Adaptation of Opossum Kidney Cells to Luminal Phosphate: Effects of Phosphonoformic Acid and Kinase Inhibitors
Conclusions: in OK cells, adaptation of Pi-transport to luminal Pi does not depend on the same signaling pathways involved in hormonal regulation.Kidney Blood Press Res 2016;41:298-310 (Source: Kidney and Blood Pressure Research)
Source: Kidney and Blood Pressure Research - May 11, 2016 Category: Urology & Nephrology Source Type: research

Urinary Metalloproteinases-9 and -2 and Their Inhibitors TIMP-1 and TIMP-2 are Markers of Early and Long-Term Graft Function After Renal Transplantation
Conclusions: TIMP-1 and-2 are primarily markers of an early function of the transplanted kidney. Early post-transplant concentration of MMP-2 is a marker of proteinuria in early and long-term post-transplant periods.Kidney Blood Press Res 2016;41:288-297 (Source: Kidney and Blood Pressure Research)
Source: Kidney and Blood Pressure Research - May 9, 2016 Category: Urology & Nephrology Source Type: research

Renal Artery Stenting Associated With Improvement in Renal Function and Blood Pressure Control in Long-Term Follow-Up
Conclusion: The results of the study suggest that interventional treatment of RAS may preserve renal function and improve blood pressure control at long-term follow-up.Kidney Blood Press Res 2016;41:278-287 (Source: Kidney and Blood Pressure Research)
Source: Kidney and Blood Pressure Research - May 4, 2016 Category: Urology & Nephrology Source Type: research

Pretreatment of Sialic Acid Efficiently Prevents Lipopolysaccharide-Induced Acute Renal Failure and Suppresses TLR4/gp91-Mediated Apoptotic Signaling
Conclusion: We suggest that pretreatment of SA significantly and preventively attenuated LPS-induced detrimental effects on systemic and renal hemodynamics, renal ROS production and renal function, as well as, LPS-activated TLR4/gp91/Caspase3 mediated apoptosis signaling.Kidney Blood Press Res 2016;41:267-277 (Source: Kidney and Blood Pressure Research)
Source: Kidney and Blood Pressure Research - May 4, 2016 Category: Urology & Nephrology Source Type: research

Evaluation of Urinary Indices for Albuminuria and Proteinuria in Patients with Chronic Kidney Disease
Conclusions: Both PCR and ACR are useful in evaluation of proteinuria. In quantifying daily proteinuria and albuminuria, ePER and eAER are superior to PCR and ACR, respectively. Compared with APR, urine PEP is more useful in diagnosing glomerular proteinuria.Kidney Blood Press Res 2016;41:258-266 (Source: Kidney and Blood Pressure Research)
Source: Kidney and Blood Pressure Research - April 29, 2016 Category: Urology & Nephrology Source Type: research

Plasma Desphospho-Uncarboxylated Matrix Gla Protein as a Marker of Kidney Damage and Cardiovascular Risk in Advanced Stage of Chronic Kidney Disease
Conclusions: High dp-ucMGP level, reflecting a poor vitamin K status seems to be associated with kidney damage and may be also a marker of cardiovascular risk in CKD patients. Supplementation with vitamin K2 may improve the carboxylation status of MGP.Kidney Blood Press Res 2016;41:231-239 (Source: Kidney and Blood Pressure Research)
Source: Kidney and Blood Pressure Research - April 21, 2016 Category: Urology & Nephrology Source Type: research

Maternal PCaaC38:6 is Associated With Preterm Birth - a Risk Factor for Early and Late Adverse Outcome of the Offspring
Conclusions: Maternal blood concentrations of PCaaC38:6 are independently associated with gestational age.Kidney Blood Press Res 2016;41:250-257 (Source: Kidney and Blood Pressure Research)
Source: Kidney and Blood Pressure Research - April 21, 2016 Category: Urology & Nephrology Source Type: research

Comparison of Ambulatory Blood Pressure Patterns in Patients With Intradialytic Hypertension and Hemodialysis Controls
Conclusions: Interdialytic BP patterns differ in IH patients and hemodialysis controls. The elevated post dialysis blood pressure persists for many hours in IH patients contributing to the overall increased BP burden.Kidney Blood Press Res 2016;41:240-249 (Source: Kidney and Blood Pressure Research)
Source: Kidney and Blood Pressure Research - April 21, 2016 Category: Urology & Nephrology Source Type: research

Lack of Serum Creatinine Decrease After Coronary Angiography Despite Prophylactic Hydration After Routine Coronary Angiography/Angioplasty in Stable Angina Patients - Pilot Study
Conclusions: This observation requires further prospective investigation on extended group of patients.Kidney Blood Press Res 2016;41:222-230 (Source: Kidney and Blood Pressure Research)
Source: Kidney and Blood Pressure Research - March 29, 2016 Category: Urology & Nephrology Source Type: research

Characterization and Activation of NLRP3 Inflammasomes in the Renal Medulla in Mice
Conclusion: Our results indicate that renal medullary Nlrp3 inflammasomes represent a new regulatory mechanism of renal MBF and sodium excretion which may not depend on classical inflammatory response.Kidney Blood Press Res 2016;41:208-221 (Source: Kidney and Blood Pressure Research)
Source: Kidney and Blood Pressure Research - March 24, 2016 Category: Urology & Nephrology Source Type: research

Cystatin C is Associated With Plaque Phenotype and Plaque Burden
Background/Aims: The relationship between carotid artery plaque burden, phenotype and serum cystatin C at normal and impaired renal function is still unclear. Methods: Demographic characteristics, carotid ultrasonography and other relevant information of 1,477 patients were collected. The association of carotid artery plaque burden, plaque phenotype with serum cystatin C was evaluated by strategy analysis based on renal function. Results: Serum cystatin C (OR=2.05, 95% CI: 1.83-2.29, P (Source: Kidney and Blood Pressure Research)
Source: Kidney and Blood Pressure Research - March 24, 2016 Category: Urology & Nephrology Source Type: research

High Resolution Ultrasonography for Assessment of Renal Cysts in the PCK Rat Model of Autosomal Recessive Polycystic Kidney Disease
Background/Aims: The PCK rat model of polycystic kidney disease is characterized by the progressive development of renal medullary cysts. Here, we evaluated the suitability of high resolution ultrasonography (HRU) to assess the kidney and cyst volume in PCK rats, testing three different ultrasound image analysis methods, and correlating them with kidneys weights and histological examinations. Methods: After inducing anesthesia, PCK rats (n=18) were subjected to HRU to visualize the kidneys, to perform numeric and volumetric measurements of the kidney and any cysts observed, and to generate 3-dimensional images of the cysts...
Source: Kidney and Blood Pressure Research - March 17, 2016 Category: Urology & Nephrology Source Type: research

Comparison of Peritoneal Low-Molecular-Weight-Protein-Removal in CCPD and CAPD Patients Based on C-Terminal Agrin Fragment Clearance
This study compares the peritoneal elimination of the low-molecular-weight-protein (LMWP) C-terminal agrin fragment (tCAF, size 22 kDa), a promising biomarker for kidney function, in continuous cycling peritoneal dialysis (CCPD) and continuous ambulatory peritoneal dialysis (CAPD). Methods: 103 sets of serum, 24h-urine and dialysate samples were obtained in 15 CCPD (63 sets) and 11 CAPD (40 sets) patients. Total, renal and peritoneal substrate removals/clearances were measured/calculated for tCAF, creatinine, blood-urea-nitrogen (BUN), cystatin C and albumin and correlated with the peritoneal transport type. Results: Serum...
Source: Kidney and Blood Pressure Research - March 10, 2016 Category: Urology & Nephrology Source Type: research

Effect of Dialysis Day on Intradialytic Hypotension Risk
Conclusions: The odds of hypotension occurrence decrease throughout dialysis sessions of the week. Minimizing modifiable risk factors may decrease IDH episodes.Kidney Blood Press Res 2016;41:168-174 (Source: Kidney and Blood Pressure Research)
Source: Kidney and Blood Pressure Research - March 3, 2016 Category: Urology & Nephrology Source Type: research

Sinomenine Attenuates Angiotensin II-Induced Autophagy via Inhibition of P47-Phox Translocation to the Membrane and Influences Reactive Oxygen Species Generation in Podocytes
Conclusion: The appropriate concentration of SN attenuated Ang II-induced podocyte autophagy through ROS generation, at least in part, by regulating NOX subunit p47-phox translocation to the membrane.Kidney Blood Press Res 2016;41:158-167 (Source: Kidney and Blood Pressure Research)
Source: Kidney and Blood Pressure Research - February 27, 2016 Category: Urology & Nephrology Source Type: research

The Clinical Significance of Uric Acid and Complement Activation in the Progression of IgA Nephropathy
Conclusions: Hyperuricemia and the deposition of C3 are independent risk factors for IgAN progression.Kidney Blood Press Res 2016;41:148-157 (Source: Kidney and Blood Pressure Research)
Source: Kidney and Blood Pressure Research - February 26, 2016 Category: Urology & Nephrology Source Type: research

Previous Vaccination and Age are More Important Predictors of Immune Response to Influenza Vaccine than Inflammation and Iron Status in Dialysis Patients
Background/Aims: The immune response to influenza vaccine may be influenced by many factors, e.g. age, comorbidities or inflammation, and iron status. Methods: We studied the vaccine-induced production of hemagglutination-inhibition antibodies (HI) in 133 hemodialysis patients (HD) and 40 controls. To identify variables associated with the immune response, uni- and multivariate regression analyses were performed with seroconversion in HI titers as a dependent variable, with demographics, comorbidities, previous vaccination, inflammation, and iron status as independent variables. Results: Seroconversion rates were lower in ...
Source: Kidney and Blood Pressure Research - February 26, 2016 Category: Urology & Nephrology Source Type: research

Mesenchymal Stromal Cell-Derived Extracellular Vesicles Protect Against Acute Kidney Injury Through Anti-Oxidation by Enhancing Nrf2/ARE Activation in Rats
Conclusions: MSC-EVs may protect against AKI possibly through anti-oxidation by enhancing Nrf2/ARE activation.Kidney Blood Press Res 2016;41:119-128 (Source: Kidney and Blood Pressure Research)
Source: Kidney and Blood Pressure Research - February 19, 2016 Category: Urology & Nephrology Source Type: research

Protective Effect of Tempol on Acute Kidney Injury Through PI3K/Akt/Nrf2 Signaling Pathway
Conclusion: Tempol (50 mg/kg) prevents lipid peroxidation and attenuates renal damage after I/R injury. The beneficial pathway apparently is not dependent on upregulation or phosphorylation of PKC, at lower tempol doses, does implicate upregulation of Akt with expression of Nrf2 that could account for the increase in the antioxidant gene HO-1 and a reduction in the cleavage of the cellular damage marker pro-caspase-3.Kidney Blood Press Res 2016;41:129-138 (Source: Kidney and Blood Pressure Research)
Source: Kidney and Blood Pressure Research - February 19, 2016 Category: Urology & Nephrology Source Type: research

Angiotensin-Converting Enzyme Inhibitor (ACEI)-Mediated Amelioration in Renal Fibrosis Involves Suppression of Mast Cell Degranulation
Background/Aims: The mechanism by which angiotensin-converting enzyme inhibitors (ACEIs) attenuate renal fibrosis has not been fully uncovered. Methods: Renal fibrosis in rats was triggered by unilateral ureteral obstruction (UUO) and treated with Enalapril. Results: Enalapril attenuated renal fibrosis, as evidenced by the fibrosis scores (1.07±0.73 versus 2.18±0.75 for 200 mg/ml Enalapril versus control, p (Source: Kidney and Blood Pressure Research)
Source: Kidney and Blood Pressure Research - February 16, 2016 Category: Urology & Nephrology Source Type: research

Partial Reversal of Tissue Calcification and Extension of Life Span following Ammonium Nitrate Treatment of Klotho-Deficient Mice
Conclusions: NH4NO3-treatment turns respiratory acidosis into metabolic acidosis and mitigates calcification thus leading to a substantial extension of kl/kl mice survival.Kidney Blood Press Res 2016;41:99-107 (Source: Kidney and Blood Pressure Research)
Source: Kidney and Blood Pressure Research - February 16, 2016 Category: Urology & Nephrology Source Type: research

Kidney Function and Cognitive Impairment in People Aged 80 Years and Over with Untreated Hypertension: A Cross-Sectional Survey
Conclusion: Our study found that both CKD and eGFR were associated with cognitive impairment among hypertensive patients aged 80 or over in China. Therefore, targeted screening for cognitive impairment should be considered in these patients with CKD.Kidney Blood Press Res 2016;41:70-77 (Source: Kidney and Blood Pressure Research)
Source: Kidney and Blood Pressure Research - February 13, 2016 Category: Urology & Nephrology Source Type: research

The Level of Anxiety and Depression in Dialysis Patients Undertaking Regular Physical Exercise Training - a Preliminary Study
Conclusions: Undertaking physical training during dialysis by patients with ESRD is beneficial in reducing their levels of anxiety and depression. Both resistance and endurance training improves mood, but only endurance training additionally results in anxiety reduction.Kidney Blood Press Res 2016;41:86-98 (Source: Kidney and Blood Pressure Research)
Source: Kidney and Blood Pressure Research - February 13, 2016 Category: Urology & Nephrology Source Type: research

Irisin is Associated with Urotensin II and Protein Energy Wasting in Hemodialysis Patients
Conclusions: Our results are the first to provide the clinical evidence of the association among irisin, UII, and protein energy wasting. Our results hint that UII and protein energy wasting might inhibit the release or synthesis of irisin from skeletal muscles in HD patients.Kidney Blood Press Res 2016;41:78-85 (Source: Kidney and Blood Pressure Research)
Source: Kidney and Blood Pressure Research - February 13, 2016 Category: Urology & Nephrology Source Type: research

The Inhibitory Effect of Rapamycin on Toll Like Receptor 4 and Interleukin 17 in the Early Stage of Rat Diabetic Nephropathy
Conclusions: Taken together, our results confirm and extend previous studies identifying the significance of the TLR4 and Th17 pathways in development of early stage DN. Furthermore, we suggest this overexpression of TLR4 might be involved in the immunopathogenesis of DN through activation of Th17 cells. Rapamycin may attenuate DN via reduction of the TLR4 signaling pathway and Th17 cells signaling. Although the underlying mechanisms need to be explored, the observed increase of TLR4 and IL-17 during the early stages of DN and their suppression with rapamycin treatment suggest the importance of TLR4 and IL-17 in DN pathoph...
Source: Kidney and Blood Pressure Research - February 5, 2016 Category: Urology & Nephrology Source Type: research

Identification of Genes and Pathways Associated with Kidney Ischemia-Reperfusion Injury by Bioinformatics Analyses
Conclusions: DEGs of Fkb1a, C5, Chpt1, and Hmox1, as well as complement and coagulation cascades pathway, glycerophospholipid metabolism pathway, and BP terms related to protein ubiquitinatione may be the potential targets for diagnosis and treatment of kidney IR injury.Kidney Blood Press Res 2016;41:48-54 (Source: Kidney and Blood Pressure Research)
Source: Kidney and Blood Pressure Research - February 4, 2016 Category: Urology & Nephrology Source Type: research

Comparison of the Estimated Glomerular Filtration Rate (eGFR) in Diabetic Patients, Non-Diabetic Patients and Living Kidney Donors
Conclusions: Based on Cin, eGFR was accurate in non-diabetic patients. However, eGFR was inaccurate in living kidney donors and relatively inaccurate in diabetic patients.Kidney Blood Press Res 2016;41:40-47 (Source: Kidney and Blood Pressure Research)
Source: Kidney and Blood Pressure Research - February 2, 2016 Category: Urology & Nephrology Source Type: research

Hypertensive/Microvascular Disease and COPD: a Case Control Study
This study tested the hypothesis that individuals with chronic obstructive pulmonary disease (COPD) have more small vessel disease and more severe disease than an age- and gender- matched hospital patient comparison group. Methods: This was a single centre, case-control study of 151 individuals with COPD (FEV1/VC)
Source: Kidney and Blood Pressure Research - January 11, 2016 Category: Urology & Nephrology Source Type: research

Polymorphisms in the SLC12A3 Gene Encoding Sodium-Chloride Cotransporter are Associated with Hypertension: A Family-Based Study in the Mongolian Population
In this study, we aimed to genotype an extended cohort of hypertensive Mongolian families for polymorphisms in the SLC12A3 locus. Methods: Eighty-eight families with a history of hypertension, including parents, offspring, and relatives underwent clinical testing. Family-based association tests and haplotype analysis were used to evaluate the association between hypertension and polymorphisms in the SLC12A3 locus. Results: We identified three single nucleotide polymorphisms (SNPs), one in the SLC12A3 coding region (p = 0.05) and two in the intron (p = 0.02 and p = 0.07), which were significantly associated with the hyperte...
Source: Kidney and Blood Pressure Research - January 11, 2016 Category: Urology & Nephrology Source Type: research

Pancreatic Kininogenase Ameliorates Renal Fibrosis in Streptozotocin Induced-Diabetic Nephropathy Rat
Background/Aims: We aimed to evaluate whether pancreatic kininogenase (PKase) can relieve renal fibrosis and investigate its mechanisms in diabetic nephropathy (DN) rats Methods: We established streptozotocin (STZ) induced-DN rats. After treatment with PKase for 4 weeks, urinary weight, urinary protein content and blood glucose concentration were detected, and then renal histopathological changes were examined using Hematoxylin and Eosin (Hamp;E) and Masson's thrchrome staining. In addition, the expressions of miR-433, transforming growth factor-β1 (TGF-β1) and antizyme inhibitor 1 (Azin1) were detected by qRT-PC...
Source: Kidney and Blood Pressure Research - January 11, 2016 Category: Urology & Nephrology Source Type: research

Changes of Serum Total and Free Testosterone Concentrations in Male Chronic Hemodialysis Patients with Secondary Hyperparathyroidism in Response to Cinacalcet Treatment
Background/Aims: Calcium sensing receptor (CaSR) is expressed, among others also in testis. Cinacalcet binds to the CaSR, increases sensitivity of CaSR to serum calcium and is used in the treatment of secondary hyperparathyroidism (sHPT) in chronic hemodialysis patients (HDP). In most of male HDP, serum testosterone concentration is lower than in healthy males. The aim of this study was to assess the influence of six-month treatment with cinacalcet on the serum total and free testosterone concentration in male HDP with sHPT. Methods: 38 male, hemodialysed CKD patients with sHPT (PTH>300 pg/ml) were enrolled into the stu...
Source: Kidney and Blood Pressure Research - January 11, 2016 Category: Urology & Nephrology Source Type: research

Erratum
Kidney Blood Press Res 2015;40:648 (Source: Kidney and Blood Pressure Research)
Source: Kidney and Blood Pressure Research - December 19, 2015 Category: Urology & Nephrology Source Type: research

Inhibition of Sodium-GlucoseCotransporter 2 with Dapagliflozin in Han: SPRD Rats with Polycystic Kidney Disease
Conclusion: The induction of glucosuria with the SGLT2-specific inhibitor DAPA was associated with improved renal function and decreased albuminuria, but had no effect on cyst growth in Cy/+ rats. Overall the beneficial effects of DAPA in this PKD model were weaker than the previously described effects of the combined SGLT1/2 inhibitor phlorizin.Kidney Blood Press Res 2015;40:638-647 (Source: Kidney and Blood Pressure Research)
Source: Kidney and Blood Pressure Research - December 19, 2015 Category: Urology & Nephrology Source Type: research

Use of Calcium Channel Blockers is Associated with Mortality in Patients with Chronic Kidney Disease
Background/Aims: The use of antihypertensive medicines has been shown to reduce proteinuria, morbidity, and mortality in patients with chronic kidney disease (CKD). A specific recommendation for a class of antihypertensive drugs is not available in this population, despite the pharmacodynamic differences. We have therefore analysed the association between antihypertensive medicines and survival of patients with chronic kidney disease. Methods: Out of 2687 consecutive patients undergoing kidney biopsy a cohort of 606 subjects with retrievable medical therapy was included into the analysis. Kidney function was assessed by gl...
Source: Kidney and Blood Pressure Research - December 17, 2015 Category: Urology & Nephrology Source Type: research

Serum Protein Thiol Levels in Patients with Hospital-Acquired Acute Kidney Injury
Conclusions: Patients with hospital-acquired AKI have remarkably low serum protein thiol levels. Elevated protein thiol levels are associated with 90-day overall mortality in hospital-acquired AKI.Kidney Blood Press Res 2015;40:623-629 (Source: Kidney and Blood Pressure Research)
Source: Kidney and Blood Pressure Research - December 17, 2015 Category: Urology & Nephrology Source Type: research

The Impact of Exercising During Haemodialysis on Blood Pressure, Markers of Cardiac Injury and Systemic Inflammation - Preliminary Results of a Pilot Study
Conclusions: This study demonstrates fluctuations in blood pressure during haemodialysis in response to exercise. However, since the fall in blood pressure occurred without evidence of cardiac injury, we regard it as a normal response to exercise superimposed onto the haemodynamic response to haemodialysis. Importantly, exercise did not exacerbate systemic inflammation or immune dysfunction; intradialytic exercise was well tolerated.Kidney Blood Press Res 2015;40:593-604 (Source: Kidney and Blood Pressure Research)
Source: Kidney and Blood Pressure Research - December 1, 2015 Category: Urology & Nephrology Source Type: research

Some Aspects of the Renin-Angiotensin-System in Hemodialysis Patients
Understanding of the renin-angiotensin system (RAS) has changed remarkably over the past decade. Renin, angiotensin converting enzyme (ACE), angiotensin II (Ang II), and Ang II receptors are the main components of the RAS. Recent studies identified the ACE2/Ang 1-7/Mas receptor axis, which counter-regulates the classical RAS. Many studies have examined the effects of the RAS on the progression of cardiovascular disease and chronic kidney disease (CKD). In addition, many studies have documented increased levels of ACE in hemodialysis (HD) patients, raising concerns about the negative effects of RAS activation on the progres...
Source: Kidney and Blood Pressure Research - December 1, 2015 Category: Urology & Nephrology Source Type: research

Effects of Renin-Angiotensin System Inhibitors on Renal Expression of Renalase in Sprague-Dawley Rats Fed With High Salt Diet
Conclusion: This study indicates that high salt intake reduces renal expression, and renal RAS may be not involved in the regulation of renalase in SD rats fed with high-salt diet.Kidney Blood Press Res 2015;40:605-613 (Source: Kidney and Blood Pressure Research)
Source: Kidney and Blood Pressure Research - December 1, 2015 Category: Urology & Nephrology Source Type: research

Recombinant Hepatitis B Vaccine Adjuvanted With AS04 in Dialysis Patients: A Prospective Cohort Study
Background/Aims: Patients undergoing maintenance dialysis have an unsatisfactory response to vaccination, including to hepatitis B vaccine. A recombinant HB vaccine containing a new adjuvant system AS04 (HBV-AS04) has been recently developed; a few data exist on the immunogenicity and safety of HBV-AS04 among patients undergoing regular dialysis. All hepatitis B virus-seronegative patients with undetectable antibody against HBsAg undergoing maintenance dialysis at two units were prospectively included. Methods: Patients received four 20-mcg doses of HBV-AS04 by intramuscular route (deltoid muscle) at months 0,1,2, and 3. A...
Source: Kidney and Blood Pressure Research - November 13, 2015 Category: Urology & Nephrology Source Type: research

Microvascular Disease After Renal Transplantation
This study compared the prevalence and severity of microvascular disease in transplant recipients and patients with CKD5. Methods: Individuals with a renal transplant or CKD5 were recruited consecutively from renal clinics, and underwent bilateral retinal photography (Canon CR5-45, Canon). Their retinal images were deidentified and reviewed for hypertensive/microvascular signs by an ophthalmologist and a trained grader (Wong and Mitchell classification), and for vessel caliber at a grading centre using a computer-assisted method and Knudtson's modification of the Parr-Hubbard formula. Results: Ninety-two transplant recipie...
Source: Kidney and Blood Pressure Research - November 9, 2015 Category: Urology & Nephrology Source Type: research

Albuminuria is Associated With Subendocardial Viability Ratio in Chronic Kidney Disease Patients
Conclusions: Nondialysis CKD patients with higher levels of albuminuria have lower SEVR and higher ED and our results have shown the importance of central hemodynamic parameters like are SEVR and ED as a better or earlier noninvasive hemodynamic indexes in these patients.Kidney Blood Press Res 2015;40:565-574 (Source: Kidney and Blood Pressure Research)
Source: Kidney and Blood Pressure Research - October 30, 2015 Category: Urology & Nephrology Source Type: research

Up-Regulation of Intestinal Phosphate Transporter NaPi-IIb (SLC34A2) by the Kinases SPAK and OSR1
Conclusions: SPAK and OSR1 are powerful stimulators of the intestinal Na+-coupled phosphate co-transporter NaPi-IIb.Kidney Blood Press Res 2015;40:555-564 (Source: Kidney and Blood Pressure Research)
Source: Kidney and Blood Pressure Research - October 27, 2015 Category: Urology & Nephrology Source Type: research

Comparative Effect of a Renin Inhibitor and a Thiazide Diuretic on Renal Tissue Oxygenation in Hypertensive Patients
Conclusion: With the classical method of evaluation using regions no difference were found between aliskiren and HCTZ on renal tissue oxygenation after 8 weeks. In contrast, with our new method that takes into account the entire kidney, within group analyses show that aliskiren slightly increases cortical and medullary renal tissue oxygenation in hypertensive patients whereas HCTZ decreases significantly renal oxygenation at trough.Kidney Blood Press Res 2015;40:542-554 (Source: Kidney and Blood Pressure Research)
Source: Kidney and Blood Pressure Research - October 27, 2015 Category: Urology & Nephrology Source Type: research

Is Nebivolol Really Effective in Preventing Contrast Induced Nephropathy?
Background/Aims: Contrast induced nephropathy (CIN) has multifactorial etiopatogenesis including oxidative stress and vasoconstriction. Nebivolol is an antioxidant and has vasodilatatory effect via NO release and may prevent CIN development. We have noticed that a few number of studies that have evaluated the effectiveness of nebivolol for the prevention of CIN used serum creatinine (sCr) levels for CIN detection. However, sCr is an insensitive marker for renal damage. Therefore in this study we used serum neutrophil-gelatinase associated lipocalin (NGAL), a more sensitive marker of renal damage, to evaluate preventive rol...
Source: Kidney and Blood Pressure Research - October 25, 2015 Category: Urology & Nephrology Source Type: research

Molecular Mechanisms and Novel Therapeutic Approaches to Rhabdomyolysis-Induced Acute Kidney Injury
Rhabdomyolysis is a syndrome caused by injury to skeletal muscle that usually leads to acute kidney injury (AKI). Rhabdomyolysis has been linked to different conditions, including severe trauma and intense physical exercise. Myoglobin-induced renal toxicity plays a key role in rhabdomyolysis-associated kidney damage by increasing oxidative stress, inflammation, endothelial dysfunction, vasoconstriction, and apoptosis. New drugs that target the harmful effects of myoglobin have been recently developed, and some have been proven to be successful in animal models of acute renal failure secondary to rhabdomyolysis. This review...
Source: Kidney and Blood Pressure Research - October 20, 2015 Category: Urology & Nephrology Source Type: research

The Effect of Preserved Residual Renal Function on Left Ventricular Structure in Non-Anuric Peritoneal Dialysis Patients
This study examined the relations between RRF and left ventricular hypertrophy (LVH) before switching on dialysis treatment and observed during 18 months on PD treatment. Methods: A prospective longitudinal study was performed in 50 non-anuric (defined as>200 mL urine output in a 24-hour period) PD patients. Echocardiography, RRF and other known risk factors for the increase of LV mass index (LVMi) were determined at study baseline and the end of follow-up. Results: There was 78% patients with LVH in end-stage renal disease (ESRD) baseline and 60% at the end of follow-up. RRF at the start of the study showed no signific...
Source: Kidney and Blood Pressure Research - October 2, 2015 Category: Urology & Nephrology Source Type: research

The Thiazide-Sensitive Co-Transporter Promotes the Development of Sodium Retention in Mice with Diet-Induced Obesity
Conclusions: Increased expression of NCC promotes the sodium loading response to institution of HFD feeding before onset of hypertension.Kidney Blood Press Res 2015;40:509-519 (Source: Kidney and Blood Pressure Research)
Source: Kidney and Blood Pressure Research - September 29, 2015 Category: Urology & Nephrology Source Type: research

Inhibition of Phosphate-Induced Vascular Smooth Muscle Cell Osteo-/Chondrogenic Signaling and Calcification by Bafilomycin A1 and Methylamine
Conclusions: Inhibition of the vacuolar H+ ATPase or dissipation of the pH gradient across the membranes of acidic cellular compartments both disrupt osteo-/chondrogenic signaling and calcium deposition in VSMCs, observations supporting the hypothesis that vascular calcification requires acidic cellular compartments.Kidney Blood Press Res 2015;40:490-499 (Source: Kidney and Blood Pressure Research)
Source: Kidney and Blood Pressure Research - September 29, 2015 Category: Urology & Nephrology Source Type: research

Blood Pressure Characteristics in Moderate to Severe Renal Insufficiency
Conclusions: BP load should be a component employed in ABPM to determine cardiovascular risk stratification. MAP and HR might be associated with risk to develop end-stage renal disease.Kidney Blood Press Res 2015;40:478-489 (Source: Kidney and Blood Pressure Research)
Source: Kidney and Blood Pressure Research - September 29, 2015 Category: Urology & Nephrology Source Type: research

Effect of Irbesartan on Chemerin in the Renal Tissues of Diabetic Rats
Conclusion: Irbesartan may inhibit intrarenal RAS in diabetic rats, which may affect the expression of chemerin in the kidneys; however, the precise underlying mechanism remains to be determined.Kidney Blood Press Res 2015;40:467-477 (Source: Kidney and Blood Pressure Research)
Source: Kidney and Blood Pressure Research - September 22, 2015 Category: Urology & Nephrology Source Type: research