Clinical precision, accuracy, number and durations of exhalations for a novel electrochemical monitor for exhaled nitric oxide

Background: Exhaled nitric oxide (FeNO) is a validated marker of eosinophilic inflammation. Fenom Pro TM is a novel FDA-cleared monitor for FeNO. The American Thoracic Guidelines from 2005 recommend at least 6 s exhalation for adults and in some cases up to 10 s, and 4 s for children, and that the average of the first two valid exhalations is taken as the FeNO value. Methods: Clinical precision, 6 versus 10 s exhalations, the first versus the average of the first two valid exhalation methods comparison were evaluated for Fenom Pro TM , as well as a methods comparison to the NIOX VERO ® monitor. Results: The intent-to-treat population (n  = 126) consisted of 83 adults, and 43 pediatric subjects with 16 subjects under 12 years of age. Clinical precision for 10 s exhalations on Fenom Pro TM was excellent with a within-subject standard deviation (SD) range of 0.57 –3.73 ppb and mean coefficient of variation (CV) range of 4.2...
Source: Journal of Breath Research - Category: Respiratory Medicine Authors: Source Type: research