Rare presentation of B-lymphoblastic leukemia/lymphoma with intussusception in an adult
We present a case of a 46-year-old man with no pertinent medical or surgical history who presented with severe abdominal pain, nausea, and emesis. An abdominal CT scan was suggestive of strangulation of the distal small bowel and ischemia, showed extensive matted lymphadenopathy in the mesentery, and multiple left suprarenal periaortic nodes. A bowel resection was performed and there was an ileocolonic intussusception with the right colon filled with the intussuscepted terminal ileum. Opening the specimen revealed a submucosal ileal mass that measured 3 × 2.2 × 1.3 cm with a well-circumscribed, yellow-white cut...
Source: Journal of Hematopathology - April 23, 2022 Category: Pathology Source Type: research
Non-Hodgkin lymphoma mimicking acute leukemia: a report of six cases and review of the literature
We describe six cases of non-Hodgkin lymphoma that mimicked acute leukemia and were identified in the pathology records of the Brigham and Women's Hospital. The patients were older adults (mean age 70 years), who presented with leukocytosis (mean 79.7 × 109/L) with circulating neoplastic cells (mean 57%), which mimicked leukemic blasts, thrombocytopenia, and anemia (4/6 patients). In each case, immunophenotypic analysis identified a population of mature B cells or mature T cells. We identified 15 additional cases of non-Hodgkin lymphoma in the literature that mimicked acute leukemia; considering all 21 cases, 11 had...
Source: Journal of Hematopathology - April 23, 2022 Category: Pathology Source Type: research
Surface CD22 is a highly sensitive and specific B lineage marker and can replace cytoplasmic CD79a/cytoplasmic CD22 in flow cytometric reagent panels for the diagnosis of B-acute lymphoblastic leukemia
AbstractWorld Health Organization (WHO) guidelines, 2008 and 2016, have laid down strict criteria for assigning the lineage to blast cells in the diagnosis and classification of acute leukemia. While cytoplasmic (c) CD22 has been recommended by WHO as a strong B lymphoid lineage-associated marker along with surface (s) CD19, cCD79a, and sCD10, there is no reference to sCD22 as a diagnostic marker in these guidelines. In view of the above fact and the technological advantage surface immunophenotyping assays provide over the cytoplasmic assays, we examined the sensitivity and specificity of sCD22 for B lymphoid lineage. Blas...
Source: Journal of Hematopathology - April 23, 2022 Category: Pathology Source Type: research
Blister cells in sickle cell anemia
(Source: Journal of Hematopathology)
Source: Journal of Hematopathology - April 19, 2022 Category: Pathology Source Type: research
Protein kinase c delta expression in primary central nervous system lymphomas
AbstractPrimary central nervous system lymphoma (PCNSL) is a highly aggressive non-Hodgkin lymphoma confined to the central nervous system. Diffuse large B cell lymphoma (DLBCL) is the most common subtype, and it follows a much more aggressive course than its systemic counterpart. Differential diagnosis of PCNSL and systemic DLBCL depends on clinical staging, which is expensive and time consuming. Protein kinase C delta (PKCD) is a protein with proapopitotic properties and has a major role in negative selection of B cells in germinal centers, a regulatory function in B cell receptor (BCR) pathway and MHC II expression. Mut...
Source: Journal of Hematopathology - April 4, 2022 Category: Pathology Source Type: research
Macrothrombocytopenia and leukocyte inclusions: May-Hegglin anomaly
(Source: Journal of Hematopathology)
Source: Journal of Hematopathology - March 30, 2022 Category: Pathology Source Type: research
Analysis of factors associated with the development of myelofibrosis in polycythemia vera and essential thrombocythemia patients: a single-center experience
AbstractIn some patients with chronic myeloproliferative neoplasms, myelofibrosis (MF) develops as natural evolution of the disease. The aim of this study was to analyze predictive factors that may cause MF in polycythemia vera (PV) and essential thrombocythemia (ET) patients. This retrospective study was conducted on PV and ET patients who attended our hospital between 2008 and 2019. The development of MF during follow-up was recorded, and comparisons were made of the patients who developed MF and those who did not develop MF. Evaluation was made of 126 ET and 105 PV patients. During follow-up period, MF had developed 5.7...
Source: Journal of Hematopathology - March 28, 2022 Category: Pathology Source Type: research
Incidence and immunophenotype of abnormal lymphoblast populations at diagnosis of chronic myeloid leukaemia in chronic phase
AbstractChronic myeloid leukaemia most commonly presents in chronic phase (CML-CP) and it is characterised by granulocytic proliferation. Many patients have an excellent response to tyrosine kinase inhibitor therapy; however, a small proportion will develop lymphoid or myeloid blast crisis, with inferior clinical outcomes. Detection of lymphoblasts at diagnosis of CML-CP has been reported in small case series with conflicting results on the risk of subsequent blast crisis. The aim of this study was to identify the incidence and immunophenotype of abnormal lymphoblast populations in CML-CP. Retrospective review of bone marr...
Source: Journal of Hematopathology - March 10, 2022 Category: Pathology Source Type: research
Kikuchi –Fujimoto disease following vaccination against COVID-19
AbstractThe purpose of this study is to explore the clinicopathological features of Kikuchi –Fujimoto disease (KFD) following vaccination against coronavirus disease 2019 (COVID-19). One case of KFD following vaccination against COVID-19 was examined clinically, histologically, and immunohistochemically. The patient was a 36-year-old Chinese man who suffered from fever and cervical lymph node swelling following simultaneous administration of the COVID-19 vaccine. The patient was diagnosed with KFD based on the histopathological findings of a lymph node core needle biopsy, and his fever and swelling resolved 2 months late...
Source: Journal of Hematopathology - March 4, 2022 Category: Pathology Source Type: research
Intracerebral manifestation of iatrogenic, immunodeficiency-associated polymorphic B-LPD with morphology mimicking Hodgkin lymphoma: a case report and literature review
We present an unusual case with isolated, intracerebral manifestation of polymorphic B-LPD with features of classic Hodgkin-lymphoma in an immunosuppressed patient treated with methotrexate and infliximab, including clinical-radiological features and a detailed description of morphological findings, together with a literature review on reported cases of primary CNS manifestation of cHL and IA-LPD with Hodgkin-like morphology. The patient achieved complete remission following neurosurgery with gross total tumor resection and drug withdrawal without any additional treatment. Post-operative staging revealed no evidence fo...
Source: Journal of Hematopathology - March 4, 2022 Category: Pathology Source Type: research
Reviewers for Journal of Hematopathology in 2021
(Source: Journal of Hematopathology)
Source: Journal of Hematopathology - March 1, 2022 Category: Pathology Source Type: research
Mixed phenotype acute leukaemia with monosomy 7 and BCR-ABL1 translocation following antimetabolite therapy for intrahepatic cholangiocarcinoma
(Source: Journal of Hematopathology)
Source: Journal of Hematopathology - February 16, 2022 Category: Pathology Source Type: research
Progressive lymphocytosis in familial hemophagocytic lymphohistiocytosis with lymphocytic interstitial pneumonia: a case report
In this study, we reported a rare case of adult-onset FHL3 with progressive lymphocytosis and lymphocytic interstitial pneumonia (LIP). A 20-year old female was admitted to our institution for persistent cough with fever. A chest high-resolution computed tomography (HRCT) scan showed diffuse bilateral ground glass opacities (GGO). A lung biopsy revealed infiltration of lymphocyte in the pulmonary interstitium. The patient was treated with corticosteroids and immunosuppressants, followed by significant clinical improvement although lymphocytosis still persisted. The definitive diagnosis of FHL was based on whole genome sequ...
Source: Journal of Hematopathology - February 15, 2022 Category: Pathology Source Type: research
Evaluation of immature granulocyte parameters in myeloid neoplasms assayed by Sysmex XN hematology analyzer
AbstractImmature granulocytes (IGs) have significance for the diagnosis of myeloid neoplasms (MNs). The current study aims to use a hematology analyzer to evaluate the accuracy of IG parameters in MNs. Blood specimens from 388 patients with MN, 524 with non-hematological neoplasms (non-HNs), including 109 patients with inflammation and 68 undergoing G-CSF administration, and 500 healthy control subjects were analyzed. IG parameters was assayed by Sysmex XN-9000 (XN) and compared with manual assessments. A high level of agreement between IG% derived from XN and manual measurements for MN patients (r = 0.828,p < ...
Source: Journal of Hematopathology - February 8, 2022 Category: Pathology Source Type: research
Histiocyte-rich pseudotumor — a post-chemotherapy radiologic dilemma
(Source: Journal of Hematopathology)
Source: Journal of Hematopathology - February 4, 2022 Category: Pathology Source Type: research
