Changes in lipid metabolism track with the progression of neurofibrillary pathology in tauopathies
Accumulation of tau leads to neuroinflammation and neuronal cell death in tauopathies, including Alzheimer ’s disease. As the disease progresses, there is a decline in brain energy metabolism. However, the role... (Source: Journal of Neuroinflammation)
Source: Journal of Neuroinflammation - March 27, 2024 Category: Neurology Authors: Dominika Ole šová, Dana Dobešová, Petra Majerová, Radana Brumarová, Aleš Kvasnička, Štěpán Kouřil, Eva Stevens, Jozef Hanes, Ľubica Fialová, Alena Michalicová, Juraj Piešťanský, Jakub Šinský, Petr Kaňovský, David Friedecký and Andre Tags: Research Source Type: research
Wnt5a/ β-catenin-mediated epithelial-mesenchymal transition: a key driver of subretinal fibrosis in neovascular age-related macular degeneration
Neovascular age-related macular degeneration (nAMD), accounts for up to 90% of AMD-associated vision loss, ultimately resulting in the formation of fibrotic scar in the macular region. The pathogenesis of subr... (Source: Journal of Neuroinflammation)
Source: Journal of Neuroinflammation - March 26, 2024 Category: Neurology Authors: Dandan Liu, Jingxiao Du, Hai Xie, Haibin Tian, Lixia Lu, Chaoyang Zhang, Guo-Tong Xu and Jingfa Zhang Tags: Research Source Type: research
Single-cell RNA sequencing reveals the immune features and viral tropism in the central nervous system of mice infected with Japanese encephalitis virus
Japanese encephalitis virus (JEV) is a neurotropic pathogen that causes lethal encephalitis. The high susceptibility and massive proliferation of JEV in neurons lead to extensive neuronal damage and inflammati... (Source: Journal of Neuroinflammation)
Source: Journal of Neuroinflammation - March 26, 2024 Category: Neurology Authors: Ling ’en Yang, Junyao Xiong, Yixin Liu, Yinguang Liu, Xugang Wang, Youhui Si, Bibo Zhu, Huanchun Chen, Shengbo Cao and Jing Ye Tags: Research Source Type: research
P2X7 receptor antagonists modulate experimental autoimmune neuritis via regulation of NLRP3 inflammasome activation and Th17 and Th1 cell differentiation
Guillain –Barré syndrome (GBS), a post-infectious, immune-mediated, acute demyelinating disease of the peripheral nerves and nerve roots, represents the most prevalent and severe acute paralyzing neuropathy. Pu... (Source: Journal of Neuroinflammation)
Source: Journal of Neuroinflammation - March 25, 2024 Category: Neurology Authors: Yuhan Xie, Ranran Han, Yulin Li, Weiya Li, Shichao Zhang, Yu Wu, Yuexin Zhao, Rongrong Liu, Jie Wu, Wei Jiang and Xiuju Chen Tags: Research Source Type: research
The mouse retinal pigment epithelium mounts an innate immune defense response following retinal detachment
The retinal pigment epithelium (RPE) maintains photoreceptor viability and function, completes the visual cycle, and forms the outer blood-retinal barrier (oBRB). Loss of RPE function gives rise to several mon... (Source: Journal of Neuroinflammation)
Source: Journal of Neuroinflammation - March 25, 2024 Category: Neurology Authors: Steven F. Abcouwer, Bruna Miglioranza Scavuzzi, Phillip E. Kish, Dejuan Kong, Sumathi Shanmugam, Xuan An Le, Jingyu Yao, Heather Hager and David N Zacks Tags: Research Source Type: research
Cryopreservation of cerebrospinal fluid cells preserves the transcriptional landscape for single-cell analysis
Cerebrospinal fluid (CSF) matrix biomarkers have become increasingly valuable surrogate markers of neuropsychiatric diseases in research and clinical practice. In contrast, CSF cells have been rarely investiga... (Source: Journal of Neuroinflammation)
Source: Journal of Neuroinflammation - March 23, 2024 Category: Neurology Authors: Mahesh Chandra Kodali, Jerry Antone, Eric Alsop, Rojashree Jayakumar, Khushi Parikh, Aude Chiot, Paula Sanchez-Molina, Bahareh Ajami, Steven E. Arnold, Kendall Jensen, Sudeshna Das and Marc S. Weinberg Tags: Research Source Type: research
Inflammation-induced TRPV4 channels exacerbate blood –brain barrier dysfunction in multiple sclerosis
Blood –brain barrier (BBB) dysfunction and immune cell migration into the central nervous system (CNS) are pathogenic drivers of multiple sclerosis (MS). Ways to reinstate BBB function and subsequently limit ne... (Source: Journal of Neuroinflammation)
Source: Journal of Neuroinflammation - March 23, 2024 Category: Neurology Authors: Cathrin E. Hansen, Alwin Kamermans, Kevin Mol, Kristina Berve, Carla Rodriguez-Mogeda, Wing Ka Fung, Bert van het Hof, Ruud D. Fontijn, Susanne M. A. van der Pol, Laura Michalick, Wolfgang M. Kuebler, Boyd Kenkhuis, Willeke van Roon-Mom, Wolfgang Liedtke, Tags: Research Source Type: research
Hypochlorous acid derived from microglial myeloperoxidase could mediate high-mobility group box 1 release from neurons to amplify brain damage in cerebral ischemia –reperfusion injury
Myeloperoxidase (MPO) plays critical role in the pathology of cerebral ischemia –reperfusion (I/R) injury via producing hypochlorous acid (HOCl) and inducing oxidative modification of proteins. High-mobility gr... (Source: Journal of Neuroinflammation)
Source: Journal of Neuroinflammation - March 21, 2024 Category: Neurology Authors: Shuang Chen, Jingrui Pan, Zhe Gong, Meiling Wu, Xiaoni Zhang, Hansen Chen, Dan Yang, Suhua Qi, Ying Peng and Jiangang Shen Tags: Research Source Type: research
Deletion of Slc9a1 in Cx3cr1+ cells stimulated microglial subcluster CREB1 signaling and microglia-oligodendrocyte crosstalk
Microglial Na/H exchanger-1 (NHE1) protein, encoded by Slc9a1, plays a role in white matter demyelination of ischemic stroke brains. To explore underlying mechanisms, we conducted single cell RNA-seq transcriptom... (Source: Journal of Neuroinflammation)
Source: Journal of Neuroinflammation - March 20, 2024 Category: Neurology Authors: Shanshan Song, Helena Oft, Shamseldin Metwally, Satya Paruchuri, John Bielanin, Victoria Fiesler, Chaim Sneiderman, Gary Kohanbash and Dandan Sun Tags: Research Source Type: research
Macrophages coordinate immune response to laser-induced injury via extracellular traps
Retinal degeneration results from disruptions in retinal homeostasis due to injury, disease, or aging and triggers peripheral leukocyte infiltration. Effective immune responses rely on coordinated actions of r... (Source: Journal of Neuroinflammation)
Source: Journal of Neuroinflammation - March 18, 2024 Category: Neurology Authors: Federica M. Conedera, Despina Kokona, Martin S. Zinkernagel, Jens V. Stein, Charles P. Lin, Clemens Alt and Volker Enzmann Tags: Research Source Type: research
Border-associated macrophages in the central nervous system
Tissue-resident macrophages play an important role in the local maintenance of homeostasis and immune surveillance. In the central nervous system (CNS), brain macrophages are anatomically divided into parenchy... (Source: Journal of Neuroinflammation)
Source: Journal of Neuroinflammation - March 13, 2024 Category: Neurology Authors: Rui Sun and Haowu Jiang Tags: Review Source Type: research
TYROBP/DAP12 knockout in Huntington ’s disease Q175 mice cell-autonomously decreases microglial expression of disease-associated genes and non-cell-autonomously mitigates astrogliosis and motor deterioration
Huntington ’s disease (HD) is a fatal neurodegenerative disorder caused by an expansion of the CAG trinucleotide repeat in the Huntingtin gene (HTT). Immune activation is abundant in the striatum of HD patients. D... (Source: Journal of Neuroinflammation)
Source: Journal of Neuroinflammation - March 8, 2024 Category: Neurology Authors: Jordi Creus-Muncunill, Jean Vianney Haure-Mirande, Daniele Mattei, Joanna Bons, Angie V. Ramirez, B. Wade Hamilton, Chuhyon Corwin, Sarah Chowdhury, Birgit Schilling, Lisa M. Ellerby and Michelle E. Ehrlich Tags: Research Source Type: research
Role of myeloid cells in ischemic retinopathies: recent advances and unanswered questions
Myeloid cells including microglia and macrophages play crucial roles in retinal homeostasis by clearing cellular debris and regulating inflammation. These cells are activated in several blinding ischemic retin... (Source: Journal of Neuroinflammation)
Source: Journal of Neuroinflammation - March 7, 2024 Category: Neurology Authors: Rami A. Shahror, Carol A. Morris, Aya A. Mohammed, Melissa Wild, Bushra Zaman, Christian D. Mitchell, Paul H. Phillips, Nancy J. Rusch, Esraa Shosha and Abdelrahman Y. Fouda Tags: Review Source Type: research
The contribution of pattern recognition receptor signalling in the development of age related macular degeneration: the role of toll-like-receptors and the NLRP3-inflammasome
Age-related macular degeneration (AMD) is a leading cause of irreversible vision loss, characterised by the dysfunction and death of the photoreceptors and retinal pigment epithelium (RPE). Innate immune cell ... (Source: Journal of Neuroinflammation)
Source: Journal of Neuroinflammation - March 5, 2024 Category: Neurology Authors: Alice Brandli, Kirstan A. Vessey and Erica L. Fletcher Tags: Review Source Type: research
Single-cell RNA sequencing reveals peripheral blood leukocyte responses to spinal cord injury in mice with humanised immune systems
Next-generation humanised mouse models and single-cell RNA sequencing (scRNAseq) approaches enable in-depth studies into human immune cell biology. Here we used NSG-SGM3 mice engrafted with human umbilical cor... (Source: Journal of Neuroinflammation)
Source: Journal of Neuroinflammation - March 1, 2024 Category: Neurology Authors: Ellen R. Gillespie, Laura F. Grice, Isabel G. Courtney, Hong Wa Lao, Woncheol Jung, Sonny Ramkomuth, Jacky Xie, David A. Brown, James Walsham, Kristen J. Radford, Quan H. Nguyen and Marc J. Ruitenberg Tags: Research Source Type: research
