Infiltrating myeloid cell-derived properdin markedly promotes microglia-mediated neuroinflammation after ischemic stroke
Emerging evidence has shown that myeloid cells that infiltrate into the peri-infarct region may influence the progression of ischemic stroke by interacting with microglia. Properdin, which is typically secrete... (Source: Journal of Neuroinflammation)
Source: Journal of Neuroinflammation - November 11, 2023 Category: Neurology Authors: Pin-yi Liu, Hui-qin Li, Meng-qi Dong, Xin-ya Gu, Si-yi Xu, Sheng-nan Xia, Xin-yu Bao, Yun Xu and Xiang Cao Tags: Research Source Type: research
Efferocytosis is restricted by axon guidance molecule EphA4 via ERK/Stat6/MERTK signaling following brain injury
Efferocytosis is a process that removes apoptotic cells and cellular debris. Clearance of these cells alleviates neuroinflammation, prevents the release of inflammatory molecules, and promotes the production o... (Source: Journal of Neuroinflammation)
Source: Journal of Neuroinflammation - November 9, 2023 Category: Neurology Authors: Eman Soliman, John Leonard, Erwin Kristobal Gudenschwager Basso, Ilana Gershenson, Jing Ju, Jatia Mills, Caroline de Jager, Alexandra M. Kaloss, Mohamed Elhassanny, Daniela Pereira, Michael Chen, Xia Wang and Michelle H. Theus Tags: Research Source Type: research
Repeated sleep deprivation decreases the flux into hexosamine biosynthetic pathway/O-GlcNAc cycling and aggravates Alzheimer ’s disease neuropathology in adult zebrafish
This study investigated chronic and repeated sleep deprivation (RSD)-induced neuronal changes in hexosamine biosynthetic pathway/O-linked N-acetylglucosamine (HBP/O-GlcNAc) cycling of glucose metabolism and furth... (Source: Journal of Neuroinflammation)
Source: Journal of Neuroinflammation - November 9, 2023 Category: Neurology Authors: Jiwon Park, Dong Yeol Kim, Geum-Sook Hwang and Inn-Oc Han Tags: Research Source Type: research
M2 macrophage-derived cathepsin S promotes peripheral nerve regeneration via fibroblast –Schwann cell-signaling relay
Although peripheral nerves have an intrinsic self-repair capacity following damage, functional recovery is limited in patients. It is a well-established fact that macrophages accumulate at the site of injury. ... (Source: Journal of Neuroinflammation)
Source: Journal of Neuroinflammation - November 9, 2023 Category: Neurology Authors: Eri Oshima, Yoshinori Hayashi, Zhen Xie, Hitoshi Sato, Suzuro Hitomi, Ikuko Shibuta, Kentaro Urata, Junjun Ni, Koichi Iwata, Tatsuo Shirota and Masamichi Shinoda Tags: Research Source Type: research
β-adrenergic signaling triggers enteric glial reactivity and acute enteric gliosis during surgery
Enteric glia contribute to the pathophysiology of various intestinal immune-driven diseases, such as postoperative ileus (POI), a motility disorder and common complication after abdominal surgery. Enteric glio... (Source: Journal of Neuroinflammation)
Source: Journal of Neuroinflammation - November 8, 2023 Category: Neurology Authors: Patrick Leven, Reiner Schneider, Linda Schneider, Shilpashree Mallesh, Pieter Vanden Berghe, Philipp Sasse, J örg C. Kalff and Sven Wehner Tags: Research Source Type: research
Mertk-expressing microglia influence oligodendrogenesis and myelin modelling in the CNS
Microglia, an immune cell found exclusively within the CNS, initially develop from haematopoietic stem cell precursors in the yolk sac and colonise all regions of the CNS early in development. Microglia have b... (Source: Journal of Neuroinflammation)
Source: Journal of Neuroinflammation - November 6, 2023 Category: Neurology Authors: Linda T. Nguyen, Andrea Aprico, Eze Nwoke, Alexander D. Walsh, Farrah Blades, Raphael Avneri, Elodie Martin, Bernard Zalc, Trevor J. Kilpatrick and Michele D. Binder Tags: Research Source Type: research
Correction: Gas6 induces infammation and reduces plaque burden but worsens behavior in a sex-dependent manner in the APP/PS1 model of Alzheimer ’s disease
(Source: Journal of Neuroinflammation)
Source: Journal of Neuroinflammation - November 6, 2023 Category: Neurology Authors: Laura D. Owlett, Berke Karaahmet, Linh Le, Elizabeth K. Belcher, Dawling Dionisio-Santos, John A. Olschowka, Michael R. Elliott and M. Kerry O ’Banion Tags: Correction Source Type: research
Characterizing the neuroimmune environment of offspring in a novel model of maternal allergic asthma and particulate matter exposure
Inflammation during pregnancy is associated with an increased risk for neurodevelopmental disorders (NDD). Increased gestational inflammation can be a result of an immune condition/disease, exposure to infecti... (Source: Journal of Neuroinflammation)
Source: Journal of Neuroinflammation - November 2, 2023 Category: Neurology Authors: Juan M. Tamayo, Hadley C. Osman, Jared J. Schwartzer, Kent E. Pinkerton and Paul Ashwood Tags: Research Source Type: research
The novel HS-mimetic, Tet-29, regulates immune cell trafficking across barriers of the CNS during inflammation
Disruption of the extracellular matrix at the blood –brain barrier (BBB) underpins neuroinflammation in multiple sclerosis (MS). The degradation of extracellular matrix components, such as heparan sulfate (HS) ... (Source: Journal of Neuroinflammation)
Source: Journal of Neuroinflammation - November 1, 2023 Category: Neurology Authors: Tessa Peck, Connor Davis, Georgia Lenihan-Geels, Maddie Griffiths, Sam Spijkers-Shaw, Olga V. Zubkova and Anne Camille La Flamme Tags: Research Source Type: research
Repeated mild traumatic brain injury causes sex-specific increases in cell proliferation and inflammation in juvenile rats
Childhood represents a period of significant growth and maturation for the brain, and is also associated with a heightened risk for mild traumatic brain injuries (mTBI). There is also concern that repeated-mTB... (Source: Journal of Neuroinflammation)
Source: Journal of Neuroinflammation - October 31, 2023 Category: Neurology Authors: Katie J. Neale, Hannah M. O. Reid, Barbara Sousa, Erin McDonagh, Jamie Morrison, Sandy Shultz, Eric Eyolfson and Brian R. Christie Tags: Research Source Type: research
Recombinant Slit2 suppresses neuroinflammation and Cdc42-mediated brain infiltration of peripheral immune cells via Robo1 –srGAP1 pathway in a rat model of germinal matrix hemorrhage
Germinal matrix hemorrhage (GMH) is a devastating neonatal stroke, in which neuroinflammation is a critical pathological contributor. Slit2, a secreted extracellular matrix protein, plays a repulsive role in a... (Source: Journal of Neuroinflammation)
Source: Journal of Neuroinflammation - October 29, 2023 Category: Neurology Authors: Qian Li, Lei Huang, Yan Ding, Prativa Sherchan, Wenjie Peng and John H. Zhang Tags: Research Source Type: research
IL-1R1 signaling in TBI: assessing chronic impacts and neuroinflammatory dynamics in a mouse model of mild closed-head injury
Neuroinflammation contributes to secondary injury cascades following traumatic brain injury (TBI), with alternating waves of inflammation and resolution. Interleukin-1 (IL-1), a critical neuroinflammatory medi... (Source: Journal of Neuroinflammation)
Source: Journal of Neuroinflammation - October 26, 2023 Category: Neurology Authors: Jonathan C. Vincent, Colleen N. Garnett, James B. Watson, Emma K. Higgins, Teresa Macheda, Lydia Sanders, Kelly N. Roberts, Ryan K. Shahidehpour, Eric M. Blalock, Ning Qaun and Adam D. Bachstetter Tags: Research Source Type: research
Cell-specific NFIA upregulation promotes epileptogenesis by TRPV4-mediated astrocyte reactivity
The astrocytes in the central nervous system (CNS) exhibit morphological and functional diversity in brain region-specific pattern. Functional alterations of reactive astrocytes are commonly present in human t... (Source: Journal of Neuroinflammation)
Source: Journal of Neuroinflammation - October 25, 2023 Category: Neurology Authors: Shuo Kong, Tao-xiang Chen, Xiang-lei Jia, Xue-lei Cheng, Meng-liu Zeng, Jing-yi Liang, Xiao-hua He, Jun Yin, Song Han, Wan-hong Liu, Yuan-teng Fan, Ting Zhou, Yu-min Liu and Bi-wen Peng Tags: Research Source Type: research
Alterations in pathogen-specific cellular and humoral immunity associated with acute peripheral facial palsy of infectious origin
Peripheral facial palsy (PFP) is a common neurologic symptom which can be triggered by pathogens, autoimmunity, trauma, tumors, cholesteatoma or further local conditions disturbing the peripheral section of th... (Source: Journal of Neuroinflammation)
Source: Journal of Neuroinflammation - October 25, 2023 Category: Neurology Authors: Leyla Mohammad, Mathias Fousse, Gentiana Wenzel, Marina Flotats Bastardas, Klaus Fa ßbender, Ulrich Dillmann, Bernhard Schick, Michael Zemlin, Barbara C. Gärtner, Urban Sester, David Schub, Tina Schmidt and Martina Sester Tags: Research Source Type: research
ASK1-K716R reduces neuroinflammation and white matter injury via preserving blood –brain barrier integrity after traumatic brain injury
Traumatic brain injury (TBI) is a significant worldwide public health concern that necessitates attention. Apoptosis signal-regulating kinase 1 (ASK1), a key player in various central nervous system (CNS) dise... (Source: Journal of Neuroinflammation)
Source: Journal of Neuroinflammation - October 24, 2023 Category: Neurology Authors: Shan Meng, Hui Cao, Yichen Huang, Ziyu Shi, Jiaying Li, Yana Wang, Yue Zhang, Shuning Chen, Hong Shi and Yanqin Gao Tags: Research Source Type: research
