Cellulose ether treatment inhibits amyloid beta aggregation, neuroinflammation and cognitive deficits in transgenic mouse model of Alzheimer ’s disease
Alzheimer ’s disease (AD) is an incurable, progressive and devastating neurodegenerative disease. Pathogenesis of AD is associated with the aggregation and accumulation of amyloid beta (Aβ), a major neurotoxic ... (Source: Journal of Neuroinflammation)
Source: Journal of Neuroinflammation - July 28, 2023 Category: Neurology Authors: Tahir Ali, Antonia N. Klein, Keegan McDonald, Lovisa Johansson, Priyanka Ganguli Mukherjee, Martin Hallbeck, Katsumi Doh-ura, Hermann M. Schatzl and Sabine Gilch Tags: Research Source Type: research
Physiological expression of mutated TAU impaired astrocyte activity and exacerbates β-amyloid pathology in 5xFAD mice
Alzheimer ’s disease (AD) is the leading cause of dementia in the world. The pathology of AD is affiliated with the elevation of both tau (τ) and β-amyloid (Aβ) pathologies. Yet, the direct link between natural... (Source: Journal of Neuroinflammation)
Source: Journal of Neuroinflammation - July 26, 2023 Category: Neurology Authors: Dorit Farfara, Meital Sooliman, Limor Avrahami, Tabitha Grace Royal, Shoshik Amram, Lea Rozenstein-Tsalkovich, Dorit Trudler, Shani Blanga-Kanfi, Hagit Eldar-Finkelman, Jens Pahnke, Hanna Rosenmann and Dan Frenkel Tags: Research Source Type: research
Emerging role of non-coding RNAs in neuroinflammation mediated by microglia and astrocytes
Neuroinflammation has been implicated in the initiation and progression of several central nervous system (CNS) disorders, including Alzheimer ’s disease, Parkinson’s disease, amyotrophic lateral sclerosis, mul... (Source: Journal of Neuroinflammation)
Source: Journal of Neuroinflammation - July 23, 2023 Category: Neurology Authors: Ruicheng Yang, Bo Yang, Wei Liu, Chen Tan, Huanchun Chen and Xiangru Wang Tags: Review Source Type: research
Iron induces B cell pyroptosis through Tom20 –Bax–caspase–gasdermin E signaling to promote inflammation post-spinal cord injury
Immune inflammatory responses play an important role in spinal cord injury (SCI); however, the beneficial and detrimental effects remain controversial. Many studies have described the role of neutrophils, macr... (Source: Journal of Neuroinflammation)
Source: Journal of Neuroinflammation - July 22, 2023 Category: Neurology Authors: Chengjie Wu, Lining Wang, Sixian Chen, Lei Shi, Mengmin Liu, Pengcheng Tu, Jie Sun, Ruihua Zhao, Yafeng Zhang, Jianwei Wang, Yalan Pan, Yong Ma and Yang Guo Tags: Research Source Type: research
Elevated blood and cerebrospinal fluid biomarkers of microglial activation and blood ‒brain barrier disruption in anti-NMDA receptor encephalitis
Anti-NMDA receptor (NMDAR) encephalitis is an autoimmune disease characterized by complex neuropsychiatric syndrome and cerebrospinal fluid (CSF) NMDAR antibodies. Triggering receptor expressed on myeloid cell... (Source: Journal of Neuroinflammation)
Source: Journal of Neuroinflammation - July 22, 2023 Category: Neurology Authors: Haoxiao Chang, Jia Ma, Kai Feng, Ning Feng, Xinxin Wang, Jiali Sun, Tianshu Guo, Yuzhen Wei, Yun Xu, Huabing Wang, Linlin Yin and Xinghu Zhang Tags: Brief Report Source Type: research
H3K27me3 of Rnf19a promotes neuroinflammatory response during Japanese encephalitis virus infection
In this study, we found that infection with Japanese encephalitis vir... (Source: Journal of Neuroinflammation)
Source: Journal of Neuroinflammation - July 21, 2023 Category: Neurology Authors: Shuo Zhu, Mengying Tao, Yunchuan Li, Xugang Wang, Zikai Zhao, Yixin Liu, Qi Li, Qiuyan Li, Yanbo Lu, Youhui Si, Shengbo Cao and Jing Ye Tags: Research Source Type: research
Alzheimer ’s disease-associated complement gene variants influence plasma complement protein levels
Alzheimer ’s disease (AD) has been associated with immune dysregulation in biomarker and genome-wide association studies (GWAS). GWAS hits include the genes encoding complement regulators clusterin (CLU) and compl... (Source: Journal of Neuroinflammation)
Source: Journal of Neuroinflammation - July 21, 2023 Category: Neurology Authors: Aurora Veteleanu, Joshua Stevenson-Hoare, Samuel Keat, Nikoleta Daskoulidou, Henrik Zetterberg, Amanda Heslegrave, Valentina Escott-Price, Julie Williams, Rebecca Sims, Wioleta M. Zelek, Sarah M. Carpanini and Bryan Paul Morgan Tags: Research Source Type: research
Lipopolysaccharide-binding protein and future Parkinson ’s disease risk: a European prospective cohort
Lipopolysaccharide (LPS) is the outer membrane component of Gram-negative bacteria. LPS-binding protein (LBP) is an acute-phase reactant that mediates immune responses triggered by LPS and has been used as a b... (Source: Journal of Neuroinflammation)
Source: Journal of Neuroinflammation - July 21, 2023 Category: Neurology Authors: Yujia Zhao, Douglas I. Walker, Christina M. Lill, Bastiaan R. Bloem, Sirwan K. L. Darweesh, Brismar Pinto-Pacheco, Brooklyn McNeil, Gary W. Miller, Alicia K. Heath, Myrthe Frissen, Dafina Petrova, Maria-Jose S ánchez, María-Dolores Chirlaque, Marcela Gu Tags: Research Source Type: research
Cerebrospinal fluid GFAP is a predictive biomarker for conversion to dementia and Alzheimer ’s disease-associated biomarkers alterations among de novo Parkinson’s disease patients: a prospective cohort study
Dementia is a prevalent non-motor manifestation among individuals with advanced Parkinson ’s disease (PD). Glial fibrillary acidic protein (GFAP) is an inflammatory marker derived from astrocytes. Research has ... (Source: Journal of Neuroinflammation)
Source: Journal of Neuroinflammation - July 20, 2023 Category: Neurology Authors: Tingting Liu, Hongzhou Zuo, Di Ma, Dan Song, Yuying Zhao and Oumei Cheng Tags: Research Source Type: research
Gastrointestinal microbiome of ARDS patients induces neuroinflammation and cognitive impairment in mice
Acute respiratory distress syndrome (ARDS) is a respiratory failure syndrome that can cause many complications, impacting patients ’ quality of life. Behavioral and cognitive disorders have attracted increasing... (Source: Journal of Neuroinflammation)
Source: Journal of Neuroinflammation - July 15, 2023 Category: Neurology Authors: Hong Zheng, Qihui Zhao, Jianuo Chen, Jiahui Lu, Yuping Li and Hongchang Gao Tags: Research Source Type: research
Tau and neuroinflammation in Alzheimer ’s disease: interplay mechanisms and clinical translation
Alzheimer ’s Disease (AD) contributes to most cases of dementia. Its prominent neuropathological features are the extracellular neuritic plaques and intercellular neurofibrillary tangles composed of aggregated ... (Source: Journal of Neuroinflammation)
Source: Journal of Neuroinflammation - July 14, 2023 Category: Neurology Authors: Yijun Chen and Yang Yu Tags: Review Source Type: research
Transfer of patient ’s peripheral blood mononuclear cells (PBMCs) disrupts blood–brain barrier and induces anti-NMDAR encephalitis: a study of novel humanized PBMC mouse model
Anti-N-methyl-D-aspartate receptor (NMDAR) encephalitis is a severe autoimmune neuropsychiatric disease. Brain access of anti-NMDAR autoantibody through the blood –brain barrier (BBB) is essential for pathogene... (Source: Journal of Neuroinflammation)
Source: Journal of Neuroinflammation - July 13, 2023 Category: Neurology Authors: Yaqing Shu, Fuhua Peng, Bingchu Zhao, Chunxin Liu, Qihui Li, Huilu Li, Yuge Wang, Yanjun Jiang, Tingting Lu, Qin Wang, Jian Sun, Huiyu Feng, Zhengqi Lu, Xiaodong Liu, Jie Wang and Wei Qiu Tags: Research Source Type: research
Disease-modifying effects of a glial-targeted inducible nitric oxide synthase inhibitor (1400W) in mixed-sex cohorts of a rat soman (GD) model of epilepsy
Acute exposure to seizurogenic organophosphate (OP) nerve agents (OPNA) such as diisopropylfluorophosphate (DFP) or soman (GD), at high concentrations, induce immediate status epilepticus (SE), reactive gliosis, ... (Source: Journal of Neuroinflammation)
Source: Journal of Neuroinflammation - July 12, 2023 Category: Neurology Authors: Suraj S. Vasanthi, Nikhil S. Rao, Manikandan Samidurai, Nyzil Massey, Christina Meyer, Meghan Gage, Mihir Kharate, Aida Almanza, Logan Wachter, Candide Mafuta, Lily Trevino, Adriana M. Carlo, Elijah Bryant, Brooke E. Corson, Morgan Wohlgemuth, Morgan Ostr Tags: Research Source Type: research
NLRP3 –GABA signaling pathway contributes to the pathogenesis of impulsive-like behaviors and cognitive deficits in aged mice
Perioperative neurocognitive disorders (PND), such as delirium and cognitive impairment, are commonly encountered complications in aged patients. The inhibitory neurotransmitter γ-aminobutyric acid (GABA) is a... (Source: Journal of Neuroinflammation)
Source: Journal of Neuroinflammation - July 11, 2023 Category: Neurology Authors: Lu-Ying Wang, Xu-Peng Wang, Jin-Meng Lv, Yu-Dong Shan, Shi-Yan Jia, Zhi-Fang Yu, Hui-Tao Miao, Yue Xin, Dong-Xue Zhang and Li-Min Zhang Tags: Research Source Type: research
Astrocyte-derived SerpinA3N promotes neuroinflammation and epileptic seizures by activating the NF- κB signaling pathway in mice with temporal lobe epilepsy
Impaired activation and regulation of the extinction of inflammatory cells and molecules in injured neuronal tissues are key factors in the development of epilepsy. SerpinA3N is mainly associated with the acut... (Source: Journal of Neuroinflammation)
Source: Journal of Neuroinflammation - July 8, 2023 Category: Neurology Authors: Chong Liu, Xue-Min Zhao, Qiao Wang, Ting-Ting Du, Mo-Xuan Zhang, Hui-Zhi Wang, Ren-Peng Li, Kun Liang, Yuan Gao, Si-Yu Zhou, Tao Xue, Jian-Guo Zhang, Chun-Lei Han, Lin Shi, Liang-Wen Zhang and Fan-Gang Meng Tags: Research Source Type: research
