Synchronous plasma cell neoplasm and B lymphoblastic leukemia/lymphoma at initial presentation: first report of an unusual association with a good outcome
We report what we believe is the first instance of a synchronous PCN and B lymphoblastic leukemia/lymphoma (B-ALL) diagnosed at initial presentation. The patient underwent laboratory evaluation for an underlying plasma cell neoplasm, including immunology studies, bone marrow biopsy, and flow cytometry immunophenotyping. Serum lambda free light chain and serum IgG were elevated, with an IgG lambda M-protein identified by serum protein electrophoresis and immunofixation. The clinical working diagnosis was plasma cell myeloma. Bone marrow biopsy was positive for a composite PCN and B-ALL. The patient received treatment with V...
Source: Journal of Hematopathology - January 7, 2022 Category: Pathology Source Type: research
Loss of sCD3 in hepatosplenic T cell lymphoma — a- case report
We report a rare case of hepatosplenic T cell lymphoma with an aberrant loss of sCD3 at diagnosis.This case report is written based on reviewing electronic health data, liver biopsy histology, bone marrow biopsy and conventional cytogenic analysis. Literature search for case reports were conducted on PubMed database and Google Scholar.Our case presents a de novo hepatosplenic T cell lymphoma with loss of surface CD3 expression on immunohistochemistry and flow cytometry. The unusual immunophenotype has been reported in three previous cases, and likely contributed to a delay in diagnosis of our patient.Hepatosplenic T cell l...
Source: Journal of Hematopathology - January 3, 2022 Category: Pathology Source Type: research
Relapse of tagraxofusp treated blastic plasmacytoid dendritic cell neoplasm with loss of CD123 expression
AbstractTagraxofusp, a CD123-based-targeted immunotherapy, was recently approved to treat blastic plasmacytoid dendritic cell neoplasm (BPDCN) with excellent response. Also, a subset of BPDCN shows resistance to tagraxofusp. These resistant cases continue to express CD123, which forms the basis of the continued utility of tagraxofusp in newer combination chemotherapies to overcome resistance in BPDCN. Herein, we report a case of an elderly male with BPDCN that achieved complete remission on initial primary treatment with tagraxofusp. However, BPDCN relapsed after 1.5 years while on treatment, with loss of CD123 expression....
Source: Journal of Hematopathology - December 2, 2021 Category: Pathology Source Type: research
Post-Lugano classification usage of bone marrow biopsy in the staging of lymphoma
(Source: Journal of Hematopathology)
Source: Journal of Hematopathology - November 8, 2021 Category: Pathology Source Type: research
Serum thymus and activation-regulated chemokine (TARC) levels in newly diagnosed patients with Hodgkin lymphoma: a new promising and predictive tool? Preliminary report
AbstractThymus and activation-regulated chemokine (TARC) is expressed on Reed-Sternberg cells of patients with classical Hodgkin lymphoma (HL) and may serve as a marker in response assessment. In our study, we correlated serum TARC levels with early response to treatment measured by PET/CT in 19 newly diagnosed patients with HL who received ABVD (Adriblastin, Bleomycin, Vinblastine, Dacarbazine) regimen. Finally, 17 patients were analyzed and six of them (35%) achieved PET/CT negativity defined as Deauville (D) 1 or 2 after 2 cycles of ABVD; 11 pts (65%) had D3 on PET/CT. None of the patients presented D 4/5. Median serum ...
Source: Journal of Hematopathology - November 5, 2021 Category: Pathology Source Type: research
Massive bone marrow infiltration of neuroendocrine carcinoma mimicking aggressive hematological malignancy
(Source: Journal of Hematopathology)
Source: Journal of Hematopathology - October 29, 2021 Category: Pathology Source Type: research
Case of acute promyelocytic leukemia with basophilic differentiation and an ETV6 mutation
We present a case of acute leukemia with evidence of t(15;17) by banding karyotype, FISH, and PCR, with rare microgranular promyelocytes and significant basophilia detected on marrow aspirate, and an ETV6 missense mutation by molecular diagnostic testing. The patient underwent treatment with isotretinoin (ATRA) and arsenic trioxide (ATO) with attainment of a morphologic remission at the end of induction. There was no evidence of coagulopathy or basophil granule release with therapy. To our knowledge, this is the first report of the co-occurrence of APL with marrow basophilia in conjunction with an ETV6 mutation. The progno...
Source: Journal of Hematopathology - October 28, 2021 Category: Pathology Source Type: research
De novo PD-1-expressing large B-cell lymphoma outside the setting of CLL: possible origin from CD5 + /PD-1 + regulatory B-cell subset
(Source: Journal of Hematopathology)
Source: Journal of Hematopathology - October 27, 2021 Category: Pathology Source Type: research
Primary sinonasal large B cell lymphoma is as histopathologically heterogeneous as systemic large B cell lymphoma but may show subtype-specific tropism for specific sinonasal anatomic sites
AbstractLarge B cell lymphomas (LBCL) are a heterogeneous group of diseases with variable presentations and prognoses. Rarely, LBCLs arise in the sinonasal tract and are distinct from extranodal NK/T-cell lymphoma which is more typical in this anatomic location. We hypothesized that large B cell lymphoma primary to the sinonasal tract (snLBCL) would be heterogeneous and include high-grade B cell lymphomas (HGBCL) described in the revised 4th edition WHO classification of lymphomas. We retrospectively evaluated cases of snLBCL at our center, and performed additional immunohistochemical and in situ hybridization studies wher...
Source: Journal of Hematopathology - October 14, 2021 Category: Pathology Source Type: research
Characterization of bone marrow CD4 to CD8 ratios and lymphocyte composition in adults by image analysis
AbstractBone marrow (BM) lymphocyte subsets are evaluated by flow cytometry or immunohistochemistry for diagnostic purposes; however, CD4:CD8 T lymphocyte ratios are often erroneously interpreted using peripheral blood ranges. There are few and no recent studies describing the composition of lymphocytes within the marrow space, or normal reference ranges. Lymphocyte subsets in cytopenic patients and hospital autopsy BM specimens were evaluated to better characterize CD4:CD8 ratios. Ten patients with a history of cytopenia were identified from 2017 to 2021. Clinical history, cytogenetic testing, and results of a next genera...
Source: Journal of Hematopathology - October 9, 2021 Category: Pathology Source Type: research
Bone marrow examination of HIV-infected children in HAART era reveals a spectrum of abnormalities: a study from single tertiary care center of North India
AbstractPediatric HIV is a significant contributor to childhood morbidity and mortality. As HIV infects bone marrow CD34-positive progenitor cells, the hematological abnormalities are well-expected. The viral load is much higher in children predisposing them to opportunistic infections and hematopoietic malignancies. The present study aimed to determine the spectrum of hematological abnormalities that may yield clinically useful information in HIV-infected children. This was a retrospective study of 19 HIV-infected children who underwent bone marrow examination. Overall, 20 peripheral blood and bone marrow samples were ana...
Source: Journal of Hematopathology - October 5, 2021 Category: Pathology Source Type: research
The role of CD44 in the assessment of minimal residual disease of multiple myeloma by flow cytometry
AbstractAlthough the guidelines recommended some biomarkers for detecting minimal residual disease (MRD) in multiple myeloma (MM) by multiparameter flow cytometry (MFC), there is still room for the exploration of the selection of biomarkers for this purpose. To seek a more effective combination of biomarkers to monitor MRD in MM. A comparison of the expression of each biomarker (CD19, etc.) by MFC in the bone marrow of the MM group (56 MM patients with MRD) in comparison with the biomarker expression in the control group (49 non-MM patients) was conducted, and an analysis of the abnormal expression of each biomarker was as...
Source: Journal of Hematopathology - October 2, 2021 Category: Pathology Source Type: research
Co-occurrence of immature T-lymphoblastic lymphoma and acute myeloid leukemia —microenvironment-dependent lineage differentiation derived from a common progenitor?
AbstractMixed phenotype acute leukemia (MPAL) is an uncommon disease characterized by currently only limited knowledge concerning biology, clinical presentation, and treatment outcome. We here describe a most unusual case of simultaneous occurrence of T-lymphoblastic lymphoma in cervical and mediastinal lymph nodes and acute myeloid leukemia in the bone marrow (BM) successfully treated with allogeneic stem cell transplantation (SCT). Although the blasts in both locations showed additional aberrant expression of other lineage markers (even B-cell markers), diagnostic criteria of MPAL were not fulfilled either in the LN or i...
Source: Journal of Hematopathology - September 14, 2021 Category: Pathology Source Type: research
An uncommon RBC membranopathy: two case reports
(Source: Journal of Hematopathology)
Source: Journal of Hematopathology - September 10, 2021 Category: Pathology Source Type: research
What, how, and when for the WHO: will the clock be turned back for the next hematolymphoid tumor classification?
(Source: Journal of Hematopathology)
Source: Journal of Hematopathology - August 19, 2021 Category: Pathology Source Type: research
