STING inhibition suppresses microglia-mediated synapses engulfment and alleviates motor functional deficits after stroke
Ischemic stroke is the leading cause of adult disability. Ischemia leads to progressive neuronal death and synapse loss. The engulfment of stressed synapses by microglia further contributes to the disruption o... (Source: Journal of Neuroinflammation)
Source: Journal of Neuroinflammation - April 8, 2024 Category: Neurology Authors: Chaoran Wu, Shiwen Zhang, Hao Sun, Ao Li, Fengsheng Hou, Long Qi and Hong Liao Tags: Research Source Type: research
Impact of microglia isolation and culture methodology on transcriptional profile and function
This study aims to evaluate five differ... (Source: Journal of Neuroinflammation)
Source: Journal of Neuroinflammation - April 8, 2024 Category: Neurology Authors: Mark Mizrachi and Betty Diamond Tags: Research Source Type: research
Profiling of long non-coding RNAs in hippocampal –entorhinal system subfields: impact of RN7SL1 on neuroimmune response modulation in Alzheimer’s disease
Alzheimer ’s disease (AD) is recognized as the predominant cause of dementia, and neuroimmune processes play a pivotal role in its pathological progression. The involvement of long non-coding RNAs (lncRNAs) in ... (Source: Journal of Neuroinflammation)
Source: Journal of Neuroinflammation - April 6, 2024 Category: Neurology Authors: Hanyou Liu, Jingying Li, Xue Wang, Shiqi Luo, Dan Luo, Wei Ge and Chao Ma Tags: Research Source Type: research
Extracellular vesicle encapsulated Homer1a as novel nanotherapeutics against intracerebral hemorrhage in a mouse model
Homer1a and A2 astrocytes are involved in the regulation of inflammation induced by intracerebral hemorrhage (ICH). However, there is no anticipated treatment strategy based on the anti-inflammatory effect of ... (Source: Journal of Neuroinflammation)
Source: Journal of Neuroinflammation - April 6, 2024 Category: Neurology Authors: Xiaowei Fei, Li Wang, Ya-nan Dou, Fei Fei, Yanyu Zhang, Weihao Lv, Xin He, Xiuquan Wu, Wangshu Chao, Hongqing Chen, Jialiang Wei, Dakuan Gao and Zhou Fei Tags: Research Source Type: research
Bi-directional neuro-immune dysfunction after chronic experimental brain injury
It is well established that traumatic brain injury (TBI) causes acute and chronic alterations in systemic immune function and that systemic immune changes contribute to posttraumatic neuroinflammation and neur... (Source: Journal of Neuroinflammation)
Source: Journal of Neuroinflammation - April 5, 2024 Category: Neurology Authors: Rodney M. Ritzel, Yun Li, Yun Jiao, Sarah J. Doran, Niaz Khan, Rebecca J. Henry, Kavitha Brunner, David J. Loane, Alan I. Faden, Gregory L. Szeto and Junfang Wu Tags: Research Source Type: research
Cranial irradiation disrupts homeostatic microglial dynamic behavior
Cranial irradiation causes cognitive deficits that are in part mediated by microglia, the resident immune cells of the brain. Microglia are highly reactive, exhibiting changes in shape and morphology depending... (Source: Journal of Neuroinflammation)
Source: Journal of Neuroinflammation - April 3, 2024 Category: Neurology Authors: Alexandra O. Strohm, Carl Johnston, Eric Hernady, Brian Marples, M. Kerry O ’Banion and Ania K. Majewska Tags: Research Source Type: research
Metformin normalizes mitochondrial function to delay astrocyte senescence in a mouse model of Parkinson ’s disease through Mfn2-cGAS signaling
Senescent astrocytes play crucial roles in age-associated neurodegenerative diseases, including Parkinson ’s disease (PD). Metformin, a drug widely used for treating diabetes, exerts longevity effects and neuro... (Source: Journal of Neuroinflammation)
Source: Journal of Neuroinflammation - April 2, 2024 Category: Neurology Authors: Min Wang, Tian Tian, Hong Zhou, Si-Yuan Jiang, Ying-Ying Jiao, Zhu Zhu, Jiang Xia, Jian-Hua Ma and Ren-Hong Du Tags: Research Source Type: research
Hypoxia inducible factor-1 α regulates microglial innate immune memory and the pathology of Parkinson’s disease
Neuroinflammation is one of the core pathological features of Parkinson ’s disease (PD). Innate immune cells play a crucial role in the progression of PD. Microglia, the major innate immune cells in the brain, ... (Source: Journal of Neuroinflammation)
Source: Journal of Neuroinflammation - March 30, 2024 Category: Neurology Authors: Hongtian Dong, Xiaoshuang Zhang, Yufei Duan, Yongtao He, Jiayin Zhao, Zishan Wang, Jinghui Wang, Qing Li, Guangchun Fan, Zhaolin Liu, Chenye Shen, Yunhe Zhang, Mei Yu, Jian Fei and Fang Huang Tags: Research Source Type: research
The immunomodulatory effect of oral NaHCO3 is mediated by the splenic nerve: multivariate impact revealed by artificial neural networks
Stimulation of the inflammatory reflex (IR) is a promising strategy for treating systemic inflammatory disorders. Recent studies suggest oral sodium bicarbonate (NaHCO3) as a potential activator of the IR, offeri... (Source: Journal of Neuroinflammation)
Source: Journal of Neuroinflammation - March 28, 2024 Category: Neurology Authors: Milena Rodriguez Alvarez, Hussam Alkaissi, Aja M. Rieger, Guillem R. Esber, Manuel E. Acosta, Stacy I. Stephenson, Allison V. Maurice, Laura Melissa Rodr íguez Valencia, Christopher A. Roman and Juan Marcos Alarcon Tags: Research Source Type: research
Liver-specific adiponectin gene therapy suppresses microglial NLRP3-inflammasome activation for treating Alzheimer ’s disease
Adiponectin (APN) is an adipokine which predominantly expresses in adipocytes with neuroprotective and anti-inflammatory effects. We have recently indicated that circulatory trimeric APN can enter the brain by... (Source: Journal of Neuroinflammation)
Source: Journal of Neuroinflammation - March 27, 2024 Category: Neurology Authors: Roy Chun-Laam Ng, Min Jian, Oscar Ka-Fai Ma, Ariya Weiman Xiang, Myriam Bunting, Jason Shing-Cheong Kwan, Curtis Wai-Kin Wong, Leung-Wah Yick, Sookja Kim Chung, Karen Siu-Ling Lam, Ian E. Alexander, Aimin Xu and Koon-Ho Chan Tags: Research Source Type: research
Changes in lipid metabolism track with the progression of neurofibrillary pathology in tauopathies
Accumulation of tau leads to neuroinflammation and neuronal cell death in tauopathies, including Alzheimer ’s disease. As the disease progresses, there is a decline in brain energy metabolism. However, the role... (Source: Journal of Neuroinflammation)
Source: Journal of Neuroinflammation - March 27, 2024 Category: Neurology Authors: Dominika Ole šová, Dana Dobešová, Petra Majerová, Radana Brumarová, Aleš Kvasnička, Štěpán Kouřil, Eva Stevens, Jozef Hanes, Ľubica Fialová, Alena Michalicová, Juraj Piešťanský, Jakub Šinský, Petr Kaňovský, David Friedecký and Andre Tags: Research Source Type: research
Wnt5a/ β-catenin-mediated epithelial-mesenchymal transition: a key driver of subretinal fibrosis in neovascular age-related macular degeneration
Neovascular age-related macular degeneration (nAMD), accounts for up to 90% of AMD-associated vision loss, ultimately resulting in the formation of fibrotic scar in the macular region. The pathogenesis of subr... (Source: Journal of Neuroinflammation)
Source: Journal of Neuroinflammation - March 26, 2024 Category: Neurology Authors: Dandan Liu, Jingxiao Du, Hai Xie, Haibin Tian, Lixia Lu, Chaoyang Zhang, Guo-Tong Xu and Jingfa Zhang Tags: Research Source Type: research
Single-cell RNA sequencing reveals the immune features and viral tropism in the central nervous system of mice infected with Japanese encephalitis virus
Japanese encephalitis virus (JEV) is a neurotropic pathogen that causes lethal encephalitis. The high susceptibility and massive proliferation of JEV in neurons lead to extensive neuronal damage and inflammati... (Source: Journal of Neuroinflammation)
Source: Journal of Neuroinflammation - March 26, 2024 Category: Neurology Authors: Ling ’en Yang, Junyao Xiong, Yixin Liu, Yinguang Liu, Xugang Wang, Youhui Si, Bibo Zhu, Huanchun Chen, Shengbo Cao and Jing Ye Tags: Research Source Type: research
P2X7 receptor antagonists modulate experimental autoimmune neuritis via regulation of NLRP3 inflammasome activation and Th17 and Th1 cell differentiation
Guillain –Barré syndrome (GBS), a post-infectious, immune-mediated, acute demyelinating disease of the peripheral nerves and nerve roots, represents the most prevalent and severe acute paralyzing neuropathy. Pu... (Source: Journal of Neuroinflammation)
Source: Journal of Neuroinflammation - March 25, 2024 Category: Neurology Authors: Yuhan Xie, Ranran Han, Yulin Li, Weiya Li, Shichao Zhang, Yu Wu, Yuexin Zhao, Rongrong Liu, Jie Wu, Wei Jiang and Xiuju Chen Tags: Research Source Type: research
The mouse retinal pigment epithelium mounts an innate immune defense response following retinal detachment
The retinal pigment epithelium (RPE) maintains photoreceptor viability and function, completes the visual cycle, and forms the outer blood-retinal barrier (oBRB). Loss of RPE function gives rise to several mon... (Source: Journal of Neuroinflammation)
Source: Journal of Neuroinflammation - March 25, 2024 Category: Neurology Authors: Steven F. Abcouwer, Bruna Miglioranza Scavuzzi, Phillip E. Kish, Dejuan Kong, Sumathi Shanmugam, Xuan An Le, Jingyu Yao, Heather Hager and David N Zacks Tags: Research Source Type: research
