Nodular lymphocyte-predominant Hodgkin lymphoma and clinical impact of its variant histology: a clinicopathologic study from tertiary cancer centre in India

AbstractNodular lymphocyte-predominant Hodgkin lymphoma (NLPHL) can show variant histological patterns, some of which may be associated with an advanced stage and increased relapse rate. Through this study, we put the various histological patterns of NLPHL under spotlight and assess their prognostic implications. A retrospective histologic and immunohistochemistry review of all archival slides of NLPHL over a period of 6  years was performed. A total of 36 cases were identified. We recognised the typical (A, B) and histopathologic variant patterns (C to F) of NLPHL as per the criteria given by Fan et al. and scored these cases using the 5 histological parameters described by Shet et al. Complete clinical follow-up information could be obtained in 25 cases. Patients with NLPHL constituted 6.4% of Hodgkin lymphoma cases in our institute. While predominant typical histological patterns were seen in 9/36 patients, variant patterns C, D, E, and F were observed in 15, 3, 7, and 2 cases respectively. All cases with typical growth patterns showed a score of ≤ 5 and those with variant histologies showed scores between 2 and 9. Relapse of lymphoma was seen in 7 cases, all of which showed a variant histology. The histopathological scores increased or stayed constant at the time of relapse. Histopathological growth patterns at the time of initial diagnosis and disease relapse were consistent in 6/7 cases. Transformation to large B-cell lymphoma was seen in 1 case. We could conclud...
Source: Journal of Hematopathology - Category: Pathology Source Type: research