The value of next generation sequencing in the diagnosis of a rare cause of eosinophilia: B cell-acute lymphoblastic leukemia with t(5;14)(q31;q32)

We present a case of B-ALL with t(5;14)(q31;q32) where the diagnosis was especially challenging given the patient ’s multiple risk factors for eosinophilia and normal chromosome analysis and fluorescence in situ hybridization studies.The diagnosis was ultimately made with the identification of t(5;14)(q31;q32) by next generation sequencing. The patient received chemotherapy and is in clinical remission. This case adds to the limited body of literature of this rare entity and illustrates the value of next generation sequencing in the evaluation of patients with eosinophilia.
Source: Journal of Hematopathology - Category: Pathology Source Type: research