biliary Pancreatitis: a Retrospective Study
Conclusion: CRRT in combination with PTGD is more effective in the treatment of ASBP than CRRT alone.Kidney Blood Press Res 2017;42:1030 –1039 (Source: Kidney and Blood Pressure Research)
Source: Kidney and Blood Pressure Research - December 6, 2017 Category: Urology & Nephrology Source Type: research

Resveratrol Does Not Protect from Ischemia-Induced Acute Kidney Injury in an in Vivo Rat Model
Conclusion: RSV did not exert protective effects on I/R-induced AKI in the present short-termin vivo rat model. The lack of protection is potentially connected to aggravation of blood pressure instability.Kidney Blood Press Res 2017;42:1090 –1103 (Source: Kidney and Blood Pressure Research)
Source: Kidney and Blood Pressure Research - December 5, 2017 Category: Urology & Nephrology Source Type: research

Cuff-Based Oscillometric Central and Brachial Blood Pressures Obtained Through ABPM are Similarly Associated with Renal Organ Damage in Arterial Hypertension
Conclusion: Compared with peripheral ABPM, cuff-based oscillometric central ABPM does not show a closer association with presence of renal organ damage in hypertensive patients. More studies, however, need to be done to better identify the role of central BP in clinical practice.Kidney Blood Press Res 2017;42:1068 –1077 (Source: Kidney and Blood Pressure Research)
Source: Kidney and Blood Pressure Research - December 1, 2017 Category: Urology & Nephrology Source Type: research

Detection of Acute Tubular Necrosis Using Blood Oxygenation Level-Dependent (BOLD) MRI
Conclusion: BOLD-MRI is able to detect even mild tubular injury but necessitates a tubule-specific pharmacological maneuver, e.g. blocking the Na+-K+-2Cl- transporter by furosemide.Kidney Blood Press Res 2017;42:1078 –1089 (Source: Kidney and Blood Pressure Research)
Source: Kidney and Blood Pressure Research - December 1, 2017 Category: Urology & Nephrology Source Type: research

Carvedilol and Cardiac Biomarkers in Dialysis Patients: Secondary Analysis of a Randomized Controlled Trial
Conclusions: NT-proBNP and hs-TnT were associated with GLS. However, changes in levels of the biomarkers from baseline to 12 months were not different between groups randomized to carvedilol and placebo.Kidney Blood Press Res 2017;42:1033 –1044 (Source: Kidney and Blood Pressure Research)
Source: Kidney and Blood Pressure Research - December 1, 2017 Category: Urology & Nephrology Source Type: research

Biopsy-Free Prediction of Pathologic Type of Primary Nephrotic Syndrome Using a Machine Learning Algorithm
Conclusion: To our knowledge, this is the first such application of machine learning to predict the pathologic type of primary nephrotic syndrome, which may be clinically useful by itself as well as helpful for guiding future efforts at machine learning-based prediction in other disease contexts.Kidney Blood Press Res 2017;42:1045 –1052 (Source: Kidney and Blood Pressure Research)
Source: Kidney and Blood Pressure Research - December 1, 2017 Category: Urology & Nephrology Source Type: research

N-Terminal Prohormone of Brain Natriuretic Peptide but not C-Terminal Pre-Pro Vasopressin (Copeptin) Level is Associated with the Response to Antihypertensive Therapy in Haemodialysis Patients
Conclusions: 1. Increased levels of NT-proBNP seems to be a better biomarker of multidrug antihypertensive therapy requirement than CT-proAVP. 2. Whether estimation of NT-proBNP in these patients will be also better biomarker than copeptin in the prediction of cardiovascular complications related to hypertension needs further investigations.Kidney Blood Press Res 2017;42:1013 –1022 (Source: Kidney and Blood Pressure Research)
Source: Kidney and Blood Pressure Research - November 30, 2017 Category: Urology & Nephrology Source Type: research

Alteration of Tight Junction Protein Expression in Dahl Salt-Sensitive Rat Kidney
Conclusions: In SS rats, SS hypertension was associated with differential changes in renal TJ protein expression. Both upregulation of claudin-4 and downregulation of occludin might increase paracellular NaCl transport in the kidney, resulting in impaired pressure natriuresis in SS rats.Kidney Blood Press Res 2017;42:951 –960 (Source: Kidney and Blood Pressure Research)
Source: Kidney and Blood Pressure Research - November 27, 2017 Category: Urology & Nephrology Source Type: research

Serum Cystatin C Predicts AKI and the Prognosis of Patients in Coronary Care Unit: a Prospective, Observational Study
Conclusions: Serum CysC is a strong predictor of AKI and the short-term prognosis of CCU patients.Kidney Blood Press Res 2017;42:961 –973 (Source: Kidney and Blood Pressure Research)
Source: Kidney and Blood Pressure Research - November 27, 2017 Category: Urology & Nephrology Source Type: research

Maternal Hypercholesterolemia Associated with Nicotine Exposure in Adulthood May Induce Kidney Injury in Male Rats if Hypomagnesemia Occurs
Conclusions: The offspring exposed to a high cholesterol milieu during intrauterine and neonatal life may show a silent kidney injury at adulthood that may be aggravated by nicotine exposure if hypomagnesemia occurs.Kidney Blood Press Res 2017;42:974 –982 (Source: Kidney and Blood Pressure Research)
Source: Kidney and Blood Pressure Research - November 27, 2017 Category: Urology & Nephrology Source Type: research

Therapeutic Effects of FK506 on IgA Nephropathy Rat
Conclusion: Taken together, these results suggest that the therapeutic effect of FK506 on IgAN might be partially associated with the down-regulated expression of TRPC channels, CaN and phosphorylation of ERK1/2.Kidney Blood Press Res 2017;42:983 –998 (Source: Kidney and Blood Pressure Research)
Source: Kidney and Blood Pressure Research - November 27, 2017 Category: Urology & Nephrology Source Type: research

KLF 15 Works as an Early Anti-Fibrotic Transcriptional Regulator in Ang II-Induced Renal Fibrosis via Down-Regulation of CTGF Expression
Conclusions: Ang II down-regulates KLF15 expression via the AT1 receptor, and KLF15 is likely to inhibit Ang II-induced CTGF expression by repressing the recruitment of the co-activator P/CAF to the CTGF promoter.Kidney Blood Press Res 2017;42:999 –1012 (Source: Kidney and Blood Pressure Research)
Source: Kidney and Blood Pressure Research - November 27, 2017 Category: Urology & Nephrology Source Type: research

Effects of L- and N-Type Ca Channel Blocker Cilnidipine on Changes in Heart Rate and QT Interval During Dialysis
Conclusion: These data suggested that cilnidipine may inhibit increases in heart rate and QT interval. Cilnidipine may have beneficial effects in reducing cardiovascular events, resulting from increased sympathetic nerve activity and lethal arrhythmias in hemodialysis patients.Kidney Blood Press Res 2017;42:933 –941 (Source: Kidney and Blood Pressure Research)
Source: Kidney and Blood Pressure Research - November 22, 2017 Category: Urology & Nephrology Source Type: research

Cylindromatosis (CYLD), a Deubiquitinase, Attenuates Inflammatory Signaling Pathways by Activating Toll-Like Receptor 3 in Human Mesangial Cells
Conclusion: CYLD inhibits post-transcriptional regulation of RIG-I and MDA5 expression following TLR3 activation in MCs. CYLD may be involved in the pathogenesis of CKD, especially pathogenesis of LN.Kidney Blood Press Res 2017;42:942 –950 (Source: Kidney and Blood Pressure Research)
Source: Kidney and Blood Pressure Research - November 22, 2017 Category: Urology & Nephrology Source Type: research

Plasma Beta-Trace Protein as a Marker of Residual Renal Function: The Effect of Different Hemodialysis Modalities and Intra-Individual Variability over Time
Conclusion: BTP is a stable marker and a promising tool for RRF estimations in PD and HD patients. In patients receiving HDF, plasma levels of BTP should be interpreted with caution.Kidney Blood Press Res 2017;42:877 –885 (Source: Kidney and Blood Pressure Research)
Source: Kidney and Blood Pressure Research - November 22, 2017 Category: Urology & Nephrology Source Type: research

Catechins Blunt the Effects of oxLDL and its Primary Metabolite Phosphatidylcholine Hydroperoxide on Endothelial Dysfunction Through Inhibition of Oxidative Stress and Restoration of eNOS in Rats
Conclusions: Our data suggests that catechins pretreatment decrease PCOOH-induced endothelial apoptosis and arterial vasoconstriction through the action of H2O2 inhibition and eNOS restoration.Kidney Blood Press Res 2017;42:919 –932 (Source: Kidney and Blood Pressure Research)
Source: Kidney and Blood Pressure Research - November 22, 2017 Category: Urology & Nephrology Source Type: research

Impact of an in-Hospital Patient Education Program on Choice of Renal Replacement Modality in Unplanned Dialysis Initiation
Conclusions: A structured, patient-centered in-hospital education program increases the frequency of PD in patients needing unplanned RRT. PD modality choice is significantly higher in young (p #x3c; 0.0001) and male (p = 0.006) patients.Kidney Blood Press Res 2017;42:865 –876 (Source: Kidney and Blood Pressure Research)
Source: Kidney and Blood Pressure Research - November 21, 2017 Category: Urology & Nephrology Source Type: research

Long-Term Renal and Cardiac Outcomes after Stenting in Patients with Resistant Hypertension and Atherosclerotic Renal Artery Stenosis
Conclusion: In patients with RHTN, stenting of hemodynamically significant ARAS decreases blood pressure, preserves renal function in a substantial proportion of patients, and improves LV structure and function, suggesting the opportunity for timely identification of ARAS in these patients.Kidney Blood Press Res 2017;42:774 –783 (Source: Kidney and Blood Pressure Research)
Source: Kidney and Blood Pressure Research - November 21, 2017 Category: Urology & Nephrology Source Type: research

Impact of Local and Systemic Factors on Kidney Dysfunction in Bardet-Biedl Syndrome
Bardet Biedl syndrome (BBS) is a rare inherited syndromic condition characterized by renal and extra-renal disorders. Renal defect, at either structural or functional level, is one of the cardinal clinical features, and is a major cause of morbidity. However, the pathogenic mechanism underlying its dysfunction remains largely unknown, and to date only symptomatic treatment with no specific therapy is available for these patients. Elucidating aberrant cellular and/or systemic processes that impact kidney function is therefore a prerequisite to develop targeted innovative therapeutic strategies for the BBS patients. Given th...
Source: Kidney and Blood Pressure Research - November 21, 2017 Category: Urology & Nephrology Source Type: research

Association Between Environmental Particulate Matter and Carpal Tunnel Syndrome in Patients Undergoing Hemodialysis
Conclusion: PM2.5 levels and PM2.5 excessing days were positively correlated with CTS.Kidney Blood Press Res 2017;42:827 –836 (Source: Kidney and Blood Pressure Research)
Source: Kidney and Blood Pressure Research - November 21, 2017 Category: Urology & Nephrology Source Type: research

Clostridium Difficile Infection in the Nephrology Ward
Clostridium difficile is currently the most frequently identified pathogen causing antibiotic-associated diarrhea and the main cause of nosocomial diarrhea. In recent years, increases incidence of infection, severe infection, recurrent infection and mortality fromClostridium difficile infection (CDI) have been observed. This may be a consequence of excessive antibiotic use and spread of the hypervirulent epidemic BI/NAP1/027 strain ofClostridium difficile. The main risk factors for CDI are: antibiotic therapy, previous hospitalizations and number of comorbid conditions. Prevention of CDI mainly is focused in two directions...
Source: Kidney and Blood Pressure Research - November 21, 2017 Category: Urology & Nephrology Source Type: research

Eryptosis - the Neglected Cause of Anemia in End Stage Renal Disease
End stage renal disease (ESRD) invariably leads to anemia which has been mainly attributed to compromised release of erythropoietin from the defective kidneys with subsequent impairment of erythropoiesis. However, erythropoietin replacement only partially reverses anemia pointing to the involvement of additional mechanisms. As shown more recently, anemia of ESRD is indeed in large part a result of accelerated erythrocyte loss due to suicidal erythrocyte death or eryptosis, characterized by cell shrinkage and cell membrane scrambling with phosphatidylserine translocation to the cell surface. Phosphatidylserine exposing eryt...
Source: Kidney and Blood Pressure Research - November 17, 2017 Category: Urology & Nephrology Source Type: research

Inflammatory and Angiogenic Factors Linked to Longitudinal Microvascular Changes in Hemodialysis Patients Irrespective of Treatment Dose Intensity
Conclusion: Hemodialysis intensity did not predict changes in either macro- or microvascular parameters. Inflammation mediated through the IL-8 pathway predicted microvascular injury while Flt-1, a potential marker of angiogenesis and endothelial repair, might have a significant protective role. Further understanding of these pathways will be necessary to improve dialysis outcomes.Kidney Blood Press Res 2017;42:905 –918 (Source: Kidney and Blood Pressure Research)
Source: Kidney and Blood Pressure Research - November 16, 2017 Category: Urology & Nephrology Source Type: research

Heavy Alcohol Consumption Effects on Blood Pressure and on Kidney Structure Persist After Long-Term Withdrawal
Conclusion: Ethanol consumption induces changes in glomerular morphology associated with increased BP and AT1R expression. Long-term withdrawal was inefficient to restore the structural integrity of renal corpuscles and in lowering systolic pressure.Kidney Blood Press Res 2017;42:664 –675 (Source: Kidney and Blood Pressure Research)
Source: Kidney and Blood Pressure Research - November 16, 2017 Category: Urology & Nephrology Source Type: research

Evaluation of Mental Disorders Using Proton Magnetic Resonance Spectroscopy in Dialysis and Predialysis Patients
Conclusions: CKD patients showed different types of mental disorders as well as metabolite disturbances in the brain. The metabolite concentrations correlated with the psychological status which was better in HD than in predialytic and PD patients.Kidney Blood Press Res 2017;42:686 –696 (Source: Kidney and Blood Pressure Research)
Source: Kidney and Blood Pressure Research - November 16, 2017 Category: Urology & Nephrology Source Type: research

Risk Factor Analysis for AKI Including Laboratory Indicators: a Nationwide Multicenter Study of Hospitalized Patients
Conclusion: In addition to traditional risk factors, uric acid level is an independent predictor of all-cause mortality after AKI.Kidney Blood Press Res 2017;42:761 –773 (Source: Kidney and Blood Pressure Research)
Source: Kidney and Blood Pressure Research - November 14, 2017 Category: Urology & Nephrology Source Type: research

Non-Diabetic Kidney Disease in Type 2 Diabetic Patients: Prevalence, Clinical Predictors and Outcomes
Conclusion: This study demonstrated a high prevalence of NDKD in patients with T2DM. The absence of DR strongly predicted NDKD. Clinical decision alone can lead to wrong diagnosis and delay in appropriate therapy. Clinicians should consider the kidney biopsy more liberally when there is uncertainty on the exact etiology of the kidney disease. However, prospective multicenter studies are needed to clarify the prognosis and outcomes of patients with diabetics.Kidney Blood Press Res 2017;42:886 –893 (Source: Kidney and Blood Pressure Research)
Source: Kidney and Blood Pressure Research - November 1, 2017 Category: Urology & Nephrology Source Type: research