Proteomic profiling identifies novel inflammation-related plasma proteins associated with ischemic stroke outcome
The inflammatory response to cerebral ischemia is complex; however, most clinical studies of stroke outcome focus on a few selected proteins. We, therefore, aimed to profile a broad range of inflammation-relat... (Source: Journal of Neuroinflammation)
Source: Journal of Neuroinflammation - October 4, 2023 Category: Neurology Authors: Annelie Angerfors, Cecilia Br ännmark, Cecilia Lagging, Kara Tai, Robert Månsby Svedberg, Björn Andersson, Christina Jern and Tara M. Stanne Tags: Research Source Type: research
Distinct features of B cell receptors in neuromyelitis optica spectrum disorder among CNS inflammatory demyelinating diseases
Neuromyelitis optica spectrum disorder (NMOSD) stands out among CNS inflammatory demyelinating diseases (CIDDs) due to its unique disease characteristics, including severe clinical attacks with extensive lesio... (Source: Journal of Neuroinflammation)
Source: Journal of Neuroinflammation - October 4, 2023 Category: Neurology Authors: Hyo Jae Kim, Jong-Eun Park, Wangyong Shin, Dayoung Seo, Seungmi Kim, Hyunji Kim, Jinsung Noh, Yonghee Lee, Hyunjin Kim, Young-Min Lim, Hyori Kim and Eun-Jae Lee Tags: Research Source Type: research
Unbiased multitissue transcriptomic analysis reveals complex neuroendocrine regulatory networks mediated by spinal cord injury-induced immunodeficiency
Spinal cord injury (SCI), which causes loss of sensory and motor function in the body below the level of injury, is a devastating disease of the central nervous system. SCI leads to severe secondary immunosupp... (Source: Journal of Neuroinflammation)
Source: Journal of Neuroinflammation - September 30, 2023 Category: Neurology Authors: Hong Zeng, Li Cheng, De-zhi Lu, Shuai Fan, Ke-xin Wang, Li-li Xu, Bin Cai, Mou-wang Zhou and Jin-wu Wang Tags: Research Source Type: research
The relationship between systemic inflammation index, systemic immune-inflammatory index, and inflammatory prognostic index and 90-day outcomes in acute ischemic stroke patients treated with intravenous thrombolysis
To explore the association of systemic inflammatory index (SIRI), systemic immune-inflammatory index (SII) and inflammatory prognosis index (IPI) with 90d outcomes in patients with acute ischemic stroke (AIS) ... (Source: Journal of Neuroinflammation)
Source: Journal of Neuroinflammation - September 30, 2023 Category: Neurology Authors: Fei Ma, Lulu Li, Liang Xu, Jiacheng Wu, Aimei Zhang, Junqi Liao, Jingyi Chen, Yunze Li, Li Li, Zhaoyao Chen, Wenlei Li, Qing Zhu, Yuan Zhu and Minghua Wu Tags: Research Source Type: research
Receptor-interacting protein kinase 2 (RIPK2) profoundly contributes to post-stroke neuroinflammation and behavioral deficits with microglia as unique perpetrators
Receptor-interacting protein kinase 2 (RIPK2) is a serine/threonine kinase whose activity propagates inflammatory signaling through its association with pattern recognition receptors (PRRs) and subsequent TAK1... (Source: Journal of Neuroinflammation)
Source: Journal of Neuroinflammation - September 30, 2023 Category: Neurology Authors: Jonathan Larochelle, Ryland J. Tishko, Changjun Yang, Yong Ge, Leah T. Phan, Rachel E. Gunraj, Sofia M. Stansbury, Lei Liu, Mansour Mohamadzadeh, Habibeh Khoshbouei and Eduardo Candelario-Jalil Tags: Research Source Type: research
Inhibition of neutrophil extracellular trap formation ameliorates neuroinflammation and neuronal apoptosis via STING-dependent IRE1 α/ASK1/JNK signaling pathway in mice with traumatic brain injury
Neuroinflammation is one of the most important pathogeneses in secondary brain injury after traumatic brain injury (TBI). Neutrophil extracellular traps (NETs) forming neutrophils were found throughout the bra... (Source: Journal of Neuroinflammation)
Source: Journal of Neuroinflammation - September 30, 2023 Category: Neurology Authors: Guihong Shi, Liang Liu, Yiyao Cao, Guangshuo Ma, Yanlin Zhu, Jianye Xu, Xu Zhang, Tuo Li, Liang Mi, Haoran Jia, Yanfeng Zhang, Xilei Liu, Yuan Zhou, Shenghui Li, Guili Yang, Xiao Liu & hellip; Tags: Research Source Type: research
Metabolic response to CNS infection with flaviviruses
Flaviviruses are arthropod-borne RNA viruses found worldwide that, when introduced into the human body, cause diseases, including neuroinfections, that can lead to serious metabolic consequences and even death... (Source: Journal of Neuroinflammation)
Source: Journal of Neuroinflammation - September 29, 2023 Category: Neurology Authors: Marta Dobrzy ńska, Anna Moniuszko-Malinowska and Elżbieta Skrzydlewska Tags: Review Source Type: research
Type I/type III IFN and related factors regulate JEV infection and BBB endothelial integrity
Japanese encephalitis virus (JEV) remains a predominant cause of Japanese encephalitis (JE) globally. Its infection is usually accompanied by disrupted blood ‒brain barrier (BBB) integrity and central nervous s... (Source: Journal of Neuroinflammation)
Source: Journal of Neuroinflammation - September 27, 2023 Category: Neurology Authors: Ya-Ge Zhang, Hong-Xin Zhang, Hao-Wei Chen, Penghao Lv, Jie Su, Yan-Ru Chen, Zhen-Fang Fu and Min Cui Tags: Research Source Type: research
Glycolytic shift during West Nile virus infection provides new therapeutic opportunities
Viral rewiring of host bioenergetics and immunometabolism may provide novel targets for therapeutic interventions against viral infections. Here, we have explored the effect on bioenergetics during the infecti... (Source: Journal of Neuroinflammation)
Source: Journal of Neuroinflammation - September 27, 2023 Category: Neurology Authors: Patricia Mingo-Casas, Ana-Bel én Blázquez, Marta Gómez de Cedrón, Ana San-Félix, Susana Molina, Estela Escribano-Romero, Eva Calvo-Pinilla, Nereida Jiménez de Oya, Ana Ramírez de Molina, Juan-Carlos Saiz, María-Jesús Pérez-Pérez and Miguel A. M Tags: Research Source Type: research
Extended interval dosing of ocrelizumab modifies the repopulation of B cells without altering the clinical efficacy in multiple sclerosis
Recent studies suggest that extended interval dosing of ocrelizumab, an anti-B cell therapy, does not affect its clinical effectiveness in most patients with multiple sclerosis (MS). However, it remains to be ... (Source: Journal of Neuroinflammation)
Source: Journal of Neuroinflammation - September 26, 2023 Category: Neurology Authors: Carla Rodriguez-Mogeda, Zo ë Y. G. J. van Lierop, Susanne M. A. van der Pol, Loet Coenen, Laura Hogenboom, Alwin Kamermans, Ernesto Rodriguez, Jack van Horssen, Zoé L. E. van Kempen, Bernard M. J. Uitdehaag, Charlotte E. Teunissen, Maarten E. Witte, Joe Tags: Research Source Type: research
miR155, TREM2, INPP5D: Disease stage and cell type are essential considerations when targeting clinical interventions based on mouse models of Alzheimer ’s amyloidopathy
Studies of microglial gene manipulation in mouse models of Alzheimer ’s disease (AD) amyloidopathy can cause unpredictable effects on various key endpoints, including amyloidosis, inflammation, neuritic dystrop... (Source: Journal of Neuroinflammation)
Source: Journal of Neuroinflammation - September 25, 2023 Category: Neurology Authors: Sam Gandy and Michelle E. Ehrlich Tags: Correspondence Source Type: research
Astrocytes evoke a robust IRF7-independent type I interferon response upon neurotropic viral infection
Type I interferons (IFN-I) are fundamental in controlling viral infections but fatal interferonopathy is restricted in the immune-privileged central nervous system (CNS). In contrast to the well-established ro... (Source: Journal of Neuroinflammation)
Source: Journal of Neuroinflammation - September 22, 2023 Category: Neurology Authors: Loreen Weichert, Henning Peter D üsedau, David Fritzsch, Sarah Schreier, Annika Scharf, Martina Grashoff, Kristin Cebulski, Kristin Michaelsen-Preusse, Christian Erck, Stefan Lienenklaus, Ildiko Rita Dunay and Andrea Kröger Tags: Research Source Type: research
Nrf2 regulates iron-dependent hippocampal synapses and functional connectivity damage in depression
Neuronal iron overload contributes to synaptic damage and neuropsychiatric disorders. However, the molecular mechanisms underlying iron deposition in depression remain largely unexplored. Our study aims to inv... (Source: Journal of Neuroinflammation)
Source: Journal of Neuroinflammation - September 21, 2023 Category: Neurology Authors: Ting Zeng, Junjie Li, Lingpeng Xie, Zhaoyang Dong, Qing Chen, Sha Huang, Shuwen Xie, Yuqi Lai, Jun Li, Weixin Yan, YuHua Wang, Zeping Xie, Changlei Hu, Jiayi Zhang, Shanshan Kuang, Yuhong Song & hellip; Tags: Research Source Type: research
Influence of complement protein C1q or complement receptor C5aR1 on gut microbiota composition in wildtype and Alzheimer ’s mouse models
The contribution of the gut microbiome to neuroinflammation, cognition, and Alzheimer ’s disease progression has been highlighted over the past few years. Additionally, inhibition of various components of the c... (Source: Journal of Neuroinflammation)
Source: Journal of Neuroinflammation - September 19, 2023 Category: Neurology Authors: Tiffany J. Petrisko, Matthew Gargus, Shu-Hui Chu, Purnika Selvan, Katrine L. Whiteson and Andrea J. Tenner Tags: Research Source Type: research
Neural precursor cell delivery induces acute post-ischemic cerebroprotection, but fails to promote long-term stroke recovery in hyperlipidemic mice due to mechanisms that include pro-inflammatory responses associated with brain hemorrhages
The intravenous delivery of adult neural precursor cells (NPC) has shown promising results in enabling cerebroprotection, brain tissue remodeling, and neurological recovery in young, healthy stroke mice. Howev... (Source: Journal of Neuroinflammation)
Source: Journal of Neuroinflammation - September 15, 2023 Category: Neurology Authors: Dongpei Yin, Chen Wang, Yachao Qi, Ya-Chao Wang, Nina Hagemann, Ayan Mohamud Yusuf, Egor Dzyubenko, Britta Kaltwasser, Tobias Tertel, Bernd Giebel, Matthias Gunzer, Aurel Popa-Wagner, Thorsten R. Doeppner and Dirk M. Hermann Tags: Research Source Type: research
