Repeated cold stress, an animal model for fibromyalgia, elicits proprioceptor-induced chronic pain with microglial activation in mice
Fibromyalgia is characterized by chronic pain, fatigue, and other somatic symptoms. We have recently revealed that proprioceptor hyperactivation induces chronic pain in a rat model of myalgic encephalomyelitis... (Source: Journal of Neuroinflammation)
Source: Journal of Neuroinflammation - January 18, 2024 Category: Neurology Authors: Koji Wakatsuki, Sumiko Kiryu-Seo, Masaya Yasui, Hiroki Yokota, Haruku Kida, Hiroyuki Konishi and Hiroshi Kiyama Tags: Research Source Type: research
Increased regulatory activity of intestinal innate lymphoid cells type 3 (ILC3) prevents experimental autoimmune encephalomyelitis severity
Experimental autoimmune encephalomyelitis (EAE) induced in inbred rodents, i.e., genetically identical animals kept under identical environmental conditions, shows variable clinical outcomes. We investigated s... (Source: Journal of Neuroinflammation)
Source: Journal of Neuroinflammation - January 18, 2024 Category: Neurology Authors: Milica Lazarevi ć, Goran Stegnjaić, Bojan Jevtić, Sanja Despotović, Đurđica Ignjatović, Suzana Stanisavljević, Neda Nikolovski, Miljana Momčilović, Graeme L. Fraser, Mirjana Dimitrijević and Đorđe Miljković Tags: Research Source Type: research
Correction: Glyphosate infiltrates the brain and increases pro-inflammatory cytokine TNF α: implications for neurodegenerative disorders
(Source: Journal of Neuroinflammation)
Source: Journal of Neuroinflammation - January 17, 2024 Category: Neurology Authors: Joanna K. Winstone, Khyatiben V. Pathak, Wendy Winslow, Ignazio S. Piras, Jennifer White, Ritin Sharma, Matthew J. Huentelman, Patrick Pirrotte and Ramon Velazquez Tags: Correction Source Type: research
Arachidonic acid-derived lipid mediators in multiple sclerosis pathogenesis: fueling or dampening disease progression?
Multiple sclerosis (MS) is a chronic autoimmune disease of the central nervous system (CNS), characterized by neuroinflammation, demyelination, and neurodegeneration. Considering the increasing prevalence amon... (Source: Journal of Neuroinflammation)
Source: Journal of Neuroinflammation - January 17, 2024 Category: Neurology Authors: Jelle Y. Broos, Rianne T. M. van der Burgt, Julia Konings, Merel Rijnsburger, Oliver Werz, Helga E. de Vries, Martin Giera and Gijs Kooij Tags: Review Source Type: research
Splenic monocytes drive pathogenic subretinal inflammation in age-related macular degeneration
Age-related macular degeneration (AMD) is invariably associated with the chronic accumulation of activated mononuclear phagocytes in the subretinal space. The mononuclear phagocytes are composed of microglial ... (Source: Journal of Neuroinflammation)
Source: Journal of Neuroinflammation - January 17, 2024 Category: Neurology Authors: Christophe Roubeix, Caroline Nous, S ébastien Augustin, Kaitryn E. Ronning, Thibaud Mathis, Frédéric Blond, Pauline Lagouge-Roussey, Sergio Crespo-Garcia, Patrick M. Sullivan, Emmanuel L. Gautier, Nadine Reichhart, José-Alain Sahel, Marie E. Burns, Mi Tags: Research Source Type: research
Transient immune activation without loss of intraepidermal innervation and associated Schwann cells in patients with complex regional pain syndrome
Complex regional pain syndrome (CRPS) develops after injury and is characterized by disproportionate pain, oedema, and functional loss. CRPS has clinical signs of neuropathy as well as neurogenic inflammation.... (Source: Journal of Neuroinflammation)
Source: Journal of Neuroinflammation - January 17, 2024 Category: Neurology Authors: Beate Hartmannsberger, Sabrina Scriba, Carolina Guidolin, Juliane Becker, Katharina Mehling, Kathrin Doppler, Claudia Sommer and Heike L. Rittner Tags: Research Source Type: research
Post-exposure intranasal IFN α suppresses replication and neuroinvasion of Venezuelan Equine Encephalitis virus within olfactory sensory neurons
Venezuelan Equine Encephalitis virus (VEEV) may enter the central nervous system (CNS) within olfactory sensory neurons (OSN) that originate in the nasal cavity after intranasal exposure. While it is known that V... (Source: Journal of Neuroinflammation)
Source: Journal of Neuroinflammation - January 17, 2024 Category: Neurology Authors: Matthew D. Cain, N. Rubin Klein, Xiaoping Jiang, Hamid Salimi, Qingping Wu, Mark J. Miller, William B. Klimstra and Robyn S. Klein Tags: Research Source Type: research
CD4 T-cell aging exacerbates neuroinflammation in a late-onset mouse model of amyotrophic lateral sclerosis
Amyotrophic lateral sclerosis (ALS) is an adult-onset progressive neurodegenerative disorder characterized by the loss of upper and lower motor neurons in the brain and spinal cord. Accumulating evidence sugge... (Source: Journal of Neuroinflammation)
Source: Journal of Neuroinflammation - January 11, 2024 Category: Neurology Authors: Shir Zaccai, Anna Nemirovsky, Livnat Lerner, Leenor Alfahel, Ekaterina Eremenko, Adrian Israelson and Alon Monsonego Tags: Research Source Type: research
Lipoxins A4 and B4 inhibit glial cell activation via CXCR3 signaling in acute retinal neuroinflammation
Lipoxins are small lipids that are potent endogenous mediators of systemic inflammation resolution in a variety of diseases. We previously reported that Lipoxins A4 and B4 (LXA4 and LXB4) have protective activiti... (Source: Journal of Neuroinflammation)
Source: Journal of Neuroinflammation - January 11, 2024 Category: Neurology Authors: Izhar Livne-Bar, Shubham Maurya, Karsten Gronert and Jeremy M. Sivak Tags: Research Source Type: research
Taming microglia: the promise of engineered microglia in treating neurological diseases
Microglia, the CNS-resident immune cells, are implicated in many neurological diseases. Nearly one in six of the world ’s population suffers from neurological disorders, encompassing neurodegenerative and neuro... (Source: Journal of Neuroinflammation)
Source: Journal of Neuroinflammation - January 11, 2024 Category: Neurology Authors: Echo Yongqi Luo and Rio Ryohichi Sugimura Tags: Review Source Type: research
Chorioamnionitis accelerates granule cell and oligodendrocyte maturation in the cerebellum of preterm nonhuman primates
Preterm birth is often associated with chorioamnionitis and leads to increased risk of neurodevelopmental disorders, such as autism. Preterm birth can lead to cerebellar underdevelopment, but the mechanisms of... (Source: Journal of Neuroinflammation)
Source: Journal of Neuroinflammation - January 10, 2024 Category: Neurology Authors: Josef Newman, Xiaoying Tong, April Tan, Toni Yeasky, Vanessa Nunes De Paiva, Pietro Presicce, Paranthaman S. Kannan, Kevin Williams, Andreas Damianos, Marione Tamase Newsam, Merline K. Benny, Shu Wu, Karen C. Young, Lisa A. Miller, Suhas G. Kallapur, Clai Tags: Research Source Type: research
Hepcidin deficiency impairs hippocampal neurogenesis and mediates brain atrophy and memory decline in mice
Hepcidin is the master regulator of iron homeostasis. Hepcidin downregulation has been demonstrated in the brains of Alzheimer ’s disease (AD) patients. However, the mechanism underlying the role of hepcidin do... (Source: Journal of Neuroinflammation)
Source: Journal of Neuroinflammation - January 9, 2024 Category: Neurology Authors: Xue Bai, Bing Wang, Yiduo Cui, Siqi Tian, Yi Zhang, Linhao You, Yan-Zhong Chang and Guofen Gao Tags: Research Source Type: research
A pre-existing Toxoplasma gondii infection exacerbates the pathophysiological response and extent of brain damage after traumatic brain injury in mice
Traumatic brain injury (TBI) is a key contributor to global morbidity that lacks effective treatments. Microbial infections are common in TBI patients, and their presence could modify the physiological respons... (Source: Journal of Neuroinflammation)
Source: Journal of Neuroinflammation - January 9, 2024 Category: Neurology Authors: Tamara L. Baker, David K. Wright, Alessandro D. Uboldi, Christopher J. Tonkin, Anh Vo, Trevor Wilson, Stuart J. McDonald, Richelle Mychasiuk, Bridgette D. Semple, Mujun Sun and Sandy R. Shultz Tags: Research Source Type: research
The microRNA-211-5p/P2RX7/ERK/GPX4 axis regulates epilepsy-associated neuronal ferroptosis and oxidative stress
Ferroptosis is an iron-dependent cell death mechanism involving the accumulation of lipid peroxides. As a critical regulator, glutathione peroxidase 4 (GPX4) has been demonstrated to be downregulated in epilep... (Source: Journal of Neuroinflammation)
Source: Journal of Neuroinflammation - January 8, 2024 Category: Neurology Authors: Xueying Li, Pusheng Quan, Yao Si, Fei Liu, Yuwei Fan, Feifan Ding, Lina Sun, Han Liu, Shuo Huang, Linlin Sun, Fan Yang and Lifen Yao Tags: Research Source Type: research
Oxidative stress and inflammation cause auditory system damage via glial cell activation and dysregulated expression of gap junction proteins in an experimental model of styrene-induced oto/neurotoxicity
Redox imbalance and inflammation have been proposed as the principal mechanisms of damage in the auditory system, resulting in functional alterations and hearing loss. Microglia and astrocytes play a crucial r... (Source: Journal of Neuroinflammation)
Source: Journal of Neuroinflammation - January 4, 2024 Category: Neurology Authors: Fabiola Paciello, Anna Pisani, Rolando Rolesi, Raffaele Montuoro, Veronica Mohamed-Hizam, Giammarco Boni, Cristian Ripoli, Jacopo Galli, Renata Sisto, Anna Rita Fetoni and Claudio Grassi Tags: Research Source Type: research
