Follicular T-cell lymphoma: a short review with brief discussion of other nodal lymphomas/lymphoproliferative disorders of T-follicular helper cell origin
AbstractFollicular peripheral T-cell lymphoma (F-PTCL) is a newly recognized provisional entity in the 2017 World Health Organization Classification revision of hematolymphoid neoplasms. It is a rare and under-recognized manifestation of peripheral T-cell lymphoma that is associated with a typically aggressive clinical course. Cases feature a predominantly follicular or perifollicular growth pattern and exhibit strong and consistent expression of T-follicular helper (TFH) markers. These cases distinctly lack histologic features commonly associated with angioimmunoblastic T-cell lymphoma, such as an associated polymorphous ...
Source: Journal of Hematopathology - August 16, 2021 Category: Pathology Source Type: research
Chronic myeloid leukaemia with p190 isoform masquerading as hypereosinophilia
(Source: Journal of Hematopathology)
Source: Journal of Hematopathology - August 11, 2021 Category: Pathology Source Type: research
The impact of CD33/CD34 ratio in the prognosis of myelodysplastic syndrome treated with azacitidine for first-line therapy
ConclusionIn the present study, a CD33/CD34 ratio > 1 in blast cells was associated with poor survival in MDS patients administered AZA as first-line therapy. (Source: Journal of Hematopathology)
Source: Journal of Hematopathology - July 15, 2021 Category: Pathology Source Type: research
Blood cell morphology and COVID-19 clinical course, severity, and outcome
In this study, we aimed to determine the morphologic changes and abnormalities of COVID-19 patients and their relation to the patients’ clinical course. In this prospective cross-sectional study, we included 89 PCR-positive COVID-19 patients. A pathologist examined the PBS findings of these patients. The patients’ clinical course, including severity, outcome, intubation, and ICU admission, was extracted from their profiles. The statistical analyses were done to find out the relation between PBS findings and patients’ clinical course. Results showed that smudge ce lls are the most frequent abnormality in our participa...
Source: Journal of Hematopathology - July 5, 2021 Category: Pathology Source Type: research
Polymerase chain reaction-restriction fragment length polymorphism method for detection of Calreticulin type-1 and type-2 mutations in myeloproliferative neoplasm
AbstractCalreticulin (CALR) mutations are included in the WHO diagnostic criteria of Myeloproliferative Neoplasm (MPN). Presence ofCALR mutation, aids in their diagnosis by excluding reactive causes. There are several molecular techniques to detectCALR mutations; however, these require advanced equipment and technical expertise. An in-house “polymerase chain reaction-restriction fragment length polymorphism (PCR- RFLP)” method, using restriction enzymes MseI and MluCI for detection ofCALR type-1 and type-2 mutations, was developed. PCR-RFLP method was validated by comparing its results with real-time PCR (RQ-PCR) using...
Source: Journal of Hematopathology - June 12, 2021 Category: Pathology Source Type: research
Coexistence of pseudo-Pelger-H üet anomaly and faggot cells in acute promyelocytic leukemia during chemotherapy
(Source: Journal of Hematopathology)
Source: Journal of Hematopathology - May 31, 2021 Category: Pathology Source Type: research
Sequential development of JAK2V617F and BCR-ABL1: a “double-hit” myeloproliferative neoplasm with morphologic transition
(Source: Journal of Hematopathology)
Source: Journal of Hematopathology - May 24, 2021 Category: Pathology Source Type: research
Sequential development of JAK2 V617F and BCR-ABL1 : a “double-hit” myeloproliferative neoplasm with morphologic transition
(Source: Journal of Hematopathology)
Source: Journal of Hematopathology - May 24, 2021 Category: Pathology Source Type: research
CD37 and CD44 evaluation by flow cytometry: can these markers improve B cell lymphoma characterization?
ConclusionsWhile our findings require confirmation in a larger case series, decreased CD44 expression by flow cytometry in an otherwise limited biopsy with DLBCL-like features may provide the impetus for FISH testing and ultimate classification. (Source: Journal of Hematopathology)
Source: Journal of Hematopathology - May 21, 2021 Category: Pathology Source Type: research
Medication-induced Pseudo-Pelger-Hu ët Anomaly and severe neutropenia
(Source: Journal of Hematopathology)
Source: Journal of Hematopathology - May 21, 2021 Category: Pathology Source Type: research
SARS-CoV-2/COVID-19 pandemic produces a new paradigm for international hematopathology meetings
(Source: Journal of Hematopathology)
Source: Journal of Hematopathology - May 17, 2021 Category: Pathology Source Type: research
Primary thyroid T cell lymphoproliferative disorder with a 10-year history of neck mass: a case report and literature review
AbstractThyroid lymphoproliferative disorder is known to be associated with Hashimoto thyroiditis. The major histological types of thyroid lymphoproliferative disorders are malignant lymphoma, such as diffuse large B cell lymphoma, extranodal marginal zone B cell lymphoma of mucosa-associated lymphoid tissue (MALT), and follicular lymphoma. All of these are B cell lymphomas; however, T cell lymphoproliferative disorders represent only a minority of cases. Since T cell lymphoproliferative disorder rarely develops and T cell lymphoma is a heterogeneous entity, it is difficult to concisely summarize this complex topic. Here, ...
Source: Journal of Hematopathology - May 12, 2021 Category: Pathology Source Type: research
Extracutaneous involvement of subcutaneous panniculitis-like T-cell lymphoma associated with hemophagocytic lymphohistiocytosis and refractory to intensive chemotherapy
We report an unusual case of subcutaneous panniculitis-like T-cell lymphoma (SPTCL) with clinically occult subcutaneous lesions and prominent biopsy-proven extracutaneous mese nteric involvement. Further investigation is required to better understand the mechanism of disease, prognosis, and optimal treatment approach for SPTCL patients presenting with extracutaneous involvement and HLH. (Source: Journal of Hematopathology)
Source: Journal of Hematopathology - May 5, 2021 Category: Pathology Source Type: research
Multiple myeloma and frequency of synchronous and second primary malignancies
AbstractMalignancies accompanying multiple myeloma (MM) can be observed at diagnosis or during the course of the disease. Several trials have investigated the type, frequency, and effects of these malignancies on the overall survival of MM patients. Here, we aimed to investigate the frequency and types of previous/synchronous and second primary malignancies, median duration to develop a second primary malignancy during the course, and the effect of these malignancies on overall survival in our MM patients. Three hundred ten symptomatic MM patients were included and analyzed retrospectively. Malignancies detected before or ...
Source: Journal of Hematopathology - May 1, 2021 Category: Pathology Source Type: research
Hemophagocytic lymphohistiocytosis, a new cause of death during ‘post-acute COVID-19 syndrome?’ A case report
We report the c ase of a 69-year-old woman who presented, two weeks after recovery from COVID-19, with hyperosmolar state and high inflammatory markers. Bone marrow aspirate, flow cytometry, extensive viral panel and total body scan were performed. Review of bone marrow aspirate smear showed hemophagocytosis. Flow cytometry, viral panel, and total body scan were normal. The diagnosis of post COVID-19-related HLH was made. Unfortunately, the patient died despite adequate treatment. To our knowledge, this is the first case establishing a high probability of COVID-19-related HLH given its occurrence two weeks fo llowing a doc...
Source: Journal of Hematopathology - April 20, 2021 Category: Pathology Source Type: research
