Correction to: Secondary B-cell lymphoma associated with the Epstein-Barr virus in chronic lymphocytic leukemia patients
The article Secondary B-cell lymphoma associated with the Epstein-Barr virus in chronic lymphocytic leukemia patients. (Source: Journal of Hematopathology)
Source: Journal of Hematopathology - June 1, 2018 Category: Pathology Source Type: research
Classic Hodgkin lymphoma involving the endometrium: an extremely rare finding associated with refractory/widespread disease
AbstractClassic Hodgkin lymphoma (HL) involving the endometrium is extremely rare as lymphoma involving the female genital tract is uncommon in general and those that do are most commonly non-Hodgkin lymphomas. Here, we present a patient with refractory classic HL where PET scan imaging results led to an endometrial biopsy that confirmed uterine involvement of her disease. (Source: Journal of Hematopathology)
Source: Journal of Hematopathology - June 1, 2018 Category: Pathology Source Type: research
Transition
(Source: Journal of Hematopathology)
Source: Journal of Hematopathology - June 1, 2018 Category: Pathology Source Type: research
Classic Hodgkin lymphoma involving the endometrium: an extremely rare finding associated with refractory/widespread disease
AbstractClassic Hodgkin lymphoma (HL) involving the endometrium is extremely rare as lymphoma involving the female genital tract is uncommon in general and those that do are most commonly non-Hodgkin lymphomas. Here, we present a patient with refractory classic HL where PET scan imaging results led to an endometrial biopsy that confirmed uterine involvement of her disease. (Source: Journal of Hematopathology)
Source: Journal of Hematopathology - May 17, 2018 Category: Pathology Source Type: research
Correction to: Secondary B-cell lymphoma associated with the Epstein-Barr virus in chronic lymphocytic leukemia patients
The article Secondary B-cell lymphoma associated with the Epstein-Barr virus in chronic lymphocytic leukemia patients. (Source: Journal of Hematopathology)
Source: Journal of Hematopathology - May 4, 2018 Category: Pathology Source Type: research
Study of platelet activation markers and plasma cytokines in sickle cell disease patients during vaso-occlusive pain crises
AbstractThe present study was designed to examine platelet function during the sickle cell disease (SCD) vaso-occlusive pain crisis (VOC) in comparison with steady-state SCD patients and healthy controls. Platelets were immunophenotyped using different activation CD markers in a group of 34 patients with SCD. Among those SCD patients, 19 patients were admitted to our hospital for symptoms of VOC pain crises. Fifteen patients of SCD were studied in parallel during asymptomatic steady state (SS) of their disease. Fifteen healthy control volunteers were immunophenotyped in parallel. In addition, all patients and healthy contr...
Source: Journal of Hematopathology - April 18, 2018 Category: Pathology Source Type: research
Leukemic mantle cell lymphoma and chronic lymphocytic leukemia: a rare composite lymphoma and literature review
We report a case of a 75-year-old male with a slowly progressing lymphocytosis, but who was otherwise asymptomatic. Flow cytometry revealed two different populations, one showing bright Lambda positivity and CD5(+), while the other was positive for both lambda and kappa and was CD5(+). Subsequently, cytogenetics revealed two different populations, one with a trisomy 12 and the other with a t(11;14). Additionally, immunohistochemistry on a bone marrow biopsy showed SOX-11 to be negative and cyclin D1 to be positive on scattered lymphocytes. This was consistent with a composite lymphoma of leukemic mantle cell lymphoma and c...
Source: Journal of Hematopathology - April 4, 2018 Category: Pathology Source Type: research
Myeloid sarcoma of the nasal septum following invasive fungal sinusitis: report of a case and review of the relevant literature
This report describes a 75-year-old male with a known history of AML who developed both AIFS and myeloid sarcoma. Several months after successful treatment for biopsy proven AIFS, this patient developed a new soft tissue mass of the nasal septum. A new biopsy was obtained which revealed infiltrating blast cells with evidence of monocytic differentiation diagnostic of myeloid sarcoma. Given symptoms of severe nasal obstruction, this patient received palliative radiotherapy to the nasal septum, which provided temporary improvement prior to the patient succumbing to his underlying malignancy. We review the existing reports of...
Source: Journal of Hematopathology - March 27, 2018 Category: Pathology Source Type: research
Mutation of the DNMT3A and IDH1/2 genes in Iranian acute myeloid leukemia patients with normal karyotype (CN-AML): association with other gene mutation and clinical and laboratory characteristics
This study was purposed to investigate the frequency of DNMT3A and IDH1/2 gene mutation and the clinical features of Iranian cytogenetically normal acute myeloid leukemia (CN-AML) patients harboring these mutations. Thirty-nine CN-AML patients were recruited at the time of diagnosis. PCR followed by direct sequencing was used to detect the mutations of DNMT3A (R882), IDH1 (R132), and IDH2 (R140 and R172). The results showed that of all CN-AML patients, DNMT3A, IDH1, and IDH2 mutations were observed in five (12.8%), five (12.8%), and five (13.2%) patients, respectively. In addition, the most frequent DNMT3A, IDH1, and IDH2 ...
Source: Journal of Hematopathology - March 20, 2018 Category: Pathology Source Type: research
Leukemic phase of primary cutaneous anaplastic large-cell lymphoma (ALK-negative), with downregulation of CD30
We present a case of primary cutaneous-ALCL (C-ALCL), who developed nodal involvement 4 years later. The patient was treated with combination chemotherapy and autologous stem cell transplantation; however, she relapsed 5 months later. At that time, the patient was given brentuximab vedotin (BV) with initial response. One year later, the patient demonstrated progressive adenopathy an d leukemic involvement by her ALCL (comparative T cell clonality showed PCR products of the same size in the diagnostic skin and relapsed leukemic blood). Interestingly, the circulating tumor cells showed only subset expression of CD30 by fl...
Source: Journal of Hematopathology - March 2, 2018 Category: Pathology Source Type: research
Isolated central nervous system post-transplant lymphoproliferative disorder in a pediatric patient: a case report with pathobiological perspective
We present a case of an 8-year-old male with a prior history of a kidney transplant who developed and ICNS-PTLD. We highlight the pathobiology and diagnostic features with a brief review of the literature on these rare cases. There is a complex interplay between CD30, Epstein Barr Virus and MYC as part of lymphocyte transformation leading to PTLD. In the appropriate clinical setting, CD30 and EBV positivity along with normal MYC expression are highly predictive of CNS-PTLD over a Primary CNS lymphoma. ICNS-PTLD has only been rarely reported in children. The faithful diagnosis is necessary for prognostication and to accrue ...
Source: Journal of Hematopathology - March 1, 2018 Category: Pathology Source Type: research
Rare aggressive natural killer cell leukemia presented with leukopenia and disseminated intravascular coagulation —a diagnostic challenge
AbstractAggressive natural killer cell leukemia/lymphoma (ANKL) is a rare and aggressive malignancy of natural killer (NK) cells. It is now regarded as a distinct subtype of leukemia as a provisional entity: “NK cell lymphoblastic leukemia/lymphoma” in the 2016 revision to the World Health Organization classification. It is important to diagnose ANKL early due to its fulminant clinical features that may rapidly progress to multiorgan failure (MOF). However, there is no definite diagnostic marker of the disease so it is difficult to make differential diagnosis from other lymphoproliferative disorders. The case reported ...
Source: Journal of Hematopathology - March 1, 2018 Category: Pathology Source Type: research
A case of very rare co-occurrence of POEMS syndrome and JAK2 V617F positive MPN
(Source: Journal of Hematopathology)
Source: Journal of Hematopathology - March 1, 2018 Category: Pathology Source Type: research
Primary lymphomatous presentation of hairy cell leukemia as osteolytic vertebral lesions: a case report
AbstractHairy cell leukemia (HCL) is a rare and indolent mature B cell neoplasm. Most patients with HCL have excellent response to purine analogs and BRAF inhibitors. Therefore, it is clinically important to identify and differentiate HCL from other B cell neoplasms. HCL is predominantly found in the peripheral blood, bone marrow, or spleen. HCL presenting initially or solely in unusual sites is extremely rare (approximately ten or fewer). We hereby report a unique case of HCL presenting as vertebral osteolytic and epidural mass lesions without bone marrow, spleen, or peripheral blood involvement. The patient was a 53-year...
Source: Journal of Hematopathology - March 1, 2018 Category: Pathology Source Type: research
