Repeatability and variation of the flow independent nitric oxide parameters
Introduction: Fractional exhaled nitric oxide (F E NO) is a non-invasive marker of airway
inflammation. Measuring F E NO at several flow rates enables the calculation of flow independent
NO-parameters (alveolar NO concentration (C A NO), bronchial flux of NO (J aw NO), bronchial mucosal
NO concentration (C aw NO) and bronchial wall NO diffusion capacity (D aw NO)) that are capable of
partitioning the source and release mechanism of NO from the lower respiratory tract. However, the
current literature on repeatability and normal variation of the NO-parameters is deficient, and this
information is needed to develop the ...
Source: Journal of Breath Research - January 28, 2020 Category: Respiratory Medicine Authors: Tuomas Karvonen and Lauri Lehtim äki Source Type: research
Reply to Comment on ‘Volatile biomarker in breath predicts lung cancer and pulmonary nodules’
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Source: Journal of Breath Research - January 23, 2020 Category: Respiratory Medicine Authors: Michael Phillips, Thomas L Bauer and Harvey I Pass Source Type: research
Comment on ‘volatile biomarker in breath predicts lung cancer and pulmonary nodules’
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Source: Journal of Breath Research - January 23, 2020 Category: Respiratory Medicine Authors: A S Modak, V Ruzsanyi, P Mochalski and C A Mayhew Source Type: research
Portable exhaled breath condensate metabolomics for daily monitoring of adolescent asthma
Description unavailable (Source: Journal of Breath Research)
Source: Journal of Breath Research - January 22, 2020 Category: Respiratory Medicine Authors: Alexander J Schmidt, Eva Borras, Anh P Nguyen, Danny Yeap, Nicholas J Kenyon and Cristina E Davis Source Type: research
Clinical precision, accuracy, number and durations of exhalations for a novel electrochemical
monitor for exhaled nitric oxide
Background: Exhaled nitric oxide (FeNO) is a validated marker of eosinophilic inflammation. Fenom
Pro TM is a novel FDA-cleared monitor for FeNO. The American Thoracic Guidelines from 2005 recommend
at least 6 s exhalation for adults and in some cases up to 10 s, and 4 s for children, and that the
average of the first two valid exhalations is taken as the FeNO value. Methods: Clinical precision,
6 versus 10 s exhalations, the first versus the average of the first two valid exhalation methods
comparison were evaluated for Fenom Pro TM , as well as a methods comparison to the NIOX VERO ®
monitor. Results: The intent-t...
Source: Journal of Breath Research - December 30, 2019 Category: Respiratory Medicine Authors: Philip E Silkoff, Brian Awabdy, Mark Sarno, Solomon Ssenyange, Vivek Balsubramanyam and Ryan Leard Source Type: research
On-line profiling of volatile compounds produced in vitro by pathogenic oral bacteria
In this study, we
have performed in vitro headspace measurements on four important oral pathogens ( P. gingivalis, T.
forsythia, P. intermedia and P. nigrescens ) using proton transfer reaction time-of-flight mass
spectrometry (PTR-TOF-MS). Some of the most abundant compounds produced by the bacteria include
hydrogen sulphide, methanethiol, acetone, dimethylsulphide, isoprene, cyclopentanone and indole as
tentatively assigned from the mass spectra. Several other abundant mass signals were recorded but
the assignment of these is less certain. Some of the bacterial species can be separated from each
oth... (Source: Jo...
Source: Journal of Breath Research - December 15, 2019 Category: Respiratory Medicine Authors: Kajsa Roslund, Markku Lehto, Pirkko Pussinen, Per-Henrik Groop, Lauri Halonen and Markus Mets älä Source Type: research
Characterization of standardized breath sampling for off-line field use
Due to several sources of potential variability associated with exhaled breath bag sampling
procedures for off-line analysis, the Respiration Collector for in vitro Analysis (ReCIVA) sampler
was developed. Although designed to improve upon several pitfalls of sampling with exhaled breath
bags, the ReCIVA remains a minimally studied research tool. In this manuscript, several attributes
of the ReCIVA sampler are investigated among three individual tests, such as background
contamination, control software version, performance of different adsorbent tubes, duplicate sample
production, and comparison to exhaled breath bag...
Source: Journal of Breath Research - December 15, 2019 Category: Respiratory Medicine Authors: Sean W Harshman, Rhonda L Pitsch, Christina N Davidson, Alexander M Scott, Elizabeth M Hill, Zachary K Smith, Kraig E Strayer, Nicole M Schaeublin, Taylor L Wiens, Michael C Brothers, Grant M Slusher, Megan L Steele, Brian A Geier, Maomian Fan, Leslie A D Source Type: research
A simple method to reduce halitosis; tongue scraping with probiotics
Objective: We aimed to assess the effects of probiotic implantation to the dorsum of the tongue
against halitosis. Materials and methods : 100 participants were randomly divided into three groups
as tongue back scraping (TS), probiotic implantation to the dorsum of the tongue (PB) and mouthwash
alone as the control group (MW). Measurements were taken before the treatment, after the first month
of treatment and one month after the cessation of treatment. Results : Halimeter, winkel and
woodlight scores were evaluated initially, in the first month and after the cessation of the
treatment. All of MW measurements showed ...
Source: Journal of Breath Research - December 3, 2019 Category: Respiratory Medicine Authors: Berk Gurpinar, G üven Yildirim, Tolgar Lütfi Kumral, Muhammed Fatih Akgun, Hüseyin Sari, Belgin Tutar and Yavuz Uyar Source Type: research
How do cancer-sniffing dogs sort biological samples? Exploring case-control samples with
non-targeted LC-Orbitrap, GC-MS, and immunochemistry methods
Early identification of disease onset is regarded as an important factor for successful medical
intervention. However, cancer and other long-term latency diseases are rare and may take years to
manifest clinically. As such, there are no gold standards with which to immediately validate
proposed preclinical screening methodologies. There is evidence that dogs can sort samples
reproducibly into yes/no categories based on case-control training, but the basis of their decisions
is unknown. Because dogs are sniffing air, the distinguishing chemicals must be either in the
gas-phase or attached to aerosols and/or airborne p...
Source: Journal of Breath Research - November 18, 2019 Category: Respiratory Medicine Authors: Joachim D Pleil, M Ariel Geer Wallace, James McCord, Michael C Madden, Jon Sobus and Glenn Ferguson Source Type: research
Relationship of tongue coating microbiome on volatile sulfur compounds in healthy and halitosis
adults
This study aims to assess the microbiome variations related to intraoral halitosis and its
relationship with volatile sulfur compounds (VSCs) among periodontally healthy Chinese adults.
Material and methods : Tongue coating samples were collected from 28 periodontally healthy subjects
(16 subjects with halitosis and 12 subjects without halitosis) who fulfilled the selection criteria.
The organoleptic score (OS) was used to evaluate the halitosis status. The characterization of
associated microbial communities was performed using 16S rRNA gene pyrosequencing and metagenomics
methods. Results : A wide range of microbia...
Source: Journal of Breath Research - November 18, 2019 Category: Respiratory Medicine Authors: Wei Ye, Yu Zhang, Mei He, Ce Zhu and Xi-Ping Feng Source Type: research
Influence of media on the differentiation of Staphylococcus spp. by volatile compounds
Staphylococcus aureus asymptomatically colonizes a third of the world ’s population, and it is an
opportunistic pathogen that can cause life threatening diseases. To diagnose S. aureus infections,
it is necessary to differentiate S. aureus from the ubiquitous human commensal Staphylococcus
epidermidis , which beneficially colonizes the skin of all humans. Efforts are underway to identify
volatile biomarkers for diagnosing S. aureus infections, but to date no studies have investigated
whether S. aureus and S. epidermidis can be reliably differentiated under a variety of growth
conditions. The overall goal of this st...
Source: Journal of Breath Research - November 18, 2019 Category: Respiratory Medicine Authors: Carrie L Jenkins and Heather D Bean Source Type: research
Online breath analysis using metal oxide semiconductor sensors (electronic nose) for diagnosis of
lung cancer
This study involved 118 individuals: 65 in the lung cancer group (cytologically verified)
and 53 in the healthy control group. The exhaled breath samples of the volunteers were analysed
using the developed E-nose system. The dataset obtained, consisting of the sensor responses, was
pre-processed ... (Source: Journal of Breath Research)
Source: Journal of Breath Research - October 21, 2019 Category: Respiratory Medicine Authors: Aleksandr Kononov, Boris Korotetsky, Igor Jahatspanian, Anna Gubal, Alexey Vasiliev, Andrey Arsenjev, Andrey Nefedov, Anton Barchuk, Ilya Gorbunov, Kirill Kozyrev, Anna Rassadina, Evgenia Iakovleva, Mika Sillanp ää, Zahra Safaei, Natalya Ivanenko, Nadez Source Type: research
Investigation of paediatric PKU breath malodour, comparing glycomacropeptide with phenylalanine free
L-amino acid supplements
In clinical practice, caregivers of children with phenylketonuria (PKU) report that their children
have breath malodour. This might be linked to the regular consumption of low phenylalanine
(Phe)/Phe-free protein substitutes (PS), which are an essential component of a low-Phe diet. Oral
malodour can negatively affect interpersonal communication, lead to bullying, low self-esteem and
social isolation. In this longitudinal cross-over study, exhaled volatile organic compounds (VOCs)
were measured using gas chromatography-ion mobility spectrometry. 40 children (20 PKU, 20 controls)
were recruited. Subjects with PKU took ...
Source: Journal of Breath Research - October 19, 2019 Category: Respiratory Medicine Authors: Akira Tiele, Anne Daly, John Hattersley, Alex Pinto, Sharon Evans, Catherine Ashmore, Anita MacDonald and James A Covington Source Type: research
Breath analysis using a spirometer and volatile organic compound sensor on driving simulator
In this study the correlation between the condition of drivers and their expiration was evaluated by
analyzing the exhalation of car drivers in a simulation setting using a spirometer and a volatile
organic compound (VOC) gas sensor. Participants wore exhalation masks and their expiration was
monitored for fluctuations in breath measurements, including VOC concentration, oxygen intake,
carbon dioxide excretion, and respiration rate. Participants used a driving simulator on four
different courses of varying difficulty for approximately five min each, with the mean and standard
deviation (SD) being calculated for each ...
Source: Journal of Breath Research - October 19, 2019 Category: Respiratory Medicine Authors: Toshio Itoh, Toshihisa Sato, Takafumi Akamatsu and Woosuck Shin Source Type: research
Volatile organic compound (VOC) emissions of CHO and T cells correlate to their expansion in
bioreactors
Volatile organic compound (VOC) emissions were measured from Chinese Hamster Ovary (CHO) cell and T
cell bioreactor gas exhaust lines with the goal of non-invasively metabolically profiling the
expansion process. Measurements of cellular ‘breath’ were made directly from the gas exhaust lines
using polydimethylsiloxane (PDMS)-coated magnetic stir bars, which underwent subsequent thermal
desorption-gas chromatography-mass spectrometry (TD –GC–MS) analysis. Baseline VOC profiles were
observed from bioreactors filled with only liquid media. After inoculation, unique VOC profiles
correlated to cell expansion over ...
Source: Journal of Breath Research - October 19, 2019 Category: Respiratory Medicine Authors: Mitchell M McCartney, Mei S Yamaguchi, Paul A Bowles, Yarden S Gratch, Rohin K Iyer, Angela L Linderholm, Susan E Ebeler, Nicholas J Kenyon, Michael Schivo, Richart W Harper, Paul Goodwin and Cristina E Davis Source Type: research
