Requirement of Na+/H+ exchanger NHE1 for vasopressin-induced osteogenic signaling and calcification in human aortic smooth muscle cells
Conclusion: Vasopressin stimulates NHE1 expression and ROS generation, an effect dependent on SGK1 and required for vasopres sin-induced stimulation of osteogenic signaling and calcification of VSMCs. (Source: Kidney and Blood Pressure Research)
Source: Kidney and Blood Pressure Research - March 25, 2022 Category: Urology & Nephrology Source Type: research
The DiaCoVAb study in South Italy: immune response to Sars-CoV-2 vaccination in dialysis patients
Conclusion. These results prompt to suggest an additional vaccine dose in DP, reducing the interval of time from the second dose. Since few data are available on immune response in DP overtime after three vaccine doses currently, our study is among the first reports demonstrating the improved seropositivity and IgG levels in DP after booster vaccine dose. (Source: Kidney and Blood Pressure Research)
Source: Kidney and Blood Pressure Research - March 22, 2022 Category: Urology & Nephrology Source Type: research
An Integrative in silico Study to Discover Key Drivers in Pathogenicity of Focal and Segmental Glomerulosclerosis
Background
FSGS (focal and segmental glomerulosclerosis) is a clinical-pathologic condition marked by segmental and localized glomerular damages. Despite investigations, the molecular mechanisms behind FSGS development remain to be more clarified. By a comprehensive analysis of a FSGS related array set, the aim of this study was to unravel the top pathways and molecules involved in the pathogenesis of this disorder.
Methods
FSGS related microarray dataset (GSE129973) from the Gene Expression Omnibus (GEO) database was quality checked, analyzed and its differentially expressed genes (DEGs) (log2FC>1) were used for constr...
Source: Kidney and Blood Pressure Research - March 18, 2022 Category: Urology & Nephrology Source Type: research
Correlation between Tubulointerstitial Lesion and Blood Pressure in Lupus Nephritis Patients: A Pathological, Retrospective Study
Conclusion: After adjusting for gender and age, TIL is related to SBP and has a linear relationship with them.Kidney Blood Press Res (Source: Kidney and Blood Pressure Research)
Source: Kidney and Blood Pressure Research - March 8, 2022 Category: Urology & Nephrology Source Type: research
Correlation between tubulointerstitial lesion and blood pressure in lupus nephritis patients a pathological, retrospective study
Conclusion: After adjusting for gender and age, TIL is related to systolic blood pressure, and has a linear relationship with them. (Source: Kidney and Blood Pressure Research)
Source: Kidney and Blood Pressure Research - March 8, 2022 Category: Urology & Nephrology Source Type: research
Circ_0037866 contributes to the tumorigenesis of renal cell carcinoma by sequestering miR-384 to elevate CBX5 expression
Conclusion: Circ_0037866 knockdown restrains the tumorigenesis of RCC by miR-384/CBX5, revealing a promising molecular target for RCC therapy. (Source: Kidney and Blood Pressure Research)
Source: Kidney and Blood Pressure Research - March 4, 2022 Category: Urology & Nephrology Source Type: research
Impact Of Post-Transplantation Hypomagnesemia On Long-Term Graft And Patient Survival After Transplantation
BACKGROUND: Post-transplant hypomagnesemia is commonly observed among patients prescribed CNIs.
METHODS: We conducted a retrospective single center analysis (2000-2013, N=726) to examine the association of hypomagnesemia with long-term patient and allograft outcomes in kidney transplant recipients. A median serum magnesium level of all measured magnesium levels from 1 month to 1 year post-transplant was calculated.
RESULTS: For every increase in Mg of 0.1 mg/dL, the risk for either graft loss or death, overall survival and death with a functioning graft increased by 11%, 14% and 12% respectively (p (Source: Kidney and Bl...
Source: Kidney and Blood Pressure Research - February 23, 2022 Category: Urology & Nephrology Source Type: research
The effect of allopurinol on renal outcomes in patients with diabetic kidney disease: A systematic review and meta-analysis
Conclusions:
The present research showed that allopurinol did not significantly improve renal function and albuminuria in patients with DKD. (Source: Kidney and Blood Pressure Research)
Source: Kidney and Blood Pressure Research - February 7, 2022 Category: Urology & Nephrology Source Type: research
Association of Urine Albumin-Creatinine Ratio and Cystatin C-Based Estimated GFR with Outcomes in Patients with Ischemic Stroke
Conclusions: Both decreased eGFRcys and albuminuria are independent risk factors for all-cause death and poststroke disability. Combining the two markers is useful for improving risk stratification even in those without chronic kidney disease. (Source: Kidney and Blood Pressure Research)
Source: Kidney and Blood Pressure Research - February 7, 2022 Category: Urology & Nephrology Source Type: research
Association of Urine Albumin-Creatinine Ratio and Cystatin C –Based Estimated GFR with Outcomes in Patients with Ischemic Stroke
Background/Aims: Data about the independent and combined effects of cystatin C based estimated glomerular filtration rate (eGFRcys) and albuminuria on the risk of poor outcome in stroke patients is limited. The aim was to elucidate how these two renal markers affect the clinical outcomes after ischemic stroke separately and jointly.
Methods: The study subjects consisted of 10,197 patients with ischemic stroke from the third China National Stroke Registry (CNSR-III). The study outcomes were all-cause mortality, post stroke disability, recurrence of stroke and cardiocerebral vascular disease (CVD) composite events. Cox prop...
Source: Kidney and Blood Pressure Research - February 7, 2022 Category: Urology & Nephrology Source Type: research
What should be responsible for eryptosis in chronic kidney disease?
Background: Renal anemia is an important complication of chronic kidney disease (CKD). In addition to insufficient secretion of erythropoietin (EPO) and erythropoiesis disorders, the impact of eryptosis on renal anemia demands attention. However, a systemic analysis concerning the pathophysiology of eryptosis has not been expounded. Summary: The complicated conditions in CKD patients, including oxidative stress, osmotic stress, metabolic stress, accumulation of uremic toxins, and iron deficiency, affects the normal skeleton structure of red blood cells (RBCs) and disturbs ionic homeostasis, causing phosphatidylserine to tr...
Source: Kidney and Blood Pressure Research - February 3, 2022 Category: Urology & Nephrology Source Type: research
Effects of L-Carnitine Treatment on Kidney Mitochondria and Macrophages in Mice with Diabetic Nephropathy
Conclusion: The positive effects of L-carnitine on DN suggest its potential as a novel therapeutic agent against obesity-linked DN.Kidney Blood Press Res (Source: Kidney and Blood Pressure Research)
Source: Kidney and Blood Pressure Research - February 1, 2022 Category: Urology & Nephrology Source Type: research
Effects of ʟ-Carnitine Treatment on Kidney Mitochondria and Macrophages in Mice with Diabetic Nephropathy
Introduction: In diabetic nephropathy (DN), mitochondrial dysfunction and leakage of mitochondrial DNA (mtDNA) are caused by the downregulation of superoxide dismutase 2 (SOD2). mtDNA induces the activation of Toll-like receptor (TLR) 9, which is present in macrophages (M φs) and triggers their activation.
Methods: We orally administered ʟ-carnitine, which exerts protective effects on the mitochondria, to obesity-induced DN (db/db) mice for 8 weeks. We then investigated the effects of ʟ-carnitine on kidney mtROS production, circulating mtDNA content, and kidney C D11b high/CD11b low Mφ functions.
Results: In db/db mi...
Source: Kidney and Blood Pressure Research - February 1, 2022 Category: Urology & Nephrology Source Type: research
Growth Differentiation Factor-15 and Syndecan-1 Are Potential Biomarkers of Cardiac and Renal Involvement in Classical Fabry Disease under Enzyme Replacement Therapy
Conclusions: GDF-15 and syndecan-1 were associated with parameters of cardiac and renal involvement in classic FD patients on ERT. Their potential association with residual risk and disease outcomes should be investigated. (Source: Kidney and Blood Pressure Research)
Source: Kidney and Blood Pressure Research - January 27, 2022 Category: Urology & Nephrology Source Type: research
Growth differentiation factor-15 (GDF-15) and syndecan-1 are potential biomarkers of cardiac and renal involvement in classical Fabry disease under enzyme replacement therapy
Abstract
Background and aims: Inflammation and endothelial damage play a pivotal role in Fabry disease (FD) manifestations. In daily clinical practice, FD are mainly monitored by traditional biomarkers of target organ injury, such as serum creatinine and proteinuria, which provide no information about inflammation and endothelial damage.
Materials and methods: We investigated the serum levels of 3-nitrotyrosine (3-NT), an oxidative stress biomarker, and of growth differentiation factor-15 (GDF-15) and syndecan-1 in classical FD patients on enzyme replacement therapy (ERT) for at least 6 months and their relationship with...
Source: Kidney and Blood Pressure Research - January 27, 2022 Category: Urology & Nephrology Source Type: research
