Fractalkine isoforms differentially regulate microglia-mediated inflammation and enhance visual function in the diabetic retina
Diabetic retinopathy (DR) affects about 200 million people worldwide, causing leakage of blood components into retinal tissues, leading to activation of microglia, the resident phagocytes of the retina, promot... (Source: Journal of Neuroinflammation)
Source: Journal of Neuroinflammation - February 4, 2024 Category: Neurology Authors: Derek Rodriguez, Kaira A. Church, Alicia N. Pietramale, Sandra M. Cardona, Difernando Vanegas, Colin Rorex, Micah C. Leary, Isabel A. Muzzio, Kevin R. Nash and Astrid E. Cardona Tags: Research Source Type: research
Immunoregulatory and neutrophil-like monocyte subsets with distinct single-cell transcriptomic signatures emerge following brain injury
Monocytes represent key cellular elements that contribute to the neurological sequela following brain injury. The current study reveals that trauma induces the augmented release of a transcriptionally distinct... (Source: Journal of Neuroinflammation)
Source: Journal of Neuroinflammation - February 3, 2024 Category: Neurology Authors: Erwin K. Gudenschwager Basso, Jing Ju, Eman Soliman, Caroline de Jager, Xiaoran Wei, Kevin J. Pridham, Michelle L. Olsen and Michelle H. Theus Tags: Research Source Type: research
Long-term impact of maternal obesity on the gliovascular unit and ephrin signaling in the hippocampus of adult offspring
Children born to obese mothers are at increased risk of developing mood disorders and cognitive impairment. Experimental studies have reported structural changes in the brain such as the gliovascular unit as w... (Source: Journal of Neuroinflammation)
Source: Journal of Neuroinflammation - February 2, 2024 Category: Neurology Authors: Seyedeh Marziyeh Jabbari Shiadeh, Fanny Goretta, Pernilla Svedin, Thomas Jansson, Carina Mallard and Maryam Ardalan Tags: Research Source Type: research
Exercise mimetics: a novel strategy to combat neuroinflammation and Alzheimer ’s disease
Neuroinflammation is a pathological hallmark of Alzheimer ’s disease (AD), characterized by the stimulation of resident immune cells of the brain and the penetration of peripheral immune cells. These inflammato... (Source: Journal of Neuroinflammation)
Source: Journal of Neuroinflammation - February 2, 2024 Category: Neurology Authors: Renqing Zhao Tags: Review Source Type: research
Herpes simplex virus infection induces necroptosis of neurons and astrocytes in human fetal organotypic brain slice cultures
Herpes simplex virus (HSV) encephalitis (HSE) is a serious and potentially life-threatening disease, affecting both adults and newborns. Progress in understanding the virus and host factors involved in neonata... (Source: Journal of Neuroinflammation)
Source: Journal of Neuroinflammation - February 1, 2024 Category: Neurology Authors: Ahmad S. Rashidi, Diana N. Tran, Caithlin R. Peelen, Michiel van Gent, Werner J. D. Ouwendijk and Georges M. G. M. Verjans Tags: Research Source Type: research
Preclinical translational platform of neuroinflammatory disease biology relevant to neurodegenerative disease
We describe a translational drug discovery platform b... (Source: Journal of Neuroinflammation)
Source: Journal of Neuroinflammation - January 31, 2024 Category: Neurology Authors: Kelley C. Larson, Lauren H. Martens, Michael Marconi, Christopher Dejesus, Suzanne Bruhn, Thomas A. Miller, Barbara Tate and Jonathan M. Levenson Tags: Research Source Type: research
Enhanced meningeal lymphatic drainage ameliorates lipopolysaccharide-induced brain injury in aged mice
Sepsis-associated encephalopathy (SAE) is an acute cerebral dysfunction caused by sepsis. Neuroinflammation induced by sepsis is considered a potential mechanism of SAE; however, very little is known about the... (Source: Journal of Neuroinflammation)
Source: Journal of Neuroinflammation - January 30, 2024 Category: Neurology Authors: Hongquan Dong, Xiaonan Dai, Yin Zhou, Chonglong Shi, Piplu Bhuiyan, Zhaochu Sun, Nana Li and Wenjie Jin Tags: Research Source Type: research
SRGN amplifies microglia-mediated neuroinflammation and exacerbates ischemic brain injury
Microglia is the major contributor of post-stroke neuroinflammation cascade and the crucial cellular target for the treatment of ischemic stroke. Currently, the endogenous mechanism underlying microglial activ... (Source: Journal of Neuroinflammation)
Source: Journal of Neuroinflammation - January 29, 2024 Category: Neurology Authors: Yi Qian, Lixuan Yang, Jian Chen, Chao Zhou, Ningning Zong, Yang Geng, Shengnan Xia, Haiyan Yang, Xinyu Bao, Yan Chen and Yun Xu Tags: Research Source Type: research
IKK β deletion from CNS macrophages increases neuronal excitability and accelerates the onset of EAE, while from peripheral macrophages reduces disease severity
Multiple sclerosis (MS) is a neuroinflammatory demyelinating disease characterized by motor deficits and cognitive decline. Many immune aspects of the disease are understood through studies in the experimental... (Source: Journal of Neuroinflammation)
Source: Journal of Neuroinflammation - January 27, 2024 Category: Neurology Authors: Maria Avloniti, Maria Evangelidou, Maria Gomini, Theodore Loupis, Mary Emmanouil, Adamantia Mitropoulou, Theodore Tselios, Hans Lassmann, Agn ès Gruart, José M. Delgado-García, Lesley Probert and Vasiliki Kyrargyri Tags: Research Source Type: research
The glucocorticoid receptor as a master regulator of the M üller cell response to diabetic conditions in mice
Diabetic retinopathy (DR) is considered a primarily microvascular complication of diabetes. M üller glia cells are at the centre of the retinal neurovascular unit and play a critical role in DR. We therefore in... (Source: Journal of Neuroinflammation)
Source: Journal of Neuroinflammation - January 25, 2024 Category: Neurology Authors: Anna M. Pfaller, Lew Kaplan, Madalena Carido, Felix Grassmann, Nundehui D íaz-Lezama, Farhad Ghaseminejad, Kirsten A. Wunderlich, Sarah Glänzer, Oliver Bludau, Thomas Pannicke, Bernhard H. F. Weber, Susanne F. Koch, Boyan Bonev, Stefanie M. Hauck and An Tags: Research Source Type: research
Associations between sex, body mass index and the individual microglial response in Alzheimer ’s disease
18-kDa translocator protein position-emission-tomography (TSPO-PET) imaging emerged for in vivo assessment of neuroinflammation in Alzheimer ’s disease (AD) research. Sex and obesity effects on TSPO-PET binding... (Source: Journal of Neuroinflammation)
Source: Journal of Neuroinflammation - January 23, 2024 Category: Neurology Authors: Gloria Biechele, Boris-Stephan Rauchmann, Daniel Janowitz, Katharina Buerger, Nicolai Franzmeier, Endy Weidinger, Selim Guersel, Sebastian Schuster, Anika Finze, Stefanie Harris, Simon Lindner, Nathalie L. Albert, Christian Wetzel, Rainer Rupprecht, Axel Tags: Research Source Type: research
Synergistic effect of sildenafil combined with controlled hypothermia to alleviate microglial activation after neonatal hypoxia –ischemia in rats
The only validated treatment to prevent brain damage associated with hypoxia –ischemia (HI) encephalopathy of the newborn is controlled hypothermia with limited benefits. Additional putative neuroprotective dru... (Source: Journal of Neuroinflammation)
Source: Journal of Neuroinflammation - January 23, 2024 Category: Neurology Authors: Pansiot Julien, Manuela Zinni, Natacha Bonnel, Marina El Kamouh, Felipe Odorcyk, Lea Peters, Emilie-Fleur Gautier, Marjorie Leduc, C édric Broussard and Olivier Baud Tags: Research Source Type: research
Modeling the neuroimmune system in Alzheimer ’s and Parkinson’s diseases
Parkinson ’s disease (PD) and Alzheimer’s disease (AD) are neurodegenerative disorders caused by the interaction of genetic, environmental, and familial factors. These diseases have distinct pathologies and sym... (Source: Journal of Neuroinflammation)
Source: Journal of Neuroinflammation - January 23, 2024 Category: Neurology Authors: Wendy Balestri, Ruchi Sharma, Victor A. da Silva, Bianca C. Bobotis, Annabel J. Curle, Vandana Kothakota, Farnoosh Kalantarnia, Maria V. Hangad, Mina Hoorfar, Joanne L. Jones, Marie- Ève Tremblay, Jehan J. El-Jawhari, Stephanie M. Willerth and Yvonne Rei Tags: Review Source Type: research
Microglia-derived exosomes modulate myelin regeneration via miR-615-5p/MYRF axis
Demyelination and failure of remyelination in the central nervous system (CNS) characterize a number of neurological disorders. Spontaneous remyelination in demyelinating diseases is limited, as oligodendrocyt... (Source: Journal of Neuroinflammation)
Source: Journal of Neuroinflammation - January 22, 2024 Category: Neurology Authors: Xiao-Yu Ji, Yu-Xin Guo, Li-Bin Wang, Wen-Cheng Wu, Jia-Qi Wang, Jin He, Rui Gao, Javad Rasouli, Meng-Yuan Gao, Zhen-Hai Wang, Dan Xiao, Wei-Feng Zhang, Bogoljub Ciric, Yuan Zhang and Xing Li Tags: Research Source Type: research
Mitochondrial and metabolic dysfunction of peripheral immune cells in multiple sclerosis
Multiple sclerosis (MS) is a chronic autoimmune disorder characterized by the infiltration of inflammatory cells and demyelination of nerves. Mitochondrial dysfunction has been implicated in the pathogenesis o... (Source: Journal of Neuroinflammation)
Source: Journal of Neuroinflammation - January 20, 2024 Category: Neurology Authors: Peng-Fei Wang, Fei Jiang, Qiu-Ming Zeng, Wei-Fan Yin, Yue-Zi Hu, Qiao Li and Zhao-Lan Hu Tags: Review Source Type: research
