Nodular lymphocyte-predominant Hodgkin lymphoma and clinical impact of its variant histology: a clinicopathologic study from tertiary cancer centre in India
AbstractNodular lymphocyte-predominant Hodgkin lymphoma (NLPHL) can show variant histological patterns, some of which may be associated with an advanced stage and increased relapse rate. Through this study, we put the various histological patterns of NLPHL under spotlight and assess their prognostic implications. A retrospective histologic and immunohistochemistry review of all archival slides of NLPHL over a period of 6 years was performed. A total of 36 cases were identified. We recognised the typical (A, B) and histopathologic variant patterns (C to F) of NLPHL as per the criteria given by Fan et al. and scored these ...
Source: Journal of Hematopathology - August 23, 2022 Category: Pathology Source Type: research
The risk and prognostic influence of caspase 9 promotor polymorphisms in Egyptian patients with acute myeloid leukemia
This study was to evaluate these polymorphisms in an independent cohort of AML patients and controls in Egypt. PCR–RFLP forCASP9 1263 rs4645978 A > G andCASP9 712 rs4645981 C > T genotypes were done in 60 de novo AML cases and 40 healthy control subjects. Our study showed thatCASP9 712 rs4645981 C > T gene polymorphism is associated with increased risk of developing AML and poor disease outcome (p value = 0.006, < 0.001;OR = 3.644, 26; and95% CI = 1.39–9.528, 6.5–103.5, respectively). In contrast,CASP9 1263 rs4645978 A > G showed no significant difference betwee...
Source: Journal of Hematopathology - August 6, 2022 Category: Pathology Source Type: research
De novo acute myeloid leukemia harboring concomitant t(8;21)(q22;q22);RUNX1::RUNX1T1 and BCR::ABL1 (p190 minor transcript)
We present a 34-year-old male patient with de novo AML harboring concomitant t(8;21) and t(9;22) in a single clone. The presence of both t(8;21) and Philadelphia chromosome (Ph+) in the same metaphases but in less than 100% of the analyzed cells, the p190 BCR::ABL transcript type, and absence of splenomegaly support that additional BCR::ABL1+ is a part of the main leukemic clone. These findings, accompanied with an encouraging outcome of continuous cytogenetic and molecular remission after induction therapy, support BCR::ABL1 being a secondary genetic event in AML with t(8;21). (Source: Journal of Hematopathology)
Source: Journal of Hematopathology - July 31, 2022 Category: Pathology Source Type: research
EBV-positive follicular lymphoma and concurrent EBV-negative diffuse large B-cell lymphoma illustrating branched evolution model and “Hit and Run” hypothesis
In this report, we describe a case of EBV-positive FL and concurrent EBV-negative diffuse large B-cell lymphoma (DLBCL), and discuss their clonal relationship, and EBV status in the process of disease progression. Histology, immunohistochemistry, in situ hybridization, and next-generation sequencing studies were performed as previously described. The 58-year-old male presented with extensive axillary and subpectoral lymphadenopathy. The patient had a history of mixed connective tissue disease treated in the past with steroids and methotrexate, and at the time of current presentation with hydroxychloroquine. The excision of...
Source: Journal of Hematopathology - July 28, 2022 Category: Pathology Source Type: research
Marrow cryptococcosis in an autologous stem cell transplant patient after standard therapy for cryptococcal meningitis
AbstractThe patient is a woman in her 60s with a history of plasma cell myeloma, status post high-dose melphalan and autologous stem cell transplant, followed by maintenance lenalidomide. She was admitted for severe headaches with concern for meningitis. CSF culture yieldedCryptococcus neoformans. Cryptococcal antigen was present at high titer in the CSF (1:640) but was negative in serum. A diagnosis of cryptococcal meningitis was rendered. She was treated with over 2 weeks of intravenous amphotericin plus flucytosine. Upon discharge, her CSF cryptococcal antigen test remained positive (1:2560) but CSF culture was negati...
Source: Journal of Hematopathology - July 21, 2022 Category: Pathology Source Type: research
Extramedullary hematopoiesis in β-thalassemia major patient: a case report and review of the literature
AbstractExtramedullary hematopoiesis (EMH), as a compensatory phenomenon, refers to the blood cell formation outside of the bone marrow that occurs once the cells in the circulatory system fail to meet individuals ’ needs. EMH is rare in moderate to severe beta thalassemia because most symptomatic patients are effectively managed with transfusion. However, patients that fail to receive transfusions like β-thalassemia intermedia (β-TI) as indicated are at increased risk for developing EMH. This paper descr ibes the case of a 15-year-old female adolescent with β-thalassemia major (β-TM), suffering from a rare form of E...
Source: Journal of Hematopathology - July 15, 2022 Category: Pathology Source Type: research
Familial hemophagocytic lymphohistiocytosis with Epstein –Barr virus infection and progression to aggressive NK-cell leukemia: a case report and review of the literature
We report a rare case of FHLH with EBV infection that mimicked CAEBV-T/NK, but progressed to childhood aggressive natural killer cell leukemia (ANKL). The patient is in clinical remission following allogeneic hematopoietic stem cell tran splantation (allo-HSCT). Our reported case suggests that patients with FHLH and EBV infection, especially those with symptoms similar to those of CAEBV-T/NK, may rapidly progress to ANKL or other neoplastic diseases. Therefore, we must be aware of these cases to ensure that patients are diagnosed co rrectly so they can be treated appropriately and in a timely manner. (Source: Journal of Hematopathology)
Source: Journal of Hematopathology - July 14, 2022 Category: Pathology Source Type: research
Mediastinal B-cell lymphoma with MYC, BCL2, and BCL6 rearrangements
AbstractPrimary mediastinal B-cell lymphoma (PMBL) is a rare but aggressive form of non-Hodgkin lymphoma (NHL) that shares significant overlap with Diffuse large B-cell lymphoma (DLBCL). Double- (DH) and triple-hit (TH) lymphomas are aggressive B-cell lymphomas with translocations involvingMYC + BCL2 or BCL6 andMYC + BCL2 + BCL6, respectively. There are only 2 previous reports of DH in PMBL and no reports of TH. Here, we present the case of a 23-year-old female with post-treatment relapse of PMBL into a PMBL-TH, after initially presenting withMYC but without eitherBCL2 orBCL6 rearrangement. Immunohistochemistry...
Source: Journal of Hematopathology - July 14, 2022 Category: Pathology Source Type: research
An atypical plasmablastic proliferation — should we suspect vedolizumab?
AbstractWe chronicle a case of an atypical plasmablastic proliferation in a patient occurring in the context of vedolizumab, a novel therapy for the treatment of inflammatory bowel disease (IBD). No documented cases exist of this potential association, and we propose a pathogenic mechanism. A 22-year-old female with IBD had a flare of colitis and required a subtotal colectomy. She had been on vedolizumab for 2 years. Histology revealed indeterminate colitis but discovered a densely cellular polypoid lesion of plasmablasts and plasma cells of varying maturation, positive for MUM1, BLIMP1, c-myc, IgG, and CD138, with a lam...
Source: Journal of Hematopathology - July 13, 2022 Category: Pathology Source Type: research
Kikuchi –Fujimoto disease in a child who had a high suspicion of COVID-19 infection
(Source: Journal of Hematopathology)
Source: Journal of Hematopathology - May 31, 2022 Category: Pathology Source Type: research
Correction to: What, how, and when for the WHO: will the clock be turned back for the next hematolymphoid tumor classification?
(Source: Journal of Hematopathology)
Source: Journal of Hematopathology - May 27, 2022 Category: Pathology Source Type: research
Reversible follicular lymphoid hyperplasia related with dasatinib: first case report from Turkey
AbstractChronic myeloid leukemia (CML) is a clonal hematopoietic stem cell disorder characterized by the presence of a cytogenetic abnormality, the Philadelphia (Ph) chromosome. BCR-ABL tyrosine kinase inhibitors (TKIs) have revolutionized the treatment of chronic myeloid leukemia (CML). Patients who respond to treatment achieve a near-normal life expectancy. In this case report, we present the first case from Turkey of reversible follicular lymphoid hyperplasia (FLH) related to the use of a second-generation TKI, dasatinib. A peripheral blood specimen was evaluated by double-fusion fluorescence in situ hybridization (FISH...
Source: Journal of Hematopathology - May 24, 2022 Category: Pathology Source Type: research
Academic boycotts of Russian science: where does the Journal of Hematopathology stand?
(Source: Journal of Hematopathology)
Source: Journal of Hematopathology - May 24, 2022 Category: Pathology Source Type: research
High expression of OX-40, ICOS, and low expression PD-L1 of follicular helper and follicular cytotoxic T cells in chronic lymphocytic leukemia
In this study, peripheral blood mononuclear cells (PBMCs) were isolated from heparinized blood samples by density gradient centrifugation using Ficoll-Paque from 34 CLL patients and 19 healthy subjects. The expression of ICOS, OX-40, and PD-L1 of TFC and TFH cells in CLL patients was investigated by flow cytometry. According to healthy subjects, TFH and TFC cell levels were increased in CLL patients. High-ICOS and low-PD-L1 expression in TFH cells and high OX-40 and ICOS, low-PD-L1 expression in TFC cells of CLL patients compared to healthy subjects. OX-40 expression was positively correlated with TFH and TFC cells levels ...
Source: Journal of Hematopathology - May 17, 2022 Category: Pathology Source Type: research
Case report of a patient with chronic myeloid leukemia, BCR::ABL1 positive presented with isolated thrombocytosis and an uncommon JAK2 alteration detected in peripheral blood
This report highlights the importance of pursuingBCR::ABL1 testing in the workup of patients with isolated thrombocytosis, even in the presence of abnormalJAK2 transcripts and unusual bone marrow features. (Source: Journal of Hematopathology)
Source: Journal of Hematopathology - May 10, 2022 Category: Pathology Source Type: research
