Familial hemophagocytic lymphohistiocytosis with Epstein –Barr virus infection and progression to aggressive NK-cell leukemia: a case report and review of the literature

We report a rare case of FHLH with EBV infection that mimicked CAEBV-T/NK, but progressed to childhood aggressive natural killer cell leukemia (ANKL). The patient is in clinical remission following allogeneic hematopoietic stem cell tran splantation (allo-HSCT). Our reported case suggests that patients with FHLH and EBV infection, especially those with symptoms similar to those of CAEBV-T/NK, may rapidly progress to ANKL or other neoplastic diseases. Therefore, we must be aware of these cases to ensure that patients are diagnosed co rrectly so they can be treated appropriately and in a timely manner.
Source: Journal of Hematopathology - Category: Pathology Source Type: research