The miRNA-24, miRNA-21 expressions and matrix metalloproteinase-7 level in exhaled breath condensate of children with primary spontaneous pneumothorax
In conclusion, the miRNA-24 levels were significantly decreased in children with PSP. Taken together, children with PSP, especially those with bullous disease, should be closely monitored in the long-term period. (Source: Journal of Breath Research)
Source: Journal of Breath Research - December 15, 2022 Category: Respiratory Medicine Authors: Tutku Soyer, Esra Birben, Servet Melike Ak ıncı, Gülnur Göllü, Özlem Boybeyi Türer, Özge Soyer, Murat Çakmak, Bülent Enis Şekerel and Feridun Cahit Tanyel Source Type: research
Characterization of the elemental and particle load of patient exhaled breath condensate and comparison with pulmonary lavages
In conclusion, the particulate content of EBC is associated with the lung particle burden and potentially correlates with pathologies, rendering it a relevant biomonitoring technique for the occupational and clinical fields. (Source: Journal of Breath Research)
Source: Journal of Breath Research - December 15, 2022 Category: Respiratory Medicine Authors: Caroline Marie-Desvergne, Muriel Dubosson, Lara Leclerc, Catherine Campo, Dimitrios Bitounis, Val érie Forest, Jérémie Pourchez, Michèle Cottier, Jean-Michel Vergnon, Adeline Tarantini and Véronique Chamel-Mossuz Source Type: research
Breast cancer detection using volatile compound profiles in exhaled breath via selected ion-flow tube mass spectrometry
This study aimed to evaluate volatile compounds in exhaled breath as a non-invasive screening method to detect breast neoplasms. Exhaled breath samples were collected from patients with breast cancer (BC; n = 45) and non-breast cancer (NBC; n = 51) controls. Selected ion-flow tube mass spectrometry was used to quantify the volatile compounds. A multiple logistic regression (MLR) model was developed by combining multiple compounds to discriminate between BC and NBC samples. Amongst the 672 quantified peaks, 17 showed significant differences between BC and NBC samples (P< 0.05 corrected by false discovery rate). Pathway a...
Source: Journal of Breath Research - December 8, 2022 Category: Respiratory Medicine Authors: Yoshie Nakayama, Mariko Hanada, Hiroshi Koda, Masahiro Sugimoto, Masahiro Takada and Masakazu Toi Source Type: research
Intelligent COVID-19 screening platform based on breath analysis
The spread of coronavirus disease 2019 (COVID-19) results in an increasing incidence and mortality. The typical diagnosis technique for severe acute respiratory syndrome coronavirus 2 infection is reverse transcription polymerase chain reaction, which is relatively expensive, time-consuming, professional, and suffered from false-negative results. A reliable, non-invasive diagnosis method is in urgent need for the rapid screening of COVID-19 patients and controlling the epidemic. Here we constructed an intelligent system based on the volatile organic compound (VOC) biomarkers in human breath combined with machine learning m...
Source: Journal of Breath Research - November 24, 2022 Category: Respiratory Medicine Authors: Cuili Xue, Xiaohong Xu, Zexi Liu, Yuna Zhang, Yuli Xu, Jiaqi Niu, Han Jin, Wujun Xiong and Daxiang Cui Source Type: research
The advantages of standardizing exhaled breath-alcohol concentration to a reference respiratory gas —water vapor
This article reviews the principles and practice of breath-alcohol analysis and introduces the concept of standardizing the results to a secondary physiological gas (water vapor), which therefore serves as an internal standard. The measured BrAC is thus adjusted to an alveolar air water content of 43.95 mg l −1 at 37 °C. This has several advantages, and means that a sample of breath can be captured without the person having to blow directly into the instrument. Adjusting the breath-alcohol concentration to water vapor concentration also compensates for variations in temperature of the expired air. Th e contact-free meth...
Source: Journal of Breath Research - November 23, 2022 Category: Respiratory Medicine Authors: Lars Lindberg and Alan Wayne Jones Source Type: research
Mixed effects of moderate exercise and subsequent various food ingestion on breath acetone
Acetone, which is exhaled with breath, is a by-product of lipolysis and could be used as a simple, useful indicator of lipolysis in the body because, unlike blood sampling, it can be measured non-invasively and repeatedly. Breath acetone concentration, however, is known to be affected by several factors such as exercise and food. We designed the experiments to evaluate the mixed effect on breath acetone of exercise and food ingestion in order to enhance the usefulness of breath acetone for monitoring fat loss. Seven healthy males performed moderate exercise for twice of 45 min with an interval of 15 min then rested for 4 h...
Source: Journal of Breath Research - November 14, 2022 Category: Respiratory Medicine Authors: Koichiro Nagamine, Daiki Mineta, Koji Ishida, Keisho Katayama and Takaharu Kondo Source Type: research
Concerning perceived and clinically-measured levels of halitosis
This study aimed to examine the objectively measured halitosis levels based on the reasons individuals are concerned about halitosis. We included 2063 patients who visited the halitosis clinic at a university dental hospital. Halitosis was assessed using GC, self-administered questionnaires, and oral examinations. Levels of volatile sulphur compounds (VSCs; H2S, CH3SH, and (CH3)2S) were set as objective measures of halitosis. Patients were grouped based on their answers to ‘What made you concerned about bad breath?’ into group s: ‘self-perceived,’ ‘attitudes of others,’ ‘told by others,’ and other reasons. ...
Source: Journal of Breath Research - November 7, 2022 Category: Respiratory Medicine Authors: Akiko Oshiro, Takashi Zaitsu, Yuko Inoue, Jarassri Srinarupat, Vy Thi Nhat Nguyen, Masato Nagai and Jun Aida Source Type: research
Effects of Bifidobacterium lactis HN019 and Lactobacillus acidophilus NCFM on volatile sulfur compounds produced by oral anaerobes
In this study, Bifidobacterium lactis HN019 and Lactobacillus acidophilus NCFM were identified from four kinds of probiotics and the antimicrobial activities against pathogens related to halitosis and inhibitory effects on VSCs were investigated. The results showed that B. lactis HN019 and L. acidophilus NCFM exhibited superior bacteriostatic action against pathogens related to halitosis and showed remarkable inhibitory effect on the production and emission of VSCs. These findings suggest that B. lactis HN019 and L. acidophilus NCFM may serve as promising parts of a successful halitosis manage plan. (Source: Journal of Breath Research)
Source: Journal of Breath Research - November 4, 2022 Category: Respiratory Medicine Authors: Peiqing Huang, Shaotang Yuan, Xin Xu and Xian Peng Source Type: research
Limitations and opportunities in breath research in the face of the COVID-19 pandemic
(Source: Journal of Breath Research)
Source: Journal of Breath Research - November 3, 2022 Category: Respiratory Medicine Authors: Makoto Sawano and Jonathan Beauchamp Source Type: research
Influences of breath sample re-use on the accuracy of lung cancer detection dogs
Evaluations of dogs as lung cancer detectors using breath samples have produced a variety of results, some quite promising. Breath samples are typically collected onto a substrate and stored in a sealed container when not in use, but volatile compounds dissipate when the substrate is exposed during training and evaluation sessions. Collection of appropriate samples for training and testing dogs requires significant resources and strict control of recruitment and sample collection processes. Therefore, some researchers re-use samples while training dogs. No systematic evaluation of the effect of sample re-use on dogs ’ tr...
Source: Journal of Breath Research - October 31, 2022 Category: Respiratory Medicine Authors: Margaret A Crawford, Catherina L Chang, Sandra Hopping, Clare M Browne and Timothy L Edwards Source Type: research
Criticism of the organoleptic examination for the diagnosis of oral halitosis
Due to the fact that only a human can judge the objectionability of an odor, organoleptic examination (sniffing and scoring oral odor) was used as a reference standard of oral halitosis measurement. However, there are several problems that make the diagnostic value of organoleptic examination questionable. There is no universally accepted, precise definition, standardization or calibration in organoleptic examination, including scoring, scaling or safety protocols. Standardization, calibration, reproducibility, reliability, objectivity, specificity, accuracy and sensitivity of organoleptic measurements are doubtful. It is ...
Source: Journal of Breath Research - October 12, 2022 Category: Respiratory Medicine Authors: Murat Aydin Source Type: research
Volatile composition of the morning breath
In this study, we found 35 such VOCs. Out of these, 33 have been previously connected to different oral niches, such as salivary and subgingival bact eria. We also compared the concentrations of the 35 VOCs found in increased amounts in the morning breath to their respective odor thresholds to evaluate their ability to cause odor. Compounds that could contribute to the breath odor include many volatile sulfur compounds, such as methanethiol, hydr ogen sulfide, dimethyl sulfide, and 2-methyl-1-propanethiol, but also other VOCs, such as acetic acid, butyric acid, valeric acid, acetaldehyde, octanal, phenol, indole, ammonia, ...
Source: Journal of Breath Research - September 18, 2022 Category: Respiratory Medicine Authors: Kajsa Roslund, Markku Lehto, Pirkko Pussinen and Markus Mets älä Source Type: research
A feasibility study of Covid-19 detection using breath analysis by high-pressure photon ionization time-of-flight mass spectrometry
This study evaluated a simple, fast, non-invasive VOCs-based COVID-19 detection method and demonstrated that it has good sensitivity and specificity in distinguishing COVID-19 infected patients from controls. It has great potential for fast and accurate COVID-19 detection. (Source: Journal of Breath Research)
Source: Journal of Breath Research - September 11, 2022 Category: Respiratory Medicine Authors: Peize Zhang, Tantan Ren, Haibin Chen, Qingyun Li, Mengqi He, Yong Feng, Lei Wang, Ting Huang, Jing Yuan, Guofang Deng and Hongzhou Lu Source Type: research
Volatolomic urinary profile analysis for diagnosis of the early stage of lung cancer
In this study, urinary VOCs were analysed with a gas chromatography-ion mobility spectrometer (GC-IMS) and an electronic nose (e-nose) made by a matrix of twelve quartz microbalances complemented by a photoionization detector. This clinical prospective study involved 127 individuals, divided into two groups: 46 with lung cancer stage I –II–III confirmed by computerized tomography or positron emission tomography—imaging techniques and histology (biopsy), and 81 healthy controls. Both instruments provided a multivariate signal which, after being analysed by a machine learning algorithm, identified eight VOCs that could...
Source: Journal of Breath Research - September 1, 2022 Category: Respiratory Medicine Authors: Roberto Gasparri, Rosamaria Capuano, Alessandra Guaglio, Valentina Caminiti, Federico Canini, Alexandro Catini, Giulia Sedda, Roberto Paolesse, Corrado Di Natale and Lorenzo Spaggiari Source Type: research
Breath response following a nutritional challenge monitored by secondary electrospray ionization high-resolution mass spectrometry
On-line breath analysis using secondary electrospray ionization coupled to high-resolution mass spectrometry (SESI-HRMS) is a sensitive method for biomarker discovery. The strengths of this technology have already been demonstrated in the clinical environment. For the first time, this study demonstrates the application of SESI-HRMS in the field of nutritional science using a standardized nutritional intervention, consisting of a high-energy shake (950 kcal, 8% protein, 35% sugar and 57% fat). Eleven subjects underwent the intervention on three separate days and their exhaled breath was monitored up to six hours postprandia...
Source: Journal of Breath Research - August 25, 2022 Category: Respiratory Medicine Authors: Cedric W üthrich, Miguel de Figueiredo, Kathryn Jane Burton-Pimentel, Guy Vergères, Fabian Wahl, Renato Zenobi and Stamatios Giannoukos Source Type: research
