Mitochondrial dysfunction: a new molecular mechanism of intervertebral disc degeneration
ConclusionWe examine the molecular mechanisms of IVDD-associated mitochondrial dysfunction and present novel directions for quality management of mitochondrial dysfunction as a treatment approach to IVDD. (Source: Inflammation Research)
Source: Inflammation Research - November 5, 2023 Category: Research Source Type: research
STAT6 promoting oxalate crystal deposition-induced renal fibrosis by mediating macrophage-to-myofibroblast transition via inhibiting fatty acid oxidation
ConclusionsThese findings establish a role for STAT6 in kidney stone injury-induced renal fibrosis, and suggest that STAT6 may be a therapeutic target for progressive renal fibrosis in patients with nephrolithiasis. (Source: Inflammation Research)
Source: Inflammation Research - November 4, 2023 Category: Research Source Type: research
Activation of the CD200/CD200R1 axis attenuates neuroinflammation and improves postoperative cognitive dysfunction via the PI3K/Akt/NF- κB signaling pathway in aged mice
ConclusionsOur findings indicate that the activation of the CD200/CD200R1 axis reduces neuroinflammation, synaptic deficits, and cognitive impairment in the hippocampus of aged mice by regulating microglial M1/M2 polarization via the PI3K/Akt/NF- κB signaling pathway. (Source: Inflammation Research)
Source: Inflammation Research - October 30, 2023 Category: Research Source Type: research
Identification of novel N7-methylguanine-related gene signatures associated with ulcerative colitis and the association with biological therapy
ConclusionThe findings of this study demonstrate that five m7G-related DEGs, including the m7G-modified recognition protein QKI, play a key role in the occurrence and progression of UC intestinal inflammation, which is closely related to intestinal immunity. These results provide valuable insights into the mechanisms of m7G modification in UC development and offer new perspectives for exploring novel therapeutic targets for UC. (Source: Inflammation Research)
Source: Inflammation Research - October 27, 2023 Category: Research Source Type: research
Treg plasticity and human diseases
ConclusionsTreg plasticity is associated with inflammatory diseases and cancers. Regulating Treg plasticity is a promising direction for the treatment of inflammatory diseases and cancers. (Source: Inflammation Research)
Source: Inflammation Research - October 25, 2023 Category: Research Source Type: research
Application of omics in Sj ögren’s syndrome
ConclusionAt present, omics research has made some gratifying achievements, but there are still many uncertainties. Therefore, in the future, we should improve research techniques, standardize the collection of samples, and adopt a combination of multi-omics techniques to jointly study the pathogenesis of SS and provide new schemes for its treatment. (Source: Inflammation Research)
Source: Inflammation Research - October 25, 2023 Category: Research Source Type: research
Epigenetic regulation of 15-lipoxygenase-1 expression in human chondrocytes by promoter methylation
ConclusionThe expression level of 15-LOX-1 was elevated in OA cartilage, which may be part of a repair process. The upregulation of 15-LOX-1 in OA cartilage was not associated with the methylation status of its promoter, suggesting that other mechanisms are involved in its upregulation. (Source: Inflammation Research)
Source: Inflammation Research - October 24, 2023 Category: Research Source Type: research
A suitable model to investigate acute neurological consequences of coronavirus infection
ConclusionsIn conclusion, the data presented emulate many aspects of the acute neurological outcomes seen in patients with COVID-19. Therefore, this model may provide a preclinical platform to study acute neurological sequelae induced by coronavirus infection and test possible therapies. (Source: Inflammation Research)
Source: Inflammation Research - October 14, 2023 Category: Research Source Type: research
Ångstrom-scale silver particles ameliorate collagen-induced and K/BxN-transfer arthritis in mice via the suppression of inflammation and osteoclastogenesis
ConclusionsF-Ag ÅPs can effectively alleviate arthritis without notable toxicities and their anti-arthritic effects are associated with the inhibition of inflammation, osteoclastogenesis, synoviocytes migration, and MMPs production. Our study suggests the prospect of F-AgÅPs as an efficient and low-toxicity agent for arthritis therapy. (Source: Inflammation Research)
Source: Inflammation Research - October 10, 2023 Category: Research Source Type: research
Role of histamine H4 receptor in the anti-inflammatory pathway of glucocorticoid-induced leucin zipper (GILZ) in a model of lung fibrosis
ConclusionIn conclusion, the role of H4R and GILZ in relation to glucocorticoids could pave the way for innovative therapies to counteract pulmonary fibrosis. (Source: Inflammation Research)
Source: Inflammation Research - October 10, 2023 Category: Research Source Type: research
Targeting MyD88: Therapeutic mechanisms and potential applications of the specific inhibitor ST2825
ConclusionTargeting MyD88 is a novel therapeutic strategy, and scientific research is presently focused on the development of MyD88 inhibitors. The peptidomimetic compound ST2825 is a widely studied small-molecule inhibitor of MyD88. Thus, ST2825 may be a potential therapeutic small-molecule agent for modulating host immune regulation in inflammatory diseases and inflammatory therapy. (Source: Inflammation Research)
Source: Inflammation Research - October 9, 2023 Category: Research Source Type: research
Recombinant human diamine oxidase prevents hemodynamic effects of continuous histamine infusion in guinea pigs
ConclusionsProphylactic infusion of rhDAO_mHBM prevents hemodynamic effects in a guinea pig model of continuous histamine infusion. These findings might help in the translation from animals to humans and in the selection of the optimal dosing of rhDAO_mHBM during human histamine challenge studies. (Source: Inflammation Research)
Source: Inflammation Research - October 9, 2023 Category: Research Source Type: research
Fraxetin alleviates BLM-induced idiopathic pulmonary fibrosis by inhibiting NCOA4-mediated epithelial cell ferroptosis
ConclusionFraxetin treatment significantly alleviated BLM-induced lung inflammation and fibrosis. Our findings imply that fraxetin possesses inhibitory roles in ferroptosis and can be a potential drug against IPF. (Source: Inflammation Research)
Source: Inflammation Research - October 5, 2023 Category: Research Source Type: research
SGLT2 inhibitors prevent LPS-induced M1 macrophage polarization and alleviate inflammatory bowel disease by downregulating NHE1 expression
ConclusionsNHE1 promotes M1 macrophage polarization and SGLT2 inhibitors are a novel strategy to treat M1 macrophage-mediated inflammatory diseases, including IBD. (Source: Inflammation Research)
Source: Inflammation Research - September 28, 2023 Category: Research Source Type: research
Advances of autoimmune rheumatic diseases related to malignant tumors
This article presents a literature review of published original articles and review articles concerning paraneoplastic rheumatic syndromes and rheumatic diseases associated with cancer treatment. We conducted a comprehensive literature search in PubMed, Web of Science and Google Scholar databases, excluding duplicated and irrelevant studies. In cases of duplicated research, we selected articles with higher impact factors for the review.ResultsThis review focuses on the clinical features, diagnosis, and treatment of paraneoplastic rheumatic diseases, as well as the pathogenesis of these diseases. Additionally, we summarize ...
Source: Inflammation Research - September 28, 2023 Category: Research Source Type: research
