Anaplasmosis and Lyme disease
(Source: Journal of Hematopathology)
Source: Journal of Hematopathology - December 16, 2022 Category: Pathology Source Type: research
CD5 as a prognostic marker in patients with diffuse large B-cell lymphoma: a multicenter study
AbstractDiffuse large B-cell lymphoma (DLBCL) is the most common subtype of non-Hodgkin lymphoma (NHL) and comprises a heterogeneous group of disease. While classification of B-cell lymphomas has been evolving to include clonality in a specific manner, morphology, and immunohistochemistry remain the backbone. We aimed to evaluate the value of CD5 expression on disease characteristics as well as prognosis in patients with DLBCL. Data of 131 patients with DLBCL with CD5 positivity and as a comparison arm, data of 129 patients with DLBCL without CD5 positivity were evaluated. Mean age was 59 and 55.7% of the patients were mal...
Source: Journal of Hematopathology - December 10, 2022 Category: Pathology Source Type: research
Announcements
(Source: Journal of Hematopathology)
Source: Journal of Hematopathology - December 10, 2022 Category: Pathology Source Type: research
The value of next generation sequencing in the diagnosis of a rare cause of eosinophilia: B cell-acute lymphoblastic leukemia with t(5;14)(q31;q32)
We present a case of B-ALL with t(5;14)(q31;q32) where the diagnosis was especially challenging given the patient ’s multiple risk factors for eosinophilia and normal chromosome analysis and fluorescence in situ hybridization studies.The diagnosis was ultimately made with the identification of t(5;14)(q31;q32) by next generation sequencing. The patient received chemotherapy and is in clinical remission. This case adds to the limited body of literature of this rare entity and illustrates the value of next generation sequencing in the evaluation of patients with eosinophilia. (Source: Journal of Hematopathology)
Source: Journal of Hematopathology - November 3, 2022 Category: Pathology Source Type: research
Concurrence of relapsed neuroblastoma and therapy-related acute myeloid leukemia in an 8-year-old patient
(Source: Journal of Hematopathology)
Source: Journal of Hematopathology - November 2, 2022 Category: Pathology Source Type: research
Florid lambda-monotypic B-cell proliferation in fatal severe fever with thrombocytopenia syndrome virus infection-associated necrotizing lymphadenitis: a potential diagnostic pitfall
We present a case of fatal SFTS virus infection-associated histiocytic necrotizing lymphadenitis showing an effaced nodal architecture due to florid lambda-monotypic B-blasts that can raise a diagnostic pitfall in hematopathology. We examined histologic and immunophenotypic features of inguinal lymph node tissue of a 49-year-old Korean woman, who presented with a high fever and painful left inguinal lymphadenopathy associated with fatal SFTS virus infection. The nodal architecture of the excised lymph node appeared to be diffusely effaced by expanded paracortical zones by an extensive proliferation of immunoblast-like larg...
Source: Journal of Hematopathology - October 27, 2022 Category: Pathology Source Type: research
Transdifferentiation of high-grade B-cell lymphoma with MYC and BCL2 rearrangements into histiocytic sarcoma after CAR T-cell therapy: a case report
We report a unique case of transdifferentiation of high-grade B-cell lymphoma with MYC and BCL2 rearrangements into histiocytic sarcoma/malignant histiocytosis shortly after receiving CAR T-cell therapy. Immunohistochemical stains on core biopsies of the patient ’s right thigh mass showed two morphologically and immunophenotypically distinct cell populations with B-cell lineage and histiocytic lineage. However, the FISH analysis revealed the same MYC and BCL2 rearrangements in both populations. The presence of the same MYC and BCL2 rearrangements detected by FISH analysis and identical immunoglobulin gene rearrangement p...
Source: Journal of Hematopathology - October 21, 2022 Category: Pathology Source Type: research
A newly detected c.180 + 1G & gt; A variant causes a decrease of FGA transcription in patients with congenital hypo-dysfibrinogenemia
This study was designed to analyze the clinical phenotype and genetic mutations of a patient with congenital hypo-dysfibrinogenemia. Prothrombin time (PT), activated partial thromboplastin time (APTT), thrombin time (TT), andD-dimer were measured using an automated coagulation analyzer. Fibrinogen (Fg) was assessed by the Clauss and PT-Fg methods. Sanger sequencing was conducted to identify the mutations inFGA,FGB, andFGG genes. The proband and proband ’s mother, maternal uncle, and maternal grandfather exhibited a prolonged TT, decreased Clauss Fg and PT-Fg, and normal PT, APTT, andD-dimer without abnormalities in liver...
Source: Journal of Hematopathology - October 17, 2022 Category: Pathology Source Type: research
Anaplastic large cell lymphoma, ALK-negative exhibiting rare CD4 [ +] CD8 [ +] double-positive immunophenotype
AbstractAnaplastic large cell lymphoma is a relatively rare type of T cell lymphoma characterized by strong and uniform CD30 expression with a typical cohesive growth pattern and hallmark cells. Most cases are single-positive for CD4 or less often CD8-positive, with only very rare descriptions of having double positivity for both antigens. Agent Orange is a herbicide which was used during the Vietnam War and has been associated with non-Hodgkin lymphoma (including chronic lymphocytic leukemia, hairy cell leukemia, and other chronic B cell leukemias), Hodgkin lymphoma and monoclonal gammopathy of undetermined significance. ...
Source: Journal of Hematopathology - October 12, 2022 Category: Pathology Source Type: research
Attack of the clones: a T-cell population resembling adult T-cell leukemia/lymphoma, and large granular lymphocytosis, in an HTLV-2-infected patient
We report a patient who presented with two concomitant clonal T-cell lymphoproliferative disorders, who was found to have an HTLV-2, but not HTLV-1 infection. The patient ’s clonal T-cell proliferations were characterized and compared using multiparameter flow cytometry, fluorescence in situ hybridization, and TCR gene rearrangement analysis on flow-sorted cell samples from blood, bone marrow, and skin biopsy specimens. The patient had a CD4 + /CD25 + T-cel l population, resembling adult T-cell leukemia/lymphoma both by clinical presentation and immunophenotype, as well as a separate clonal CD8 + population o...
Source: Journal of Hematopathology - September 29, 2022 Category: Pathology Source Type: research
Clonal relationship of extranodal marginal zone lymphomas of mucosa-associated lymphoid tissue (MALT lymphoma) involving multiple organ systems with review of the literature
AbstractMucosa-associated lymphoid tissue (MALT) lymphomas are often multifocal with patchy distribution that can be scattered throughout an involved organ. Previous studies have shown that each of these surrounding foci is often clonally related. Less is known about the clonal relationship of MALT lymphomas that involve multiple different organ systems. To investigate the clonal relationship of MALT lymphomas that involve multiple different organ systems, we retrospectively reviewed records of all marginal zone lymphoma from our database. Three cases were found to have multiple organ involvement and subjected to the analy...
Source: Journal of Hematopathology - September 20, 2022 Category: Pathology Source Type: research
Hemoglobin Reims —a rare alpha globin chain variant and its interaction with beta thalassemia
We describe here two brothers (patients 1 and 2) with Hb Reims, a rare alpha globin chain variant that eluted in HbS window. Hb analysis was performed by HPLC. Covalent reverse dot blot and refractory mutation system (ARMS) were used for detection of common beta globin gene mutations. Alpha and beta globin gene mutation analysis was performed by DNA sequencing. Both brothers had “thalassemia trait-like” red cell indices. HbA2 was high (4.9%) in patient 2 and normal (2.7%) in patient 1. HbF was normal (0.3%) in both. The abnormal Hb peaks in patient 1 (21.7%) and patient 2 (13.8%) eluted at 4.51 and 4.48 min, respecti...
Source: Journal of Hematopathology - September 20, 2022 Category: Pathology Source Type: research
Co-inheritance of Hb Ottawa and HbS: a rare interaction leading to an interesting diagnostic challenge
(Source: Journal of Hematopathology)
Source: Journal of Hematopathology - September 14, 2022 Category: Pathology Source Type: research
The first case of peripheral T cell lyphoma with a CSF3R variant resulted in relapsing febrile neutropenia and aplastic anemia
AbstractColony-stimulating factor 3 receptor (CSF3R) gene mutations have been previously identified in chronic neutrophilic leukemia, atypical chronic myeloid leukemia, chronic myelomonocytic leukemia, de novo acute myeloid leukemia, and severe congenital neutropenia, although there is limited data regarding lymphoid malignancies. Here, we present the first case of peripheral T cell lymphoma withCSF3R variant that developed persistent neutropenia in the follow-up visit and aplastic anemia after autologous hematopoietic stem cell transplantation. Next-generation sequencing (NGS) was performed on bone marrow aspiration (Qiag...
Source: Journal of Hematopathology - September 6, 2022 Category: Pathology Source Type: research
Competing hematolymphoid classification schemes on deck
(Source: Journal of Hematopathology)
Source: Journal of Hematopathology - August 30, 2022 Category: Pathology Source Type: research
