Repeatability of exhaled breath fingerprint collected by a modern sampling system in asthmatic and
healthy children
E-noses provide potential non-invasive metabolic biomarkers for diagnosing and monitoring pulmonary
diseases. The primary aim of the present study was to assess the within-day and between-day
repeatability of a modern breath sampling system (Pneumopipe ® plus an array of e-nose sensors) in
asthmatic and healthy children. The secondary aim was to compare the repeatability of the breath
sampling system, spirometry and exhaled nitric oxide (eNO). Fifteen children (age 6 –11 years) with
asthma and thirty healthy children matched by age and gender (1:2 allocation) were recruited; of
them, three healthy children did not...
Source: Journal of Breath Research - April 29, 2019 Category: Respiratory Medicine Authors: Salvatore Fasola, Giuliana Ferrante, Anna Sabatini, Marco Santonico, Alessandro Zompanti, Simone Grasso, Raffaele Antonelli Incalzi and Stefania La Grutta Source Type: research
A comparison of online and offline measurement of exhaled breath for diabetes pre-screening by
graphene-based sensor; from powder processing to clinical monitoring prototype
Several breath analysis studies have suggested a correlation between blood glucose (BG) levels and
breath acetone, indicating acetone as a primary biomarker in exhaled breath for diabetes diagnosis.
Herein, we have (i) fabricated and validated graphene-based chemi-resistive sensors for selective
and sensitive detection of acetone, (ii) performed offline breath analysis by a static gas sensing
set-up to acquire olfactory signals, and (iii) developed an LED-based portable on/off binary e-nose
system for pre-screening diabetes through online analysis. The fabricated sensors showed selective
detection for acetone with hi...
Source: Journal of Breath Research - April 29, 2019 Category: Respiratory Medicine Authors: Ramji Kalidoss and Snekhalatha Umapathy Source Type: research
cfDNA in exhaled breath condensate (EBC) and contamination by ambient air: toward volatile biopsies
This study examined whether EBC is an appropriate source of cfDNA using housekeeping-gene-specific
primer p... (Source: Journal of Breath Research)
Source: Journal of Breath Research - April 29, 2019 Category: Respiratory Medicine Authors: Altug Koc, Tuncay Goksel, Levent Pelit, Korcan Korba, Tugberk N Dizdas, Ertan Baysal, Umut C Uzun, Ozge Ozer Kaya, Berk Ozyilmaz, Yasar B Kutbay, Taha Resid Ozdemir, Ozgur Kirbiyik, Kadri M Erdogan, Merve Saka Guvenc, Gizem Calibasi Kocal and Yasemin Basb Source Type: research
Effect of H 2 O 2 induced oxidative stress (OS) on volatile organic compounds (VOCs) and
intracellular metabolism in MCF-7 breast cancer cells
In this study, an OS model of MCF-7 cells was
constructed through H 2 O 2 -treatment, which for the first time combined volatile organic compounds
(VOCs) and intracellular metabolic analysis for a comprehensive and in-depth study of the OS effect
on cell metabolism. The VOCs produced by cells in H 2 O 2 -treated groups and control groups were
extracted with solid-phase microextraction (SPME) and analyzed by gas chromatography-mass
spectrometer (GC-MS). Meanwhile, the intracellular metabolites were extracted by methanol and
analyzed by GC-MS coupled with silyl-derivatization. The results indicated 15 VOCs and 29
intr...
Source: Journal of Breath Research - April 22, 2019 Category: Respiratory Medicine Authors: Yuanling Liu, Wenwen Li and Yixiang Duan Source Type: research
The potential of breath analysis to improve outcome for patients with lung cancer
Lung cancer remains the most common cause of cancer related death in both the UK and USA.
Development of diagnostic approaches that have the ability to detect lung cancer early are a
research priority with potential to improve survival. Analysis of exhaled breath metabolites, or
volatile organic compounds (VOCs) is an area of considerable interest as it could fulfil such
requirements. Numerous studies have shown that VOC profiles are different in the breath of patients
with lung cancer compared to healthy individuals or those with non-malignant lung diseases. This
review provides a scientific and clinical assessment ...
Source: Journal of Breath Research - April 22, 2019 Category: Respiratory Medicine Authors: S X Antoniou, E Gaude, M Ruparel, M P van der Schee, S M Janes, R C Rintoul and on behalf of LuCID research group Source Type: research
