Design, synthesis, and characterization of novel system xC − transport inhibitors: inhibition of microglial glutamate release and neurotoxicity

Neuroinflammation appears to involve some degree of excitotoxicity promulgated by microglia, which release glutamate via the system xC − (SxC−) cystine-glutamate antiporter. With the aim of mitigating this source ...

Source: Journal of Neuroinflammation - December 6, 2023 Category: Neurology Authors: Mariusz P. Gajewski and Steven W. Barger Tags: Research Source Type: research