Lipopolysaccharide-binding protein and future Parkinson ’s disease risk: a European prospective cohort
Lipopolysaccharide (LPS) is the outer membrane component of Gram-negative bacteria. LPS-binding protein (LBP) is an acute-phase reactant that mediates immune responses triggered by LPS and has been used as a b... (Source: Journal of Neuroinflammation)
Source: Journal of Neuroinflammation - July 21, 2023 Category: Neurology Authors: Yujia Zhao, Douglas I. Walker, Christina M. Lill, Bastiaan R. Bloem, Sirwan K. L. Darweesh, Brismar Pinto-Pacheco, Brooklyn McNeil, Gary W. Miller, Alicia K. Heath, Myrthe Frissen, Dafina Petrova, Maria-Jose S ánchez, María-Dolores Chirlaque, Marcela Gu Tags: Research Source Type: research
Cerebrospinal fluid GFAP is a predictive biomarker for conversion to dementia and Alzheimer ’s disease-associated biomarkers alterations among de novo Parkinson’s disease patients: a prospective cohort study
Dementia is a prevalent non-motor manifestation among individuals with advanced Parkinson ’s disease (PD). Glial fibrillary acidic protein (GFAP) is an inflammatory marker derived from astrocytes. Research has ... (Source: Journal of Neuroinflammation)
Source: Journal of Neuroinflammation - July 20, 2023 Category: Neurology Authors: Tingting Liu, Hongzhou Zuo, Di Ma, Dan Song, Yuying Zhao and Oumei Cheng Tags: Research Source Type: research
Gastrointestinal microbiome of ARDS patients induces neuroinflammation and cognitive impairment in mice
Acute respiratory distress syndrome (ARDS) is a respiratory failure syndrome that can cause many complications, impacting patients ’ quality of life. Behavioral and cognitive disorders have attracted increasing... (Source: Journal of Neuroinflammation)
Source: Journal of Neuroinflammation - July 15, 2023 Category: Neurology Authors: Hong Zheng, Qihui Zhao, Jianuo Chen, Jiahui Lu, Yuping Li and Hongchang Gao Tags: Research Source Type: research
Tau and neuroinflammation in Alzheimer ’s disease: interplay mechanisms and clinical translation
Alzheimer ’s Disease (AD) contributes to most cases of dementia. Its prominent neuropathological features are the extracellular neuritic plaques and intercellular neurofibrillary tangles composed of aggregated ... (Source: Journal of Neuroinflammation)
Source: Journal of Neuroinflammation - July 14, 2023 Category: Neurology Authors: Yijun Chen and Yang Yu Tags: Review Source Type: research
Transfer of patient ’s peripheral blood mononuclear cells (PBMCs) disrupts blood–brain barrier and induces anti-NMDAR encephalitis: a study of novel humanized PBMC mouse model
Anti-N-methyl-D-aspartate receptor (NMDAR) encephalitis is a severe autoimmune neuropsychiatric disease. Brain access of anti-NMDAR autoantibody through the blood –brain barrier (BBB) is essential for pathogene... (Source: Journal of Neuroinflammation)
Source: Journal of Neuroinflammation - July 13, 2023 Category: Neurology Authors: Yaqing Shu, Fuhua Peng, Bingchu Zhao, Chunxin Liu, Qihui Li, Huilu Li, Yuge Wang, Yanjun Jiang, Tingting Lu, Qin Wang, Jian Sun, Huiyu Feng, Zhengqi Lu, Xiaodong Liu, Jie Wang and Wei Qiu Tags: Research Source Type: research
Disease-modifying effects of a glial-targeted inducible nitric oxide synthase inhibitor (1400W) in mixed-sex cohorts of a rat soman (GD) model of epilepsy
Acute exposure to seizurogenic organophosphate (OP) nerve agents (OPNA) such as diisopropylfluorophosphate (DFP) or soman (GD), at high concentrations, induce immediate status epilepticus (SE), reactive gliosis, ... (Source: Journal of Neuroinflammation)
Source: Journal of Neuroinflammation - July 12, 2023 Category: Neurology Authors: Suraj S. Vasanthi, Nikhil S. Rao, Manikandan Samidurai, Nyzil Massey, Christina Meyer, Meghan Gage, Mihir Kharate, Aida Almanza, Logan Wachter, Candide Mafuta, Lily Trevino, Adriana M. Carlo, Elijah Bryant, Brooke E. Corson, Morgan Wohlgemuth, Morgan Ostr Tags: Research Source Type: research
NLRP3 –GABA signaling pathway contributes to the pathogenesis of impulsive-like behaviors and cognitive deficits in aged mice
Perioperative neurocognitive disorders (PND), such as delirium and cognitive impairment, are commonly encountered complications in aged patients. The inhibitory neurotransmitter γ-aminobutyric acid (GABA) is a... (Source: Journal of Neuroinflammation)
Source: Journal of Neuroinflammation - July 11, 2023 Category: Neurology Authors: Lu-Ying Wang, Xu-Peng Wang, Jin-Meng Lv, Yu-Dong Shan, Shi-Yan Jia, Zhi-Fang Yu, Hui-Tao Miao, Yue Xin, Dong-Xue Zhang and Li-Min Zhang Tags: Research Source Type: research
Astrocyte-derived SerpinA3N promotes neuroinflammation and epileptic seizures by activating the NF- κB signaling pathway in mice with temporal lobe epilepsy
Impaired activation and regulation of the extinction of inflammatory cells and molecules in injured neuronal tissues are key factors in the development of epilepsy. SerpinA3N is mainly associated with the acut... (Source: Journal of Neuroinflammation)
Source: Journal of Neuroinflammation - July 8, 2023 Category: Neurology Authors: Chong Liu, Xue-Min Zhao, Qiao Wang, Ting-Ting Du, Mo-Xuan Zhang, Hui-Zhi Wang, Ren-Peng Li, Kun Liang, Yuan Gao, Si-Yu Zhou, Tao Xue, Jian-Guo Zhang, Chun-Lei Han, Lin Shi, Liang-Wen Zhang and Fan-Gang Meng Tags: Research Source Type: research
Correction: Smek1 deficiency exacerbates experimental autoimmune encephalomyelitis by activating proinflammatory microglia and suppressing the IDO1-AhR pathway
(Source: Journal of Neuroinflammation)
Source: Journal of Neuroinflammation - July 6, 2023 Category: Neurology Authors: Ruo-Nan Duan, Chun-Lin Yang, Tong Du, Ai Liu, An-Ran Wang, Wen-Jie Sun, Xi Li, Jiang-Xia Li, Chuan-Zhu Yan and Qi-Ji Liu Tags: Correction Source Type: research
The aging ovary impairs acute stroke outcomes
In experimental stroke, ovariectomized (OVX) adult rats have larger infarct volumes and greater sensory-motor impairment as compared to ovary-intact females and is usually interpreted to indicate that ovarian ... (Source: Journal of Neuroinflammation)
Source: Journal of Neuroinflammation - July 5, 2023 Category: Neurology Authors: Taylor E. Branyan, Jocelyn Aleksa, Esteban Lepe, Kelby Kosel and Farida Sohrabji Tags: Research Source Type: research
Caudal DMN neurons innervate the spleen and release CART peptide to regulate neuroimmune function
Inflammation is a fundamental biological response to injury and infection, which if unregulated can contribute to the pathophysiology of many diseases. The vagus nerve, which primarily originates from the dors... (Source: Journal of Neuroinflammation)
Source: Journal of Neuroinflammation - July 4, 2023 Category: Neurology Authors: Nobuhide Kobori, Anthony N. Moore, John B. Redell and Pramod K. Dash Tags: Research Source Type: research
Neuroprotective effects of GSK-343 in an in vivo model of MPTP-induced nigrostriatal degeneration
Parkinson ’s disease (PD) is characterized by the degeneration of dopaminergic nigrostriatal neurons, which causes disabling motor disorders. Scientific findings support the role of epigenetics mechanism in the... (Source: Journal of Neuroinflammation)
Source: Journal of Neuroinflammation - June 30, 2023 Category: Neurology Authors: Deborah Mannino, Sarah Adriana Scuderi, Giovanna Casili, Valentina Bova, Laura Cucinotta, Marika Lanza, Alessia Filippone, Emanuela Esposito and Irene Paterniti Tags: Research Source Type: research
Endothelial progenitor cell-derived exosomes promote anti-inflammatory macrophages via SOCS3/JAK2/STAT3 axis and improve the outcome of spinal cord injury
Macrophage in the spinal cord injury (SCI) area imparts a chronic pro-inflammation effect that challenges the recovery of SCI. Previously, endothelial progenitor cell-produced exosomes (EPC-EXOs) have been not... (Source: Journal of Neuroinflammation)
Source: Journal of Neuroinflammation - June 30, 2023 Category: Neurology Authors: Feifei Yuan, Wei Peng, Yuying Yang, Jiaqi Xu, Yudong Liu, Yong Xie, Tingmo Huang, Chaoran Shi, Yinghe Ding, Chengjun Li, Tian Qin, Shanshan Xie, Fengzhang Zhu, Hongbin Lu, Jianjun Huang and Jianzhong Hu Tags: Research Source Type: research
CD200 in dentate gyrus improves depressive-like behaviors of mice through enhancing hippocampal neurogenesis via alleviation of microglia hyperactivation
Neuroinflammation and microglia play critical roles in the development of depression. Cluster of differentiation 200 (CD200) is an anti-inflammatory glycoprotein that is mainly expressed in neurons, and its re... (Source: Journal of Neuroinflammation)
Source: Journal of Neuroinflammation - June 30, 2023 Category: Neurology Authors: Xi Chen, Qian-Qian Cui, Xiao-Hai Hu, Jian Ye, Zi-Cun Liu, Yuan-Xi Mei, Fang Wang, Zhuang-Li Hu and Jian-Guo Chen Tags: Research Source Type: research
Chronic social defeat alters brain vascular-associated cell gene expression patterns leading to vascular dysfunction and immune system activation
Brain vascular integrity is critical for brain health, and its disruption is implicated in many brain pathologies, including psychiatric disorders. Brain-vascular barriers are a complex cellular landscape comp... (Source: Journal of Neuroinflammation)
Source: Journal of Neuroinflammation - June 28, 2023 Category: Neurology Authors: Joshua D. Samuels, Madison L. Lotstein, Michael L. Lehmann, Abdel G. Elkahloun, Subhadra Banerjee and Miles Herkenham Tags: Research Source Type: research
