Plasma cell leukemia masquerading as lymphoplasmacytic lymphoma: a diagnostic challenge
(Source: Journal of Hematopathology)
Source: Journal of Hematopathology - February 7, 2019 Category: Pathology Source Type: research
Leukemic presentation of high-grade B cell lymphoma with MYC and BCL2 rearrangement —a series of two cases and review of literature
AbstractHigh-grade B cell lymphoma (HGBL) is a recently introduced category of aggressive mature B cell lymphoma which is clinically and biologically distinct from diffuse large B cell lymphoma (DLBCL), NOS, and Burkitt Lymphoma. HGBL consists of two categories; the first category includes HGBL withMYC andBCL2 and/orBCL6 rearrangement which is so-called double or triple hit lymphoma. The second category includes HGBL, NOS which lacks genetic double or triple hit; however, its morphology is intermediate between DLBCL and Burkitt lymphoma or appear blastoid. Clinically, patients present with advanced disease, bone marrow inv...
Source: Journal of Hematopathology - January 31, 2019 Category: Pathology Source Type: research
Mediastinal germ cell tumor with associated myeloid sarcoma: An exceptional co-occurrence
AbstractThe association of mediastinal germ cell tumor (GCT) and hematological malignancy is a well-documented but extremely rare phenomenon. This syndrome is characterized by the occurrence of nonseminomatous mediastinal germ cell tumor and an associated hematological neoplasm that usually involve the megakaryocytic lineage. The hematopoietic malignancies can involve the mediastinum or present as infiltration of bone marrow or lymphoid organs. In majority of cases, the hematological malignancy was detected in the bone marrow simultaneously or within 6 months after the detection of mediastinal germ cell tumor. There are ...
Source: Journal of Hematopathology - January 28, 2019 Category: Pathology Source Type: research
When the diagnosis is difficult to digest: severe vitamin B 12 deficiency secondary to pernicious anemia mimicking life-threatening thrombotic thrombocytopenic purpura
AbstractThrombotic thrombocytopenic purpura (TTP) is an uncommon yet life-threatening condition, usually marked by a classic pentad of microangiopathic hemolytic anemia (MAHA), thrombocytopenia, acute kidney injury (AKI), neurological disturbances, and fevers. Prompt recognition and treatment is essential to reduce morbidity and mortality. The rarity and variability of presentations, however, makes this a difficult diagnosis to make reliably, and in many cases, treatment is initiated empirically before the appropriate diagnostic testing is completed. After TTP and other common causes of thrombotic microangiopathy (TMA) hav...
Source: Journal of Hematopathology - January 11, 2019 Category: Pathology Source Type: research
Autoimmune hemolytic anemia: an uncommon cause of elevated fetal hemoglobin
(Source: Journal of Hematopathology)
Source: Journal of Hematopathology - January 8, 2019 Category: Pathology Source Type: research
CD38 negative anaplastic plasma cell myeloma with (14;16) translocation: a diagnostic dilemma for highly aggressive neoplasm: case report
AbstractAnaplastic plasma cell myeloma (PCM) is an aggressive morphological variant of myeloma characterized by involvement of extramedullary sites and extremely poor prognosis. Moreover, anaplastic PCM is frequently associated with high frequency of 17p(p53) deletions, 1q21(CKS1B) amplifications and immunoglobulin A (IgA) isotype. It usually manifests as an adverse progression of previously treated conventional plasma cell myeloma. However, the anaplastic morphology can be encountered in newly diagnosed cases and might pose a major diagnostic challenge. Herein, we present a rare case of anaplastic plasma cell myeloma with...
Source: Journal of Hematopathology - January 2, 2019 Category: Pathology Source Type: research
Nodal mesenteric marginal zone lymphoma with amyloid deposits, calcification, and ossification
AbstractMarginal zone lymphomas (MZLs) are rarely associated with amyloid deposits, calcification, and ossification. Herein, we describe a case of a MZL with a primary nodal mesenteric presentation, associated with amyloid deposits, calcification, and ossification, highlighting its clinicopathological features, based on our findings, but also on a brief review of the literature. (Source: Journal of Hematopathology)
Source: Journal of Hematopathology - December 18, 2018 Category: Pathology Source Type: research
Distribution of lymphomas in Mexico: a multicenter descriptive study
AbstractEpidemiology of lymphoma is not well described in Mexico. We determined the frequencies and subtypes of the main non-Hodgkin ’s and Hodgkin’s lymphomas in the Mexican population. Files for tissue samples for lymphomas stored in five different hospitals in Mexico City were retrieved for re-analysis and further immunostaining. The most common mature B cell, T cell/NK cell, Hodgkin’s, and precursor lymphoid neoplasms w ere identified according to the 2008 WHO classification of tumors. All stains were performed in the same laboratory and interpreted by three pathologists. Five thousand seven hundred seventy-two n...
Source: Journal of Hematopathology - December 7, 2018 Category: Pathology Source Type: research
Nonconventional morphology in plasma cell leukemia
We present such a case that emphasizes the importance of integrating flow cytometric immunophenotyping to confirm the diagnosis. (Source: Journal of Hematopathology)
Source: Journal of Hematopathology - November 13, 2018 Category: Pathology Source Type: research
Synchronous discordant Epstein-Barr virus (EBV) –positive nodal T/NK-cell lymphoma and EBV-positive diffuse large B cell lymphoma in a patient with a history of EBV-positive Burkitt lymphoma
We report a case of discordant Epstein-Barr virus –associated lymphoma consisting of nodal T/NK-cell lymphoma and diffuse large B cell lymphoma in a patient with a history of EBV-positive Burkitt lymphoma post treatment. Simultaneous biopsies of the left and right femoral lymph nodes showed a synchronous nodal T/NK-cell lymphoma (left) and diffus e large B cell lymphoma (right). The nodal T/NK-cell lymphoma was morphologically and immunohistochemical distinct from the diffuse large B cell. Both the T/NK-cell component and the B cell component showed bright nuclear positivity with in situ hybridization for EBER. Molecular...
Source: Journal of Hematopathology - November 3, 2018 Category: Pathology Source Type: research
Primary spinal T cell/histiocyte-rich large B cell lymphoma (THRLBCL) —a rare diagnosis at a rare site
We describe a case of THRLBCL with an uncommon isolated spinal involvement. A 37-year-old male came to the neurosurgery outpatient department with weakness of both upper and lower limbs. Histopathology and immunohistochemistry revealed features consistent with THRLBCL. The patient was treated with D5-D6 laminectomy followed by six cycles of chemotherapy (CHOP; cyclophosphamide, hydroxydaunorubicin, oncovin, prednisolone) and was disease free for 5 years until he had relapse of disease at the same location in 2016 for which he is receiving palliative radiation therapy. Isolated spinal involvement as the first or only mani...
Source: Journal of Hematopathology - October 28, 2018 Category: Pathology Source Type: research
Post-transplant CD4+ non-cytotoxic γδ T cell lymphoma with lymph node involvement
AbstractGamma delta T cells represent a minor subset of the normal lymphocyte component of the human immune system, largely inhabiting mucosal surfaces. Gamma delta T cell lymphomas ( γδ TCLs) are thought to be derived from these cells and are rare, extremely aggressive lymphomas that typically exhibit a cytotoxic phenotype and often present in extranodal sites, most commonly as cutaneous or hepatosplenic subtypes. The immunophenotype usually lacks both CD4 and CD8 expression, but occasional cases express CD8. CD4 expression in γδ TCLs is exceedingly rare. The few reported cases tend to show a non-cytotoxic phenotype w...
Source: Journal of Hematopathology - September 8, 2018 Category: Pathology Source Type: research
A unique case of mixed phenotype acute leukemia with t(9;22)(q34.1;q11.2); BCR-ABL1 sarcoma with epitheliotropism mimicking intestinal T cell lymphoma
We present an unusual case of myeloid sarcoma of T/myelomonocytic biphenotypic nature andBCR-ABL1 translocation demonstrating an epitheliotropism in the gastrointestinal tract and mass-forming lesions in the lungs without bone marrow involvement. A 69-year-old gentleman presented with non-bloody diarrhea and abdominal pain complicated by weight loss. CT scan showed diffuse mural thickening in the jejunum, distal ileum, transverse colon, and splenic flexure and bilateral pulmonary nodules. Biopsies of the ileum and colon were performed. An initial diagnosis of T cell lymphoma was made based on intestinal infiltration with C...
Source: Journal of Hematopathology - September 1, 2018 Category: Pathology Source Type: research
Disseminated BCG-osis with haemophagocytosis, tubercular bacteraemia, and unusual haematological findings with its haematology analyser-based expression
AbstractInfantile disseminated BCG-osis is an uncommon complication of BCG vaccination and the presence of haemophagocytic lymphohistiocytosis (HLH) further complicates the clinical course due to its fatal outcome. Here, we describe a rare case of disseminated BCG-osis with HLH in a 3-month-old male child and the unusual morphological findings in the peripheral blood with its haematology analyser-based expression. The child presented with fever, failure to thrive, hepatosplenomegaly, erythematous skin rashes, and left axillary lymphadenopathy with history of BCG vaccination at birth. He was the first born of second-degree ...
Source: Journal of Hematopathology - September 1, 2018 Category: Pathology Source Type: research
