Hypochlorous acid derived from microglial myeloperoxidase could mediate high-mobility group box 1 release from neurons to amplify brain damage in cerebral ischemia –reperfusion injury

Myeloperoxidase (MPO) plays critical role in the pathology of cerebral ischemia –reperfusion (I/R) injury via producing hypochlorous acid (HOCl) and inducing oxidative modification of proteins. High-mobility gr...

Source: Journal of Neuroinflammation - March 21, 2024 Category: Neurology Authors: Shuang Chen, Jingrui Pan, Zhe Gong, Meiling Wu, Xiaoni Zhang, Hansen Chen, Dan Yang, Suhua Qi, Ying Peng and Jiangang Shen Tags: Research Source Type: research