Remibrutinib (LOU064) inhibits neuroinflammation driven by B cells and myeloid cells in preclinical models of multiple sclerosis
Bruton ’s tyrosine kinase (BTK) is a key signaling node in B cell receptor (BCR) and Fc receptor (FcR) signaling. BTK inhibitors (BTKi) are an emerging oral treatment option for patients suffering from multiple... (Source: Journal of Neuroinflammation)
Source: Journal of Neuroinflammation - August 26, 2023 Category: Neurology Authors: Barbara Nuesslein-Hildesheim, Enrico Ferrero, Cindy Schmid, Catherine Huck, Paul Smith, Sarah Tisserand, Joelle Rubert, Frederic Bornancin, Denis Eichlisberger and Bruno Cenni Tags: Research Source Type: research
GSDMD knockdown attenuates phagocytic activity of microglia and exacerbates seizure susceptibility in TLE mice
Temporal lobe epilepsy (TLE) is often characterized pathologically by severe neuronal loss in the hippocampus. Phagocytic activity of microglia is essential for clearing apoptotic neuronal debris, allowing for... (Source: Journal of Neuroinflammation)
Source: Journal of Neuroinflammation - August 23, 2023 Category: Neurology Authors: Xiaoxia Yang, Qingqing Cao, Yi Guo, Jingchuan He, Demei Xu and Aolei Lin Tags: Research Source Type: research
Biomass smoke inhalation promotes neuroinflammatory and metabolomic temporal changes in the hippocampus of female mice
Smoke from wildland fires has been shown to produce neuroinflammation in preclinical models, characterized by neural infiltrations of neutrophils and monocytes, as well as altered neurovascular endothelial phe... (Source: Journal of Neuroinflammation)
Source: Journal of Neuroinflammation - August 22, 2023 Category: Neurology Authors: David Scieszka, Yan Jin, Shahani Noor, Ed Barr, Marcus Garcia, Jessica Begay, Guy Herbert, Russell P. Hunter, Kiran Bhaskar, Rahul Kumar, Rama Gullapalli, Alicia Bolt, Mark A. McCormick, Barry Bleske, Haiwei Gu and Matthew J. Campen Tags: Research Source Type: research
The connexin hemichannel inhibitor D4 produces rapid antidepressant-like effects in mice
Depression is a common mood disorder characterized by a range of clinical symptoms, including prolonged low mood and diminished interest. Although many clinical and animal studies have provided significant ins... (Source: Journal of Neuroinflammation)
Source: Journal of Neuroinflammation - August 20, 2023 Category: Neurology Authors: Huanhuan Li, Anni Guo, Magdiel Salgado, Juan C. S áez and Chunyue Geoffrey Lau Tags: Research Source Type: research
Influenza A virus infection disrupts oligodendrocyte homeostasis and alters the myelin lipidome in the adult mouse
Recent data suggest that myelin may be altered by physiological events occurring outside of the central nervous system, which may cause changes to cognition and behavior. Similarly, peripheral infection by non... (Source: Journal of Neuroinflammation)
Source: Journal of Neuroinflammation - August 19, 2023 Category: Neurology Authors: Allison Y. Louie, Justin S. Kim, Jenny Drnevich, Payam Dibaeinia, Hisami Koito, Saurabh Sinha, Daniel B. McKim, Katiria Soto-Diaz, Romana A. Nowak, Aditi Das and Andrew J. Steelman Tags: Research Source Type: research
Cerebrospinal fluid levels of neuroinflammatory biomarkers are increased in athletes with persistent post-concussive symptoms following sports-related concussion
A sports-related concussion (SRC) is often caused by rapid head rotation at impact, leading to shearing and stretching of axons in the white matter and initiation of secondary inflammatory processes that may e... (Source: Journal of Neuroinflammation)
Source: Journal of Neuroinflammation - August 17, 2023 Category: Neurology Authors: Anna Gard, Fredrik Vedung, Fredrik Piehl, Mohsen Khademi, Maria Portonova Wernersson, Ia Rorsman, Yelverton Tegner, H élène Pessah-Rasmussen, Karsten Ruscher and Niklas Marklund Tags: Research Source Type: research
Microglial senescence contributes to female-biased neuroinflammation in the aging mouse hippocampus: implications for Alzheimer ’s disease
Microglia, the brain ’s principal immune cells, have been implicated in the pathogenesis of Alzheimer’s disease (AD), a condition shown to affect more females than males. Although sex differences in microglial ... (Source: Journal of Neuroinflammation)
Source: Journal of Neuroinflammation - August 16, 2023 Category: Neurology Authors: Sarah R. Oca ñas, Kevin D. Pham, Jillian E. J. Cox, Alex W. Keck, Sunghwan Ko, Felix A. Ampadu, Hunter L. Porter, Victor A. Ansere, Adam Kulpa, Collyn M. Kellogg, Adeline H. Machalinski, Manu A. Thomas, Zsabre Wright, Ana J. Chucair-Elliott and Willard M Tags: Research Source Type: research
Exacerbating effects of single-dose acute ethanol exposure on neuroinflammation and amelioration by GPR110 (ADGRF1) activation
Neuroinflammation is a widely studied phenomenon underlying various neurodegenerative diseases. Earlier study demonstrated that pharmacological activation of GPR110 in both central and peripheral immune cells ... (Source: Journal of Neuroinflammation)
Source: Journal of Neuroinflammation - August 14, 2023 Category: Neurology Authors: Sharmistha Banerjee, Taeyeop Park, Yoo Sun Kim and Hee-Yong Kim Tags: Research Source Type: research
The mitochondrial protein TSPO in Alzheimer ’s disease: relation to the severity of AD pathology and the neuroinflammatory environment
The 18kD translocator protein (TSPO) is used as a positron emission tomography (PET) target to quantify neuroinflammation in patients. In Alzheimer ’s disease (AD), the cerebellum is the pseudo-reference region... (Source: Journal of Neuroinflammation)
Source: Journal of Neuroinflammation - August 14, 2023 Category: Neurology Authors: Emma F. Garland, Oliver Dennett, Laurie C. Lau, David S. Chatelet, Michel Bottlaender, James A. R. Nicoll and Delphine Boche Tags: Research Source Type: research
Lysosomal acidification dysfunction in microglia: an emerging pathogenic mechanism of neuroinflammation and neurodegeneration
Microglia are the resident innate immune cells in the brain with a major role in orchestrating immune responses. They also provide a frontline of host defense in the central nervous system (CNS) through their ... (Source: Journal of Neuroinflammation)
Source: Journal of Neuroinflammation - August 5, 2023 Category: Neurology Authors: Joseph D. Quick, Cristian Silva, Jia Hui Wong, Kah Leong Lim, Richard Reynolds, Anna M. Barron, Jialiu Zeng and Chih Hung Lo Tags: Review Source Type: research
Differential effects of SARS-CoV-2 variants on central nervous system cells and blood –brain barrier functions
Although mainly causing a respiratory syndrome, numerous neurological symptoms have been identified following of SARS-CoV-2 infection. However, how the virus affects the brain and how the mutations carried by ... (Source: Journal of Neuroinflammation)
Source: Journal of Neuroinflammation - August 3, 2023 Category: Neurology Authors: Aliz é Proust, Christophe J. Queval, Ruth Harvey, Lorin Adams, Michael Bennett and Robert J. Wilkinson Tags: Research Source Type: research
Prmt5 deficiency inhibits CD4+ T-cell Klf2/S1pr1 expression and ameliorates EAE disease
Protein arginine methyltransferase 5 (Prmt5) is the main type II methyltransferase, catalyzes protein arginine residue symmetric dimethylation, and modulates normal cellular physiology and disease progression.... (Source: Journal of Neuroinflammation)
Source: Journal of Neuroinflammation - August 2, 2023 Category: Neurology Authors: Yingxia Zheng, Zheyi Chen, Bingqian Zhou, Shiyu Chen, Ningdai Chen and Lisong Shen Tags: Research Source Type: research
Transcriptome alterations in peripheral blood B cells of patients with multiple sclerosis receiving immune reconstitution therapy
Multiple sclerosis (MS) is a chronic, inflammatory and neurodegenerative disease that leads to irreversible damage to the brain and spinal cord. The goal of so-called "immune reconstitution therapies" (IRTs) i... (Source: Journal of Neuroinflammation)
Source: Journal of Neuroinflammation - August 2, 2023 Category: Neurology Authors: Michael Hecker, Brit Fitzner, Nina Boxberger, Elena Putscher, Robby Engelmann, Wendy Bergmann, Michael M üller, Isis Ludwig-Portugall, Margit Schwartz, Stefanie Meister, Ales Dudesek, Alexander Winkelmann, Dirk Koczan and Uwe Klaus Zettl Tags: Research Source Type: research
Topographic distribution of inflammation factors in a healing aneurysm
Healing of intracranial aneurysms following endovascular treatment relies on the organization of early thrombus into mature scar tissue and neointima formation. Activation and deactivation of the inflammation ... (Source: Journal of Neuroinflammation)
Source: Journal of Neuroinflammation - August 2, 2023 Category: Neurology Authors: Basil E. Gr üter, Gwendoline Canzanella, Joshua Hägler, Jeannine Rey, Stefan Wanderer, Michael von Gunten, José A. Galvan, Rainer Grobholz, Hans-Rudolf Widmer, Luca Remonda, Lukas Andereggen and Serge Marbacher Tags: Research Source Type: research
ATP-P2X7R-mediated microglia senescence aggravates retinal ganglion cell injury in chronic ocular hypertension
Dysfunction of microglia during aging affects normal neuronal function and results in the occurrence of neurodegenerative diseases. Retinal microglial senescence attributes to retinal ganglion cell (RGC) death... (Source: Journal of Neuroinflammation)
Source: Journal of Neuroinflammation - July 31, 2023 Category: Neurology Authors: Miao Wei, Guowei Zhang, Zeyu Huang, Xuemeng Ding, Qing Sun, Yujian Zhang, Rongrong Zhu, Huaijin Guan and Min Ji Tags: Research Source Type: research
