Targeting CB2R in astrocytes for Parkinson's disease therapy: unraveling the Foxg1-mediated neuroprotective mechanism through autophagy-mediated NLRP3 degradation
Inflammasomes in astrocytes have been shown to play a crucial role in the pathogenesis of neurodegenerative diseases such as Parkinson's disease (PD) and Alzheimer's disease (AD). Cannabinoid Receptor 2(CB2R),... (Source: Journal of Neuroinflammation)
Source: Journal of Neuroinflammation - December 19, 2023 Category: Neurology Authors: Hong Zhu, Feng Xiao, Yao Xiao, Yun Guo, Xuesong Shan, Zhe Zhang, Lieliang Zhang and Hua Guo Tags: Research Source Type: research
27-hydroxycholesterol causes cognitive deficits by disturbing Th17/Treg balance and the related immune responses in mild cognitive impairment patients and C57BL/6J mice
Cognitive impairment is associated with dysregulated immune responses. Emerging evidence indicates that Th17 cells and their characteristic cytokine-IL-17 are receiving growing interest in the pathogenesis of ... (Source: Journal of Neuroinflammation)
Source: Journal of Neuroinflammation - December 19, 2023 Category: Neurology Authors: Tao Wang, Wenjing Feng, Mengwei Ju, Huiyan Yu, Zhiting Guo, Xuejing Sun, Kexin Yang, Miao Liu and Rong Xiao Tags: Research Source Type: research
TNFR1 signaling converging on FGF14 controls neuronal hyperactivity and sickness behavior in experimental cerebral malaria
Excess tumor necrosis factor (TNF) is implicated in the pathogenesis of hyperinflammatory experimental cerebral malaria (eCM), including gliosis, increased levels of fibrin(ogen) in the brain, behavioral chang... (Source: Journal of Neuroinflammation)
Source: Journal of Neuroinflammation - December 19, 2023 Category: Neurology Authors: Nolan M. Dvorak, Nadia D. Domingo, Cynthia M. Tapia, Paul A. Wadsworth, Mate Marosi, Yosef Avchalumov, Chanida Fongsaran, Leandra Koff, Jessica Di Re, Catherine M. Sampson, Timothy J. Baumgartner, Pingyuan Wang, Paula P. Villarreal, Olivia D. Solomon, Son Tags: Research Source Type: research
CSF-1R inhibitor PLX3397 attenuates peripheral and brain chronic GVHD and improves functional outcomes in mice
Graft-versus-host disease (GVHD) is a serious complication of otherwise curative allogeneic haematopoietic stem cell transplants. Chronic GVHD induces pathological changes in peripheral organs as well as the b... (Source: Journal of Neuroinflammation)
Source: Journal of Neuroinflammation - December 15, 2023 Category: Neurology Authors: Samreen N. Shaikh, Emily F. Willis, Max Dierich, Yi Xu, Samuel J. S. Stuart, Glenda C. Gobe, Abate A. Bashaw, Oliver Rawashdeh, Seung Jae Kim and Jana Vukovic Tags: Research Source Type: research
Inhaled nitric oxide suppresses neuroinflammation in experimental ischemic stroke
Ischemic stroke is a major global health issue and characterized by acute vascular dysfunction and subsequent neuroinflammation. However, the relationship between these processes remains elusive. In the curren... (Source: Journal of Neuroinflammation)
Source: Journal of Neuroinflammation - December 15, 2023 Category: Neurology Authors: Rebecca I. Sienel, Uta Mamrak, Janina Biller, Stefan Roth, Andreas Zellner, Tipparat Parakaw, Rayomand S. Khambata, Arthur Liesz, Christof Haffner, Amrita Ahluwalia, Burcu F. Seker and Nikolaus Plesnila Tags: Research Source Type: research
Human-derived air –liquid interface cultures decipher Alzheimer’s disease–SARS-CoV-2 crosstalk in the olfactory mucosa
The neurological effects of the coronavirus disease of 2019 (COVID-19) raise concerns about potential long-term consequences, such as an increased risk of Alzheimer's disease (AD). Neuroinflammation and other ... (Source: Journal of Neuroinflammation)
Source: Journal of Neuroinflammation - December 14, 2023 Category: Neurology Authors: Muhammad Ali Shahbaz, Suvi Kuivanen, Riikka Lampinen, Laura Mussalo, Tom áš Hron, Táňa Závodná, Ravi Ojha, Zdeněk Krejčík, Liudmila Saveleva, Numan Ahmad Tahir, Juho Kalapudas, Anne M. Koivisto, Elina Penttilä, Heikki Löppönen, Prateek Singh, Tags: Research Source Type: research
Longitudinal cerebrospinal fluid measurements show glial hypo- and hyperactivation in predementia Alzheimer ’s disease
Brain innate immune activation is associated with Alzheimer ’s disease (AD), but degrees of activation may vary between disease stages. Thus, brain innate immune activation must be assessed in longitudinal clin... (Source: Journal of Neuroinflammation)
Source: Journal of Neuroinflammation - December 13, 2023 Category: Neurology Authors: Kaja Nordengen, Bj ørn-Eivind Kirsebom, Grit Richter, Lene Pålhaugen, Berglind Gísladóttir, Nikias Siafarikas, Arne Nakling, Arvid Rongve, Geir Bråthen, Gøril Rolfseng Grøntvedt, Fernando Gonzalez, Knut Waterloo, Kulbhushan Sharma, Thomas Karikari, Tags: Research Source Type: research
Empagliflozin targets Mfn1 and Opa1 to attenuate microglia-mediated neuroinflammation in retinal ischemia and reperfusion injury
Neuroinflammation and mitochondrial dysfunction play crucial roles in retinal ischemia and reperfusion (IR) injury. Recent studies have identified mitochondrial function as a promising target for immunomodulat... (Source: Journal of Neuroinflammation)
Source: Journal of Neuroinflammation - December 12, 2023 Category: Neurology Authors: Zhenlan Yang, Yidan Liu, Xuhao Chen, Shaofen Huang, Yangyang Li, Guitong Ye, Xu Cao, Wenru Su and Yehong Zhuo Tags: Research Source Type: research
Extracellular vesicles from hiPSC-NSCs can prevent peripheral inflammation-induced cognitive dysfunction with inflammasome inhibition and improved neurogenesis in the hippocampus
Extracellular vesicles (EVs) released by human induced pluripotent stem cell-derived neural stem cells (hiPSC-NSCs) are enriched with miRNAs and proteins capable of mediating robust antiinflammatory activity. ... (Source: Journal of Neuroinflammation)
Source: Journal of Neuroinflammation - December 12, 2023 Category: Neurology Authors: Gunel Ayyubova, Maheedhar Kodali, Raghavendra Upadhya, Leelavathi N. Madhu, Sahithi Attaluri, Yogish Somayaji, Bing Shuai, Shama Rao, Goutham Shankar and Ashok K. Shetty Tags: Research Source Type: research
Vesicular HMGB1 release from neurons stressed with spreading depolarization enables confined inflammatory signaling to astrocytes
The role of high mobility group box 1 (HMGB1) in inflammation is well characterized in the immune system and in response to tissue injury. More recently, HMGB1 was also shown to initiate an “inflammatory signa... (Source: Journal of Neuroinflammation)
Source: Journal of Neuroinflammation - December 11, 2023 Category: Neurology Authors: Zeynep Kaya, Nevin Belder, Melike Sever-Bahcekapili, Buket Donmez-Demir, Şefik Evren Erdener, Naz Bozbeyoglu, Canan Bagci, Emine Eren-Kocak, Muge Yemisci, Hulya Karatas, Esra Erdemli, Ihsan Gursel and Turgay Dalkara Tags: Research Source Type: research
Lateralized response of skull bone marrow via osteopontin signaling in mice after ischemia reperfusion
Skull bone marrow is thought to be an immune tissue closely associated with the central nervous system (CNS). Recent studies have focused on the role of skull bone marrow in central nervous system disorders. I... (Source: Journal of Neuroinflammation)
Source: Journal of Neuroinflammation - December 9, 2023 Category: Neurology Authors: Chaoran Xu, Qia Zhang, Yi Zhang, Huaijun Chen, Tianchi Tang, Junjie Wang, Siqi Xia, Gao Chen and Jianmin Zhang Tags: Brief Report Source Type: research
The hypothalamic steroidogenic pathway mediates susceptibility to inflammation-evoked depression in female mice
Depression is two-to-three times more frequent among women. The hypothalamus, a sexually dimorphic area, has been implicated in the pathophysiology of depression. Neuroinflammation-induced hypothalamic dysfunc... (Source: Journal of Neuroinflammation)
Source: Journal of Neuroinflammation - December 7, 2023 Category: Neurology Authors: Fu-Rong Xu, Zhen-Hong Wei, Xiao-Xia Xu, Xiao-Gang Zhang, Chao-Jun Wei, Xiao-Ming Qi, Yong-Hong Li, Xiao-Ling Gao and Yu Wu Tags: Research Source Type: research
An engineered Fc fusion protein that targets antigen-specific T cells and autoantibodies mitigates autoimmune disease
Current effective therapies for autoimmune diseases rely on systemic immunomodulation that broadly affects all T and/or B cell responses. An ideal therapeutic approach would combine autoantigen-specific target... (Source: Journal of Neuroinflammation)
Source: Journal of Neuroinflammation - December 6, 2023 Category: Neurology Authors: Mathangi Janakiraman, Alexei Leliavski, Jeeva Varadarajulu, Dieter Jenne and Gurumoorthy Krishnamoorthy Tags: Brief Report Source Type: research
Design, synthesis, and characterization of novel system xC − transport inhibitors: inhibition of microglial glutamate release and neurotoxicity
Neuroinflammation appears to involve some degree of excitotoxicity promulgated by microglia, which release glutamate via the system xC − (SxC−) cystine-glutamate antiporter. With the aim of mitigating this source ... (Source: Journal of Neuroinflammation)
Source: Journal of Neuroinflammation - December 6, 2023 Category: Neurology Authors: Mariusz P. Gajewski and Steven W. Barger Tags: Research Source Type: research
Astrocyte-specific knockout of YKL-40/Chi3l1 reduces A β burden and restores memory functions in 5xFAD mice
Glial cell-mediated neuroinflammation and neuronal attrition are highly correlated with cognitive impairment in Alzheimer ’s disease. YKL-40 is a secreted astrocytic glycoprotein that serves as a diagnostic bio... (Source: Journal of Neuroinflammation)
Source: Journal of Neuroinflammation - December 2, 2023 Category: Neurology Authors: Xiaoyan Zeng, Stanley K. K. Cheung, Mengqi Shi, Penelope M. Y. Or, Zhining Li, Julia Y. H. Liu, Wayne L. H. Ho, Tian Liu, Kun Lu, John A. Rudd, Yubing Wang and Andrew M. Chan Tags: Research Source Type: research
