The risk and prognostic influence of caspase 9 promotor polymorphisms in Egyptian patients with acute myeloid leukemia

This study was to evaluate these polymorphisms in an independent cohort of AML patients and controls in Egypt. PCR–RFLP forCASP9 1263 rs4645978 A  >  G andCASP9 712 rs4645981 C  >  T genotypes were done in 60 de novo AML cases and 40 healthy control subjects. Our study showed thatCASP9 712 rs4645981 C  >  T gene polymorphism is associated with increased risk of developing AML and poor disease outcome (p value = 0.006, <  0.001;OR = 3.644, 26; and95% CI = 1.39–9.528, 6.5–103.5, respectively). In contrast,CASP9 1263 rs4645978 A  >  G showed no significant difference between AML patients and the controls regarding the risk of developing AML or disease outcome (p value = 0.301, 0.573, respectively).CASP9 712 rs4645981 C  >  T could be involved in the pathophysiology and development of AML in Egypt and may be useful as a predictive molecular markers for inferior prognosis in AML. Notably, risk was highest and outcomes worst in patients with both the 712C >  T and 1263A >  G alleles.
Source: Journal of Hematopathology - Category: Pathology Source Type: research