Integration of National Health Insurance claims data and animal models reveals fexofenadine as a promising repurposed drug for Parkinson ’s disease
Parkinson ’s disease (PD) is a common and costly progressive neurodegenerative disease of unclear etiology. A disease-modifying approach that can directly stop or slow its progression remains a major unmet need... (Source: Journal of Neuroinflammation)
Source: Journal of Neuroinflammation - February 21, 2024 Category: Neurology Authors: Jae-Bong Kim, Yujeong Kim, Soo-Jeong Kim, Tae ‑Young Ha, Dong-Kyu Kim, Dong Won Kim, Minyoung So, Seung Ho Kim, Hyun Goo Woo, Dukyong Yoon and Sang Myun Park Tags: Research Source Type: research
The insular cortex is not insular in thyroid eye disease: neuroimaging revelations of central –peripheral system interaction
This study aimed to explo... (Source: Journal of Neuroinflammation)
Source: Journal of Neuroinflammation - February 17, 2024 Category: Neurology Authors: Haiyang Zhang, Yuting Liu, Duojin Xia, Mengda Jiang, Yinwei Li, Jing Sun, Haixia Guan, Ling Zhu, Xuefei Song, Jue Wang, Xianqun Fan and Huifang Zhou Tags: Research Source Type: research
Combination protein biomarkers predict multiple sclerosis diagnosis and outcomes
Establishing biomarkers to predict multiple sclerosis diagnosis and prognosis has been challenging using a single biomarker approach. We hypothesised that a combination of biomarkers would increase the accurac... (Source: Journal of Neuroinflammation)
Source: Journal of Neuroinflammation - February 17, 2024 Category: Neurology Authors: Eleftheria Kodosaki, W. John Watkins, Sam Loveless, Karim L. Kreft, Aidan Richards, Valerie Anderson, Lisa Hurler, Neil P. Robertson, Wioleta M. Zelek and Emma C. Tallantyre Tags: Research Source Type: research
Advanced patient-specific microglia cell models for pre-clinical studies in Alzheimer ’s disease
Alzheimer ’s disease (AD) is an incurable neurodegenerative disorder with a rapidly increasing prevalence worldwide. Current approaches targeting hallmark pathological features of AD have had no consistent clin... (Source: Journal of Neuroinflammation)
Source: Journal of Neuroinflammation - February 15, 2024 Category: Neurology Authors: Carla Cun í-López, Romal Stewart, Lotta E. Oikari, Tam Hong Nguyen, Tara L. Roberts, Yifan Sun, Christine C. Guo, Michelle K. Lupton, Anthony R. White and Hazel Quek Tags: Research Source Type: research
Intracerebellar injection of monocytic immature myeloid cells prevents the adverse effects caused by stereotactic surgery in a model of cerebellar neurodegeneration
Myeloid-derived suppressor cells (MDSCs) constitute a recently discovered bone-marrow-derived cell type useful for dealing with neuroinflammatory disorders. However, these cells are only formed during inflamma... (Source: Journal of Neuroinflammation)
Source: Journal of Neuroinflammation - February 14, 2024 Category: Neurology Authors: Carlos del Pilar, Luc ía Garrido-Matilla, Lucía del Pozo-Filíu, Rafael Lebrón-Galán, Raúl F. Arias, Diego Clemente, José Ramón Alonso, Eduardo Weruaga and David Díaz Tags: Research Source Type: research
Progranulin haploinsufficiency mediates cytoplasmic TDP-43 aggregation with lysosomal abnormalities in human microglia
Progranulin (PGRN) haploinsufficiency due to progranulin gene (GRN) variants can cause frontotemporal dementia (FTD) with aberrant TAR DNA-binding protein 43 (TDP-43) accumulation. Despite microglial burden with ... (Source: Journal of Neuroinflammation)
Source: Journal of Neuroinflammation - February 13, 2024 Category: Neurology Authors: Wonjae Sung, Min-Young Noh, Minyeop Nahm, Yong Sung Kim, Chang-Seok Ki, Young-Eun Kim, Hee-Jin Kim and Seung Hyun Kim Tags: Research Source Type: research
The role of CD56bright NK cells in neurodegenerative disorders
Emerging evidence suggests a potential role for natural killer (NK) cells in neurodegenerative diseases, such as multiple sclerosis, Alzheimer ’s disease, Parkinson’s disease and amyotrophic lateral sclerosis. ... (Source: Journal of Neuroinflammation)
Source: Journal of Neuroinflammation - February 13, 2024 Category: Neurology Authors: Carla Rodriguez-Mogeda, Chaja M. J. van Ansenwoude, Lennart van der Molen, Eva M. M. Strijbis, Reina E. Mebius and Helga E. de Vries Tags: Review Source Type: research
Inflammatory biomarkers for neurobehavioral dysregulation in former American football players: findings from the DIAGNOSE CTE Research Project
Traumatic encephalopathy syndrome (TES) is defined as the clinical manifestation of the neuropathological entity chronic traumatic encephalopathy (CTE). A core feature of TES is neurobehavioral dysregulation (... (Source: Journal of Neuroinflammation)
Source: Journal of Neuroinflammation - February 9, 2024 Category: Neurology Authors: Suzan van Amerongen, Surya V. Pulukuri, Fatima Tuz-Zahra, Yorghos Tripodis, Jonathan D. Cherry, Charles Bernick, Yonas E. Geda, Jennifer V. Wethe, Douglas I. Katz, Michael L. Alosco, Charles H. Adler, Laura J. Balcer, Nicholas J. Ashton, Kaj Blennow, Henr Tags: Research Source Type: research
Peritoneal sepsis caused by Escherichia coli triggers brainstem inflammation and alters the function of sympatho-respiratory control circuits
Sepsis has a high mortality rate due to multiple organ failure. However, the influence of peripheral inflammation on brainstem autonomic and respiratory circuits in sepsis is poorly understood. Our working hyp... (Source: Journal of Neuroinflammation)
Source: Journal of Neuroinflammation - February 8, 2024 Category: Neurology Authors: Gjinovefa Kola, Caitlyn W. Clifford, Cara K. Campanaro, Rishi R. Dhingra, Mathias Dutschmann, Frank J. Jacono and Thomas E. Dick Tags: Research Source Type: research
Mitochondrial stress: a key role of neuroinflammation in stroke
Stroke is a clinical syndrome characterized by an acute, focal neurological deficit, primarily caused by the occlusion or rupture of cerebral blood vessels. In stroke, neuroinflammation emerges as a pivotal ev... (Source: Journal of Neuroinflammation)
Source: Journal of Neuroinflammation - February 6, 2024 Category: Neurology Authors: Ling Gao, Li Peng, Jian Wang, John H. Zhang and Ying Xia Tags: Review Source Type: research
Th1 cells contribute to retinal ganglion cell loss in glaucoma in a VCAM-1-dependent manner
Glaucoma is a complex neurodegenerative disorder characterized by the progressive loss of retinal ganglion cells (RGC) and optic nerve axons, leading to irreversible visual impairment. Despite its clinical sig... (Source: Journal of Neuroinflammation)
Source: Journal of Neuroinflammation - February 5, 2024 Category: Neurology Authors: Chong He, Kun Peng, Xiong Zhu, Zuo Wang, Wenbo Xiu, Gao Zhang, Yang Chen, Chaonan Sun, Xiao Xiao, Donghua Liu, An Li, Yanping Gao, Jinxia Wang, Ping Shuai, Yilian Chen, Ling Yu & hellip; Tags: Research Source Type: research
Fractalkine isoforms differentially regulate microglia-mediated inflammation and enhance visual function in the diabetic retina
Diabetic retinopathy (DR) affects about 200 million people worldwide, causing leakage of blood components into retinal tissues, leading to activation of microglia, the resident phagocytes of the retina, promot... (Source: Journal of Neuroinflammation)
Source: Journal of Neuroinflammation - February 4, 2024 Category: Neurology Authors: Derek Rodriguez, Kaira A. Church, Alicia N. Pietramale, Sandra M. Cardona, Difernando Vanegas, Colin Rorex, Micah C. Leary, Isabel A. Muzzio, Kevin R. Nash and Astrid E. Cardona Tags: Research Source Type: research
Immunoregulatory and neutrophil-like monocyte subsets with distinct single-cell transcriptomic signatures emerge following brain injury
Monocytes represent key cellular elements that contribute to the neurological sequela following brain injury. The current study reveals that trauma induces the augmented release of a transcriptionally distinct... (Source: Journal of Neuroinflammation)
Source: Journal of Neuroinflammation - February 3, 2024 Category: Neurology Authors: Erwin K. Gudenschwager Basso, Jing Ju, Eman Soliman, Caroline de Jager, Xiaoran Wei, Kevin J. Pridham, Michelle L. Olsen and Michelle H. Theus Tags: Research Source Type: research
Long-term impact of maternal obesity on the gliovascular unit and ephrin signaling in the hippocampus of adult offspring
Children born to obese mothers are at increased risk of developing mood disorders and cognitive impairment. Experimental studies have reported structural changes in the brain such as the gliovascular unit as w... (Source: Journal of Neuroinflammation)
Source: Journal of Neuroinflammation - February 2, 2024 Category: Neurology Authors: Seyedeh Marziyeh Jabbari Shiadeh, Fanny Goretta, Pernilla Svedin, Thomas Jansson, Carina Mallard and Maryam Ardalan Tags: Research Source Type: research
Exercise mimetics: a novel strategy to combat neuroinflammation and Alzheimer ’s disease
Neuroinflammation is a pathological hallmark of Alzheimer ’s disease (AD), characterized by the stimulation of resident immune cells of the brain and the penetration of peripheral immune cells. These inflammato... (Source: Journal of Neuroinflammation)
Source: Journal of Neuroinflammation - February 2, 2024 Category: Neurology Authors: Renqing Zhao Tags: Review Source Type: research
