Is there a relationship between the clinicopathological features of classic Hodgkin lymphoma subtypes and an increase in IgG4-positive plasma cells?
AbstractAn IgG4 ( +) plasma cell increase can be observed in classic Hodgkin lymphoma (CHL) in addition to IgG4-related disease. IgG4 ( +) plasma cells can affect therapy or prognosis in CHL because the microenvironment of CHL can help cancer escape immune surveillance. Therefore, we aimed to determine the relat ionship between IgG4 ( +) plasma cell increase and the clinicopathological parameters of CHL subtypes. A total of 76 cases diagnosed with CHL by lymph node excision between 2006 and 2020 in our hospital were selected. The probable histological features of IgG4-related disease were utilized for dia gnosis. Th...
Source: Journal of Hematopathology - April 13, 2021 Category: Pathology Source Type: research
Bone marrow aspiration and gross appearance of trephine biopsy in routine practice: a preliminary descriptive data on 176 consecutive cases from a single tertiary care center in South India
The objective was to study the usefulness of on-site procedural information in routine marrow reporting. The nature of marrow aspirate, gross appearance, and core length of iliac crest trephine biopsies from 174 consecutive subjects (109 males, 65 females, mean age 47.5 ± 19.2 years) were reviewed by a pathologist blinded to the final diagnosis. The nature of aspirate had a significant correlation with a positive diagnostic yield among 149/176 (84.6%) cases (P = 0.03). Among cytopenic subjects, megaloblastic anemias (MA) (N = 27) and aplastic anemias (AA) (N = 14) had richly particulate and greasy/fat ri...
Source: Journal of Hematopathology - March 31, 2021 Category: Pathology Source Type: research
Dry tap on bone marrow aspiration: a red flag
AbstractA dry tap obtained on bone marrow aspiration is considered a failure to aspirate marrow particles. However, it is often related to an underlying bone marrow pathology that hinders successful aspiration of hematopoietic cells. In this retrospective analysis, 2768 bone marrow aspirates and trephine biopsies were reviewed. Of these, 223 patients with bone marrow aspirations which yielded no marrow particles (dry tap) were included in the study. Patients in whom adequate trephine biopsy could not be obtained were excluded from the study. The final diagnosis was made by studying the trephine biopsy and correlating it wi...
Source: Journal of Hematopathology - March 31, 2021 Category: Pathology Source Type: research
Lymphomatoid granulomatosis in one patient with newly diagnosed HIV infection and Kaposi ’s sarcoma: a case report and literature review
AbstractLymphomatoid granulomatosis is a very rare B cell lymphoproliferative disease associated with Epstein –Barr virus infection. It is related to states of immunosuppression and affects the lung in more than 90% of cases, forcing the clinician to establish a differential diagnosis with other diseases such as infections, Wegener’s granulomatosis, lymphoma, or lung metastases. There is no standard tre atment for this disease. In this paper, we describe a rare case of a patient with grade 3 lymphomatoid granulomatosis with newly diagnosed HIV infection who started antiretroviral treatment with a gradual improvement of...
Source: Journal of Hematopathology - March 20, 2021 Category: Pathology Source Type: research
T-lymphoblastic leukemia/lymphoma with interfollicular growth pattern and Castleman-like morphologic features
We present an unusual T-LBL/L in a lymph node mimicking iT-LBP. The case showed preserved nodal architecture, morphologic features of hyaline vascular Castleman disease, proliferation of T-lymphoblasts in the interfollicular area, and no clonal T-cell receptor gene rearrangement. The follow-up lymph node specimen excised 6 months later showed full-blown lymphoblastic lymphoma with an abnormal karyotype, near-early-T-precursor phenotype, partial CD19 expression, andSETD2 mutation. (Source: Journal of Hematopathology)
Source: Journal of Hematopathology - March 12, 2021 Category: Pathology Source Type: research
EDTA-induced platelet hypogranulation: beware of dysplasia mimic!
(Source: Journal of Hematopathology)
Source: Journal of Hematopathology - February 23, 2021 Category: Pathology Source Type: research
A radiology survey and sub-sub-specialization in hematopathology
(Source: Journal of Hematopathology)
Source: Journal of Hematopathology - February 11, 2021 Category: Pathology Source Type: research
Reviewers for Journal of Hematopathology in 2020
(Source: Journal of Hematopathology)
Source: Journal of Hematopathology - February 2, 2021 Category: Pathology Source Type: research
Cutaneous ALK-positive histiocytosis
(Source: Journal of Hematopathology)
Source: Journal of Hematopathology - January 27, 2021 Category: Pathology Source Type: research
Bronchoalveolar lavage fluid review in acute promyelocytic leukemia differentiation syndrome
AbstractThe patient was a 62-year-old Caucasian man with blood smear and flow cytometry concerning for acute promyelocytic leukemia with FISH ultimately confirming PML-RARA translocation. He had a 30-year history of employment at a nuclear power plant. He presented with diffuse intravascular coagulation, hyperleukocytosis, and quickly developed acute respiratory distress syndrome. On day four of ATRA + Hydrea, a bronchoalveolar lavage was performed and was non-bloody. On microscopic fluid review, abnormal immature cells with bilobed nuclear contours were identified, similar in morphology to those seen on the diagnostic blo...
Source: Journal of Hematopathology - January 17, 2021 Category: Pathology Source Type: research
Cutaneous marginal zone lymphoma of the nose arising after rhinoplasty with filler injection
AbstractChronic inflammation induced by infection, autoimmune disorders, and immune reaction against foreign bodies are recognized as causative factors for the development of lymphoma. Here, a case of B cell lymphoma arising after augmentation rhinoplasty with filler injection is reported. A 48-year-old Japanese woman underwent rhinoplasty with filler injection at a cosmetic clinic 10 years ago. She, presently, came with complaints of a nodule at the nasal root. Histologic examination of the biopsy specimen revealed diffuse infiltration of centrocyte-like cells with plasmacytic differentiation in the subcutis and proceru...
Source: Journal of Hematopathology - January 12, 2021 Category: Pathology Source Type: research
A case mimicking chronic myeloid leukemia with t(8;22)(p11;q11)/BCR-FGFR1 and sequential transformation to B-acute lymphoblastic leukemia and acute myeloid leukemia
We report a case of 48-year-old woman who complained of weakness and gastric pain. She had splenomegaly, eosinophilia, and elevated white blood cells. Bone marrow (BM) aspiration biopsy was performed with an initial diagnosis of CML. Cytogenetic analysis of the BM showed a 46,XX,t(8;22)(p11.2;q11.2). She was diagnosed with myeloid/lymphoid neoplasm with eosinophilia and rearrangement ofFGFR1 gene. Throughout the chronic phase, the patient was treated with hydroxurea. Additional chromosomal abnormalities developed during therapy. Owing to the (8;22) clone, our patient did not respond to the treatment and rapidly transformed...
Source: Journal of Hematopathology - January 8, 2021 Category: Pathology Source Type: research
p53 immunohistochemistry discriminates between pure erythroid leukemia and reactive erythroid hyperplasia
AbstractPure erythroid leukemia (PEL) is a rare, aggressive subtype of acute myeloid leukemia with a poor prognosis. The diagnosis of PEL is often medically urgent, quite challenging, and is typically a diagnosis of exclusion requiring meticulous distinction from non-neoplastic erythroid proliferations, particularly florid erythroid hyperplasia/regeneration. Given the frequency ofTP53 mutations in the molecular signature of PEL, we hypothesize that differential p53 expression by immunohistochemistry (IHC) may be useful in distinguishing PEL versus non-neoplastic erythroid conditions. We performed p53 IHC on 5 normal bone m...
Source: Journal of Hematopathology - January 8, 2021 Category: Pathology Source Type: research
Enumeration of CD34+ haemopoietic stem cells: comparative study of the performance of the SYSMEX XN-1000 hematology analyzer in a dual-platform approach versus a single-platform approach
The objective of this study is to compare the performance of the DP approach on quantification of CD34+ HSC using a new generation of hematological analyzer featuring dedicated nRBC channel, Sysmex XN-1000, with the single-plate (SP) form approach using Beckman Coulter ’s Navios flow cytometer. Using the International Society for Hematotherapy and Transplantation protocol, a total of 86 samples were analyzed in multiple myeloma patients planned for autologous HSC transplantation. The Beckman Coulter’s Stem-Kit™ reagents were used to perform both approaches D P and SP. The count of CD34+ cells of the SP deduced direct...
Source: Journal of Hematopathology - January 8, 2021 Category: Pathology Source Type: research
Molecular methods for measurable residual disease in acute myeloid leukemia: where are we and where are we going?
AbstractMeasurable residual disease (MRD) testing has become a standard practice for patients with acute myeloid leukemia (AML) following therapy. However, MRD testing in AML is not straightforward, and both molecular methods and multiparameter flow cytometric (MFC) methods demonstrate clinical utility. While MFC methods are potentially applicable to all AML patients, current molecular MRD methods must be individually tailored to the patient ’s AML disease genetics, a strategy that is currently applied for patients with acute promyelocytic leukemia, core binding factor AML, and AML with mutatedNPM1. However, there is gre...
Source: Journal of Hematopathology - January 8, 2021 Category: Pathology Source Type: research
