Progressive inflammation reduces high-frequency EEG activity and cortical dendritic arborisation in late gestation fetal sheep
Antenatal infection/inflammation is associated with disturbances in neuronal connectivity, impaired cortical growth and poor neurodevelopmental outcomes. The pathophysiological substrate that underpins these c... (Source: Journal of Neuroinflammation)
Source: Journal of Neuroinflammation - May 24, 2023 Category: Neurology Authors: Sharmony B. Kelly, Justin M. Dean, Valerie A. Zahra, Ingrid Dudink, Alison Thiel, Graeme R. Polglase, Suzanne L. Miller, Stuart B. Hooper, Laura Bennet, Alistair J. Gunn and Robert Galinsky Tags: Research Source Type: research
High levels of endothelial ICAM-1 prohibit natalizumab mediated abrogation of CD4+ T cell arrest on the inflamed BBB under flow in vitro
The humanized anti- α4 integrin blocking antibody natalizumab (NTZ) is an effective treatment for relapsing–remitting multiple sclerosis (RRMS) that is associated with the risk of progressive multifocal leukoen... (Source: Journal of Neuroinflammation)
Source: Journal of Neuroinflammation - May 23, 2023 Category: Neurology Authors: Sasha Soldati, Alexander B är, Mykhailo Vladymyrov, Dale Glavin, James L. McGrath, Fabien Gosselet, Hideaki Nishihara, Susan Goelz and Britta Engelhardt Tags: Research Source Type: research
Circular RNA Tmcc1 improves astrocytic glutamate metabolism and spatial memory via NF- κB and CREB signaling in a bile duct ligation mouse model: transcriptional and cellular analyses
Hepatic encephalopathy-induced hyperammonemia alters astrocytic glutamate metabolism in the brain, which is involved in cognitive decline. To identify specific therapeutic strategies for the treatment of hepat... (Source: Journal of Neuroinflammation)
Source: Journal of Neuroinflammation - May 22, 2023 Category: Neurology Authors: Danbi Jo, Yeong-Hwan Lim, Yoon Seok Jung, Young-Kook Kim and Juhyun Song Tags: Research Source Type: research
Lactobacillus paracasei L9 affects disease progression in experimental autoimmune neuritis by regulating intestinal flora structure and arginine metabolism
Autoimmune neuropathies are common peripheral nervous system (PNS) disorders. Environmental influences and dietary components are known to affect the course of autoimmune diseases. Intestinal microorganisms ca... (Source: Journal of Neuroinflammation)
Source: Journal of Neuroinflammation - May 22, 2023 Category: Neurology Authors: Yuting Meng, Xiangjie Qiu, Zhongxiang Tang, Yu Mao and Yurong Tan Tags: Research Source Type: research
The BET PROTAC inhibitor dBET6 protects against retinal degeneration and inhibits the cGAS-STING in response to light damage
Chronic inflammation significantly contributes to photoreceptor death in blinding retinal diseases such as age-related macular degeneration (AMD) and retinitis pigmentosa (RP). Bromodomain and extraterminal do... (Source: Journal of Neuroinflammation)
Source: Journal of Neuroinflammation - May 22, 2023 Category: Neurology Authors: Xingfei Zhu, Wei Liu, Xiangcheng Tang, Yulin Chen, Xiangyu Ge, Qin Ke, Xingmiao Liang, Yuwen Gan, Yingfeng Zheng, Ming Zou, Mi Deng, Yizhi Liu, David Wan-Cheng Li and Lili Gong Tags: Research Source Type: research
