Modeling the neuroimmune system in Alzheimer ’s and Parkinson’s diseases
Parkinson ’s disease (PD) and Alzheimer’s disease (AD) are neurodegenerative disorders caused by the interaction of genetic, environmental, and familial factors. These diseases have distinct pathologies and sym... (Source: Journal of Neuroinflammation)
Source: Journal of Neuroinflammation - January 23, 2024 Category: Neurology Authors: Wendy Balestri, Ruchi Sharma, Victor A. da Silva, Bianca C. Bobotis, Annabel J. Curle, Vandana Kothakota, Farnoosh Kalantarnia, Maria V. Hangad, Mina Hoorfar, Joanne L. Jones, Marie- Ève Tremblay, Jehan J. El-Jawhari, Stephanie M. Willerth and Yvonne Rei Tags: Review Source Type: research
Microglia-derived exosomes modulate myelin regeneration via miR-615-5p/MYRF axis
Demyelination and failure of remyelination in the central nervous system (CNS) characterize a number of neurological disorders. Spontaneous remyelination in demyelinating diseases is limited, as oligodendrocyt... (Source: Journal of Neuroinflammation)
Source: Journal of Neuroinflammation - January 22, 2024 Category: Neurology Authors: Xiao-Yu Ji, Yu-Xin Guo, Li-Bin Wang, Wen-Cheng Wu, Jia-Qi Wang, Jin He, Rui Gao, Javad Rasouli, Meng-Yuan Gao, Zhen-Hai Wang, Dan Xiao, Wei-Feng Zhang, Bogoljub Ciric, Yuan Zhang and Xing Li Tags: Research Source Type: research
Mitochondrial and metabolic dysfunction of peripheral immune cells in multiple sclerosis
Multiple sclerosis (MS) is a chronic autoimmune disorder characterized by the infiltration of inflammatory cells and demyelination of nerves. Mitochondrial dysfunction has been implicated in the pathogenesis o... (Source: Journal of Neuroinflammation)
Source: Journal of Neuroinflammation - January 20, 2024 Category: Neurology Authors: Peng-Fei Wang, Fei Jiang, Qiu-Ming Zeng, Wei-Fan Yin, Yue-Zi Hu, Qiao Li and Zhao-Lan Hu Tags: Review Source Type: research
Circulating mitochondria promoted endothelial cGAS-derived neuroinflammation in subfornical organ to aggravate sympathetic overdrive in heart failure mice
Sympathoexcitation contributes to myocardial remodeling in heart failure (HF). Increased circulating pro-inflammatory mediators directly act on the Subfornical organ (SFO), the cardiovascular autonomic center,... (Source: Journal of Neuroinflammation)
Source: Journal of Neuroinflammation - January 19, 2024 Category: Neurology Authors: Shutian Zhang, Dajun Zhao, Zhaohua Yang, Fanshun Wang, Shouguo Yang and Chunsheng Wang Tags: Research Source Type: research
Repeated cold stress, an animal model for fibromyalgia, elicits proprioceptor-induced chronic pain with microglial activation in mice
Fibromyalgia is characterized by chronic pain, fatigue, and other somatic symptoms. We have recently revealed that proprioceptor hyperactivation induces chronic pain in a rat model of myalgic encephalomyelitis... (Source: Journal of Neuroinflammation)
Source: Journal of Neuroinflammation - January 18, 2024 Category: Neurology Authors: Koji Wakatsuki, Sumiko Kiryu-Seo, Masaya Yasui, Hiroki Yokota, Haruku Kida, Hiroyuki Konishi and Hiroshi Kiyama Tags: Research Source Type: research
Increased regulatory activity of intestinal innate lymphoid cells type 3 (ILC3) prevents experimental autoimmune encephalomyelitis severity
Experimental autoimmune encephalomyelitis (EAE) induced in inbred rodents, i.e., genetically identical animals kept under identical environmental conditions, shows variable clinical outcomes. We investigated s... (Source: Journal of Neuroinflammation)
Source: Journal of Neuroinflammation - January 18, 2024 Category: Neurology Authors: Milica Lazarevi ć, Goran Stegnjaić, Bojan Jevtić, Sanja Despotović, Đurđica Ignjatović, Suzana Stanisavljević, Neda Nikolovski, Miljana Momčilović, Graeme L. Fraser, Mirjana Dimitrijević and Đorđe Miljković Tags: Research Source Type: research
Correction: Glyphosate infiltrates the brain and increases pro-inflammatory cytokine TNF α: implications for neurodegenerative disorders
(Source: Journal of Neuroinflammation)
Source: Journal of Neuroinflammation - January 17, 2024 Category: Neurology Authors: Joanna K. Winstone, Khyatiben V. Pathak, Wendy Winslow, Ignazio S. Piras, Jennifer White, Ritin Sharma, Matthew J. Huentelman, Patrick Pirrotte and Ramon Velazquez Tags: Correction Source Type: research
Arachidonic acid-derived lipid mediators in multiple sclerosis pathogenesis: fueling or dampening disease progression?
Multiple sclerosis (MS) is a chronic autoimmune disease of the central nervous system (CNS), characterized by neuroinflammation, demyelination, and neurodegeneration. Considering the increasing prevalence amon... (Source: Journal of Neuroinflammation)
Source: Journal of Neuroinflammation - January 17, 2024 Category: Neurology Authors: Jelle Y. Broos, Rianne T. M. van der Burgt, Julia Konings, Merel Rijnsburger, Oliver Werz, Helga E. de Vries, Martin Giera and Gijs Kooij Tags: Review Source Type: research
Splenic monocytes drive pathogenic subretinal inflammation in age-related macular degeneration
Age-related macular degeneration (AMD) is invariably associated with the chronic accumulation of activated mononuclear phagocytes in the subretinal space. The mononuclear phagocytes are composed of microglial ... (Source: Journal of Neuroinflammation)
Source: Journal of Neuroinflammation - January 17, 2024 Category: Neurology Authors: Christophe Roubeix, Caroline Nous, S ébastien Augustin, Kaitryn E. Ronning, Thibaud Mathis, Frédéric Blond, Pauline Lagouge-Roussey, Sergio Crespo-Garcia, Patrick M. Sullivan, Emmanuel L. Gautier, Nadine Reichhart, José-Alain Sahel, Marie E. Burns, Mi Tags: Research Source Type: research
Transient immune activation without loss of intraepidermal innervation and associated Schwann cells in patients with complex regional pain syndrome
Complex regional pain syndrome (CRPS) develops after injury and is characterized by disproportionate pain, oedema, and functional loss. CRPS has clinical signs of neuropathy as well as neurogenic inflammation.... (Source: Journal of Neuroinflammation)
Source: Journal of Neuroinflammation - January 17, 2024 Category: Neurology Authors: Beate Hartmannsberger, Sabrina Scriba, Carolina Guidolin, Juliane Becker, Katharina Mehling, Kathrin Doppler, Claudia Sommer and Heike L. Rittner Tags: Research Source Type: research
Post-exposure intranasal IFN α suppresses replication and neuroinvasion of Venezuelan Equine Encephalitis virus within olfactory sensory neurons
Venezuelan Equine Encephalitis virus (VEEV) may enter the central nervous system (CNS) within olfactory sensory neurons (OSN) that originate in the nasal cavity after intranasal exposure. While it is known that V... (Source: Journal of Neuroinflammation)
Source: Journal of Neuroinflammation - January 17, 2024 Category: Neurology Authors: Matthew D. Cain, N. Rubin Klein, Xiaoping Jiang, Hamid Salimi, Qingping Wu, Mark J. Miller, William B. Klimstra and Robyn S. Klein Tags: Research Source Type: research
CD4 T-cell aging exacerbates neuroinflammation in a late-onset mouse model of amyotrophic lateral sclerosis
Amyotrophic lateral sclerosis (ALS) is an adult-onset progressive neurodegenerative disorder characterized by the loss of upper and lower motor neurons in the brain and spinal cord. Accumulating evidence sugge... (Source: Journal of Neuroinflammation)
Source: Journal of Neuroinflammation - January 11, 2024 Category: Neurology Authors: Shir Zaccai, Anna Nemirovsky, Livnat Lerner, Leenor Alfahel, Ekaterina Eremenko, Adrian Israelson and Alon Monsonego Tags: Research Source Type: research
Lipoxins A4 and B4 inhibit glial cell activation via CXCR3 signaling in acute retinal neuroinflammation
Lipoxins are small lipids that are potent endogenous mediators of systemic inflammation resolution in a variety of diseases. We previously reported that Lipoxins A4 and B4 (LXA4 and LXB4) have protective activiti... (Source: Journal of Neuroinflammation)
Source: Journal of Neuroinflammation - January 11, 2024 Category: Neurology Authors: Izhar Livne-Bar, Shubham Maurya, Karsten Gronert and Jeremy M. Sivak Tags: Research Source Type: research
Taming microglia: the promise of engineered microglia in treating neurological diseases
Microglia, the CNS-resident immune cells, are implicated in many neurological diseases. Nearly one in six of the world ’s population suffers from neurological disorders, encompassing neurodegenerative and neuro... (Source: Journal of Neuroinflammation)
Source: Journal of Neuroinflammation - January 11, 2024 Category: Neurology Authors: Echo Yongqi Luo and Rio Ryohichi Sugimura Tags: Review Source Type: research
Chorioamnionitis accelerates granule cell and oligodendrocyte maturation in the cerebellum of preterm nonhuman primates
Preterm birth is often associated with chorioamnionitis and leads to increased risk of neurodevelopmental disorders, such as autism. Preterm birth can lead to cerebellar underdevelopment, but the mechanisms of... (Source: Journal of Neuroinflammation)
Source: Journal of Neuroinflammation - January 10, 2024 Category: Neurology Authors: Josef Newman, Xiaoying Tong, April Tan, Toni Yeasky, Vanessa Nunes De Paiva, Pietro Presicce, Paranthaman S. Kannan, Kevin Williams, Andreas Damianos, Marione Tamase Newsam, Merline K. Benny, Shu Wu, Karen C. Young, Lisa A. Miller, Suhas G. Kallapur, Clai Tags: Research Source Type: research
