Deletion of CD47 from Schwann cells and macrophages hastens myelin disruption/dismantling and scavenging in Schwann cells and augments myelin debris phagocytosis in macrophages
Myelin that surrounds axons breaks in trauma and disease; e.g., peripheral nerve and spinal cord injuries (PNI and SCI) and multiple sclerosis (MS). Resulting myelin debris hinders repair if not effectively sc... (Source: Journal of Neuroinflammation)
Source: Journal of Neuroinflammation - October 23, 2023 Category: Neurology Authors: Miri Gitik, Gerard Elberg, Fanny Reichert, Michael Tal and Shlomo Rotshenker Tags: Research Source Type: research
Distinguishing the effects of systemic CSF1R inhibition by PLX3397 on microglia and peripheral immune cells
Microglia, the primary immune cells of the central nervous system (CNS), are derived from the yolk sac and populate the brain during development. Once microglia migrate to the CNS, they are self-renewing and r... (Source: Journal of Neuroinflammation)
Source: Journal of Neuroinflammation - October 21, 2023 Category: Neurology Authors: Akhabue K. Okojie, Joseph O. Uweru, Morgan A. Coburn, Sihan Li, Vivian D. Cao-Dao and Ukpong B. Eyo Tags: Research Source Type: research
Impairing Gasdermin D-mediated pyroptosis is protective against retinal degeneration
Inflammasome activation and the subsequent release of pro-inflammatory cytokines including Interleukin 1 β (IL-1β) have been widely reported to contribute to the progression of retinal degenerations, including ... (Source: Journal of Neuroinflammation)
Source: Journal of Neuroinflammation - October 20, 2023 Category: Neurology Authors: Rakshanya Sekar, Yvette Wooff, Adrian V. Cioanca, Melan Kurera, Chinh Ngo, Si Ming Man and Riccardo Natoli Tags: Research Source Type: research
Intermittent hypoxia therapy ameliorates beta-amyloid pathology via TFEB-mediated autophagy in murine Alzheimer's disease
Alzheimer's disease (AD) is the most prevalent neurodegenerative disorder. Impaired autophagy in plaque-associated microglia (PAM) has been reported to accelerate amyloid plaque deposition and cognitive impair... (Source: Journal of Neuroinflammation)
Source: Journal of Neuroinflammation - October 20, 2023 Category: Neurology Authors: Xueting Wang, Yuqi Xie, Guijuan Chen, Yapeng Lu, Dan Wang and Li Zhu Tags: Research Source Type: research
A systematic review of immune-based interventions for perinatal neuroprotection: closing the gap between animal studies and human trials
Perinatal infection/inflammation is associated with a high risk for neurological injury and neurodevelopmental impairment after birth. Despite a growing preclinical evidence base, anti-inflammatory interventio... (Source: Journal of Neuroinflammation)
Source: Journal of Neuroinflammation - October 20, 2023 Category: Neurology Authors: Sharmony B. Kelly, Nhi T. Tran, Graeme R. Polglase, Rodney W. Hunt, Marcel F. Nold, Claudia A. Nold-Petry, David M. Olson, Sylvain Chemtob, Gregory A. Lodygensky, Sarah A. Robertson, Alistair J. Gunn and Robert Galinsky Tags: Review Source Type: research
NR4A1 deletion promotes pro-angiogenic polarization of macrophages derived from classical monocytes in a mouse model of neovascular age-related macular degeneration
Neovascular age-related macular degeneration causes vision loss from destructive angiogenesis, termed choroidal neovascularization (CNV). Cx3cr1 −/− mice display alterations in non-classical monocytes and microgli... (Source: Journal of Neuroinflammation)
Source: Journal of Neuroinflammation - October 19, 2023 Category: Neurology Authors: Steven Droho, Andrew P. Voigt, Jacob K. Sterling, Amrita Rajesh, Kyle S. Chan, Carla M. Cuda, Harris Perlman and Jeremy A. Lavine Tags: Research Source Type: research
Downregulation of the glucose transporter GLUT 1 in the cerebral microvasculature contributes to postoperative neurocognitive disorders in aged mice
Glucose transporter 1 (GLUT1) is essential for glucose transport into the brain and is predominantly expressed in the cerebral microvasculature. Downregulation of GLUT1 precedes the development of cognitive im... (Source: Journal of Neuroinflammation)
Source: Journal of Neuroinflammation - October 19, 2023 Category: Neurology Authors: Ying Chen, Jin Joo, John Man-Tak Chu, Raymond Chuen-Chung Chang and Gordon Tin-Chun Wong Tags: Research Source Type: research
Voltammetry in the spleen assesses real-time immunomodulatory norepinephrine release elicited by autonomic neurostimulation
The noradrenergic innervation of the spleen is implicated in the autonomic control of inflammation and has been the target of neurostimulation therapies for inflammatory diseases. However, there is no real-tim... (Source: Journal of Neuroinflammation)
Source: Journal of Neuroinflammation - October 17, 2023 Category: Neurology Authors: Ibrahim T. Mughrabi, Michael Gerber, Naveen Jayaprakash, Santhoshi P. Palandira, Yousef Al-Abed, Timir Datta-Chaudhuri, Corey Smith, Valentin A. Pavlov and Stavros Zanos Tags: Research Source Type: research
Chronic neuroinflammation during aging leads to cholinergic neurodegeneration in the mouse medial septum
Low-grade, chronic inflammation in the central nervous system characterized by glial reactivity is one of the major hallmarks for aging-related neurodegenerative diseases like Alzheimer ’s disease (AD). The bas... (Source: Journal of Neuroinflammation)
Source: Journal of Neuroinflammation - October 13, 2023 Category: Neurology Authors: Rashmi Gamage, Ilaria Rossetti, Garry Niedermayer, Gerald M ünch, Yossi Buskila and Erika Gyengesi Tags: Research Source Type: research
Astrocyte interferon-gamma signaling dampens inflammation during chronic central nervous system autoimmunity via PD-L1
Multiple sclerosis (MS) is an inflammatory and neurodegenerative disease of the central nervous system (CNS). Infiltrating inflammatory immune cells perpetuate demyelination and axonal damage in the CNS and si... (Source: Journal of Neuroinflammation)
Source: Journal of Neuroinflammation - October 12, 2023 Category: Neurology Authors: Brandon C. Smith, Rachel A. Tinkey, Orion D. Brock, Arshiya Mariam, Maria L. Habean, Ranjan Dutta and Jessica L. Williams Tags: Research Source Type: research
Insulin-degrading enzyme (IDE) as a modulator of microglial phenotypes in the context of Alzheimer ’s disease and brain aging
The insulin-degrading enzyme (IDE) is an evolutionarily conserved zinc-dependent metallopeptidase highly expressed in the brain, where its specific functions remain poorly understood. Besides insulin, IDE is a... (Source: Journal of Neuroinflammation)
Source: Journal of Neuroinflammation - October 11, 2023 Category: Neurology Authors: Miriam Corraliza-Gomez, Teresa Bermejo, Jingtao Lilue, Noelia Rodriguez-Iglesias, Jorge Valero, Irene Cozar-Castellano, Eduardo Arranz, Diego Sanchez and Maria Dolores Ganfornina Tags: Research Source Type: research
Human iPSC-derived glia models for the study of neuroinflammation
Neuroinflammation is a complex biological process that plays a significant role in various brain disorders. Microglia and astrocytes are the key cell types involved in inflammatory responses in the central ner... (Source: Journal of Neuroinflammation)
Source: Journal of Neuroinflammation - October 10, 2023 Category: Neurology Authors: Nina St öberl, Emily Maguire, Elisa Salis, Bethany Shaw and Hazel Hall-Roberts Tags: Review Source Type: research
CD13 facilitates immune cell migration and aggravates acute injury but promotes chronic post-stroke recovery
Acute stroke leads to the activation of myeloid cells. These cells express adhesion molecules and transmigrate to the brain, thereby aggravating injury. Chronically after stroke, repair processes, including an... (Source: Journal of Neuroinflammation)
Source: Journal of Neuroinflammation - October 10, 2023 Category: Neurology Authors: Justin N. Nguyen, Eric C. Mohan, Gargee Pandya, Uzma Ali, Chunfeng Tan, Julia K. Kofler, Linda Shapiro, Sean P. Marrelli and Anjali Chauhan Tags: Research Source Type: research
BAFF blockade in experimental autoimmune encephalomyelitis reduces inflammation in the meninges and synaptic and neuronal loss in adjacent brain regions
Multiple sclerosis (MS) has traditionally been viewed as a chronic inflammatory disease affecting the white matter of the central nervous system. However, over the past two decades, increasing evidence has hig... (Source: Journal of Neuroinflammation)
Source: Journal of Neuroinflammation - October 7, 2023 Category: Neurology Authors: Kanak Gupta, Ajay Kesharwani, Steven Rua, Saumitra Sen Singh, Catherine Siu, Larissa Jank, Matthew D. Smith, Peter A. Calabresi and Pavan Bhargava Tags: Brief Report Source Type: research
Stabilizing histamine release in gut mast cells mitigates peripheral and central inflammation after stroke
Stroke is the most common cause of long-term disability and places a high economic burden on the global healthcare system. Functional outcomes from stroke are largely determined by the extent of ischemic injur... (Source: Journal of Neuroinflammation)
Source: Journal of Neuroinflammation - October 7, 2023 Category: Neurology Authors: Maria P. Blasco Conesa, Frank W. Blixt, Pedram Peesh, Romeesa Khan, Janelle Korf, Juneyoung Lee, Gayathri Jagadeesan, Alexander Andersohn, Tushar K. Das, Chunfeng Tan, Claudia Di Gesu, Gabriela Delevati Colpo, Jose F élix Moruno-Manchón, Louise D. McCul Tags: Research Source Type: research
