Indolent T-lymphoblastic proliferation involving hepatocellular carcinoma —presentation in novel settings and comprehensive review of literature
We present two cases of iT-LBP associated with HCC in novel settings —in post-liver transplant patients and in recurrent/metastatic sites of HCC. In addition, a comprehensive literature review of clinical, histological, and immunophenotypic characteristics of reported cases of iT-LBP is presented. (Source: Journal of Hematopathology)
Source: Journal of Hematopathology - July 16, 2023 Category: Pathology Source Type: research
Correction: Initial and follow-up evaluations on cerebrospinal fluid involvement by hematologic malignancy
(Source: Journal of Hematopathology)
Source: Journal of Hematopathology - July 5, 2023 Category: Pathology Source Type: research
Research use only and cell population data items obtained from the Beckman Coulter DxH800 automated hematology analyzer are useful in discriminating MDS patients from those with cytopenia without MDS
AbstractWe investigated the performance of research use only/cell population data (RUO/CPD) items obtained from the Beckman Coulter DxH800 automated hematologic analyzer in discriminating MDS patients from cytopenic patients without MDS.Total of 14 routine CBC, 18 research use only (RUO) items, and 70 CPD items were obtained retrospectively at diagnosis. The results were then compared between 94 MDS patients and 100 cytopenic patients without MDS. In items with statistically significant differences, receiver operating characteristic (ROC) analysis was performed and the results were compared.Four CBC/RUO items [red cell dis...
Source: Journal of Hematopathology - July 1, 2023 Category: Pathology Source Type: research
Initial and follow-up evaluations on cerebrospinal fluid involvement by hematologic malignancy
AbstractCentral nervous system (CNS) involvement is a serious complication in hematologic malignancy, and early detection and management of CNS involvement in these cases significantly impact the prognosis. Currently, there is no consensus on the use of multiparametric flow cytometry (MFC) and conventional cytology (CC) testing for initial and follow-up cerebrospinal fluid (CSF) specimens to diagnose CNS involvement by hematologic malignancy. In our institution, after initial MFC and CC, two subsequent negative MFCs are required before discontinuing MFC. The aim of this study is to evaluate the outcome of this approach. CS...
Source: Journal of Hematopathology - June 16, 2023 Category: Pathology Source Type: research
Disseminated Talaromyces marneffei infection in a child with HIV infection
(Source: Journal of Hematopathology)
Source: Journal of Hematopathology - June 15, 2023 Category: Pathology Source Type: research
Correction to: Another cause of pseudobasophilia: flower cells
(Source: Journal of Hematopathology)
Source: Journal of Hematopathology - June 2, 2023 Category: Pathology Source Type: research
The lymph node in IgA vasculitis (Hen öch-Schonlein purpura)
(Source: Journal of Hematopathology)
Source: Journal of Hematopathology - May 26, 2023 Category: Pathology Source Type: research
Another cause of pseudobasophilia: flower cells
(Source: Journal of Hematopathology)
Source: Journal of Hematopathology - May 15, 2023 Category: Pathology Source Type: research
Staphylococcal toxic shock syndrome
AbstractToxic Shock Syndrome (TSS) is a severe acute disease characterized by high fever, hypotension, rash, multiple organ dysfunction and desquamation during convalescence. TSS is caused by toxin-producing strains ofStaphylococcus aureus or Streptococcus pyogenes. TSS remains a rare but severe disease. Early diagnosis is important because specific treatments with antitoxin effects must be started as soon as possible. This manuscript presents a set of images that illustrate the main findings in the peripheral blood film of a patient with TSS. (Source: Journal of Hematopathology)
Source: Journal of Hematopathology - May 11, 2023 Category: Pathology Source Type: research
Genetic mutation analysis of hereditary spherocytosis in Guangxi Zhuang Autonomous Region
AbstractHereditary spherocytosis (HS) is a common, hereditary hemolytic anemia (HHA) that is attributed to the disturbance of five erythrocyte membrane proteins. HS is also common in Guangxi, China. Target region capture high-throughput sequencing technology was used to analyze genetic mutations found in HS patients. Pedigree analysis was also performed, in some cases, to provide an optimized approach for the etiological diagnosis of complex, hereditary hemolytic anemia. Blood samples from the probands and their families were assessed by laboratory tests, target region capture high-throughput sequencing technology, and San...
Source: Journal of Hematopathology - May 5, 2023 Category: Pathology Source Type: research
B-lymphoblastic leukemia/lymphoma with MYC and BCL2 gene rearrangements shows evidence for clonal evolution and mitotic recombination
ConclusionsA clonal evolution model involving multiple chromosomal translocations and mitotic recombination is postulated to account for the karyotype, FISH, and microarray results but leaves unresolved the exact order of the evolutionary changes. (Source: Journal of Hematopathology)
Source: Journal of Hematopathology - April 20, 2023 Category: Pathology Source Type: research
Publisher Correction: Reviewer Thank You
(Source: Journal of Hematopathology)
Source: Journal of Hematopathology - April 15, 2023 Category: Pathology Source Type: research
Multiparameter flow cytometry and ClonoSEQ correlation to evaluate precursor B-lymphoblastic leukemia measurable residual disease
AbstractMeasurable residual disease (MRD) detection for precursor B-lymphoblastic leukemia (B-ALL) has become the standard of care. However, the testing methodology has not been standardized. We aim to correlate COG multiparameter flow cytometry (MFC) and ClonoSEQ techniques to assess the test characteristics, to study abnormal immunophenotype for B-ALL MRD, and to observe B-ALL clonal evolution and the impact of blinatumomab therapy on MFC testing. MFC and molecular reports were retrieved from electronic medical records and data was reviewed. Included in this study were 74 bone marrow samples collected from 31 B-ALL patie...
Source: Journal of Hematopathology - April 14, 2023 Category: Pathology Source Type: research
Coincidence of plasma cell leukemia and COVID-19: a diagnostic pitfall
We report the case of a 66-year-old man with a known history of IgD multiple myeloma (MM) which was admitted to hospital because of acute renal failure. Routine PCR testing on admission yielded a positive result for SARS-CoV-2 infection. Examination of the peripheral blood (PB) smear revealed 17% lymphoplasmacytoid cells and a few small plasma cells mimicking morphological changes frequently seen in viral diseases. However, flow cytometric examination showed 20% clonal lambda-restricted plasma cells being consistent with a diagnosis of secondary plasma cell leukemia. Circulating plasma cells as well as similar appearing ly...
Source: Journal of Hematopathology - April 10, 2023 Category: Pathology Source Type: research
SATB2 expression in hematolymphoid neoplasms
(Source: Journal of Hematopathology)
Source: Journal of Hematopathology - April 3, 2023 Category: Pathology Source Type: research
